
UBC researchers awarded more than $6.5 million from Brain Canada to advance neuroscience research Français
VANCOUVER, BC, June 13, 2025 /CNW/ - UBC Faculty of Medicine researchers have been awarded more than $6.5 million from Brain Canada's Platform Support Grants program to support two pioneering neuroscience research platforms. The funding will help accelerate discovery and foster open science, positioning Canada at the forefront of global brain and spine health innovation.
The two newly funded platforms are:
International Spinal Cord Injury Biobank (ISCIB): Promoting Global Spinal Cord Injury Research Through Human Biobanking, led by Dr. Brian Kwon, which will expand access to vital human biological samples for spinal cord injury research, enabling researchers worldwide to advance treatments and improve outcomes for patients.
Total Grant Awarded: $1,866,750
The University of British Columbia Genes, Cells and Circuits (UBC-GC2) Platform for Next-Generation Multiscale Brain Research, led by Dr. Mark Cembrowski, which will integrate state-of-the-art technologies to map brain function and connectivity from molecules to entire circuits, unlocking insights into complex brain disorders.
Total Grant Awarded: $4,845,000
"This platform represents a critical step toward advancing spinal cord injury research globally," said Dr. Brian Kwon, a Professor in the Department of Orthopaedics and the Director of ICORD. "By providing access to high-quality human biosamples, we're enabling researchers worldwide to develop and test new treatments that could dramatically improve quality of life for patients."
"With the UBC-GC2 platform, we're bridging the gap between molecular biology and systems neuroscience," said Dr. Mark Cembrowski, an Associate Professor in the Department of Cellular and Physiological Sciences. "By integrating cutting-edge technologies, we'll be able to study brain function at an unprecedented scale and resolution. This will not only advance our understanding of brain disorders but also open new avenues for treatments."
These platforms exemplify UBC's commitment to advancing neuroscience and fostering collaboration within and beyond Canada's borders.
"The UBC neuroscience community is grateful for Brain Canada's continued support," said Dr. Lynn Raymond, Co-Director of the Djavad Mowafaghian Centre for Brain Health at UBC. "These investments will strengthen our capacity to deliver world-class research and transform brain health for people across the lifespan."
Viviane Poupon, President and CEO of Brain Canada, emphasized the importance of these initiatives: "By supporting these cutting-edge platforms, Brain Canada is building the infrastructure that will accelerate brain and spinal cord research and foster open science collaboration. We're proud to partner with UBC to drive innovations that will impact millions of lives."
These two platforms are part of Brain Canada's broader Platform Support Grants (PSG) initiative, which has already invested in numerous projects across Canada to empower researchers with shared tools, data resources, and collaborative opportunities. The full list of funded platforms will be unveiled later this month.
Brain Canada is contributing over $18 million in this year's PSG program through the Canada Brain Research Fund (CBRF), funded by Health Canada, as well as matching donations from sponsors for a total investment of $36.8 million. By enabling access to cutting-edge tools and specialized skills beyond the reach of individual researchers, the PSG program plays a vital role in strengthening the research landscape.
"Research and innovation are essential to unlocking new treatments, improving recovery, and enhancing quality of life for people affected by brain health issues and injuries," said the Honourable Marjorie Michel, Minister of Health. "Through the Canada Brain Research Fund, the Government of Canada is very pleased to support these new neuroscience research platforms, which bring together experts from different fields, integrate cutting-edge technologies and focus on improving patient outcomes."
