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RFK Jr. is dismantling trust in vaccines, the crown jewel of American public health

RFK Jr. is dismantling trust in vaccines, the crown jewel of American public health

Los Angeles Times10 hours ago

When it comes to vaccines, virtually nothing that comes out of Robert F. Kennedy Jr.'s mouth is true.
The man in charge of the nation's health and well being is impervious to science, expertise and knowledge. His brand of arrogance is not just dangerous, it is lethal. Undermining trust in vaccines, he will have the blood of children around the world on his hands.
Scratch that.
He already does, as he presides over the second largest measles outbreak in this country since the disease was declared 'eliminated' a quarter century ago.
'Vaccines have become a divisive issue in American politics,' Kennedy wrote the other day in a Wall Street Journal essay, 'but there is one thing all parties can agree on: The U.S. faces a crisis of public trust.'
The lack of self-awareness would be funny if it weren't so tragic.
Over the past two decades or so, Kennedy has done more than almost any other American to destroy the public's trust in vaccines and science. And now he's bemoaning the very thing he has helped cause.
Earlier this month, Kennedy fired the 17 medical and public health experts of the Centers for Disease Control and Prevention's Advisory Committee on Immunization Practices — qualified doctors and public health experts — and replaced them with a group of (mostly) anti-vaxxers in order to pursue his relentless, ascientific crusade.
On Thursday, at its first meeting, his newly reconstituted council voted to ban the preservative thimerosal from the few remaining vaccines that contain it, despite many studies showing that thimerosal is safe. On that point, even the Food and Drug Administration website is blunt: 'A robust body of peer-reviewed scientific studies conducted in the U.S. and other countries support the safety of thimerosal-containing vaccines.'
'If you searched the world wide, you could not find a less suitable person to be leading healthcare efforts in the United States or the world,' psychiatrist Allen Frances told NPR on Thursday. Frances, who chaired the task force that changed how the Diagnostic and Statistical Manual of Mental Disorders, or DSM, defines autism, published an essay in the New York Times on Monday explaining why the incidence of autism has increased but is neither an epidemic nor related to vaccines.
'The rapid rise in autism cases is not because of vaccines or environmental toxins,' Frances wrote, 'but is rather the result of changes in the way that autism is defined and assessed — changes that I helped put into place.'
But Kennedy is not one to let the facts stand in the way of his cockamamie theories. Manufacturers long ago removed thimerosal from childhood vaccines because of unfounded fears it contained mercury that could accumulate in the brain and unfounded fears about a relationship between mercury and autism.
That did not stop one of Kennedy's new council members, Lyn Redwood, who once led Children's Health Defense, the anti-vaccine group founded by Kennedy, from declaring a victory for children.
'Removing a known neurotoxin from being injected into our most vulnerable population is a good place to start with making America healthy again,' Redwood told the committee.
Autism rates, by the way, have continued to climb despite the thimerosal ban. But fear not, gullible Americans, Kennedy has promised to pinpoint a cause for the complex condition by September!
Like his boss, Kennedy just makes stuff up.
On Wednesday, he halted a $1-billion American commitment to Gavi, an organization that provides vaccines to millions of children around the world, wrongly accusing the group of failing to investigate adverse reactions to the diptheria vaccine.
'This is utterly disastrous for children around the world and for public health,' Atul Gawande, a surgeon who worked in the Biden administration, told the New York Times.
Unilaterally, and contrary to the evidence, Kennedy decided to abandon the CDC recommendation that healthy pregnant women receive COVID vaccines. But an unvaccinated pregnant woman's COVID infection can lead to serious health problems for her newborn. In fact, a study last year found that babies born to such mothers had 'unusually high rates' of respiratory distress at or just after birth. According to the CDC, nearly 90% of babies who were hospitalized for COVID-19 had unvaccinated mothers. Also, vaccinated moms can pass protective antibodies to their fetuses, who will not be able to get a COVID shot until they are 6 months old.
What else? Oh yes: Kennedy once told podcaster Joe Rogan that the 1918 Spanish flu epidemic was 'vaccine-induced flu' even though no flu vaccine existed at the time.
He also told Rogan that a 2003 study by physician scientist Michael Pichichero, an expert on the use of thimerosal in vaccines, involved feeding babies 6 months old and younger mercury-contaminated tuna sandwiches, and that 64 days later, the mercury was still in their system. 'Who would do that?' Kennedy demanded.
Well, no one.
In the study, 40 babies were injected with vaccines containing thimerosal, while a control group of 21 babies got shots that did not contain the preservative. None was fed tuna. Ethylmercury, the form of mercury in thimerosal, the researchers concluded, 'seems to be eliminated from blood rapidly via the stools.' (BTW, the mercury found in fish is methylmercury, a different chemical, which can damage the brain and nervous system. In a 2012 deposition for his divorce, which was revealed last year, Kennedy said he suffered memory loss and brain fog from mercury poisoning caused by eating too much tuna fish. He also revealed he has a dead worm in his brain.)
Kennedy's tuna sandwich anecdote on Rogan's podcast was 'a ChatGPT-level of hallucination,' said Morgan McSweeney, a.k.a. 'Dr. Noc,' a scientist with a doctorate in pharmaceutical sciences, focusing on immunology and antibodies. McSweeney debunks the idiotic medical claims of non-scientists like Kennedy in his popular social media videos.
Speaking of AI hallucinations, on Tuesday, at a congressional committee hearing, Kennedy was questioned about inaccuracies, misinformation and made up research and citations for nonexistent studies in the first report from his Make America Healthy Again Commission.
The report focused on how American children are being harmed by their poor diets, exposure to environmental toxins and, predictably, over-vaccination. It was immediately savaged by experts. 'This is not an evidence-based report, and for all practical purposes, it should be junked at this point,' Georges C. Benjamin, executive director of the American Public Health Assn. told the Washington Post.
If Kennedy was sincere about improving the health of American children he would focus on combating real scourges like gun violence, drug overdoses, depression, poverty and lack of access to preventive healthcare. He would be fighting the proposed cuts to Medicaid tooth and nail.
Do you suppose he even knows that over the past 50 years, the lives of an estimated 154 million children have been saved by vaccines?
Or that he cares?
@rabcarian.bsky.social @rabcarian

