
New daily weight loss pill to rival injections
In trials, patients receiving weekly amycretin injections lost an average of 24.3 percent of their body weight over 36 weeks.
Patients taking daily amycretin tablets achieved an average w eight loss of 13.1 percent over 12 weeks.
Amycretin works by targeting GLP-1 and amylin receptors to help control blood sugar and appetite.
Side effects, including nausea and vomiting, were reported as mostly mild to moderate and resolved by the end of treatment.

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Daily Mail
36 minutes ago
- Daily Mail
British woman, 29, is fighting for life in a coma after falling seriously ill moments after getting a tattoo during friend's hen do in Benidorm
A British woman has been left fighting for her life in a coma after falling ill moments after getting a tattoo during her friend's hen do in Benidorm. Poppy-mae Crutchley, a 29-year-old from Worcester, is currently in a coma in Benidorm, with her heart, kidneys and lungs all failing. Jodie Odell, Poppy's friend who set up a GoFundMe page to raise money for her treatment, said the 29-year-old 'instantly' felt unwell after getting a tattoo. '[She was] that unwell that she had taken herself to the hospital where instantly and amazingly they acted straight away due to no oxygen in her body and fluid on her heart', Jodie said. 'Poppy was transferred to another hospital in Spain that specialise [sic] in what she needs. 'We all have faith in getting her back to her normal, bubbly beautiful self, and with your help we can give her the best chance possible.' It is not known what Poppy, described as 'a beautiful, bright, charismatic kind young woman with her whole life ahead of her', is ill with. But doctors say she may have either suffered a bacterial infection or was the victim of spiking, and is now in a 'critical' condition. Jodie has asked the public to donate to the GoFundMe to allow Jodie to 'to get her the treatment she needs, to pay for the ongoing medical bills, to support the family whilst out there at her bedside and most importantly to bring her home where she belongs.' 'Our family are so close and we see each other almost every day, she doesn't deserve this and our hearts are breaking with out her home. 'We all have faith in getting her back to her normal bubbly beautiful self, and with your help we can give her the best chance possible. 'The last thing the family need to be worrying about at a time like this is the ongoing costs, which as you can imagine are rising daily.' So far, the GoFundMe page has raised more than £4,600 of the £14,000 target.


Daily Mail
an hour ago
- Daily Mail
Startling discovery about The Pill and cancer that's rising in young people
Thousands of women who take the Pill are not at higher risk of potentially deadly liver cancer, research today suggested. Studies have long suggested there may be a link between the combined oral contraceptive pill and the risk of developing tumours in the liver. This is because the birth control pill contains the hormone oestrogen, which scientists believe can stimulate some cancer cells to grow. But now, in one of the largest studies to date involving more than 1.5million British women, researchers discovered there was 'little to no association' between taking the Pill and liver cancer. Experts, who said the study was the 'most comprehensive to date', concluded there was 'no overall link'. Liver cancer now kills 5,800 people in the UK each year compared with 2,200 in the late 1990s, making it the UKs fastest rising killer and responsible for double the deaths of skin cancer. It's currently the eighth most common cause of cancer death in the UK, but by 2040, the charity warns that it could rank sixth. Cancer Research UK figures also suggest rates of the disease have increased by 86 per cent among 25-to-49-year-olds since the 1990s. In the study, researchers analysed data from 23 previous studies as well as the UK biobank health study involving over a million women. They compared women who had ever used a birth control pill with those who never used them and found there were 5,400 liver cancer cases logged across all studies. Writing in the journal The Lancet Oncology, the researchers said there was 'no association with liver cancer risk'. However, they added, there was 'weak evidence that women who used the birth control pill for longer periods had a very slight increased risk of liver cancer (6 per cent) per 5 years of use.' This they said, was likely to due to unmeasured factors such as patients who had Hepatitis B or C infection—a major risk factor for liver cancer. Around one in four liver cancer cases in the UK are also caused by obesity, while a fifth are related to smoking, and one in 14 are due to excessive alcohol, research shows. Latest NHS figures for suggest there were almost 3million prescriptions for the combined pill and more than 4million for the mini pill, which just contains progestogen. Around a quarter of all women aged 15 to 49 are on either the combined or progesterone only pill. The proportion of women taking oral contraceptives has fallen by more than two-thirds, from 420,600 in 2012/13 to 126,400 in 2022/23, according to the NHS data. Around 555,400 women turned to the health service's sexual and reproductive health services in 2022/23 — equivalent to four per cent of 13 to 54-year-olds Taken every day, it works by stopping the ovaries releasing an egg each month. It also thickens the cervical mucus and thinning the womb lining to stop sperm reaching an egg, and attaching itself in the womb. It is over 99 per cent effective with perfect use but if used incorrectly—such as missing a pill or experiencing nausea and diarrhoea while on it—around one in ten women (9 per cent) may get pregnant. Known side effects of the Pill include nausea, breast tenderness, mood swings and headaches. Others claim they pile on pounds while taking the because of increased fluid retention and appetite, yet the NHS says there is no evidence it leads to weight gain. Decades of research has failed to provide any conclusive evidence that this supposed side effect is real. However, rarer side effects include blood clots and a slightly heightened risk of breast and cervical cancer.


