Brain Tumors Clinical Practice Guidelines (2025)
Updated guidelines on therapy of adult diffuse astrocytic and oligodendroglial tumors were published in April 2025 by the American Society of Clinical Oncology and the Society for Neuro-Oncology in the Journal of Clinical Oncology .[1]
In patients with oligodendroglioma that is IDH -mutant, 1p19q co-deleted, central nervous system (CNS) World Health Organization (WHO) grade 2, offer radiation in combination with procarbazine, lomustine (CCNU), and vincristine (PCV). If toxicity is a concern, temozolomide is a reasonable alternative to PCV.
Consider offering vorasidenib to patients who have oligodendroglioma that is IDH -mutant, 1p19q codeleted, CNS WHO grade 2; who have undergone one or more surgeries; and in whom further treatment with radiation and chemotherapy has been or can be deferred.
In astrocytoma that is IDH -mutant, 1p19q non-codeleted, CNS WHO grade 2, initial radiation therapy and chemotherapy (with temozolomide or PCV) may be deferred until radiographic or symptomatic progression in some patients with favorable prognostic factors (eg, complete resection, younger age) or concerns about short- and long-term toxicity.
Consider offering vorasidenib in patients who have astrocytoma that is IDH -mutant, 1p19q non-codeleted, CNS WHO grade 2; who have undergone one or more surgeries; and in whom further treatment with radiation and chemotherapy has been or can be deferred.
For more information, please go to Brain Neoplasms.
Hashtags
Try Our AI Features
Explore what Daily8 AI can do for you:
Comments
No comments yet...
Related Articles
Associated Press
24 minutes ago
- Associated Press
Darren Waller Returns to NFL With the Dolphins - Brings Addiction Recovery Mission With Him
Eight years into sobriety, Darren Waller returns to the NFL not to reclaim the spotlight, but to deepen his purpose - sharing a journey of resilience, service and healing, with a mission to make recovery more visible, more human and truly accessible to all. MIAMI, FLORIDA / ACCESS Newswire / July 3, 2025 / Pro Bowl tight end Darren Waller is returning to the NFL, signing with the Miami Dolphins in what fans are calling one of the most exciting comebacks in recent years. But for Waller, this return isn't just about football - it's about purpose, recovery, and service to something greater than Waller X Anywhere Clinic Darren Waller teams up with Anywhere Clinic to help tackle the opioid pandemic with national addiction recovery services and telepsychiatry. 'I've been in my growth journey since rehab,' says Waller, who nearly lost his life to a fentanyl overdose eight years ago. 'Recovery isn't just about abstaining. It's about rediscovering who you really are. Right now, my mission is to serve the Miami Dolphins and the surrounding community. I'm here to play, to lead, and to give. The goal is to spread hope and healing. And we all deserve a shot at that.' Waller's return is part of a larger movement - one that includes a nationwide mental health partnership with Anywhere Clinic, a telepsychiatry and mental wellness organization working to tackle the opioid epidemic. 'We're not just treating addiction. We're helping people remember who they really are,' says Dr. Sam Zand, psychiatrist and founder of Anywhere Clinic. 'In a world that overwhelms the nervous system, numbs the spirit, and rewards disconnection, recovery isn't just about sobriety; it's about coming home to yourself.' With over 100 compassionate clinicians, AI-guided support tools, group therapy, coaching, and psychiatric care covered by most insurance plans, including Medicaid and Medicare, Anywhere Clinic meets people where they are. For those without coverage, low-cost self-pay options and scholarship-based services ensure no one is left behind. 'Whether you're struggling with opioids, anxiety, digital burnout or simply feeling lost, we believe everyone deserves access to healing. And we walk that path together.' Together, Waller and Dr. Zand have quietly been hosting free recovery support groups for nearly two years, helping people navigate addiction, trauma, identity, and emotional healing. Now, they're expanding their work with a bold mission: making mental health care radically accessible, especially for those struggling with opioid addiction and other compulsive behaviors like gambling, tech addiction, emotional eating, pornography, and overspending. Darren has been working with Anywhere Clinic for over five years, receiving consistent virtual care through every chapter of his recovery. That continuity helped him realize addiction isn't just about substances - it's often rooted in unprocessed trauma, buried emotions, and a loss of self-worth. Through a blend of holistic care and evidence-based psychiatry, Anywhere Clinic is reshaping what recovery looks like: grounded, connected, and built for lasting transformation. Waller's new team is fully behind the mission. Head Coach Mike McDaniel, who has publicly shared his own recovery journey, understands the power of turning pain into purpose and recognizes the leadership Darren brings on and off the field. From the field to the studio to the recovery circle, Waller's impact is growing. His music reflects his story. His journey reflects his strength. And his presence reminds us all that no matter how far gone we feel, healing is possible. 