Ibogaine by David Dardashti Warns of Kratom's ‘Gateway' Dangers, Citing Alarming Trend in Patient Addiction Cases
The recent FDA actions targeting concentrated 7-OH products—dubbed 'legal morphine' by some researchers—underscore a danger the clinical team at Ibogaine by David Dardashti sees daily. The clinic has witnessed a significant increase in patients arriving with a primary or secondary addiction to kratom, often after being misled by marketing that promotes it as a safe, herbal alternative to opioids. This firsthand clinical data forms the basis for their urgent public warning.
'We are seeing a disturbing pattern,' states David Dardashti. 'Patients come to us after starting with kratom, thinking it's a safe, natural remedy. They don't realize they are developing a true opioid dependency until it's too late. The initial effects fade, tolerance builds, and suddenly they are facing a full-blown addiction with severe withdrawals. The next logical step for many is to seek out something stronger and deadlier, like fentanyl. We are on the front lines of this trend, and it is alarming.'
As referenced in recent reports, experts confirm that while the kratom leaf itself may be mild, concentrated extracts containing 7-OH are significantly more potent and act as pure opioids. This creates the dangerous cycle of dependency that the clinic observes. Users require ever-increasing doses, eventually finding that the legal substance no longer satisfies the addiction it created, driving them toward the illicit drug market.
Despite the alarming trend, the team at Ibogaine by David Dardashti reports significant success in treating kratom addiction and offers a message of hope. Based on extensive clinical experience, the center has found a notable distinction in the recovery process for these patients.
'The good news in this growing crisis is that we've found that individuals dependent on kratom can be brought back to sobriety with less difficulty than those entrenched in long-term Suboxone or fentanyl use,' Dardashti explains. 'Ibogaine therapy works to reset the brain's neurotransmitters and interrupt addiction at the source. For our kratom patients, the process is often smoother and the path to a full recovery is remarkably clear. Our goal is to intervene effectively before the addiction escalates into a far more tragic story.'
About Ibogaine by David Dardashti:
Ibogaine by David Dardashti is a leading treatment center dedicated to helping individuals overcome chemical dependency through a unique combination of ibogaine therapy and holistic care. Founded by David Dardashti, the clinic leverages extensive clinical experience to provide a safe, medically supervised environment for profound psycho-spiritual healing and neurological reset, offering a definitive interruption to the cycle of addiction.
Media Contact
Company Name: Ibogaine By David Dardashti
Contact Person: Cole Barressi
Email: Send Email
Country: United States
Website: http://www.ibogaineclinic.com
Press Release Distributed by ABNewswire.com
To view the original version on ABNewswire visit: Ibogaine by David Dardashti Warns of Kratom's 'Gateway' Dangers, Citing Alarming Trend in Patient Addiction Cases
Try Our AI Features
Explore what Daily8 AI can do for you:
Comments
No comments yet...
Related Articles
Yahoo
11 minutes ago
- Yahoo
Castle Biosciences Reports Second Quarter 2025 Results
Delivered Q2 2025 revenue of $86 million Q2 2025 total test reports for our core revenue drivers (DecisionDx®-Melanoma, TissueCypher®) increased 33% over Q2 2024 Raising full-year 2025 revenue guidance range to $310-320 million from $287-297 million Conference call and webcast today at 4:30 p.m. ET FRIENDSWOOD, Texas, Aug. 04, 2025 (GLOBE NEWSWIRE) -- Castle Biosciences, Inc. (Nasdaq: CSTL), a company improving health through innovative tests that guide patient care, today announced its financial results for the second quarter and six months ended June 30, 2025.'Following a strong first quarter, our team closed out a very successful second quarter that we believe continued to reflect the clinical value our tests provide to clinicians and their patients,' said Derek Maetzold, president and chief executive officer of Castle Biosciences. 'We saw very solid total year-over-year test volume growth in our core revenue drivers, with both DecisionDx-Melanoma and TissueCypher exceeding our volume expectations for the quarter, driving our top-line performance. 'In alignment with our capital allocation priorities and M&A strategy, we closed the Previse tuck-in acquisition and announced an exciting collaboration and license agreement with SciBase, both of which we believe will support our mid- to long-term value creation goals. At the same time, we remain deeply focused on execution across our current test portfolio, which we believe positions us well for continued near-term success. Our ability to invest in the future while advancing our core franchises reflects the strength of our growth initiatives and commitment to delivering sustainable value to our stakeholders.'Second Quarter Ended June 30, 2025, Financial and Operational Highlights Revenues were $86.2 million, compared to $87.0 million in the second quarter of 2024. Affecting second quarter 2025 revenue was the Novitas local coverage determination (LCD), Genetic Testing in Oncology: Specific Tests, that included DecisionDx®-SCC as noncovered, which became effective April 24, 2025, as well as discontinuation of IDgenetix® in May 2025. Adjusted Revenues, which exclude the effects of revenue adjustments related to tests delivered in prior periods, were $86.2 million, compared to $86.6 million for the same period in 2024. Delivered 26,574 total test reports in the second quarter of 2025, an increase of 6% compared to 25,102 in the same period of 2024. Affecting second quarter 2025 test report volume was the Novitas LCD, Genetic Testing in Oncology: Specific Tests, that included DecisionDx-SCC as noncovered, which became effective April 24, 2025, as well as discontinuation of IDgenetix in May 2025: DecisionDx-Melanoma test reports delivered in the quarter were 9,981, compared to 9,585 in the second quarter of 2024. TissueCypher Barrett's Esophagus test reports delivered in the quarter were 9,170, compared to 4,782 in the second quarter of 2024. DecisionDx-SCC test reports delivered in the quarter were 4,762, compared to 4,277 in the second quarter of 2024. Affecting second quarter test report volume was the Novitas LCD, Genetic Testing in Oncology: Specific Tests, that included DecisionDx-SCC as noncovered, which became effective April 24, 2025. MyPath® Melanoma test reports delivered in the quarter were 1,166, compared to 1,099 