Verona Pharma to Present Seven Analyses of the Phase 3 ENHANCE Studies in COPD at ATS 2025
Analyses support Ohtuvayre® (ensifentrine) as a first-in-class selective dual
inhibitor of PDE3 and PDE4 for a broad COPD population
LONDON and RALEIGH, N.C., May 06, 2025 (GLOBE NEWSWIRE) -- Verona Pharma plc (Nasdaq: VRNA) ('Verona' or the 'Company'), a biopharmaceutical company focused on respiratory diseases, announces ten posters including seven additional analyses from its Phase 3 ENHANCE studies with Ohtuvayre (ensifentrine) for the treatment of chronic obstructive pulmonary disease ('COPD'), two from nonclinical studies, and one from a real-world data analysis, will be presented at the American Thoracic Society Conference ('ATS') 2025. The posters are published on the ATS website and in the publication, American Journal of Respiratory and Critical Care Medicine.
Ohtuvayre is a first-in-class selective dual inhibitor of the enzymes phosphodiesterase 3 and 4 ('PDE3 and PDE4') that combines bronchodilator and non-steroidal anti-inflammatory effects in one molecule. Ohtuvayre is the first novel inhaled mechanism for the maintenance treatment of COPD in more than 20 years.
The ENHANCE posters highlight subgroup analyses of patients when used as monotherapy, in patients with COPD and comorbid cardiac disorders and, separately, in patients with COPD and comorbid type 2 diabetes. An analysis of Ohtuvayre's effect on COPD exacerbations relative to lung function results will also be presented. Nonclinical posters describe a tissue distribution study in rat demonstrating lack of brain exposure, and a bleomycin model in rat demonstrating antifibrotic effects following inhaled ensifentrine dosing. In addition, the Company will have an exhibition booth, 2237, which will host presentations led by clinical experts.
Details of Verona's posters are listed below and linked to the ATS website.
Poster P275: Ensifentrine Monotherapy Improved Lung Function and Reduced Exacerbation Rate and Risk in Symptomatic Patients With Moderate-to-Severe COPD
Presenter: Isaac Biney, MBChB, University of Tennessee Medical Center
Session: B52 – Hot Topics in COPD
Poster P283: Ensifentrine Improved Lung Function and Reduced Exacerbation Rate in Patients with COPD and Concomitant Type 2 Diabetes
Presenter: Matthew Moll, MD, Brigham and Women's Hospital
Session: B52 – Hot Topics in COPD
Poster P284: Ensifentrine Improved Lung Function and Reduced Exacerbations in Patients with COPD and Concomitant Cardiac Disorders
Presenter: Nirupama Putcha, MD, Johns Hopkins University
Session: B52 – Hot Topics in COPD
Poster P285: Ensifentrine Monotherapy Reduced Dyspnea and Improved Quality of Life in Patients With Symptomatic, Moderate-to-Severe COPD
Presenter: Michael Bradley Drummond, MD, University of North Carolina at Chapel Hill
Session: B52 – Hot Topics in COPD
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