Bridge Capture™ enables sensitive, scalable liquid biopsy in colorectal cancer pilot
TURKU, Finland, July 14, 2025 /CNW/ -- Genomill Health, a biotechnology company pioneering simplified targeted library preparation for next-generation sequencing announces the results of a clinical pilot study published in Scientific Reports, demonstrating the high sensitivity of its Bridge Capture™ technology for mutation profiling in cell free DNA of metastatic colorectal cancer patients. Study shows that Bridge Capture™ matches the sensitivity of droplet digital PCR (ddPCR) - a gold standard in the field - while providing unlimited panel scalability and simple and cost-efficient workflow that enables decentralized NGS testing.
The study was performed in collaboration with professor Ari Ristimäki's group (Helsinki University Hospital) and demonstrated a high concordance of Bridge Capture™ to ddPCR and Ion AmpliSeq™ while revealing several other, previously unknown oncogenic mutations that reflected disease progression across longitudinal plasma samples. Prof. Ristimäki was impressed by Bridge Capture™'s capability to combine highly scalable, sensitive targeted sequencing with cost-efficiency and ease of use. He sees this as an important advance that could significantly expand the use of liquid biopsies in treatment monitoring.
"Bridge Capture matched or exceeded gold-standard methods in detecting mutations in patient samples. Its ability to track changes over time could be a powerful tool for monitoring cancer progression and relapse." said Simona Adamusová, Doctoral Researcher and co-first author. "This clinical pilot study highlights Bridge Capture's readiness for real-world applications in liquid biopsy," added Manu Tamminen, CEO and Co-Founder of Genomill. "The unparalleled simplicity of the laboratory workflow and the compatibility across multiple sequencing platforms lays ground for distributed, decentralized, longitudinal cancer diagnostics. By removing cost and infrastructural constraints that currently hinder the routine use of liquid biopsies, we seek to establish Bridge Capture as an enabling technology for highly accessible cancer diagnostics."
Bridge Capture™ is an embodiment of Genomill's Geno1 ® technologies that are based on circular DNA and linear DNA amplification. Juha-Pekka Pursiheimo, CTO and inventor of the technology, added: "Bridge Capture establishes a new standard for NGS library design by using circular single-stranded DNA - a more flexible and robust alternative to traditional linear libraries. Together with our PCR-free DNA amplification approaches, this positions Genomill to revolutionize NGS library preparation."
The full study, titled "Evaluation of Bridge Capture technology for mutation profiling in liquid biopsies of metastatic colorectal cancer patients", is available in Scientific Reports (link https://www.nature.com/articles/s41598-025-04827-2).
Contact
CEO Manu Tamminen
[email protected]
Tel: +358403513712
Hashtags
Try Our AI Features
Explore what Daily8 AI can do for you:
Comments
No comments yet...
Related Articles
Cision Canada
2 hours ago
- Cision Canada
H55 DEMONSTRATES HIGH-DENSITY ALTITUDE ELECTRIC FLIGHT IN COLORADO, SHOWCASING AIRCRAFT PERFORMANCE IN EXTREME CONDITIONS
SION, Switzerland and CENTENNIAL, Colo., July 15, 2025 /CNW/ -- H55, the electric aviation pioneer born from the Solar Impulse project, has completed a series of high-density altitude, high- temperature demonstration flights in Colorado as part of its Across USA Tour. These tests confirm the real-world performance of the H55-powered Bristell B23 Energic, illustrating the operational performance of electric aviation. Operating in Challenging Conditions The Colorado mission flights took place from an airfield situated at 5,800 feet above sea level, with temperatures reaching 36°C (96.8°F) and a takeoff density altitude of 9,500ft. The B23 Energic performed flawlessly providing smooth, 500 feet per minute climbs using normal runway distance for departures. This 'hot and high' scenario tests an aircraft's take-off distance, climb performance, and overall efficiency. In contrast to conventional combustion engines which face degraded performance in such operating environments, the electric propulsion system of the B23 Energic delivered steady and reliable results. "Colorado offers one of the most demanding environments for aviation," said Gregory Blatt, Co- Founder and Mission Director of H55. "This stop gives us a chance to demonstrate how electric propulsion is not only sustainable, but operationally consistent in conditions previously considered restrictive for many aircraft types. We're especially grateful to Centennial Airport and jetCenters of Colorado for their warm welcome and support. Their commitment to innovation and sustainability reflects the shared mission of accelerating the adoption of clean aviation solutions." A First for Colorado Centennial Flyers, a leading flight school based at Centennial Airport (KAPA), signed a Letter of Intent (LOI) during H55's Colorado stop-over, becoming the first operator in the State to formally commit to adopting electric aviation. Their