in the second quarter of 2024. IDgenetix test reports delivered in the quarter were 1,027, compared to 4,903 in the second quarter of 2024. The Company discontinued its IDgenetix test offering effective May 2025. DecisionDx®-UM test reports delivered in the quarter were 468, compared to 456 in the second quarter of 2024. Gross margin was 77%, and Adjusted Gross Margin was 80%, compared to 81% and 83%, respectively, for the same periods in 2024. Net cash provided by operations was $20.8 million, compared to net cash provided by operations of $24.0 million for the same period in 2024. Net income, which includes non-cash stock-based compensation expense of $11.2 million, was $4.5 million, compared to net income of $8.9 million for the same period in 2024. Net income per share and Adjusted Net Income per Share, Basic and Diluted, was $0.16 and $0.15, respectively, compared to $0.32 and $0.31, respectively, for the same period in 2024. Adjusted EBITDA was $10.4 million, compared to $21.5 million for the same period in 2024. Six Months Ended June 30, 2025, Financial and Operational Highlights Revenues were $174.2 million, a 9% increase compared to $160.0 million during the same period in 2024. Affecting six months ended June 30, 2025 revenue was the Novitas LCD, Genetic Testing in Oncology: Specific Tests, that included DecisionDx-SCC as noncovered, which became effective April 24, 2025, as well as discontinuation of IDgenetix in May 2025. Adjusted Revenues, which exclude the effects of revenue adjustments related to tests delivered in prior periods, were $176.2 million, an 11% increase compared to $159.0 million for the same period in 2024. Delivered 50,976 total test reports in the six months ended June 30, 2025, an increase of 11% compared to 45,990 in the same period of 2024. Affecting six months ended June 30, 2025 test report volume was the Novitas LCD, Genetic Testing in Oncology: Specific Tests, that included DecisionDx-SCC as noncovered, which became effective April 24, 2025, as well as discontinuation of IDgenetix in May 2025: DecisionDx-Melanoma test reports delivered in the six months ended June 30, 2025, were 18,602, compared to 17,969 for the same period in 2024. TissueCypher Barrett's Esophagus test reports delivered in the six months ended June 30, 2025, were 16,602, compared to 8,211 for the same period in 2024. DecisionDx-SCC test reports delivered in the six months ended June 30, 2025, were 9,137, compared to 7,854 for the same period in 2024. Affecting six months ended June 30, 2025 volume was the Novitas LCD, Genetic Testing in Oncology: Specific Tests, that included DecisionDx-SCC as noncovered, which became effective April 24, 2025. MyPath Melanoma test reports delivered in the six months ended June 30, 2025, were 2,092, compared to 2,097 for the same period in 2024. IDgenetix test reports delivered in the six months ended June 30, 2025, were 3,605, compared to 8,981 for the same period in 2024. The Company discontinued its IDgenetix test offering effective May 2025. DecisionDx-UM test reports delivered in the six months ended June 30, 2025, were 938, compared to 878 for the same period in 2024. Gross margin for the six months ended June 30, 2025, was 63%, and Adjusted Gross Margin was 81%. Net cash provided by operations was $14.8 million, compared to $17.2 million net cash provided by operations for the same period in 2024. Net loss, which includes non-cash stock-based compensation expense of $22.4 million, was $21.3 million, compared to net income of $6.4 million for the same period in 2024. Net loss per share, Basic and Diluted, was $0.74 and Adjusted Net Loss per Share, Basic and Diluted, was $0.04, compared to Net income per share and Adjusted Net Income per Share, Basic and Diluted, of $0.23 and $0.22, respectively, for the same period in 2024. Adjusted EBITDA was $23.4 million, compared to $32.1 million for the same period in 2024. Cash, Cash Equivalents and Marketable Investment Securities As of June 30, 2025, the Company's cash, cash equivalents and marketable investment securities totaled $275.9 million. 2025 Outlook Castle Biosciences is raising its guidance for anticipated total revenue in 2025. The Company now anticipates generating between $310-320 million in total revenue in 2025, compared to the previously provided guidance of between $287-297 million. Second Quarter and Recent Accomplishments and HighlightsDecisionDx-Melanoma: DecisionDx-Melanoma test has been granted Breakthrough Device designation from the U.S. Food and Drug Administration (FDA). The FDA grants Breakthrough Device designation to select qualifying devices that may offer improved treatment or diagnosis of life-threatening or irreversibly debilitating diseases when compared to currently available alternatives. The Breakthrough Devices Program is intended to provide patients and healthcare providers with timely access to medical devices by speeding up development, assessment and review. See the Company's news release from July 23, 2025, for more information. DecisionDx-Melanoma: Prior studies have shown that clinicians use DecisionDx-Melanoma to inform both avoiding sentinel lymph node biopsy procedures in low-risk patients and initiation of surveillance imaging and referrals to medical oncology in high-risk patients, which enables early detection of recurrences and initiation of therapy. Early detection has been shown to improve outcomes to a greater extent when therapy is initiated with smaller metastatic burden, which can improve net health outcomes. The Company presented novel research as part of Castle's ongoing collaboration with the NCI's SEER Program Registries at the 2025 American Society of Clinical Oncology (ASCO) Annual Meeting. The study presented an updated matching of patients who received DecisionDx-Melanoma as part of their clinical care to those who did not. In this large, real-world cohort of 13,560 patients with CM – the largest real-world study of gene expression profile testing to date – the DecisionDx-Melanoma was associated with a 32% reduction in mortality risk compared to untested patients, providing further evidence of the test's association with improved patient survival. Additionally, test performance on independent risk stratification was re-confirmed. See the Company's news release from May 29, 2025, for more information. DecisionDx-SCC: The Company submitted a DecisionDx-SCC reconsideration request for the Novitas LCD and received notification confirming acceptance of the reconsideration submission. DecisionDx-SCC: Two new studies were published in SKIN The Journal of Cutaneous Medicine supporting the clinical utility of DecisionDx-SCC in patients with high-risk cutaneous