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Globe and Mail
3 hours ago
- Globe and Mail
Making their mark
In every corner of the country, in labs, hospitals and universities, a new generation of Canadians is making small but mighty advances in health, science and medicine. They are in the early stages of their promising careers. And yet, they are already deepening our understanding of diseases, from Type 1 diabetes to Alzheimer's and epilepsy – and finding new ways to help Canadians and people around the world. As well, they are making strides in learning how early-life exposures shape long-term outcomes and developing new methods for performing brain surgery on cancer patients. Canada has many early-career researchers making their mark. The Globe and Mail set out to profile five of them. The neuron was first identified in the late 1800s, but more than a century would pass before Canadian scientists found the 'ovoid,' cells nestled deep inside the brain that help us store memories of new objects so they can be recognized down the road. The discovery of this highly specialized neuron unlocks insights into how memory works, while cracking open new research pathways for better understanding – and potentially treating – neurological conditions like Alzheimer's disease. It was a breakthrough made with powerful genetic tools and tiny DIY microscopes strapped to the heads of genetically engineered mice. But the enterprising scientist who first peered into their brains in 2020 and catalyzed the discovery was a PhD student at the University of British Columbia named Adrienne Kinman. 'This is a big discovery for what we call foundational neuroscience, or just understanding how the brain works on a day-to-day level,' says Mark Cembrowski, an associate professor in the department of cellular and physiological sciences at UBC and Ms. Kinman's PhD supervisor. Growing up in Abbotsford, B.C., Ms. Kinman was a keen student and self-described 'sampler' of extracurricular interests. 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He was eager to study them in a line of genetically modified mice using a miniaturized microscope that allows brain activity to be observed in real time – a tool he didn't have at the time. He tapped Ms. Kinman. 'I needed a hero,' he says. Using soldering skills learned from YouTube and open-source plans, Ms. Kinman taught herself to build these 'one-photon fluorescence miniscopes,' which she then strapped onto the heads of these mice, 'like a tiny top hat.' She watched as these intriguing brain cells lit up whenever the mouse interacted with a novel object – say, a tiny orange pylon. But as the pylon grew familiar, the cells began to fade, never to light up again when confronted by the same object. 'It was our 'holy smokes' moment,' Dr. Cembrowski recalls. 'We were like, this is something special that nobody knows about.' More lab mates were recruited to the research effort, with Ms. Kinman at the helm. 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The result is a powerful and ever-expanding dataset that's already produced more than 200 peer-reviewed papers on everything from the infant gut microbiome to risk factors for asthma. 'It's a world-renowned research initiative,' Dr. Miliku says. 'It's an amazing study, one of the best and the largest cohorts we have in Canada.' After receiving her medical degree from the Medical University of Tirana in 2013, Dr. Miliku moved to the Netherlands to pursue her masters and PhD at Erasmus University Medical Center, where she worked on Generation R, another prospective cohort study. She became fascinated with breastmilk, especially its beneficial impact on kidney development. 'I couldn't sleep,' she says. 'I was like, what is in breastmilk that is driving these important health outcomes?' At some point, she decided to look for breastmilk experts. The first name she came across was Meghan Azad, a University of Manitoba professor and deputy director of CHILD. Dr. Miliku fired off an e-mail to Dr. Azad and they connected the next day. 'She said, 'Do you want to work as a postdoctoral fellow in my lab?'' Dr. Miliku recalls, chuckling. 'It happened so quickly.' After moving to Manitoba in 2017, Dr. Miliku worked with Dr. Azad to continue studying breastmilk, investigating the components that might be protective against childhood asthma or allergies. Three years later, she was recruited to McMaster University, home to CHILD's national collaborating centre, and appointed the study's clinical science officer. In this role, Dr. Miliku designs study protocols for the child visits, consulting with CHILD's massive expert network to determine what data to collect, as well as the research questions to explore. Dr. Miliku says CHILD researchers want to empower study participants – something she credits for the study's high retention rate, even throughout the early pandemic. 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He brings a personal connection to this work: Two of his five children have autism; both present differently. He said his eldest son is completely verbal, can attend high school and interacts with his peers. His younger son struggled to find the right words for several years and wasn't using full sentences until about two years ago. 'I think that it's important for people to understand that autism is very complex,' Prof. Bruno said. Much of what people know about autism is influenced by a medical model that often involves the use of negative language, he added. But he said that his cultural teachings see it in a very different way. 'We don't have a word that directly translates as autism; we don't even have a word for disability,' he said. 'And I think that's really beautiful, because we're not looking for differences in people. We're celebrating those, and so elders have often told me that these children, they're sacred children.' Prof. Bruno said he brings these teachings to the families that he works with. He is passionate about offering supports, which motivated him to create a program called the Indigenous Caregiving Collective. The goal of the project is to build a network of organizations, Indigenous elders, researchers and health care providers that can share knowledge to improve policies for caregivers who may encounter challenges, such as delayed assessments and treatment. While he was conducting research across many First Nations for his doctorate, caregivers shared that they can feel isolated and like no one understands them. Often, he said, families have questions or simply want to connect. 