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RFK Jr. is bringing psychedelics to the Republican party
RFK Jr. is bringing psychedelics to the Republican party

Politico

time6 hours ago

  • Politico

RFK Jr. is bringing psychedelics to the Republican party

Driven by a desire to help ex-servicemembers with mental illness, GOP lawmakers led a failed campaign last year to persuade the Biden administration to approve psychedelic drugs. Now they may have found the ally they need in President Donald Trump's health secretary, Robert F. Kennedy Jr. A longtime believer in psychedelics' potential to help people with illnesses like post-traumatic stress disorder and depression, despite the lack of supportive evidence Biden officials found, Kennedy is ramping up government-run clinical studies and telling the disappointed lawmakers doctors will be prescribing the drugs soon. 'These are people who badly need some kind of therapy, nothing else is working for them,' Kennedy said at a House hearing Tuesday. 'This line of therapeutics has tremendous advantage if given in a clinical setting. And we are working very hard to make sure that that happens within 12 months.' The GOP's embrace of psychedelics is another, and perhaps one of the more jarring, examples of cultural transformation that Trump's populist politics have brought. Veterans seeking cures for mental illnesses associated with combat, combined with the Kennedy-backed Make America Healthy Again movement's enthusiasm for natural medicine, have strengthened a libertarian strain on the right in favor of drug experimentation. Meanwhile, the left, where hippies are giving way to technocrats, has become more skeptical. When Joe Biden was president, for example, agencies studied the drugs' medical potential, but an air of doubt prevailed. The head of the National Institute on Drug Abuse, Nora Volkow, compared the hype for psychedelics as a cure for mental illness to belief in 'fairy tales' in Senate testimony last year. Then in August, the Food and Drug Administration rejected drugmaker Lykos Therapeutics' application to offer ecstasy, alongside therapy, as a treatment for PTSD. FDA advisers worried the company's researchers were more evangelists than scientists and determined that they'd failed to prove their regimen was either safe or effective. Republicans complained the loudest. 'These technocrats think they know better,' Texas GOP Rep. Dan Crenshaw, a former Navy SEAL who lost an eye in Afghanistan, wrote on X after FDA advisers recommended Lykos' application be rejected. 'Their job is to say NO and support the status quo.' But Crenshaw, who's helped secure funding for psychedelic research at the Defense Department, got the response he wanted from Kennedy at Tuesday's budget hearing. Kennedy said results from early government studies at the Department of Veterans Affairs and FDA were 'very, very encouraging.' He added that his FDA commissioner, Marty Makary, sees it the same way. 'Marty has told me that we don't want to wait two years to get this done,' he said. Crenshaw was pleased. 'I've spent years supporting clinical trials to study the use of psychedelics to treat PTSD,' he told POLITICO. 'It's been a long fight, and it's taken a lot of grit. I'm grateful Secretary Kennedy is taking this seriously — helping to mainstream what could be a groundbreaking shift in mental health.' Kennedy's comments have revived hope among psychedelics' advocates that the Lykos decision was more hiccup than death knell. 'It's important for the entire community and the entire value chain around psychedelic therapy to hear that he wants to responsibly explore the benefits and risks of these therapies,' said Dr. Shereef Elnahal, a health official at the VA under Biden who sees promise in the drugs. The VA, under Trump's secretary, Doug Collins, is working directly with Kennedy on clinical research. Collins has referenced psychedelics on a podcast appearance, on X and at a cabinet meeting this spring when Trump pressed him on what he's doing to drive down the high suicide rate among veterans. 