squamous cell carcinoma (SCC). The first study represents a new validation milestone, establishing DecisionDx-SCC as a significant predictor of local recurrence (LR) in patients classified as high-risk by National Comprehensive Cancer Network (NCCN) guidelines, thereby adding a third utility to the test's existing capabilities. The test has now been validated to predict individual risk of metastasis, benefit from adjuvant radiation therapy (ART) and risk of LR, providing comprehensive results to support tailored post-surgical management and treatment pathway recommendations for patients with SCC. The second study shares results from a clinician survey, affirming the impact of the test's results in guiding these recommendations, specifically the use of ART and surveillance imaging, by providing actionable decision points based on individual patient Company closed its acquisition of Capsulomics, Inc., d/b/a Previse. This acquisition has the potential to increase Castle's GI offerings. There is the potential to create a multiomics approach for improved patient care in Barrett's esophagus, as well as a nonendoscopic sample collection device for pipeline opportunities to potentially expand screening and diagnostic support for patients with Barrett's esophagus and other GI diseases. See the Company's news release from May 5, 2025, for more Company announced new data from the first independent validation of the recently published Collaborative Ocular Oncology Group Study No. 2 (COOG2.) by Harbour et al. The data, from a real-world cohort of 1,297 patients with uveal melanoma (UM), was presented at the Association for Research in Vision and Ophthalmology (ARVO) 2025 Annual Meeting in Salt Lake City. The findings provided further support for adding Preferentially Expressed Antigen in Melanoma (PRAME) gene expression information to the DecisionDx-UM test result to further refine metastatic risk prediction for patients with UM, which is a rare but aggressive eye cancer. See the Company's news release from May 9, 2025, for more Company announced that it entered into a collaboration and license agreement with SciBase Holding AB ('SciBase') utilizing SciBase's Electrical Impedance Spectroscopy technology, which includes both desktop and point-of-care instruments. The initial goal of the collaboration is to advance the development of a diagnostic test that predicts flares in patients diagnosed with atopic dermatitis (AD), a U.S., market with an estimated up to 24 million patients.1,2 See the Company's news release from June 16, 2025, for more Company announced that its founder, president and chief executive officer Derek Maetzold was awarded a distinguished Lifetime Achievement Award in the Management: Business Products Industries category in the 23rd Annual American Business Awards. The American Business Awards recognizes outstanding business performances in the United States, with more than 3,600 nominations from organizations of all sizes submitted this year for consideration in a wide range of categories. See the Company's news release from June 4, 2025, for more information. The Company announced that it earned multiple awards through the 2025 Top Workplaces program: a third consecutive national Healthcare Industry Top Workplaces award, with Castle ranking third among other recognized companies in its size bracket; a fourth consecutive regional Arizona Top Workplaces award from AZ Central; and consecutive national Top Workplaces Culture Excellence awards for Innovation, Work-Life Flexibility, Compensation & Benefits, Leadership and Purpose & Values. Top Workplaces award designations are garnered solely through anonymous employee feedback gathered through a third-party survey administered by Energage. The confidential survey measures the workplace experience and various culture themes that are indicative of successful organizations. See the Company's news release from July 17, 2025, for more information. The Company announced that Maetzold was also named a 2025 Most Admired CEO by the Houston Business Journal. This prestigious honor celebrates leaders who have demonstrated outstanding financial stewardship, fostered inclusive and thriving workplace cultures, and made meaningful contributions to the greater Houston community. See the Company's news release from July 25, 2025, for more information. Conference Call and Webcast Details Castle Biosciences will hold a conference call on Monday, August 4, 2025, at 4:30 p.m. Eastern time to discuss its second quarter 2025 results and provide a corporate update. A live webcast of the conference call can be accessed here: or via the webcast link on the Investor Relations page of the Company's website, Please access the webcast at least 10 minutes before the conference call start time. An archive of the webcast will be available on the Company's website until August 25, 2025. To access the live conference call via phone, please dial 833 470 1428 from the United States, or +1 404 975 4839 internationally, at least 10 minutes prior to the start of the call, using the conference ID 638217. There will be a brief Question & Answer session following management commentary. Use of Non-GAAP Financial Measures (UNAUDITED) In this release, we use the metrics of Adjusted Revenues, Adjusted Gross Margin, Adjusted EBITDA and Adjusted Net Income (Loss) per Share, Basic and Diluted, which are non-GAAP financial measures and are not calculated in accordance with generally accepted accounting principles in the United States (GAAP). Adjusted Revenues and Adjusted Gross Margin reflect adjustments to GAAP net revenues to exclude net positive and/or net negative revenue adjustments recorded in the current period associated with changes in estimated variable consideration related to test reports delivered in previous periods. Adjusted Gross Margin further excludes acquisition-related intangible asset amortization. Adjusted EBITDA excludes from net income (loss): interest income, interest expense, income tax benefit, depreciation and amortization expense, stock-based compensation expense and changes in fair value of trading securities. Adjusted Net Income (Loss) per Share, Basic and Diluted, excludes a one-time adjustment of an acceleration of amortization expense for our IDgenetix test from net income (loss). We use Adjusted Revenues, Adjusted Gross Margin, Adjusted EBITDA and Adjusted Net Income (Loss) per Share, Basic and Diluted, internally because we believe these metrics provide useful supplemental information in assessing our revenue and operating performance reported in accordance with GAAP, respectively. We believe that Adjusted Revenues, when used in conjunction with our test report