'I felt like starting the Indigenous Caregiving Collective was a really good step, at least to start to support and connect with caregivers right across Canada,' Prof. Bruno said. Prof. Bruno is hopeful neurodevelopmental differences can be supported and embraced. His perspective is rooted in a cultural teaching: children choose us. (His relationship with his sons was captured in a documentary called The Gift of Being Different.) 'I think that's really important, because that allows me just to practise unconditional acceptance with them,' he said. - Kristy Kirkup Yi-Chun Chen, who started working as an assistant professor of anatomy, physiology and pharmacology at the University of Saskatchewan in the past year, has focused her research on the body's endocrine system – and specifically its relationship with diabetes. The endocrine system uses hormones as messengers to tell organs and tissue what to do in different situations. After humans eat food, blood glucose goes up and the body makes and releases insulin. For a patient with diabetes, the body doesn't respond to insulin well, or they don't make enough of it. And while Canadian scientists have already made tremendous progress in diabetes research, including discovering insulin more than 100 years ago in Toronto, researchers want to learn more about when, and how much of, the hormone is needed. Dr. Chen is also looking at preventative strategies. 'Our research focuses on studying how insulin is produced in a specialized cell called beta cells, in the pancreas.' If she can discover how insulin functions in these cells, it could help unlock future therapies for stopping diabetes from developing in the first place. At 39, Dr. Chen also is excited to see what researchers even younger than herself will uncover in her field – and she's guiding students who will be the next wave of researchers. 'The young scientists, they are actually the future of Canada,' she said. 'We're hoping to support them and mentor them and they are going to do great things.' - Kristy Kirkup Even as a young boy growing up in Scarborough, Ont., Dilakshan Srikanthan was keenly interested in the brain – both because of its pre-eminence and its vulnerability as the body's control centre. He knew that a neurological condition had affected his grandmother in Sri Lanka, a personal experience that eventually steered him toward a degree in neuroscience at the University of Toronto, and then onto graduate work on brain tumours. But it was a timely bit of made-in-Canada wisdom that set him on his current course. 'Skate to where you think the puck is going to be, not to where it's already been,' he was told by James Rutka, a renowned brain surgeon at Toronto's Hospital for Sick Children who was his master's degree supervisor and mentor. 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The work involves developing computer algorithms and using deep-learning techniques to teach the computer to reliably identify tissue types based on the constituents found in tiny wisps of smoke. It is a new skill that he has added to his medical and neurological training, and a glimpse at what the future of surgery could offer. 'The possibilities are limitless,' said Mr. Srikanthan, who received a prestigious Vanier scholarship in 2023 to support his PhD research. The ultimate goal, he said, is to accelerate the translation of such AI-driven experimental methods to the point where they can be of benefit to patients. 'I know that if I saw that future as a clinician I'd want to be able to do something about it,' he said. 'So I'm really focused on learning the skill set as a scientist that I can apply to whatever problem I see.' - Ivan Semeniuk


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Cision Canada
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ESHRE 41st Annual Meeting: Older paternal age linked to higher miscarriage risk and lower live birth rates in donor egg IVF cycles
A new international study presented today at the 41 st Annual Meeting of the European Society of Human Reproduction and Embryology (ESHRE) reveals that IVF cycles involving male partners over the age of 45 carry significantly increased miscarriage risks and lower live birth rates – even when young donor eggs are used. PARIS, June 29, 2025 /CNW/ -- By isolating paternal age from female reproductive factors through the exclusive use of donor eggs from young women, the study provides robust evidence that male age plays a critical role in reproductive success, challenging the common assumption that sperm age has little impact once fertilisation occurs. The retrospective study analysed 1,712 first oocyte donation cycles conducted between 2019 and 2023 across six IVF centres in Italy and Spain. All cycles used fresh donor oocytes and frozen sperm from male partners, with only the first single blastocyst transfer included. Female recipients had a mean age of 43.3 years. Participants were divided into two groups: men aged 45 or younger (n=1,066) and those over 45 (n=646). While fertilisation rates and embryo development were comparable between groups, significant differences emerged in clinical outcomes. Miscarriage rates were notably higher among couples where the male partner was over 45, reaching 23.8% compared to 16.3% in the younger paternal age group. Similarly, live birth rates were significantly lower in the older paternal age group, at 35.1% versus 41% for men aged 45 or younger. Discussing the findings, Dr. Maria Cristina Guglielmo, Embryologist at Eugin Italy, said, "Traditionally, maternal age has been the central focus in reproductive medicine, but our results show that the age of the male partner also plays a crucial and independent role. Even when using eggs from young, healthy donors and transferring only a single, high-quality embryo, we observed poorer outcomes in men over 45." She also emphasised the importance of examining how paternal age affects the health of offspring. "There is growing evidence linking advanced paternal age to an increased risk of neurodevelopment disorders in children. Our future work will investigate the long-term health and developmental outcomes of children conceived through donor egg cycles with older fathers, where maternal factors are minimised, to isolate paternal effects more clearly." The study abstract will be published today in Human Reproduction, one of the world's leading reproductive medicine journals.