logo
Repare Therapeutics Jumps 15% After $10M Licensing Deal With Debiopharm

Repare Therapeutics Jumps 15% After $10M Licensing Deal With Debiopharm

Yahoo17-07-2025
Repare Therapeutics (RPTX, Financials) shares surged 15% Tuesday after the company announced a global licensing agreement with Switzerland-based Debiopharm to develop its PKMYT1 inhibitor, lunresertib a drug targeting hard-to-treat solid tumors.
Warning! GuruFocus has detected 5 Warning Signs with RPTX.
Under the deal, Repare will receive $10 million upfront and could earn up to $257 million in milestone payments, including $5 million in near-term payouts. The company is also entitled to single-digit royalties on future global sales of lunresertib.
Debiopharm will now take over the MYTHIC study and lead all development efforts for the drug, which had previously been tested in combination with Debiopharm's own WEE1 inhibitor, Debio 0123.
This deal ensures lunresertib continues development without draining internal resources, said Repare CEO Steve Forte, who also serves as president and CFO. Forte added that the drug has shown "encouraging results" in early trials.
Following the deal, Repare plans to concentrate on two internal programs:
RP-1664, a PLK4 inhibitor under study in the LIONS trial
RP-3467, a Pol? ATPase inhibitor being tested in the POLAR trial
The company expects data readouts from both studies in H2 2025.
Debiopharm CEO Bertrand Ducrey called the combination of lunresertib and Debio 0123 highly synergistic and potentially capable of producing rapid and deep tumor regressions.
This article first appeared on GuruFocus.
擷取數據時發生錯誤
登入存取你的投資組合
擷取數據時發生錯誤
擷取數據時發生錯誤
擷取數據時發生錯誤
擷取數據時發生錯誤
Orange background

Try Our AI Features

Explore what Daily8 AI can do for you:

Comments

No comments yet...

Related Articles

This More Than 4%-Yielding Stock's Smart Strategy Continues to Pay Big Dividends
This More Than 4%-Yielding Stock's Smart Strategy Continues to Pay Big Dividends

