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EXCLUSIVE Breakthrough British prostate cancer test could avoid need for biopsies in 80pc of men

EXCLUSIVE Breakthrough British prostate cancer test could avoid need for biopsies in 80pc of men

Daily Mail​19 hours ago

A British-made prostate cancer test could avoid the need for biopsies in four out of five cases, according to a study.
The EpiSwitch PSE next generation blood test uses advances in technology to identify prostate cancer, the most common form of the disease among men in the UK.
The test, made by Oxford BioDynamics, has an accuracy of 94 per cent in identifying prostate cancer, a dramatic leap compared with the standard test along, which is reckoned to be correct in only around half of cases.
Crucially, a peer-reviewed study due to be published in the Cancers medical journal, accepts the findings that up to 80 per cent of patients could potentially avoid unnecessary prostate biopsies - an often invasive procedue considered one of the biggest stumbling blocks in men going to get tested in the first place.
The study concludes: 'Across models, up to 79.1 per cent of patients could safely defer biopsy based on PSE results, highlighting the test's potential to reduce invasive procedures without compromising diagnostic safety.'
Dr Alexandre Akoulitchev, chief scientific officer at Oxford BioDynamics, said: 'This study builds on our earlier robust clinical validation work which demonstrated the application of EpiSwitch PSE as a precise, minimally invasive test that empowers clinicians and patients with clarity, reduced patient risk, and improved outcomes, while easing the pressure on the diagnostic pathway.'
The paper said the innovation could effectively save the NHS significant amounts of money by reducing the amount of men sent for biopsies and MRI scans, reducing pressure on the service.
The study reckoned this translated to a saving of almost £1,000 per patient.
Oliver Kemp, chief executive of UK charity Prostate Cancer Research (PCR), said: 'This study shows how smarter testing can save millions while improving care for patients.
'Reducing unnecessary biopsies and scans means less stress for men and more capacity in the system.'
Oxford BioDynamics worked with leading researchers and clinicians at the Imperial NHS Trust, Imperial College London, and the University of East Anglia to produce EpiSwitch.
It is used following a PSA test - meaning prostate-specific antigen, identifying whether the protein levels produced by the gland are raised - and measures five markers to identify the likelihood of cancer being present.
The firm's headquarters were visited by former Prime Minister Rishi Sunak in February this year, as he backed calls for a targeted national screening programme for men most at risk of prostate cancer.
In government, Mr Sunak announced with charity PCR a £42 million screening trial to find ways of detecting prostate cancer earlier.
But it is hoped a national screening programme would be the most effective way to prevent unnecessary deaths.
The Mail has long campaigned for a national roll-out, a cause backed by the likes of Sir Stephen Fry, a former prostate cancer patient.
The UK national screening committee has come under increasing pressure to reconsider testing policy following the news last year of Sir Chris Hoy's diagnosis with the terminal illness.
Prostate cancer most frequently affects black men and those with a family history. It is often symptomless, meaning early detection is crucial in stopping the disease's spread.
Earlier this week, newscaster Dermot Murnaghan revealed he is battling stage-four prostate cancer.

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Beastly Britain by Karen R Jones review – how animals shaped British identity
Beastly Britain by Karen R Jones review – how animals shaped British identity