'The world is hurting, but we're not alone. The comeback isn't just about the game. This is bigger than ball,' Waller says. 'It's a call to those still in the dark. We can be that light. I'm not just here to play. I'm here to remind people that healing is possible, purpose is real, and inner peace requires both patience and persistence.' For Support or More Information: If you or your community is in need of addiction recovery or mental health support, visit Anywhere Clinic is a national holistic mental health program leveraging virtual psychiatric care to create lasting transformation. Media Inquiries: [email protected] (805) 590-8099 @drsamzand @rackkwall @ Contact InformationNick Schwarz Marketing Manager 805-590-8099 SOURCE: Anywhere Clinic press release
Medscape
an hour ago
- Medscape
MRI May Aid Early Pancreatic Cancer Detection in Diabetes
TOPLINE: MRI-based screening in patients older than 50 years with new-onset or deteriorating diabetes detected stage IB pancreatic cancer in a patient with deteriorating diabetes, highlighting the need for targeted screening in this high-risk population. METHODOLOGY: New-onset diabetes in patients older than 50 years was found to increase the risk for pancreatic cancer by six- to eight-fold, and recent evidence suggests that the deterioration of diabetes in individuals with stable, long-standing disease may also be an indicator of subclinical pancreatic cancer. Researchers conducted the PANDOME study to evaluate the effectiveness and safety of MRI-based screening for the early detection of pancreatic cancer in patients with new-onset diabetes (n = 97; median age, 61 years; 63.9% women) or deteriorating diabetes (n = 12; median age, 68 years; 58.3% women). New-onset diabetes was defined as elevated A1c levels within the past 12 months, whereas deteriorating diabetes was defined as long-standing diabetes (> 2 years) with a > 2% increase in A1c levels over the past 6 months not linked to weight gain or diabetes medication noncompliance. All patients underwent MRI/cholangiopancreatography, blood biobanking, and anxiety/depression monitoring; MRI results were scored as normal, benign-abnormal, suspicious, or incidental findings. TAKEAWAY: Compared with patients with new-onset diabetes, those with deteriorating diabetes had significantly higher A1c levels (P = .02), greater weight loss (P = .0038), and increased insulin requirements (P < .0001). Among 109 participants, more than 50% had small cystic lesions with an average size of 6 mm, prompting seven endoscopic ultrasound procedures — four of which required biopsies. Of the four pancreatic biopsies performed, one revealed stage IB pancreatic ductal adenocarcinoma in a patient with deteriorating diabetes. Extra-pancreatic incidental findings were detected in 8.2% of cases, with two requiring biopsies, revealing one new diagnosis of follicular lymphoma and one diagnosis of recurrent lymphoma. According to the Enriching New-Onset Diabetes for Pancreatic Cancer score — where a high-risk score predicts a 3.6% probability of pancreatic cancer within 3 years — the deteriorating diabetes group had a higher proportion of high-risk individuals than the new-onset diabetes group (75% vs 35.6%). IN PRACTICE: 'Preliminary results from the PANDOME study support further MRI-based PC [pancreatic cancer] screening research efforts in individuals with NOD [new-onset diabetes] and DD [deteriorating diabetes],' the authors concluded. SOURCE: This study was led by Richard Frank, MD, Division of Hematology/Oncology, Nuvance Health, Norwalk, Connecticut. It was published online in The Journal of Clinical Endocrinology & Metabolism. LIMITATIONS: T his study faced challenges with low accrual rates due to healthcare network realignments and high declination rates by potential participants. Selection bias potentially led to lower detection rates, as most participants were referred by primary care physicians or endocrinologists. Moreover, the majority of participants were White individuals (83%), despite higher pancreatic cancer risk among Black populations, limiting generalizability. DISCLOSURES: This study received support from a Tribute to Pamela/The Naughton Family Fund, the Rallye for Pancreatic Cancer, Pacific Crest Trail for Pancreatic Cancer, and the Glenn W. Bailey Foundation. The authors declared no conflicts of interest. This article was created using several editorial tools, including AI, as part of the process. Human editors reviewed this content before publication.
Wall Street Journal
an hour ago
- Wall Street Journal
The Sky-High Cyber Risk in Healthcare: WSJ Readers Weigh In
Cybersecurity in healthcare is a big problem. So far this year, the U.S. Department of Health and Human Services is investigating 307 new breaches. With six months to go in 2025, the sector is on pace to top the 385 breach cases HHS opened during all of 2024.