volume information, facilitates investors' analysis of our current-period revenue performance and average selling price performance by excluding the effects of revenue adjustments related to test reports delivered in prior periods, since these adjustments may not be indicative of the current or future performance of our business. We believe that providing Adjusted Revenues may also help facilitate comparisons to our historical periods. Adjusted Gross Margin is calculated using Adjusted Revenues and therefore excludes the impact of revenue adjustments related to test reports delivered in prior periods, which we believe is useful to investors as described above. We further exclude acquisition-related intangible asset amortization in the calculation of Adjusted Gross Margin. We believe that excluding acquisition-related intangible asset amortization may facilitate gross margin comparisons to historical periods and may be useful in assessing current-period performance without regard to the historical accounting valuations of intangible assets, which are applicable only to tests we acquired rather than internally developed. Adjusted Net Income (Loss) per Share, Basic and Diluted, is calculated by excluding a one-time adjustment of an acceleration of amortization expense for our IDgenetix test from net loss. We believe that providing Adjusted Net Income (Loss) per Share, Basic and Diluted, may also help facilitate comparisons to our historical periods. We believe Adjusted EBITDA may enhance an evaluation of our operating performance because it excludes the impact of prior decisions made about capital investment, financing, investing and certain expenses we believe are not indicative of our ongoing performance. However, these non-GAAP financial measures may be different from non-GAAP financial measures used by other companies, even when the same or similarly titled terms are used to identify such measures, limiting their usefulness for comparative purposes. These non-GAAP financial measures are not meant to be considered in isolation or used as substitutes for net revenues, gross margin net income (loss) or net income (loss) per share reported in accordance with GAAP; should be considered in conjunction with our financial information presented in accordance with GAAP; have no standardized meaning prescribed by GAAP; are unaudited; and are not prepared under any comprehensive set of accounting rules or principles. In addition, from time to time in the future, there may be other items that we may exclude for purposes of these non-GAAP financial measures, and we may in the future cease to exclude items that we have historically excluded for purposes of these non-GAAP financial measures. Likewise, we may determine to modify the nature of adjustments to arrive at these non-GAAP financial measures. Because of the non-standardized definitions of non-GAAP financial measures, the non-GAAP financial measure as used by us in this press release and the accompanying reconciliation tables have limits in their usefulness to investors and may be calculated differently from, and therefore may not be directly comparable to, similarly titled measures used by other companies. Accordingly, investors should not place undue reliance on non-GAAP financial measures. Reconciliations of these non-GAAP financial measures to the most directly comparable GAAP financial measures are presented in the tables at the end of this release. About Castle Biosciences Castle Biosciences (Nasdaq: CSTL) is a leading diagnostics company improving health through innovative tests that guide patient care. The Company aims to transform disease management by keeping people first: patients, clinicians, employees and investors. Castle's current portfolio consists of tests for skin cancers, Barrett's esophagus and uveal melanoma. Additionally, the Company has active research and development programs for tests in these and other diseases with high clinical need, including its test in development to help guide systemic therapy selection for patients with moderate-to-severe atopic dermatitis seeking biologic treatment. To learn more, please visit and connect with us on LinkedIn, Facebook, X and Instagram. DecisionDx-Melanoma, DecisionDx-CMSeq, i31-SLNB, i31-ROR, DecisionDx-SCC, MyPath Melanoma, TissueCypher, DecisionDx-UM, DecisionDx-PRAME and DecisionDx-UMSeq are trademarks of Castle Biosciences, Inc. Forward-Looking Statements This press release contains forward-looking statements within the meaning of Section 27A of the Securities Act of 1933, as amended, and Section 21E of the Securities Exchange Act of 1934, as amended, which are subject to the 'safe harbor' created by those sections. These forward-looking statements include, but are not limited to, statements concerning our expectations regarding: Castle's 2025 total revenue guidance of $310-320 million; continued top-line performance and growth of test volumes; the potential mid- to long-term value possibly generated from the Previse and SciBase transactions; the ability of DecisionDx-Melanoma and DecisionDx-SCC to bring substantial added value to clinicians and their patients; the ability of DecisionDx-Melanoma to (i) reduce mortality risk compared to untested patients and (ii) improve patient survival; the ability of DecisionDx-SCC to (i) predict individual risk of metastasis, benefit from /ART and risk of LR and (ii) provide comprehensive results to support tailored post-surgical management and treatment pathway recommendations; the success of Castle's DecisionDx-SCC reconsideration request for the Novitas LCD determination; and Castle's ability to achieve near- and long-term success and the continued growth of our portfolio. The words 'anticipate,' 'can,' 'could,' 'expect,' 'goal,' 'may,' 'plan' and similar expressions are intended to identify forward-looking statements, although not all forward-looking statements contain these identifying words. We may not actually achieve the plans, intentions, or expectations disclosed in our forward-looking statements and you should not place undue reliance on our forward-looking statements. Actual results or events could differ materially from the plans, intentions and expectations disclosed in the forward-looking statements that we make. These forward-looking statements involve risks and uncertainties that could cause our actual results to differ materially from those in the forward-looking statements, including, without limitation: our assumptions or expectations regarding reimbursement for our products and subsequent coverage decisions, our estimated total addressable markets for our products and product candidates and the related expenses, capital requirements