'I talk with Collins about it all the time,' Kennedy said Tuesday. 'It's something that both of us are deeply interested in.' Earlier this month, Texas' Republican governor, Greg Abbott, signed a law to put $50 million into clinical trials of the psychedelic ibogaine, as a mental health treatment. 'That culture shift is underway,' W. Bryan Hubbard, who spearheaded the Texas bill and is executive director of the American Ibogaine Initiative, told POLITICO. As Hubbard sees it, the narrative around psychedelics has evolved from counterculture recreation to a promising medical treatment for the 'deaths of despair' from alcohol, drug overdoses and suicides the United States has grappled with in recent decades. Kennedy was happy to see it. 'It's super positive. It is really notable that the Republicans have become the party of some of these issues you wouldn't have expected before,' Calley Means, a top Kennedy adviser, told POLITICO. 'States pushing the envelope is certainly aligned with what Secretary Kennedy is trying to do. It gives him leverage to push bolder reforms.' The Texas effort involved a six-month sprint by Hubbard and former GOP Gov. Rick Perry to convince state lawmakers to pass the bill. Rep. Morgan Luttrell, another Lone Star Republican who credits ibogaine he took in Mexico with helping him overcome trauma he incurred during military service, also lobbied for it. Hubbard attributes their success partly to Texas' independent pioneer culture and a red-state philosophy that was receptive to his pitch for a medicalized psychedelics model. It didn't hurt that Abbott had signed a bill to study ecstasy, psilocybin and ketamine as treatments for veterans with PTSD with Baylor College of Medicine. And since Texans are no stranger to religion, conversations about the spiritual aspect of ibogaine treatment seemed to resonate with lawmakers. 'We had a message that was tailor-made for the Lone Star State,' he said. Veterans turned out at public hearings to describe traveling out of the country, often to Mexico, where ibogaine is unregulated, to receive treatment they couldn't access in the U.S. 'These heroes have gone to war to defend the land of the free, only to come home and be faced with inflexible, bureaucratic systems that offer ineffectual solutions, paired with the Controlled Substances Act that has forced them to flee the country that they have defended in order to access treatment in a foreign country,' Hubbard said. But the biggest momentum push was likely the boost Hubbard and Perry got from conservative kingmaker Joe Rogan when the two went on Rogan's podcast in January. 'That really put a tremendous amount of wind in our sails,' Hubbard said. Still, last year's FDA decision to reject Lykos Therapeutics' application underscores the concerns raised by many scientists that the utility of the drugs is oversold. FDA advisers raised ecstasy's potential to damage the heart and liver; a suspicion that trial researchers were more advocates than scientists; and a worry that results had been skewed by the psychedelics' pronounced effects, since participants could figure out if they got the drug. Ibogaine also poses heart risks. The Drug Enforcement Administration lists both it and ecstasy on its schedule of drugs with no currently acceptable medical use and high risk of abuse. That would have once been enough to make law-and-order Republicans say no. Kennedy's adviser Means says things are changing for the better. 'Ten years ago, nobody expected the Republican Party as the party of healthy food, as the party of exercise, as the party of questioning pharmaceutical companies, as the party of psychedelic research — but that's where we are,' Means said. 'The Democratic Party has become the party of blindly trusting experts,' he concluded. 'The Republican Party has become the countercultural party that's asking common-sense questions.'

