What happens if CAR T-cell therapy fails to treat multiple myeloma?

24-06-2025

Chimeric antigen receptor (CAR) T-cell therapy is a type of immunotherapy. Immunotherapy helps the body's immune system locate and attack the cancer cells.The Food and Drug Administration (FDA) has approved two CAR T-cell therapies to treat multiple myeloma (MM): Idecabtagene vicleucel (ide-cel, Abecma) and Ciltacabtagene autoleucel (cilta-cel, Carvykti). These target a protein called BCMA, which is found on myeloma cells. CAR T-cell therapy has shown great success in treating MM that has not responded to other treatments or has come back. However, this treatment may not work for everybody. Most CAR T-cell therapy failures occur within 6 months of treatment.According to a 2022 article, there is no agreed-upon standard of care if CAR T-cell therapy fails. Instead, a person will work with their healthcare team to come up with a different treatment plan. In some cases, they may suggest a second round of CAR T-cell therapy.Alternatively, the most commonly used therapies after CAR T-cell failure include:chemotherapy with the drug lenalidomidetargeted therapychemoimmunotherapybispecific antibodieslocalized radiation therapyFinding out that a treatment option has not worked can be challenging to manage. A person may benefit from seeking support from loved ones, support groups, mental health professionals, and a member of their healthcare team. A mental health professional can help a person manage the psychological aspects of living with a medical condition, and a healthcare professional will be able to answer any questions a person may have.Those undergoing treatment for MM can find support and resources at the following organizations:American Cancer SocietyLeukemia & Lymphoma SocietyCancerCareMultiple Myeloma Research FoundationInternational Myeloma FoundationLearn moreWhat to do next when multiple myeloma treatment stops workingCan multiple myeloma be cured?Multiple myeloma: Treatment and moreTypes of maintenance therapy for multiple myelomaWhat are some risks of stopping treatment for multiple myeloma?

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NFL star Joshua Hines-Allen reveals his seven-year-old son has been battling cancer

Daily Mail

22 minutes ago

Daily Mail

NFL star Joshua Hines-Allen reveals his seven-year-old son has been battling cancer

Jacksonville Jaguars star Joshua Hines-Allen has revealed his seven-year-old son Wesley is nearly cancer free after battling leukemia for the past seven months. Hines-Allen, who did not travel to Indianapolis for the Jaguars' 2024 season finale in January due to personal reasons at the time, made the emotional announcement on social media along with his wife Kaitlyn. Kaitlyn recalled the initial concern they had when Wesley began bleeding from his tooth after a weekend at Disneyland. 'I was just hugging him 'cause he was crying and he started bleeding even more in the gums, then he started to catch a fever,' she explained. Joshua continued: 'It just didn't get better, and the bleeding was consistent every day.' The couple, who also have another son and daughter together, were then forced to take Wesley to hospital when his symptoms showed no signs of slowing down. The dreaded six-letter word that no parent ever wants to hear: Cancer. Seven months ago, our world stopped when our son, Wesley, was diagnosed with leukemia. As parents, we've held each other through tears we didn't know we had, watching our little boy fight the biggest battle… — Joshua Hines-Allen (@JoshHinesAllen) July 25, 2025 'I was just leaving practice,' Hines-Allen remembered. 'Kate called me [saying], "Hey, we're going to the hospital. I need you to go home and pack a bag for Wes." Not thinking anything of it, really. 'He wasn't feeling good at all still, so he's like cuddling up and we're waiting in the lobby to go back there. We finally get in the back, and then later that night [they] came back, pulled us out and they told us that he had leukemia. 'It just kind of like hit me, and nothing else mattered after that.' Doctors informed Joshua and Kaitlyn that Wesley's journey was going to be a long one, explaining how he will need to undergo regular testing for the next 21 years of his life aside from chemotherapy. Fortunately, Wesley has responded well to the treatment and is now nearing a full recovery, Kaitlyn revealed. He is set to undergo his final chemotherapy treatment in late August at Nemours Children's Health in Jacksonville. 'Wesley is doing great,' she said. 'He's swimming every day, he's running around, he's playing sports.' 'He's got back to being the big brother he is,' Joshua added. Along with the video and the encouraging update on Wesley's progress, Hines-Allen also announced that his foundation, Four One For All, is conducting a season-long campaign called Four One For Hope that aims to give back to four cancer-focused nonprofits throughout the 2025 campaign. 'We recently received the good news that Wesley is on his way to a full recovery,' he said in a separate statement, via ESPN. 'We are grateful to the dedicated team of doctors, nurses, and caretakers who contributed to our son's well-being and counseled us through this time. 'Our goal is to ensure that families going through something similar feel the same level of love and support as we did.' Hines-Allen is now gearing up for his seventh season with the Jaguars after being selected by the team with the seventh overall pick in the 2019 NFL Draft.