and potential needs for additional financing, the anticipated cost, timing and success of our product candidates, and our plans to research, develop and commercialize new tests and our ability to successfully integrate new businesses, assets, products or technologies acquired through acquisitions, the effects of macroeconomic events and conditions, including inflation and monetary supply shifts, labor shortages, liquidity concerns at, and failures of, banks and other financial institutions or other disruptions in the banking system or financing markets and recession risks, supply chain disruptions, tariffs, outbreaks of contagious diseases and geopolitical events (such as the ongoing conflicts in the Middle East and Ukraine-Russia conflict), among others, on our business and our efforts to address its impact on our business; the possibility that subsequent study or trial results and findings may contradict earlier study or trial results and findings or may not support the results discussed in this press release, including with respect to the tests discussed in this press release; our planned installation of additional equipment and supporting technology infrastructures and implementation of certain process efficiencies may not enable us to increase the future scalability of our TissueCypher Test; the possibility that actual application of our tests may not provide the aforementioned benefits to patients; the possibility that our newer gastroenterology franchise may not contribute to the achievement of our long-term financial targets as anticipated; and the risks set forth under the heading 'Risk Factors' in our Annual Report on Form 10-K for the year ended December 31, 2024 and our Quarterly Report on Form 10-Q for the quarter ended June 30, 2025, each filed or to be filed with the SEC, and in our other filings with the SEC. The forward-looking statements are applicable only as of the date on which they are made, and we do not assume any obligation to update any forward-looking statements, except as may be required by law. Investor Relations Contact: Camilla Zuckeroczuckero@ Media Contact: Allison Marshall amarshall@ CASTLE BIOSCIENCES, CONSOLIDATED STATEMENTS OF OPERATIONS(UNAUDITED)(in thousands, except per share data) Three Months EndedJune 30, Six Months EndedJune 30, 2025 2024 2025 2024 NET REVENUES $ 86,188 $ 87,002 $ 174,176 $ 159,976 OPERATING EXPENSES Cost of sales (exclusive of amortization of acquired intangible assets) 17,626 14,519 34,009 28,413 Research and development 12,787 14,136 25,375 27,945 Selling, general and administrative 58,065 51,088 116,685 99,583 Amortization of acquired intangible assets 1,961 2,247 30,286 4,494 Total operating expenses, net 90,439 81,990 206,355 160,435 Operating (loss) income (4,251 ) 5,012 (32,179 ) (459 ) Interest income 2,944 3,144 6,043 6,140 Changes in fair value of trading securities 1,185 — (240 ) — Interest expense (21 ) (270 ) (38 ) (284 ) (Loss) income before income taxes (143 ) 7,886 (26,414 ) 5,397 Income tax benefit (4,666 ) (1,034 ) (5,089 ) (989 ) Net income (loss) $ 4,523 $ 8,920 $ (21,325 ) $ 6,386 Earnings (loss) per share: Basic $ 0.16 $ 0.32 $ (0.74 ) $ 0.23 Diluted $ 0.15 $ 0.31 $ (0.74 ) $ 0.22 Weighted-average shares outstanding: Basic 28,914 27,646 28,763 27,566 Diluted 29,545 28,738 28,763 28,542 Stock-based compensation expense is included in the unaudited condensed consolidated statements of operations as follows (in thousands): Three Months EndedJune 30, Six Months EndedJune 30, 2025 2024 2025 2024 Cost of sales (exclusive of amortization of acquired intangible assets) $ 1,422 $ 1,401 $ 2,878 $ 2,715 Research and development 1,962 2,637 3,857 5,266 Selling, general and administrative 7,824 9,141 15,652 17,873 Total stock-based compensation expense $ 11,208 $ 13,179 $ 22,387 $ 25,854 CASTLE BIOSCIENCES, CONSOLIDATED STATEMENTS OF COMPREHENSIVE (LOSS) INCOME(UNAUDITED)(in thousands) Three Months EndedJune 30, Six Months EndedJune 30, 2025 2024 2025 2024 Net income (loss) $ 4,523 $ 8,920 $ (21,325 ) $ 6,386 Other comprehensive loss: Net unrealized loss on marketable investment securities (92 ) (61 ) (191 ) (308 ) Comprehensive income (loss) $ 4,431 $ 8,859 $ (21,516 ) $ 6,078 CASTLE BIOSCIENCES, CONSOLIDATED BALANCE SHEETS(in thousands) June 30, 2025 December 31, 2024 ASSETS (unaudited) Current Assets Cash and cash equivalents $ 82,233 $ 119,709 Marketable investment securities 193,697 173,421 Accounts receivable, net 52,311 51,218 Inventory 8,366 8,135 Prepaid expenses and other current assets 12,061 7,671 Total current assets 348,668 360,154 Long-term accounts receivable, net 1,132 918 Property and equipment, net 74,060 51,122 Operating lease assets 15,503 11,584 Goodwill and other intangible assets, net 104,125 106,229 Other assets – long-term 1,241 1,228 Total assets $ 544,729 $ 531,235 LIABILITIES AND STOCKHOLDERS' EQUITY Current Liabilities Accounts payable $ 13,181 $ 6,901 Accrued compensation 24,973 32,555 Contingent consideration 1,000 — Operating lease liabilities 1,571 1,665 Current portion of long-term debt 1,944 278 Other accrued and current liabilities 8,221 7,993 Total current liabilities 50,890 49,392 Long-term debt 8,096 9,745 Noncurrent portion of contingent consideration 1,500 — Noncurrent operating lease liabilities 25,377 14,345 Noncurrent finance lease liabilities 364 311 Deferred tax liability 3,126 1,607 Total liabilities 89,353 75,400 Stockholders' Equity Preferred stock — — Common stock 29 28 Additional paid-in capital 676,759 655,703 Accumulated deficit (221,451 ) (200,126 ) Accumulated other comprehensive income 39 230 Total stockholders' equity 455,376 455,835 Total liabilities and stockholders' equity $ 544,729 $ 531,235 CASTLE BIOSCIENCES, CONSOLIDATED STATEMENTS OF CASH FLOWS(UNAUDITED)(in thousands) Six Months EndedJune 30, 2025 2024 OPERATING ACTIVITIES Net (loss) income $ (21,325 ) $ 6,386 Adjustments to reconcile net (loss) income to net cash used in operating activities: Depreciation and amortization 33,178 6,688 Stock-based compensation expense 22,387 25,854 Change in fair value of trading securities 240 — Deferred income taxes (5,437 ) (1,542 ) Accretion of discounts on marketable investment securities (2,606 ) (3,422 ) Other 219 83 Change in operating assets and liabilities: Accounts receivable (1,307 ) (7,620 ) Prepaid expenses and other current assets (4,696 ) (294 ) Inventory (231 ) (71 ) Operating lease assets 664 678 Other assets (13 ) 143 Accounts payable 1,689 (1,650 ) Operating lease liabilities (869 ) (432 ) Accrued compensation (7,582 ) (7,706 ) Other accrued and current liabilities 474 68 Net cash provided by operating activities 14,785 17,163 INVESTING ACTIVITIES Purchases of