The Liberal Misinformation Bubble About Youth Gender Medicine
The Liberal Misinformation Bubble About Youth Gender Medicine

Atlantic

time7 hours ago

  • Atlantic

The Liberal Misinformation Bubble About Youth Gender Medicine

Allow children to transition, or they will kill themselves. For more than a decade, this has been the strongest argument in favor of youth gender medicine—a scenario so awful that it stifled any doubts or questions about puberty blockers and cross-sex hormones. 'We often ask parents, 'Would you rather have a dead son than a live daughter?'' Johanna Olson-Kennedy of Children's Hospital Los Angeles once explained to ABC News. Variations on the phrase crop up in innumerable media articles and public statements by influencers, activists, and LGBTQ groups. The same idea—that the choice is transition or death—appeared in the arguments made by Elizabeth Prelogar, the Biden administration's solicitor general, before the Supreme Court last year. Tennessee's law prohibiting the use of puberty blockers and cross-sex hormones to treat minors with gender dysphoria would, she said, 'increase the risk of suicide.' But there is a huge problem with this emotive formulation: It isn't true. When Justice Samuel Alito challenged the ACLU lawyer Chase Strangio on such claims during oral arguments, Strangio made a startling admission. He conceded that there is no evidence to support the idea that medical transition reduces adolescent suicide rates. At first, Strangio dodged the question, saying that research shows that blockers and hormones reduce 'depression, anxiety, and suicidality'—that is, suicidal thoughts. (Even that is debatable, according to reviews of the research literature.) But when Alito referenced a systematic review conducted for the Cass report in England, Strangio conceded the point. 'There is no evidence in some—in the studies that this treatment reduces completed suicide,' he said. 'And the reason for that is completed suicide, thankfully and admittedly, is rare, and we're talking about a very small population of individuals with studies that don't necessarily have completed suicides within them.' Here was the trans-rights movement's greatest legal brain, speaking in front of the nation's highest court. And what he was saying was that the strongest argument for a hotly debated treatment was, in fact, not supported by the evidence. Even then, his admission did not register with the liberal justices. When the court voted 6–3 to uphold the Tennessee law, Sonia Sotomayor claimed in her dissent that 'access to care can be a question of life or death.' If she meant any kind of therapeutic support, that might be defensible. But claiming that this is true of medical transition specifically—the type of care being debated in the Skrmetti case—is not supported by the current research. Advocates of the open-science movement often talk about 'zombie facts' —popular sound bites that persist in public debate, even when they have been repeatedly discredited. Many common political claims made in defense of puberty blockers and hormones for gender-dysphoric minors meet this definition. These zombie facts have been flatly contradicted not just by conservatives but also by prominent advocates and practitioners of the treatment—at least when they're speaking candidly. Many liberals are unaware of this, however, because they are stuck in media bubbles in which well-meaning commentators make confident assertions for youth gender medicine—claims from which its elite advocates have long since retreated. Perhaps the existence of this bubble shouldn't be surprising. Many of the most fervent advocates of youth transition are also on record disparaging the idea that it should be debated at all. Strangio—who works for the country's best-known free-speech organization—once tweeted that he would like to scuttle Abigail Shrier's book Irreversible Damage, a skeptical treatment of youth gender medicine. Strangio declared, 'Stopping the circulation of this book and these ideas is 100% a hill I will die on.' Marci Bowers, the former head of the World Professional Association for Transgender Health (WPATH), the most prominent organization for gender-medicine providers, has likened skepticism of child gender medicine to Holocaust denial. 'There are not two sides to this issue,' she once said, according to a recent episode of The Protocol, a New York Times podcast. Boasting about your unwillingness to listen to your opponents probably plays well in some crowds. But it left Strangio badly exposed in front of the Supreme Court, where it became clear that the conservative justices had read the most convincing critiques of hormones and blockers—and had some questions as a result. Trans-rights activists like to accuse skeptics of youth gender medicine—and publications that dare to report their views—of fomenting a ' moral panic.' But the movement has spent the past decade telling gender-nonconforming children that anyone who tries to restrict access to puberty blockers and hormones is, effectively, trying to kill them. This was false, as Strangio's answer tacitly conceded. It was also irresponsible. After England restricted the use of puberty blockers in 2020, the government asked an expert psychologist, Louis Appleby, to investigate whether the suicide rate for patients at the country's youth gender clinic rose dramatically as a result. It did not: In fact, he did not find any increase in suicides at all, despite the lurid claims made online. 'The way that this issue has been discussed on social media has been insensitive, distressing and dangerous, and goes against guidance on safe reporting of suicide,' Appleby reported. 'One risk is that young people and their families will be terrified by predictions of suicide as inevitable without puberty blockers.' When red-state bans are discussed, you will also hear liberals say that conservative fears about the medical-transition pathway are overwrought—because all children get extensive, personalized assessments before being prescribed blockers or hormones. This, too, is untrue. Although the official standards of care recommend thorough assessment over several months, many American clinics say they will prescribe blockers on a first visit. This isn't just a matter of U.S. health providers skimping on talk therapy to keep costs down; some practitioners view long evaluations as unnecessary and even patronizing. 