decision reflects the growing momentum across the U.S. for the Bristell B23 Energic, which continues to attract interest from flight schools, pilot individuals, operators, and regional airports seeking sustainable and cost-efficient training solutions. This engagement further strengthens H55's expanding order book and underscores the market's readiness for certified electric aircraft. Proving Electric Flight in Real Environmental Settings Electric propulsion systems face heightened scrutiny when tested outside of controlled environments. In Colorado's hot, high-altitude climate, H55's certified Electric Propulsion System (EPS) excels, maintaining optimal performance despite the challenges posed by both elevated temperatures and reduced air density. The system delivered consistent climb rates and demonstrated efficient battery cooling, proving that electric flight can operate effectively in diverse climates and geographies year-round. Key Questions Answered in Colorado Can electric aircraft operate effectively at high-density altitudes? Yes—the B23 Energic performed in conditions of 36°C (96.8°F) and a 9,500 ft density altitude with stability and strong climb rates, at 500 feet per minute. How does heat affect electric propulsion? H55's battery and EPS architecture performed within nominal thermal limits, with no signs of degradation despite high ambient temperatures, up to 40°C (104°F). Advancing Climate Resilient Flight Training As electric aircraft join training fleets, climate resilient performance is essential. The B23 Energic offers zero emissions, low noise, and minimal vibration—ideal for flight schools and airports under stricter environmental rules. Colorado illustrated flawless performance in conditions that normally strain conventional aircraft. With no performance loss or system degradation, H55's EPS proves electric propulsion is ready for high-altitude, high-temperature flight. Next Stop: Oshkosh Following the Colorado tour stop, the Across USA Tour continues with its seventh stop at EAA AirVenture Oshkosh 2025 — 'The World's Greatest Aviation Celebration'. Attendees can learn more about the future of electric aviation at the 2025 Electric Aircraft Symposium (July 19-20), followed by the annual airshow (July 21-27) — a first for both H55 and Bristell BRM AERO. A Bristell/H55 press conference will be held on Tuesday, July 22 at 11:00 AM CST at Booths 296-297. About H55 H55 is a Swiss-based company founded by the former Solar Impulse management team: André Borschberg, Sebastien Demont, and Gregory Blatt. Dedicated to revolutionizing the aviation industry, H55 provides certified electric propulsion and battery management systems tailored to a diverse range of aircraft, aiming to achieve sustainable air travel. H55 supplies certified electric propulsion systems with full airplane integration solutions for general aviation and regional transport aircraft. Through its pioneering legacy and commitment to certified solutions, H55's team of visionary engineers and aerospace experts are at the forefront of driving the aviation industry setting new standards and pushing the boundaries of electric aviation. Media Contact [email protected] H55 SA Route de l'Aéroport 10 1950 Sion Switzerland
Cision Canada
3 hours ago
- Cision Canada
QualiZeal Receives Frost & Sullivan's 2025 India Technology Innovation Leadership Recognition for Excellence in GenAI Quality Engineering Platforms
QualiZeal's AI-powered platforms are revolutionizing software quality engineering and accelerating innovation through GenAI-driven automation. SAN ANTONIO, July 15, 2025 /CNW/ -- Frost & Sullivan is pleased to announce that QualiZeal has been awarded the 2025 India Technology Innovation Leadership Recognition in the GenAI quality engineering platform industry for its outstanding achievements in advancing software quality engineering through artificial intelligence and automation. This recognition highlights QualiZeal's consistent leadership in driving measurable outcomes, strengthening its market position, and delivering customer-centric innovation in an increasingly automated and competitive technology landscape. Frost & Sullivan evaluates companies through a rigorous benchmarking process across two core dimensions: strategy effectiveness and strategy execution. QualiZeal excelled in both, demonstrating its ability to align strategic initiatives with market demand while executing them with consistency, scale, and innovation. "QualiZeal's deep-rooted focus on GenAI integration and its independent QE model allow it to address critical challenges that traditional embedded approaches cannot resolve. Its flagship platforms, QMentisAI and QualiCentral, represent a next-gen approach to software testing—data-driven, intelligent, and deeply aligned with customer success," said Heena Juneja, Industry Principal at Frost & Sullivan. Guided by a long-term growth strategy focused on innovation, strategic collaboration, and workforce inclusion, QualiZeal has shown its ability to adapt and lead in a rapidly evolving digital ecosystem. The company's investments in AI-driven accelerators, agentic AI, and scalable