Harmony Biosciences Preclinical Data for Narcolepsy Drug BP1.15205 Shows Promise
The data showed significant wake-promoting and cataplexy-suppressing effects in a standard transgenic mouse model of narcolepsy type 1. Narcolepsy is a chronic neurological disease affecting ~170,000 Americans, primarily characterized by excessive daytime sleepiness/EDS and cataplexy, along with other manifestations of REM sleep dysregulation.
A close-up of a pharmaceutical drug bottle, showcasing the potential of the company's innovative therapies.
The disease is often caused by the loss of hypocretin/orexin, a neuropeptide crucial for sleep-wake stability. BP1.15205 features a new and unique chemical scaffold optimized for high potency, which showed statistically significant wake-promoting effects at very low oral doses in the transgenic mouse model. These findings support dosing flexibility to potentially treat all 3 central disorders of hypersomnolence at low doses, which could offer an optimized benefit-risk profile.
Harmony Biosciences Holdings Inc. (NASDAQ:HRMY) is a commercial-stage pharmaceutical company that develops & commercializes therapies for patients with rare & other neurological diseases in the US.
While we acknowledge the potential of HRMY as an investment, we believe certain AI stocks offer greater upside potential and carry less downside risk. If you're looking for an extremely undervalued AI stock that also stands to benefit significantly from Trump-era tariffs and the onshoring trend, see our free report on the .
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Disclosure: None. This article is originally published at Insider Monkey.
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Newsweek
25 minutes ago
- Newsweek
Map Shows Countries Offering Easy Path to Citizenship for Americans
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Citizenship by Descent Some European countries offer citizenship to those with ancestors who originated there, such as Portugal, Ireland and Italy. GovAssist, another organization working in the field, explained in a July 7 article that individuals seeking a second passport in these countries would enjoy greater financial and personal freedom, including the ability to travel visa-free. With a large proportion of Americans having immigrant roots, particularly from European nations many decades ago, Baumann said that several U.S. citizens who have held onto the idea of obtaining a second passport someday in the future are now taking steps to make it happen. Stock image of a visa for Spain tucked inside a passport. Stock image of a visa for Spain tucked inside a passport. Getty Images "What most people want is the right to live somewhere," Baumann said. "That when they decide to get on a plane and fly abroad, they don't have to come back in 90 days. 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Yahoo
an hour ago
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