'I don't send someone to a therapist when I'm going to start them on insulin,' Olson-Kennedy told The Atlantic in 2018. Her published research shows that she has referred girls as young as 13 for double mastectomies. And what if these children later regret their decision? 'Adolescents actually have the capacity to make a reasoned logical decision,' she once told an industry seminar, adding: 'If you want breasts at a later point in your life, you can go and get them.' Perhaps the greatest piece of misinformation believed by liberals, however, is that the American standards of care in this area are strongly evidence-based. In fact, at this point, the fairest thing to say about the evidence surrounding medical transition for adolescents—the so-called Dutch protocol, as opposed to talk therapy and other support—is that it is weak and inconclusive. (A further complication is that American child gender medicine has deviated significantly from this original protocol, in terms of length of assessments and the number and demographics of minors being treated.) Yes, as activists are keen to point out, most major American medical associations support the Dutch protocol. But consensus is not the same as evidence. And that consensus is politically influenced. Rachel Levine, President Joe Biden's assistant secretary for health and human services, successfully lobbied to have age minimums removed for most surgeries from the standards of care drawn up by WPATH. That was a deeply political decision—Levine, according to emails from her office reviewed by the Times, believed that listing any specific limits under age 18 would give opponents of youth transition hard targets to exploit. More recently, another court case over banning blockers and hormones, this time in Alabama, has revealed that WPATH members themselves had doubts about their own guidelines. In 2022, Alabama passed a law criminalizing the prescription of hormones and blockers to patients under 19. After the Biden administration sued to block the law, the state's Republican attorney general subpoenaed documents showing that WPATH has known for some time that the evidence base for adolescent transition is thin. 'All of us are painfully aware that there are many gaps in research to back up our recommendations,' Eli Coleman, the psychologist who chaired the team revising the standards of care, wrote to his colleagues in 2023. Yet the organization did not make this clear in public. Laura Edwards-Leeper—who helped bring the Dutch protocol to the U.S. but has since criticized in a Washington Post op-ed the unquestioningly gender-affirmative model—has said that the specter of red-state bans made her and her op-ed co-author reluctant to break ranks. The Alabama litigation also confirmed that WPATH had commissioned systematic reviews of the evidence for the Dutch protocol. However, close to publication, the Johns Hopkins University researcher involved was told that her findings needed to be 'scrutinized and reviewed to ensure that publication does not negatively affect the provision of transgender health care.' This is not how evidence-based medicine is supposed to work. You don't start with a treatment and then ensure that only studies that support that treatment are published. In a legal filing in the Alabama case, Coleman insisted 'it is not true' that the WPATH guidelines 'turned on any ideological or political considerations' and that the group's dispute with the Johns Hopkins researcher concerned only the timing of publication. Yet the Times has reported that at least one manuscript she sought to publish 'never saw the light of day.' The Alabama disclosures are not the only example of this reluctance to acknowledge contrary evidence. Last year, Olson-Kennedy said that she had not published her own broad study on mental-health outcomes for youth with gender dysphoria, because she worried about its results being 'weaponized.' That raised suspicions that she had found only sketchy evidence to support the treatments that she has been prescribing—and publicly advocating for—over many years. Last month, her study finally appeared as a preprint, a form of scientific publication where the evidence has not yet been peer-reviewed or finalized. Its participants 'demonstrated no significant changes in reported anxious/depressed, withdrawn/depressed, somatic complaints, social problems, thought problems, attention problems, aggressive behavior, internalizing problems or externalizing problems' in the two years after starting puberty blockers. (I have requested comment from Olson-Kennedy via Children's Hospital Los Angeles but have not yet heard back.) The reliance on elite consensus over evidence helps make sense of WPATH's flatly hostile response to the Cass report in England, which commissioned systematic reviews and recommended extreme caution over the use of blockers and hormones. The review was a direct challenge to WPATH's ability to position itself as the final arbiter of these treatments—something that became more obvious when the conservative justices referenced the British document in their questions and opinions in Skrmetti. One of WPATH's main charges against Hilary Cass, the senior pediatrician who led the review, was that she was not a gender specialist—in other words, that she was not part of the charmed circle who already agreed that these treatments were beneficial. Because of WPATH's hostility, many on the American left now believe that the Cass review has been discredited. 