Yahoo

time20 minutes ago

  • Yahoo

This More Than 4%-Yielding Stock's Smart Strategy Continues to Pay Big Dividends

Key Points Brookfield Infrastructure reported solid second-quarter results. The company made excellent progress on its capital recycling strategy. That smart strategy positions it to deliver strong growth in the coming years. 10 stocks we like better than Brookfield Infrastructure › Brookfield Infrastructure (NYSE: BIPC)(NYSE: BIP) has a straightforward investment strategy. The global infrastructure operator acquires high-quality assets on a value basis, enhances their operations, and, eventually, sells the mature business. The company then recycles that capital into new investments with higher returns. This strategy has driven healthy growth in its funds from operations (FFO) and its high-yielding dividend. The payout, which yields over 4%, has grown at a 9% compound annual rate over the past 16 years. The company's wise strategy was on full display during the second quarter. It puts Brookfield in an excellent position to continue increasing its high-yielding dividend, making it an appealing option for those seeking passive dividend income. Where to invest $1,000 right now? Our analyst team just revealed what they believe are the 10 best stocks to buy right now. Learn More » Image source: Getty Images. Another solid showing Brookfield Infrastructure generated $638 million of FFO during the second quarter. This is a 5% increase from the prior year. The company benefited from strong organic growth and recently closed acquisitions. Organic growth drivers included inflation-linked rate increases in its utilities and transport sector. It also received contributions from over $1.5 billion in capital project completions, primarily new data centers. These growth catalysts helped mitigate the impact of foreign exchange rate fluctuations and asset sales associated with its capital recycling initiatives. The company's data segment provided the largest quarterly boost. FFO jumped 45% to $113 million. Brookfield benefited from its acquisition of a tower portfolio in India, which closed last year. It also commissioned several new data centers. Brookfield's midstream sector also delivered a strong quarter. FFO rose 10% to $157 million. The company's diversified midstream operations in Canada were standout performers thanks to high customer activity. This helped offset the sale of its U.S. gas pipeline in the second quarter. The robust growth from these two segments offset relatively flat results from the company's transportation and utilities businesses. Solid organic growth from rate increases and capital project completions muted the impact of asset sales and foreign exchange fluctuations in those businesses. Ready for the next wave Brookfield Infrastructure has been busy executing its capital recycling strategy this year. The company has already secured $2.4 billion in proceeds from nine asset sales. "This would be a good result in any given year, and we are only in July," the company noted in the second-quarter earnings press release. It secured four sales in the second quarter. Brookfield sold a 23% interest in its Australian export terminal, a 60% stake in a 244-megawatt portfolio of European data centers, a 33% interest in a portfolio of fully contracted shipping containers, and a partial interest in its U.K. ports operation. The company is selling these assets at very attractive values. The infrastructure operator will deploy this capital in new, higher-returning investment opportunities. Brookfield has secured three new investments to enhance its data, transport, and midstream sectors: Hotwire: Brookfield is investing $500 million into Hotwire, a leading bulk fiber-to-the-home service company. This business generates stable and steadily rising cash flow backed by long-term, take-or-pay, and inflation-linked contracts. Hotwire currently has over 300,000 billing customers and a significant contracted backlog. Railcar leasing platform: Brookfield is investing $300 million into a leading railcar leasing platform through a joint venture with GATX. The portfolio is the second-largest railcar leasing platform in North America, with over 125,000 railcars that generate very stable cash flow. Colonial Enterprises: The company is investing $500 million into the acquisition of Colonial, the largest refined products pipeline system in the country. It's paying an attractive value for an asset that generates very stable cash flows. Brookfield expects even more deals ahead. The company has several additional asset sales in advanced stages that could close in the coming months. These deals will provide more capital to recycle into new investment opportunities, which should be plentiful. In its earnings release, the company wrote, "We also continue to advance a large and diversified array of new investment opportunities that continues to grow and is driven by the digitalization, decarbonization, and deglobalization megatrends impacting our entire investable universe." The company believes that its organic growth and capital recycling strategy will drive annual FFO per share growth of over 10% in the long term. That supports its plan to increase its high-yielding dividend by 5% to 9% per year. Brookfield's brilliant growth strategy continues to pay big dividends Brookfield's approach of selling mature assets to reinvest in higher-return opportunities continues to drive growth. While the asset sales side of this strategy was a minor headwind in the second quarter, it should become a tailwind as the company closes its recently secured new investments. This strategy should also continue boosting its results in the future as Brookfield secures additional sales and new investments. Combined with healthy organic growth drivers, Brookfield should have plenty of power to continue increasing its high-yielding dividend going forward. Should you invest $1,000 in Brookfield Infrastructure right now? Before you buy stock in Brookfield Infrastructure, consider this: The Motley Fool Stock Advisor analyst team just identified what they believe are the for investors to buy now… and Brookfield Infrastructure wasn't one of them. The 10 stocks that made the cut could produce monster returns in the coming years. Consider when Netflix made this list on December 17, 2004... if you invested $1,000 at the time of our recommendation, you'd have $625,254!* Or when Nvidia made this list on April 15, 2005... if you invested $1,000 at the time of our recommendation, you'd have $1,090,257!* Now, it's worth noting Stock Advisor's total average return is 1,036% — a market-crushing outperformance compared to 181% for the S&P 500. Don't miss out on the latest top 10 list, available when you join Stock Advisor. See the 10 stocks » *Stock Advisor returns as of July 29, 2025 Matt DiLallo has positions in Brookfield Infrastructure and Brookfield Infrastructure Partners. The Motley Fool recommends Brookfield Infrastructure Partners. The Motley Fool has a disclosure policy.