US court upholds California's implicit bias training mandate for doctors

Reuters

34 minutes ago

Reuters

US court upholds California's implicit bias training mandate for doctors

July 25 (Reuters) - A U.S. appeals court on Friday rejected claims that California violated the free speech rights of doctors who teach continuing medical education courses by mandating that they include information on implicit bias. A unanimous three-judge panel, opens new tab of the 9th U.S. Circuit Court of Appeals said that because the content of the courses, known as CMEs, is dictated by the state, it amounts to government speech shielded from constitutional scrutiny regardless of who delivers the message. The Medical Board of California requires physicians and surgeons to complete CMEs to maintain their licenses, and approves and accredits courses offered by doctors including Azadeh Khatibi, an ophthalmologist and the plaintiff in Friday's case. A 2021 state law requires that CMEs include information about implicit, or unconscious, bias and the potential for doctors to treat patients differently based on their race, sex or other factors. Khatibi and the nonprofit Do No Harm, which advocates against what it calls "radical, divisive and discriminatory ideologies" in the medical profession, say the law unlawfully forces instructors to endorse speech with which they may not agree in violation of the First Amendment of the U.S. Constitution. But the 9th Circuit said that speech belongs to the government, as it has more than a century of closely regulating the medical profession and adopting detailed requirements for CMEs. "If physicians are cognizant that their profession is heavily regulated [and] that they attend CMEs primarily to secure credits to maintain their licenses ... then 'common sense' commands that licensees could attribute approved CMEs' content to California," Circuit Judge Jacqueline Nguyen wrote. The panel included Circuit Judges A. Wallace Tashima and Salvador Mendoza. All three judges are appointees of Democratic presidents. Caleb Trotter of Pacific Legal Foundation, who represents Khatibi and Do No Harm, said the libertarian group was disappointed with the ruling and is considering its options. "If continuing medical education courses in California are 'government speech' as the panel decided today, then there is little to stop governments around the country from compelling continuing education instructors in any trade or profession to profess all manner of controversial state-endorsed topics," Trotter said in an emailed statement. Many states in recent years have conditioned professional licenses for doctors, lawyers, teachers and others on completing diversity or anti-racism training, prompting backlash from some professionals and conservative groups. A Michigan dentist represented by Pacific Legal filed a lawsuit, opens new tab in April over a state licensing requirement that healthcare providers complete implicit bias training. Last year, the St. Louis-based 8th Circuit rejected claims, opens new tab that a Missouri school district violated employees' free-speech rights by requiring them to attend anti-racism training. Friday's decision affirms a 2024 ruling by U.S. District Judge Monica Ramirez Almadani in Santa Ana, California, that dismissed the lawsuit by Khatibi and Do No Harm. The case is Khatibi v. Hawkins, 9th U.S. Circuit Court of Appeals, No. 24-3108. For Khatibi and Do No Harm: Joshua Thompson and Caleb Trotter of Pacific Legal Foundation For the state: Kristin Liska of the California Attorney General's office Read more: US court leery of free-speech challenge to school's anti-racism training U.S. law students to receive anti-bias training after ABA passes new rule

US FDA investigates third death after treatment with Sarepta's gene therapy Elevidys

Reuters

an hour ago

Reuters

US FDA investigates third death after treatment with Sarepta's gene therapy Elevidys

July 25 (Reuters) - The U.S. Food and Drug Administration said on Friday it was investigating the death of an eight-year-old boy who received Sarepta Therapeutics' (SRPT.O), opens new tab muscular disorder gene therapy Elevidys. The death occurred on June 7, the agency said.