marketable investment securities (92,832 ) (113,194 ) Proceeds from maturities of marketable investment securities 80,300 86,450 Purchases of debt securities classified as held-to-maturity (5,569 ) — Asset acquisition, net of cash and cash equivalents acquired (18,726 ) — Purchases of property and equipment (14,003 ) (14,381 ) Proceeds from sale of property and equipment 21 7 Net cash used in investing activities (50,809 ) (41,118 ) FINANCING ACTIVITIES Proceeds from exercise of common stock options 37 73 Payment of employees' taxes on vested restricted stock units (3,104 ) (1,089 ) Proceeds from contributions to the employee stock purchase plan 1,482 1,749 Repayment of principal portion of finance lease liabilities (57 ) (47 ) Proceeds from lease incentives received 190 — Proceeds from issuance of term debt — 10,000 Net cash (used in) provided by financing activities (1,452 ) 10,686 NET CHANGE IN CASH AND CASH EQUIVALENTS (37,476 ) (13,269 ) Beginning of period 119,709 98,841 End of period $ 82,233 $ 85,572 CASTLE BIOSCIENCES, INC. Reconciliation of Non-GAAP Financial Measures (UNAUDITED) The table below presents the reconciliation of Adjusted Revenues, Adjusted Gross Margin and Adjusted Net Income (Loss) Per Share, Basic and Diluted, which are non-GAAP financial measures. See "Use of Non-GAAP Financial Measures (UNAUDITED)" above for further information regarding the Company's use of non-GAAP financial measures. Three Months EndedJune 30, Six Months EndedJune 30, 2025 2024 2025 2024 (in thousands, except per share data) Adjusted Revenues Net revenues (GAAP) $ 86,188 $ 87,002 $ 174,176 $ 159,976 Revenue associated with test reports delivered in prior periods (6 ) (363 ) 1,996 (959 ) Adjusted Revenues (Non-GAAP) $ 86,182 $ 86,639 $ 176,172 $ 159,017 Adjusted Gross Margin Gross margin (GAAP)1 $ 66,601 $ 70,236 $ 109,881 $ 127,069 Amortization of acquired intangible assets 1,961 2,247 30,286 4,494 Revenue associated with test reports delivered in prior periods (6 ) (363 ) 1,996 (959 ) Adjusted Gross Margin (Non-GAAP) $ 68,556 $ 72,120 $ 142,163 $ 130,604 Gross Margin percentage (GAAP)2 77.3 % 80.7 % 63.1 % 79.4 % Adjusted Gross Margin percentage (Non-GAAP)3 79.5 % 83.2 % 80.7 % 82.1 % Adjusted Net Income (Loss) per Share, Basic and Diluted Net income (loss) (GAAP) $ 4,523 $ 8,920 $ (21,325 ) $ 6,386 Amortization of acquired intangible assets4 — — 20,099 — Adjusted Net Income (Loss) (Non-GAAP) $ 4,523 $ 8,920 $ (1,226 ) $ 6,386 Weighted-average shares outstanding Basic 28,914 27,646 28,763 27,566 Diluted 29,545 28,738 28,763 28,542 Net income (loss) per share (GAAP)5 Basic $ 0.16 $ 0.32 $ (0.74 ) $ 0.23 Diluted $ 0.15 $ 0.31 $ (0.74 ) $ 0.22 Adjusted Net Income (Loss) per share (Non-GAAP)6 Basic $ 0.16 $ 0.32 $ (0.04 ) $ 0.23 Diluted $ 0.15 $ 0.31 $ (0.04 ) $ 0.22 Calculated as net revenues (GAAP) less the sum of cost of sales (exclusive of amortization of acquired intangible assets) and amortization of acquired intangible assets. Calculated as gross margin (GAAP) divided by net revenues (GAAP). Calculated as Adjusted Gross Margin (Non-GAAP) divided by Adjusted Revenues (Non-GAAP). Represents a one-time adjustment of an acceleration of amortization expense for our IDgenetix test during the three months ended March 31,2025. Calculated as net income (loss) (GAAP) divided by weighted-average shares outstanding, basic and diluted. Calculated as Adjusted Net Income (Loss) (Non-GAAP) divided by weighted-average shares outstanding, basic and diluted. The table below presents the reconciliation of Adjusted EBITDA, which is a non-GAAP financial measure. See "Use of Non-GAAP Financial Measures (UNAUDITED)" above for further information regarding the Company's use of non-GAAP financial measures. Three Months EndedJune 30, Six Months EndedJune 30, 2025 2024 2025 2024 (in thousands) Adjusted EBITDA Net income (loss) $ 4,523 $ 8,920 $ (21,325 ) $ 6,386 Interest income (2,944 ) (3,144 ) (6,043 ) (6,140 ) Interest expense 21 270 38 284 Income tax benefit (4,666 ) (1,034 ) (5,089 ) (989 ) Depreciation and amortization expense 3,414 3,348 33,178 6,688 Stock-based compensation expense 11,208 13,179 22,387 25,854 Change in fair value of trading securities (1,185 ) — 240 — Adjusted EBITDA (Non-GAAP) $ 10,371 $ 21,539 $ 23,386 $ 32,083 1
Yahoo
11 minutes ago
- Yahoo
RespiClear Becomes 2025's Most Talked-About Lung Support Ritual as '7s Mucus Flush' Trend Explodes Across TikTok and Long COVID Forums
Backed by 78,000+ Daily Users, This Clean-Label Lung Ritual Taps 2025's Mucus Reset Trend—No Inhalers, No Prescriptions, Just 7 Seconds a Day Tampa, Aug. 04, 2025 (GLOBE NEWSWIRE) -- DISCLAIMER: This press release is for informational purposes only. The information contained herein does not constitute medical advice, diagnosis, or treatment and has not been evaluated by the Food and Drug Administration (FDA). RespiClear is not intended to diagnose, treat, cure, or prevent any disease. Always consult your physician or qualified healthcare provider before beginning any new supplement, routine, or health links in this release may be promotional in nature and may lead to third-party websites. The publisher or author may receive compensation through affiliate commissions if a purchase is made through these links. This compensation does not affect the price you pay and helps support continued research and content publication. Results described or implied may not be typical and should not be interpreted as made about ingredients or outcomes reflect public discussion and historical usage only, and are not endorsed by medical professionals or regulatory agencies. Always do your own research and make informed decisions. RespiClear Becomes 2025's Most Talked-About Lung Support Ritual as '7s Mucus Flush' Trend Explodes Across TikTok and Long COVID Forums In an era where environmental stress, urban air quality, and post-viral fatigue dominate wellness conversations, one ritual is quietly changing the way Americans think about breathing. The buzz? A simple 7-second daily lung routine powered by RespiClear, a clean-label formula now used by over 78,000 with mucolytic herbs like Mullein, Ginger, and Cordyceps, RespiClear supports those seeking clearer breath, lighter mornings, and long-term respiratory confidence — without prescriptions, powders, or Interest in '7s Ritual Clears Stuck Mucus' Is Surging in 2025 The viral interest in short-form rituals and natural breathing remedies has collided with the global need for respiratory recovery. As more people turn away from pharmaceutical-first approaches, they are embracing simple, integrative health routines they can control. RespiClear fits into this evolving health narrative by providing a