Tell Your Story and Share Your Strategies with the $49 Youbooks Tool
Tell Your Story and Share Your Strategies with the $49 Youbooks Tool

Entrepreneur

time43 minutes ago

  • Entrepreneur

Tell Your Story and Share Your Strategies with the $49 Youbooks Tool

Use AI to craft full-length non-fiction books that can help build your brand. Disclosure: Our goal is to feature products and services that we think you'll find interesting and useful. If you purchase them, Entrepreneur may get a small share of the revenue from the sale from our commerce partners. If you've ever thought, I should write a book about this, but then remembered you're also running a business, managing clients, and keeping 47 tabs open just to stay afloat—well, same. That's why Youbooks is a stunning tool. And right now, you can use it for life for just $49. This AI-powered non-fiction book generator was made for entrepreneurs, founders, coaches, consultants, and all-around busy people with a lot of know-how and no time to type it out. For less than one dinner out, you get lifetime access to a powerhouse writing platform that collaborates with multiple top-tier AI models (ChatGPT, Claude, Gemini, Llama—you name it). That means smarter content, sharper structure, and zero writer's block. Youbooks doesn't just spit out fluff—it builds full-on manuscripts up to 300,000 words, and it pulls in real-time research from the web to back up your ideas with facts, stats, and sources. Want your voice to shine through? Upload writing samples or internal documents so your final product reads like you—not like a robot. Whether you're turning a coaching framework into a course companion, expanding a podcast series into a book, or publishing an industry guide to establish yourself as the expert in your niche, Youbooks makes it all possible—with full commercial rights to your content. Plus, every month, you get 150,000 credits to generate new books, upload your sources, and keep the content flowing. No upsells. No subscriptions. No ghostwriters ghosting you. Just you, your ideas, and a very smart machine helping you bring them to life. Your story is worth telling. Now it's easier—and way cheaper—than ever to tell it. Get lifetime access to Youbooks for just $49 (MSRP: $540) for a limited time. Youbooks – AI Non-Fiction Book Generator: Lifetime Subscription See Deal StackSocial prices subject to change.

Solana's SOL Vs. Ripple's XRP: Which Crypto Is Better For Long-Term Investors?
Solana's SOL Vs. Ripple's XRP: Which Crypto Is Better For Long-Term Investors?

Forbes

time44 minutes ago

  • Forbes

Solana's SOL Vs. Ripple's XRP: Which Crypto Is Better For Long-Term Investors?