delivery models have enabled it to maintain a competitive edge and deliver transformative results across global markets. QualiZeal's suite of platforms, including the breakthrough QMentisAI (patent pending), uses GenAI to address software testing needs. Built on the MAYA (Most Advanced Yet Acceptable) design principle, QMentisAI offers 18 advanced capabilities for generating test cases, automating scripting, delivering real-time defect insights, and more. Engineered to integrate GenAI across the software testing lifecycle, QMentisAI helps cut test durations by nearly 60% while enabling up to 95% test coverage. The platform's agentic architecture (e.g., Test Strategy Agent, User Story Refinement Agent) includes built-in explainability features using RAG (Retrieval-Augmented Generation), providing users visibility into how decisions and suggestions are made—facilitating better trust and human oversight. The complementary platform and powerful suite of Quality Engineering assets and accelerators, QualiCentral, provides actionable QE analytics, equipping enterprises with data to improve decision-making, automation strategy, and release readiness. "As software engineering evolves, QMentisAI is our answer to bridging the gap between technology and human ingenuity. We are honored by this recognition for our platform's ability to significantly reduce manual effort, accelerate timelines, and foster seamless collaboration, making it a game-changer for teams striving for excellence," added Pradeep Govindasamy, Co-Founder, President & CEO, QualiZeal." "QMentisAI and QualiCentral are built in-house without any third-party dependencies. These platforms embody our vision of combining cutting-edge technology with human expertise to deliver superior results," said Madhu Murty, Co-Founder & Head of India Operations, QualiZeal. "By harnessing GenAI and a human-in-the-loop approach, we're enabling teams to reduce manual effort, expedite delivery timelines, and achieve unprecedented levels of efficiency in software testing." QualiZeal's unwavering commitment to customer experience further strengthens its market position. By enabling AI-powered self-service capabilities, adopting outcome-based pricing models, and expanding local delivery hubs—such as its newly launched Global Capability Center in Hyderabad—the company continues to exceed expectations for speed, quality, and efficiency. Its partner-led innovation strategy, including collaborations with Tricentis and Panaya, reinforces its ability to co-create innovations and deliver next-generation testing solutions at scale. Frost & Sullivan commends QualiZeal for setting a high standard in competitive strategy, execution, and market responsiveness. The company's vision, innovation pipeline, and customer-first culture are shaping the future of software quality engineering and driving tangible results across industries. Each year, Frost & Sullivan presents the Technology Innovation Leadership Recognition to a company that demonstrates outstanding strategy development and implementation, resulting in measurable improvements in market share, customer satisfaction, and competitive positioning. The recognition celebrates forward-thinking organizations that are reshaping their industries through innovation and growth excellence. Frost & Sullivan Best Practices Recognitions acknowledge companies in various regional and global markets for demonstrating outstanding achievement and superior performance in leadership, technological innovation, customer service, and strategic product development. Industry analysts compare market participants and measure performance through in-depth interviews, analyses, and extensive secondary research to identify best practices in the industry. About Frost & Sullivan For six decades, Frost & Sullivan has been world-renowned for its role in helping investors, corporate leaders, and governments navigate economic changes and identify disruptive technologies, megatrends, new business models, and companies to action, resulting in a continuous flow of growth opportunities to drive future success. Contact us: Start the discussion. About QualiZeal QualiZeal is North America's fastest-growing independent, AI-powered modern Quality Engineering company, delivering services across Quality Engineering, Digital Engineering, Advisory, and Emerging Tech Testing. Empowering global organizations through award-winning proprietary platforms like QMentisAI (patent pending) and QualiCentral, QualiZeal leverages AI and GenAI to solve complex QE challenges at scale and speed. Recognized by Gartner, Everest Group, Forrester, Frost & Sullivan, and NelsonHall, the company has earned multiple accolades—including the 2025 Gold Stevie® Award for Fastest Growing Tech Company of the Year (American Business Awards®), ET NOW's Best Organizations for Women, and the Economic Times' IT/ITES Services Provider of the Year, the 2022 Global Choice Award and 2024 American Business Award®. Trusted by 70+ global enterprise clients and backed by 850+ elite quality engineers, QualiZeal drives seamless digital transformation—reflected in an exceptional NPS score of 75.
