Three-drug treatment combo ‘holds back aggressive breast cancer for a year'
The treatment could benefit thousands of British women
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A NEW triple threat drug combination could hold aggressive breast cancer at bay for an extra year, a trial found.
Adding the medicine inavolisib to an already used pair of drugs delayed the need for chemotherapy by almost two years.
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Breast cancer gets harder to treat as cells become resistant to drugs (stock image)
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It prevented tumours from growing for an average of 17 months, compared to seven months in patients using the standard drug pairing palbociclib and fulvestrant.
An estimated 1,000 British women per year could benefit.
The combo works for women with a specific breast cancer type called HR+ HER2- with a PIK3CA mutation, which accounts for about three in 10 cases.
Professor Kristian Helin, chief of The Institute of Cancer Research in London, said: 'We need to tackle treatment resistance head-on to continue improving survival rates.
'This triple combination approach effectively shuts down cancer's escape routes, giving people with metastatic breast cancer the opportunity to live well for longer.'
The trial included 325 patients with aggressive and advanced breast cancer from 28 countries.
Cancers shrank in two thirds of people receiving the triple drug combination, compared to 28 per cent of those on standard treatment.
New go-to option for docs
Study author Professor Nicholas Turner, of the Royal Marsden NHS hospital in London, said: 'This therapy not only helped patients live longer but it more than doubled the time before their cancer progressed or worsened.
'It also gave them more time before needing chemotherapy which is something that patients really fear and want to delay for as long as possible.'
'These results give us confidence that this treatment could become the new go-to option.'
The study was presented at the conference of the American Society of Clinical Oncology.
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