'Upon first reading, especially to a person with limited knowledge of the history of transgender health care, much of the report might seem reasonable,' Lydia Polgreen wrote in the Times last August. However, after 'poring over the document' and 'interviewing experts in gender-affirming care,' Polgreen realized that the Cass review was 'fundamentally a subjective, political document.' Advocates of youth gender medicine have reacted furiously to articles in the Times and elsewhere that take Cass's conclusions seriously. Indeed, some people inside the information bubble appear to believe that if respectable publications would stop writing about this story, all the doubts and questions—and Republican attempts to capitalize on them electorally—would simply disappear. Whenever the Times has published a less-than-cheerleading article about youth transition, supporters of gender medicine have accused the newspaper of manufacturing a debate that otherwise would not exist. After the Skrmetti decision, Strangio was still describing media coverage of the issue as 'insidious,' adding: ' The New York Times, especially, has been fixated on casting the medical care as being of an insufficient quality.' Can this misinformation bubble ever be burst? On the left, support for youth transition has been rolled together with other issues—such as police reform and climate activism—as a kind of super-saver combo deal of correct opinions. The 33-year-old democratic socialist Zohran Mamdani has made funding gender transition, including for minors, part of his pitch to be New York's mayor. But complicated issues deserve to be treated individually: You can criticize Israel, object to the militarization of America's police forces, and believe that climate change is real, and yet still not support irreversible, experimental, and unproven medical treatments for children. The polarization of this issue in America has been deeply unhelpful for getting liberals to accept the sketchiness of the evidence base. When Vice President J. D. Vance wanted to troll the left, he joined Bluesky—where skeptics of youth gender medicine are among the most blocked users—and immediately started talking about the Skrmetti judgment. Actions like that turn accepting the evidence base into a humiliating climbdown. Acknowledging the evidence does not mean that you also have to support banning these treatments—or reject the idea that some people will be happier if they transition. Cass believes that some youngsters may indeed benefit from the medical pathway. 'Whilst some young people may feel an urgency to transition, young adults looking back at their younger selves would often advise slowing down,' her report concludes. 'For some, the best outcome will be transition, whereas others may resolve their distress in other ways.' I have always argued against straightforward bans on medical transition for adolescents. In practice, the way these have been enacted in red states has been uncaring and punitive. Parents are threatened with child-abuse investigations for pursuing treatments that medical professionals have assured them are safe. Children with severe mental-health troubles suddenly lose therapeutic support. Clinics nationwide, including Olson-Kennedy's, are now abruptly closing because of the political atmosphere. Writing about the subject in 2023, I argued that the only way out of the culture war was for the American medical associations to commission reviews and carefully consider the evidence. From the July/August 2018 issue: When children say they're trans However, the revelations from Skrmetti and the Alabama case have made me more sympathetic to commentators such as Leor Sapir, of the conservative Manhattan Institute, who supports the bans because American medicine cannot be trusted to police itself. 'Are these bans the perfect solution? Probably not,' he told me in 2023. 'But at the end of the day, if it's between banning gender-affirming care and leaving it unregulated, I think we can minimize the amount of harm by banning it.' Once you know that WPATH wanted to publish a review only if it came to the group's preferred conclusion, Sapir's case becomes more compelling. Despite the concerted efforts to suppress the evidence, however, the picture on youth gender medicine has become clearer over the past decade. It's no humiliation to update our beliefs as a result: I regularly used to write that medical transition was 'lifesaving,' before I saw how limited the evidence on suicide was. And it took another court case, brought by the British detransitioner Keira Bell, for me to realize fully that puberty blockers were not what they were sold as—a 'safe and reversible' treatment that gave patients 'time to think' —but instead a one-way ticket to full transition, with physical changes that cannot be undone. Some advocates for the Dutch protocol, as it's applied in the United States, have staked their entire career and reputation on its safety and effectiveness. They have strong incentives not to concede the weakness of the evidence. In 2023, the advocacy group GLAAD drove a truck around the offices of The New York Times to declare that the ' science is settled.' Doctors such as Olson-Kennedy and activists such as Strangio are unlikely to revise their opinions. For everyone else, however, the choice is still open. We can support civil-rights protections for transgender people without having to endorse an experimental and unproven set of medical treatments—or having to repeat emotionally manipulative and now discredited claims about suicide. I am not a fan of the American way of settling political disputes, by kicking them over to an escalating series of judges. But in the case of youth gender medicine, the legal system has provided clarity and disclosure that might otherwise not exist. Thanks to the Supreme Court's oral questioning in Skrmetti and the discovery process in Alabama, we now have a clearer picture of how youth gender medicine has really been operating in the United States, and an uncomfortable insight into how advocacy groups and medical associations have tamped down their own concerns about its evidence base. Those of us who have been urging caution now know that many of our ostensible opponents had the same concerns. They just smothered them, for political reasons.