structured, easy-to-implement ritual that aligns with what digital audiences want: low friction, high impact. Social platforms are increasingly flooded with testimonials and trend-spotting videos featuring phrases like "mucus flush," "breathing hack," and "clean lung ritual." The rise in attention is not merely hype — it reflects a growing concern over residual respiratory symptoms post-illness, as well as an increased desire to offset everyday air pollution, wildfire exposure, and indoor toxin buildup. These conversations, while anecdotal, are informing how millions view respiratory health in 2025. RespiClear's Ingredient-First Response to These Trends What sets RespiClear apart in this movement isn't just what's inside the formula — it's how the product is positioned. RespiClear does not promise medical outcomes, but rather contributes to a broader movement of proactive daily wellness. The sublingual format delivers the plant-based ingredients quickly, a nod to both modern efficiency and traditional herbalism. As part of a trend emphasizing radical transparency, RespiClear lists every ingredient, dose, and third-party verification step. Consumers can trace the product from source to supplement — a critical factor in building trust at a time when misinformation and wellness fatigue are rampant. More than a product, RespiClear is a reflection of what today's health-conscious individual wants: simplicity, integrity, and data-backed natural formulations. In addition to excluding stimulants, allergens, and questionable additives, the formula is designed for long-term daily use, reinforcing the shift from reactive care to continuous support. Ingredient Spotlight – What's Inside the Formula RespiClear's formulation is a showcase of historically relevant, globally respected ingredients that have seen renewed interest in recent years. Each ingredient is dosed in a way that reflects its respected usage in wellness traditions and is supported by observational discussion in public health forums. Mullein Leaf Extract (1,000 mg) – Used for centuries as a tea for easing cough and congestion, mullein is currently enjoying a renaissance. RespiClear's version is highly bioavailable, liquified for easy delivery and maximal absorption. Ginger Root Extract (100 mg) – Popular in both Eastern and Western traditions, ginger is associated with circulation, digestive relief, and airway clarity. Its inclusion is based on its role in helping users feel open-chested and warmed. Bromelain (50 mg) – Often found in sports recovery products, bromelain supports the breakdown of proteins and is valued for tissue wellness — particularly in high-stress respiratory situations. Lemon Peel Extract (25 mg) – With high concentrations of natural antioxidants, lemon peel is a crowd-favorite in discussions around immune resilience and cellular protection. Cordyceps militaris (25 mg) – As an adaptogen, cordyceps has grown popular among performance optimizers and long-COVID recoverees alike. It is explored for its relationship with oxygen processing and vitality. Collectively, these ingredients form a coherent and intentional stack. They're not designed to replace medicine — they offer a structured entry point for those seeking lung support via natural Reddit, Podcasts & TikTok Creators Are Saying RespiClear's rise in popularity isn't driven by advertising — it's fueled by thousands of anecdotal micro-mentions from communities that trade wellness tips peer-to-peer. On TikTok, creators frequently highlight the product in morning ritual videos or "what's in my bag" wellness rundowns. Reddit's wellness subforums feature in-depth user experiences detailing RespiClear's impact on congestion, focus, and even emotional clarity. Podcasts hosted by holistic health educators, performance coaches, and yoga therapists often include RespiClear in 'non-invasive support tools' lists. The language is consistent: RespiClear doesn't fix everything — but it helps people feel more in control of their breath, especially after difficult seasons of respiratory stress. Importantly, users are not framing the product in clinical terms. Instead, the product shows up as part of a mindset shift — one where simplicity, consistency, and breath awareness are becoming foundational. Who Might Be Drawn to This Type of Supplementation in 2025 While the audience for RespiClear is wide-ranging, certain demographics are leading adoption: Post-viral recovery groups who want gentle, everyday routines that feel empowering Older adults and ex-smokers focused on daily lung hygiene and resilience Urban professionals navigating poor indoor air quality, wildfire smoke, and long hours Fitness and wellness enthusiasts who use breath as a foundation for movement and recovery Spiritual communities drawn to breath as a sacred component of calm, control, and emotional stability These audiences are not defined by illness — they are defined by a desire to optimize wellness preventatively. For this reason, RespiClear often becomes part of broader lifestyle rituals that include stretching, mindfulness, hydration, and clean eating. 5 Steps to Support Lung Health (and Why RespiClear Complements Them) While no supplement can replace smart lifestyle choices, RespiClear is structured to align perfectly with the five most recommended practices in 2025 for protecting respiratory integrity: Quit Smoking: The #1 recommendation. Removing tobacco toxins allows the lungs to regenerate over time. RespiClear users who have recently quit say it helps them stay motivated by giving them an immediate, supportive action each day. Daily Movement: Light cardiovascular exercise expands lung capacity, clears stale air, and supports circulation. RespiClear's energizing, clear-breath feel pairs well with morning walks, yoga, or breathwork. Antioxidant Nutrition: Flavonoids reduce systemic inflammation. RespiClear complements these effects with ingredients like ginger and lemon, which are already valued for their antioxidant properties. Clean Air Exposure: In urban areas where clean air is rare, RespiClear users report a sense of protection after returning from travel, fires, or heavily polluted cities. Breath Practice: Deep breathing resets the nervous system. Users often take their RespiClear dose right before meditation or breath training for synergy. This is what makes RespiClear unique: it is not positioned as a cure — it is an amplifier of the most essential health Optimization & Detox Culture: Where RespiClear Fits In Wellness is not just about the body — it's about mental, emotional, and spiritual lightness in 2025. RespiClear appears increasingly in conversations about: 'Third-lung cleansing' in energy work Daily routines