The Guardian

time18 minutes ago

  • The Guardian

Beastly Britain by Karen R Jones review – how animals shaped British identity

When newts go a-wooing, sometime in the spring, their signature move is the handstand. Girl newts cluster round to watch, while the boy newts flip on to their creepily human hands and shake their tails in the air. The waggiest newt is the winner, although the actual act of love is a strictly no-contact sport. The male deposits a packet of sperm on an underwater leaf for the female to collect and insert into her own reproductive tract. The whole business is best thought of, says Karen R Jones, as a 'sexually charged game of pass-the-parcel'. This kind of anthropomorphising often strikes naturalists as unscientific or even downright distasteful. But Jones is an environmental historian and her methodology allows, indeed impels, her to start from the principle that Britain's human and animal populations are culturally entwined. Consequently, we cannot 'see' a fox, hedgehog or newt without bringing to it a rich stew of presumptions and fantasy, drawn from childhood picturebooks, out-of-date encyclopedias and, in my case, the 1970s TV classic Tales of the Riverbank, in which small critters say funny things in the West Country burr of . This pre-knowing can have a radical impact on the chances of a particular species flourishing or going under. Take hedgehogs, which, Jones tells us in this beautifully written book, have been in Britain for the last 15m years. They witnessed the extinction of the woolly mammoth and saw the first humans arrive in Europe. It was at this point that they started to pick up a reputation for general malevolence. Bandit-like, hedgehogs were reputed to sneak into human settlements at night and steal poultry eggs (true) and suck the udders of sleeping cows (almost certainly false). Their ability to munch on toxic toads without getting sick (true) and willingness to ferry any witch who had lost her broomstick (surely very uncomfortable) confirmed that hedgehogs had gone over to the dark side. No wonder that killing them counted as a public service: the records of one Cheshire village show 8,585 hedgehogs destroyed over a 35-year period in the late 1600s. How different from today, when the hedgehog routinely tops those 'Britain's favourite animal' polls. Now we build shelters for them in our gardens and worry about how they will fare when crossing the road. This radical shift of opinion, says Jones, can be traced back to one hugely popular book, Beatrix Potter's The Tale of Mrs Tiggy-Winkle. Mrs Tiggy-Winkle is an industrious washerwoman who keeps her neighbours, including Peter Rabbit and his signature blue coat, spick and span. The influence of Potter's 1905 classic has been so enduring that, when a charity was set up in 1983 to care for injured hedgehogs, it was obvious what its name should be. These days, Tiggywinkles is the largest wildlife hospital in the world. Beastly Britain is full of stories like this, which take an everyday animal – newt, hedgehog, pigeon, sheep, flea – and map out both its physical life (a matter of burrows, breeding cycles and flight paths) as well as its cultural traces, which concern legend, loathing and desire. Often these two kinds of knowing collide in startling ways. Take sheep, which are mostly seen as 'white noise in the countryside', bland and bleating and only good for counting yourself to sleep. In fact, Jones reveals, they are crackingly clever, able to recognise the faces of up to 50 of their sheep-friends, not to mention their human guardians. The revelations keep on coming. For instance, that we are still living among dinosaurs. The next time a pigeon swoops down to steal a chip, take a close look at its scaly, reptilian feet. They are the legacy of the Archaeopteryx, a winged dinosaur the size of a raven, with a bony tail, flight feathers and an ability to glide over short distances. Less persuasive, though even more intriguing, is the possibility that a pod of plesiosaurs still bobs off the Devon and Cornwall coast. How else to account for the string of sightings of a giant grey sea snake, with a long neck, snakey head and vicious tusks? The rational part of us knows that this sea monster is likely to be a basking shark or a giant piece of flotsam. Our dreaming part longs for it to be a remnant from ancient times, what Jones calls a 'proximate peculiar', that refuses to quite come into view. Beastly Britain by Karen R Jones is published by Yale (£20). To support the Guardian, order your copy at Delivery charges may apply.

Putting cancer warnings on alcohol would help me drink less
Putting cancer warnings on alcohol would help me drink less