Solana's SOL and Ripple's XRP are very popular digital tokens. Both of these tokens have drawn the interest of investors around the world, and they have managed to become some of the most valuable digital assets by total market capitalization. Investors might consider putting their money into one, or both, of these cryptocurrencies, so this guide can help provide them with information they need to make well-informed decisions. Overview Of Solana's SOL And Ripple's XRP SOL is the native digital asset of Solana, a high-performance blockchain platform that developers can use to create apps. The platform is capable of handling impressive amounts of transactions, so interested parties can build all kinds of software programs on it. Solana has a unique proof-of-stake (POS) consensus mechanism that uses an innovation called proof-of-history (POH), which helps enable significant transaction volume. Another major draw of Solana is its low transaction fees. At the time of this writing, Solana's median fee per transaction was $0.00064, which was far lower than Ethereum's median fee of roughly $0.51. XRP is the native digital asset of a blockchain called the XRP ledger, which can settle transactions in a time frame of three to five seconds. XRP can function as a bridge currency, meaning that it can be used to exchange one fiat currency for another without relying on a centralized intermediary like a financial institution or bank. Ripple has generated significant visibility over the years, and its digital asset, XRP, has repeatedly ranked as one of the most valuable digital currencies by total market capitalization, according to CoinMarketCap. One major draw of XRP is its low transaction fees; the token can settle transactions for $0.0002 each. Understanding The Technology Behind SOL And XRP Solana uses a POS consensus mechanism that relies on POH, in which the system provides each individual block with a timestamp. This unique innovation has provided the Solana network with high bandwidth and very low transaction costs. The platform processes thousands of transactions per second. Ripple relies on a blockchain called the XRP Ledger, which records all transactions involving XRP. The ledger has its own unique consensus mechanism called the XRP Ledger Consensus Protocol, which is capable of approving transactions even if some participants do not act appropriately. Solana can process thousands of transactions per second, due to its unique POS consensus mechanism that relies on POH. At the time of this writing, the network was processing roughly 3,750 transactions per second, according to the Solana homepage. Ripple, on the other hand, can process 1,500 transactions per second. Both Solana and Ripple use smart contracts, although they are used for different purposes. Solana is a platform for decentralized applications or dApps, and its smart contracts are called 'programs.' Users can harness these contracts by executing transactions that contain instructions telling them what to do. Ripple smart contracts are different in that they allow participants to make transactions without a centralized intermediary. Ripple smart contracts work by holding funds in conditionally held escrows. Once the needed conditions are met, the escrows release the relevant funds. Asset Adoption There is more than one way of measuring a digital asset's adoption, with one of those being transaction volume. As mentioned, the Solana network can process roughly 3,750 transactions per second. Figures for XRP transactions on the Ripple network came with a monthly cadence, and the network processed more than 10 billion XRP transactions every month between July 2024 and July 2027, according to XRPSCAN figures from The Block. If one wants to evaluate SOL and XRP as speculative assets, they can look at the total market capitalization of these digital currencies. At the time of this writing, XRP was the third-largest cryptocurrency by total market capitalization, according to CoinMarketCap. Solana's SOL was the sixth-largest by this particular measure. Market Performance And Future Outlook The XRP token has gone from being worth $0.01 in late 2013 to roughly $3.21 at the time of this writing, according to CoinMarketCap. This represents an increase of roughly 32,000%. There are many predictions involving the XRP cryptocurrency. One such prediction, which appeared on the Binance website, indicated that the digital token would be worth close to $4 by 2030. The page displaying this prediction stated that the exact figures contained were formulated based on the input of verified Binance users and third parties. The SOL token has also displayed some very impressive returns over the years, going from roughly $0.66 in April 2020 to approximately $187.00 at the time of this writing, according to CoinMarketCap. This represented a gain of more than 28,000%. Some analysts have predicted that under certain conditions, the SOL token could surpass $1,000 by 2030, according to a Benzinga article. More specifically, this price forecast is based on Solana's ability to scale successfully while avoiding security issues. However, other market observers are less bullish, voicing their concerns about Solana's repeated network failures and competition from rival platforms like Ethereum. Regulatory Challenges And Risks The regulatory environment is still far from mature, and this creates uncertainty for both SOL and XRP. In July 2025, the crypto community lauded the approval of the Guiding and Establishing National Innovation for U.S. Stablecoins Act (GENIUS Act), the first piece of federal legislation specifically written for cryptocurrencies. However, policymakers have a long way to go, as U.S. lawmakers were considering both the CLARITY Act and the Anti-CBDC Surveillance State Act at the time of this writing. As of now, the extent to which the U.S. Securities and Exchange Commission (SEC) and Commodity Futures Trading Commission (CFTC) have jurisdiction over digital currencies has not been clarified. More specifically, the CFTC has asserted that it has jurisdiction over virtual currencies under the Commodity Exchange Act, a claim that has been upheld in federal court. However, the SEC has previously taken action against those involved with certain digital currencies. The CLARITY Act is meant to shed some light on exactly where the jurisdiction of these two government agencies lies. In 2023, the SEC filed a lawsuit against Coinbase and in which it claimed