designed to calm the nervous system through somatic breathing Post-psychedelic integration practices where breath is used to ground and center Its presence in these communities is not because of marketing, but because it fulfills a demand: something subtle, safe, and supportive. With no caffeine, no overstimulation, and no gut disturbance, RespiClear is often used during fasting windows, pre-sleep wind-downs, or pre-yoga grounding. Public Debate Around 'Mucus Formulas' — Caution Meets Curiosity RespiClear's popularity has not shielded it from scrutiny. Critics have raised questions about the legitimacy of mucus-targeting products and whether claims made by influencers overstate the experience. The brand has responded by doubling down on transparency. Their website includes detailed sourcing, dosage explanations, and third-party test protocols — uncommon in the supplement space. It's a bet on intelligence and trust: by giving users all the facts, they invite scrutiny as a sign of integrity. Wellness forums now often cite RespiClear as a "test case" for whether natural lung supplements can carve out a legitimate category — not as miracle pills, but as daily partners in long-term breath clarity. About RespiClear RespiClear is a U.S.-manufactured natural formula designed to support daily breath clarity, mucus management, and clean-label supplementation. The company behind RespiClear believes in empowering individuals with proactive tools that foster calm, clarity, and long-term wellness. Every batch is: GMP certified and third-party tested Packaged with a 180-day satisfaction guarantee Shipped within the U.S. with transparent customer support With a mission to improve breathing for 1,000,000 Americans, RespiClear is a quiet but growing part of 2025's shift toward breathable living. Contact RespiClear – Clean-Label Lung Support Backed by Transparency Email: support@ Phone: (833) 576-9777 Website: FINAL DISCLAIMER This press release is for informational purposes only. The information contained herein does not constitute medical advice, diagnosis, or treatment and has not been evaluated by the Food and Drug Administration (FDA). RespiClear is not intended to diagnose, treat, cure, or prevent any disease. Always consult your physician or qualified healthcare provider before beginning any new supplement, routine, or health program. Some links in this release may be promotional in nature and may lead to third-party websites. The publisher or author may receive compensation through affiliate commissions if a purchase is made through these links. This compensation does not affect the price you pay and helps support continued research and content publication. Results described or implied may not be typical and should not be interpreted as guarantees. Statements made about ingredients or outcomes reflect public discussion and historical usage only, and are not endorsed by medical professionals or regulatory agencies. Always do your own research and make informed decisions. CONTACT: Email: support@ Phone: (833) 576-9777
Yahoo
11 minutes ago
- Yahoo
Acadia Pharmaceuticals Appoints Scott Cenci as Chief Information and Data Officer
SAN DIEGO, August 04, 2025--(BUSINESS WIRE)--Acadia Pharmaceuticals Inc. (Nasdaq: ACAD) today announced the appointment of Scott Cenci as Senior Vice President, Chief Information and Data Officer. In this role, Scott will lead Acadia's digital transformation including technology, data and AI strategy and will serve as a member of the company's Executive Leadership Team, reporting to Catherine Owen Adams, Chief Executive Officer of Acadia. "We are thrilled to welcome Scott to Acadia," said Catherine Owen Adams. "Scott's extensive leadership in digital transformation, AI-driven innovation, and global IT operations across leading biopharmaceutical companies makes him an ideal fit for our organization. His proven ability to scale digital capabilities and drive business value will be instrumental as we continue to grow and evolve." Scott brings over 25 years of experience in the pharmaceutical and biotechnology industries, having held senior leadership roles at Genmab, Biogen, Zoetis, and Pfizer. Most recently, he served as Senior Vice President of Global Information Technology and Digital at Genmab, where he transformed the IT function into a full-scale digital organization, supporting the company's growth from 500 to 2,700 employees and from $750 million to over $3 billion in revenue. Throughout his career, Scott has led enterprise-wide digital and AI initiatives, implemented global ERP and cloud platforms, and driven operational efficiencies through agile methodologies and data analytics. He has also played key roles in major corporate transformations, including IPOs, spin-offs, and M&A integrations. "I am honored to join Acadia at such a pivotal time," said Scott Cenci. "The opportunity to contribute to a company that is deeply committed to investing in data, technology, and AI to accelerate innovation and improved patient care is incredibly exciting. I look forward to partnering with the team to advance Acadia's digital capabilities and support its mission to bring new therapies to patients." Scott holds an MBA in Management Information Systems from Seton Hall University and a BS in Computer Science and a minor in Mathematics from The College of New Jersey. He has served as an advisor to professional organizations and is an active member of the Osage Venture Partners Technology Advisory Board. Additionally, Scott has served as a speaker on topics such as Generative AI and digital transformation. About Acadia Pharmaceuticals Acadia is advancing breakthroughs in neurological and rare diseases to elevate life. Since our founding we have been working at the forefront of healthcare to bring vital solutions to people who need them most. We developed and commercialized the first and only FDA-approved drug to treat hallucinations and delusions associated with Parkinson's disease psychosis and the first and only approved drug in the United States and Canada for the treatment of Rett syndrome. Our clinical-stage development efforts are focused on Prader-Willi syndrome, Alzheimer's disease psychosis and multiple other programs targeting neuroscience and neuro-rare diseases. For more information, visit us at and follow us on LinkedIn and X. View source version on Contacts Investor Contact: Acadia Pharmaceuticals Kildani(858) 261-2872ir@ Acadia Pharmaceuticals Tieszen(858) 261-2950ir@ Media Contact: Acadia Pharmaceuticals Kazenelson(818) 395-3043media@ Error in retrieving data Sign in to access your portfolio Error in retrieving data Error in retrieving data Error in retrieving data Error in retrieving data