The Independent

time41 minutes ago

  • The Independent

Putting cancer warnings on alcohol would help me drink less

Back in the early noughties, the indoor smoking ban led to an outcry over 'the nanny state'. The same happened when cigarette advertising was banned, and when manufacturers were required to plaster packs with images of diseased lungs. Yet over the past 40 years, according to Cancer Research, lung cancer rates in men have dropped by around 60 per cent. We may think we crave the rugged freedoms of the Marlboro Man, but given the facts, it turns out we don't actually want to die. And yet when it comes to alcohol, one of the world's biggest killers, a key driver of cancers, heart disease, strokes and obesity, there are no images of rotting livers on the chilled Sauvignon. The presentation of booze in the supermarket aisles is as benign as kitchen roll and chicken pie. It's described on restaurant menus with biblical reverence, it's advertised on TV in a hazy, golden-hour glow, and every other greetings card carries a hilarious reference to the booze-addled nature of the recipient. It is both normalised and celebrated, despite being the fifth greatest risk factor for death in the UK. Now, a group of major medical and health organisations have signed a letter to the Prime Minister calling for alcohol to carry explicit warnings that its consumption can cause cancer. The World Cancer Research Fund, which spearheaded the letter, cited 'shockingly low' public awareness that alcohol raises the risk of seven types of cancer – these being breast, bowel, stomach, head, neck, liver and mouth – and insisted that 'bold and unambiguous labelling' is urgently need to help save lives. Token efforts have long been made by the industry to toe a wavering line of responsibility – the number of units a bottle of wine contains written in a font the size of a gnat's IKEA instructions, or a glancing mention that pregnant women shouldn't drink. According to the Advertising Standards Authority, 'Lively, but responsible, social interaction or party scenes with alcohol present are allowed but…no behaviour may be adolescent or childish.' If only that diktat held true in real-life 'party scenes.' Initially, like much of Gen X and our wine-necking Boomer parents, I was resistant to the idea of cancer warnings. If I wanted to slowly kill myself in a responsible and socially acceptable manner, I felt it should be my choice to do so. But after another night of drinking slightly too much with friends, waking bathed in shame and a light prosecco sweat, I reconsidered. Women, particularly, are at risk of harm from alcohol, simply because we're smaller. If every time I picked up the wine bottle to top up my glass – over a healthy dinner! So civilised! – it reminded me that I was increasing my risk of cancer, I suspect I might put it back down. Humans like to ignore the dangers when it's something we want to do until it becomes impossible to turn a blind eye. But this time, it's not so much the consumers resisting warnings as the enormously powerful drinks industry. It's already up against Gen Z's wellbeing crusade, with a tsunami of kumbucha and kefir washing away the old-school shots and spirits from nights out. The risk of drinkers murmuring, 'Actually, I don't think I do want seven types of cancer' and switching the kettle on instead is a step too far. A spokesperson for the Portman Group, which oversees UK alcohol labelling in the UK, says: 'Whilst we do not dispute the link between alcohol and certain cancers… blanket cancer warning labels…can create unnecessary anxiety, eroding trust in health advice and alienating the very people who require support.' As an argument, this is weaker than a sixth-form debating point scribbled on the bus. Imagine the motor industry saying, 'Road signs create unnecessary anxiety. Let's not warn people that they might crash, lest we alienate drivers.' The spokesperson added that most alcohol products already include advice to limit drinking to 14 units a week, and claimed that 'most people drink within guidelines.' According to NHS Digital, however, 24 per cent of Brits drink more than this, while the charity Drinkaware has found that 32 per cent of men and 15 per cent of women regularly sink more than the recommended limit – and it is a limit, not a target. Doctors repeatedly warn that there is no safe level of alcohol consumption, and in April, the World Health Organisation advised that women should drink no alcohol at all to avoid a heightened risk of breast cancer. I'm aware that even reading this is annoying. I share the general British resentment over finger-wagging admonishments from the Fun Police. I want to say, 'You'll prise my Picpoul from my cold, dead hand.' The only thing is, I'd rather not be cold and dead – and I'm increasingly convinced that warning labels can only be a good thing. Although, of course, we must be careful how we approach this new regime. After all, we wouldn't want to alienate anybody.

Update on Guildford paddling pool plagued by problems
Update on Guildford paddling pool plagued by problems

BBC News

timean hour ago

  • BBC News

Update on Guildford paddling pool plagued by problems

The public paddling pool in Guildford's Stoke Park is no stranger to opened a month late last year because of staff sickness and in 2022 was forced to shut just days after a £141,000 refurbishment because parents said its floor was too slippery for the pool is once again more than a month late to open as engineers try to balance the chlorine levels, and are yet to determine what is causing the asked how much the ongoing work is costing the taxpayer, the leader of Guildford Borough Council was unable to answer. So what exactly is going on at Stoke Park and what needs to happen for the pool to reopen? Respiratory problems Council leader Julia McShane told BBC Radio Surrey that the current high levels of chlorine in the water could be a public health said it would particularly affect vulnerable people and might lead to skin or eye irritation as well as stomach and breathing problems."We don't want to be causing people those issues to their health," she said. "I can reassure people that the teams are working incredibly hard with experts to try to find out what the problem is and to resolve this as quickly as possible so we can get this pool open again."But with temperatures in Guildford set to hit 32C on Monday, many families have been left feeling frustrated."It doesn't seem like they can get it right on anything really, it's a real shame that it's like that again, we had a lovely summer here last year once it was sorted," one parent told us: "We're all sad because we used it last year and it was lovely, a lot of people enjoyed being there, but unfortunately it's not open." What happens now? Ms McShane said it would not be fair to give a reopening date to the public as a timeframe for repairs is not yet clear, but she did say work would continue from next week."The team are going to empty the pool again, flush it through, fill it back up again, probably try a different chemical treatment and then test it again," she said."When we're absolutely certain that the pool is safe to use, then we'll reopen."And how much is this all costing?Ms McShane was unable to give a figure and the council did not provide us with one either when we followed it for now, families will just have to keep their fingers crossed and hope the sun is still around when the pool eventually reopens.

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