that SOL was an unregistered security, according to CoinDesk. The Solana Foundation, a nonprofit whose website describes it as being 'dedicated to the decentralization, adoption, and security of the Solana ecosystem,' disagreed with this assertion, claiming that SOL is not a security. The regulatory status of XRP is complicated. In 2023, a federal judge ruled that Ripple's sales of XRP to institutions did in fact represent sales of unregistered securities. However, the same judge decided that Ripple's sales of XRP through exchanges did not represent sales of securities. At the time, the judge fined Ripple $125 million, according to CoinDesk. While Ripple had previously stated that it planned to appeal, CEO Brad Garlinghouse stated in June 2025 that 'Ripple is dropping our cross appeal, and the SEC is expected to drop their appeal, as they've previously said.' This should leave the current ruling, along with the $125 million fine, in place. Real-World Use Cases XRP is meant to provide liquidity for those looking to send money from one place to another. A good use case for these is remittances, where an individual might send money to their relatives overseas. By using XRP, a user can make a cross-border payment that will settle quite quickly. The XRP token can also be used as a bridge currency, making it so that parties can make a transaction using two different fiat currencies without going through a centralized intermediary like a financial institution. The XRP token is also used to pay for transactions that take place on the XRP ledger. SOL has many use cases. For starters, it is the native digital asset of the Solana network, and as a result, users harness it to pay the network's transaction fees. Some of these rewards then go to validators. Another use case of SOL is staking. Users can stake their SOL in order to contribute to the security of the network and also earn rewards by doing so. Past that, holders of SOL can use the token to vote on potential network upgrades. Investment Potential Both SOL and XRP have experienced some very impressive upside during their lifetimes. Past that, analysts have made some very bullish predictions about how much the two digital tokens could appreciate. As stated earlier in this article, one prediction contained on the Binance website indicated that XRP could be worth over $4 by 2030. A separate panel of experts, whose input was featured in a Benzinga article, stated that XRP could reach $5.81 this year. Analysts have also supplied bullish predictions for SOL, with market observers stating in a Binance article that it could surpass $180 this year and $230 by 2030. Which Is Better For Long-Term Investors? Investors should keep in mind that both XRP and SOL are speculative assets. They are not like stocks, which represent ownership rights in companies that generate revenue and earnings. They also don't make regular interest payments like many bonds. In other words, interested parties cannot perform fundamental analysis on XRP and SOL the same way they would analyze shares of stock (or bonds). Nobody knows what the future will hold. However, investors may want to keep in mind that SOL is the native digital asset of the Solana blockchain, which has benefited from significant activity over the years. In 2024, more than 80% of decentralized exchange (DEX) transactions took place on the Solana network, according to a Helius report. Further, during the first five months of this year, close to $900 billion' worth of DEX trading volume took place on this network. Ripple, on the other hand, has been relevant for over a decade. Ripple first came into existence in 2012, and its native token has therefore been around longer than Solana's SOL, as Solana first became available to the public in 2020. Ripple's XRP also benefits from a robust community, which has some very enthusiastic supporters. The engagement this token receives on platforms like X (formerly Twitter) is a testament to how much support it has. Bottom Line Investors considering XRP and SOL need to remember that while these two have both generated significant visibility and some very compelling gains over the years, they are both speculative assets that do not produce income, revenue or earnings. Risk is inherent to investment, and it is difficult to reliably predict how these digital assets will perform in the future. At the same time, investors should remember that if the entire crypto space continues to draw investment and rise in value, SOL and XRP could both continue to appreciate. Frequently Asked Questions (FAQs) Which Has A Higher ChanceOof Mass Adoption, SOL or XRP? Nobody knows for certain what the future will hold. However, if the future mirrors what has happened in the past, Solana's SOL has a better chance of obtaining mass adoption, considering how much traction it has generated during its relatively brief lifespan. Is SOLOor XRP Better For Short-term Trading? Short-term cryptocurrency trading is highly risky and subject to market manipulation, and it would be difficult to name one of these digital assets as better for this particular purpose. Any investors who are considering such activity should perform thorough due diligence. What Are The Biggest Risks For Investing In SOL? SOL is a purely speculative asset, and its price is driven by factors like hype and sentiment. Many have described Solana as an 'Ethereum killer,' and its native token SOL could potentially fall in value if competitor platforms rise in popularity. What Are The Biggest Risks For investing In XRP? XRP is a purely speculative asset, and its price fluctuations are driven by hope and sentiment. The XRP token has generated significant visibility as the native token of the XRP Ledger, and if one or more competitors take the market position of this blockchain, it could cause the XRP token to lose favor and fall in value. Is It A Good Idea To Hold Both SOL and XRP? While diversification, or not putting all your eggs in one basket, is always a good idea, there are many ways to establish a diverse portfolio of digital assets without owning both SOL and XRP. There are thousands of digital assets available, and if investors are considering any of them, they can benefit from conducting thorough due diligence.

DOWNLOAD THE APP

Get Started Now: Download the App

Ready to dive into a world of global content with local flavor? Download Daily8 app today from your preferred app store and start exploring.
app-storeplay-store