Truist Reiterates Eli Lilly (LLY) Buy Rating on Orforglipron Diabetes Drug Data
Truist Reiterates Eli Lilly (LLY) Buy Rating on Orforglipron Diabetes Drug Data

Yahoo

time8 hours ago

  • Yahoo

Truist Reiterates Eli Lilly (LLY) Buy Rating on Orforglipron Diabetes Drug Data

Eli Lilly and Company (NYSE:LLY) is one of the 12 stocks that will make you rich in 10 years. On June 23, Truist Securities reiterated its 'Buy' rating on Eli Lilly stock. The firm also maintained the price target of $1,038.00. Truist's move followed Eli Lilly's presentation at the American Diabetes Association (ADA) 85th Annual Meeting. Pixabay/Public Domain The rating pertains to Eli Lilly's oral diabetes drug, orforglipron (OFG), evaluated in the Phase 3 ACHIEVE-1 study for Type 2 diabetes treatment. The ACHIEVE-1 study results were presented at the ADA conference, showcasing orforglipron's efficacy and safety profile. The trial demonstrated statistically significant reductions in A1C (a long-term blood sugar metric) and body weight compared to placebo, with efficacy increasing at higher doses. Truist's analysis was informed by attending the orforglipron presentation, gathering feedback from KOLs at the ADA conference, and participating in Eli Lilly's investor event, where management provided clarity to alleviate safety concerns. The firm noted that longer-term data are required to further strengthen orforglipron's safety profile, particularly for chronic use in diabetes and potential obesity indications. Eli Lilly and Company (NYSE:LLY) is an American global biopharmaceutical company. The company discovers, develops, and markets prescription medicines for diabetes, obesity, cancer, immunological disorders, and neurological diseases. Its key products include Mounjaro, Zepbound, Trulicity, Verzenio, Taltz, and Jardiance. While we acknowledge the potential of LLY as an investment, we believe certain AI stocks offer greater upside potential and carry less downside risk. If you're looking for an extremely undervalued AI stock that also stands to benefit significantly from Trump-era tariffs and the onshoring trend, see our free report on the best short-term AI stock. READ NEXT: and . Disclosure: None.

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