Cision Canada
8 hours ago
- Cision Canada
KEPSA and MindHYVE.ai™ Sign Strategic Agreement to Launch National-Scale AGI Workforce, SME, and Innovation Initiatives Across Kenya
NAIROBI, Kenya and NEWPORT BEACH, Calif., July 14, 2025 /CNW/ -- The Kenya Private Sector Alliance (KEPSA) has signed a landmark Memorandum of Understanding with Inc., one of the world's fastest-growing developers of agentic artificial intelligence (AGI). Executed on June 5, 2025, the agreement establishes a national-scale collaboration to deploy domain-specialized AGI agents in service of Kenya's economic transformation, starting with workforce development, SME digital enablement, and innovation policy co-creation. At the core of this partnership are Arthur, Justine, and Eli, intelligent agents engineered for education, legal, and financial domains respectively. Each agent is powered by a dedicated Ava-Series large reasoning model: Arthur is powered by Ava-Education™ Justine by Ava-Legal™ Eli by Ava-Finance™ These agents, operating within platforms like ArthurAI™, are autonomous, adaptive, and capable of delivering real-time impact aligned with Kenya's national objectives. Strategic Programs and Initiatives 1. AGI Workforce Enablement Through ArthurAI™, KEPSA will upskill Kenya's workforce with multilingual learning, credentialing frameworks, and real-time analytics tailored to sector-specific needs. 2. SME Innovation Support A national AI Toolkit will empower small businesses with: Eli: Intelligent finance insights, credit simulation, and tax optimization Justine: Legal contract interpretation, compliance alerts, and literacy tools Arthur: Micro-course training and entrepreneurial education 3. Policy Co-Creation and Thought Leadership The partnership includes collaborative authorship of AGI policy readiness frameworks, public-private dialogue simulations using Justine, and deployment of Ava-Fusion™ to model policy impact scenarios. 4. National AI Innovation Council The parties will establish a cross-sector governance body to guide pilots, compliance, stakeholder feedback, and AGI scaling frameworks. 5. Flagship Launch Programs Ajira Digital AI Academy SME Digital Credit Lab Legal Literacy for Enterprises Executive Commentary "Our mission at MindHYVE is to engineer intelligence that doesn't just automate but elevates," said Bill Faruki, Founder and CEO of "This partnership with KEPSA shows what's possible when artificial general intelligence is built with purpose and deployed with trust. We are not simply supporting Kenya's digital transformation, we are co-architecting a future in which national intelligence infrastructure is adaptive, inclusive, and locally governed." Dr. Ehud Gachugu, Deputy CEO and Global Director of KEPSA, added: "With this partnership, Kenya takes a bold leap into applied AGI. We are not waiting to be shaped by the future; we are shaping it from within." Framework & Governance Term: Five years with renewable terms Oversight: Joint Steering Committee, quarterly reviews Compliance: Kenya's Data Protection Act (2019) IP & Licensing: Retained by original creator; joint assets governed cooperatively Public References: By mutual review and approval About KEPSA The Kenya Private Sector Alliance (KEPSA) is the country's principal private sector body, representing over one million businesses across sectors. It drives Kenya's economic policy agenda, digital transformation initiatives, and national development strategies through inclusive, enterprise-led solutions. About is a global leader in agentic AI systems, orchestrating intelligent agents built on large reasoning models tailored to specific domains. Through Ava-Fusion™ and the Ava-Series including Ava-Education™, Ava-Legal™, and Ava-Finance™. is redefining how intelligence is deployed in law, healthcare, governance, education, and economic development. Media Contact Marc Ortiz Email: [email protected] Phone: +1 (949) 200-8668 Website: SOURCE Inc.