The Guardian
2 hours ago
- The Guardian
Nearly 1,000 Britons adopt permanently shorter working week after trial
Nearly 1,000 British workers will adopt a permanently shorter working week, after the latest trial of a four-day week and similar changes to traditional working patterns. All 17 British businesses in a six-month trial of the four-day week said they would continue with an arrangement consisting of either four days a week or nine days a fortnight. All the employees remained on their full salary. The trial was organised by the 4 Day Week Foundation, a group campaigning for more businesses to take up shorter working weeks. The latest test follows a larger six-month pilot in 2022, involving almost 3,000 employees, which ended in 56 of 61 companies cutting down their hours from a five-day working week. The 4 Day Week Foundation is hoping to build on the shift around the end of the 19th century and the start of the 20th century, when campaigns led by trade unions gave birth to the two-day weekend. The previous norm for many people in Britain and other traditionally Christian countries had been a six-day working week, with time off only on Sundays. Campaigners and some economists argue that the four-day week can offer benefits to workers such as less strain on their mental health, and to businesses, including more motivated staff and easier recruitment and retention. Researchers at Boston College, a US university, said that the findings from the latest trial were 'extremely positive' for workers. They found that 62% of workers reported that they experienced less burnout during the trial, according to a poll of 89 people. Forty-five percent of those polled said they felt 'more satisfied with life'. The 4 Day Week Foundation has run successive trials to gather data and demonstrate how companies can make the switch. In January, the foundation said more than 5,000 people from a previous wave had started the year permanently working a four-day week. Companies involved in the latest trial, which started in November, included charities and professional services firms, with the number of employees at each employer ranging between five and 400. They included the British Society for Immunology and Crate Brewery in Hackney, east London, Campaigners hope that they can build momentum for the change. The 4 Day Week Foundation said the government should create a working time council to coordinate policy between business and industry leaders as well as trade unions. The concept of the four-day week faced strong opposition from the previous Conservative government. Labour ministers have previously expressed more support for the concept, although they have offered little in the way of formal recognition since coming to power in 2024. Sign up to Business Today Get set for the working day – we'll point you to all the business news and analysis you need every morning after newsletter promotion In 2023, Angela Rayner, who has since become deputy prime minister, said: 'If you can deliver within a four-day working week, then why not. I think people will cotton on to the fact that it's really good, if it works for their sector and boosts productivity.' The small web software company BrandPipe said that the latest trial had been a success for the business, coinciding with increased sales. Geoff Slaughter, the BrandPipe chief executive, said: 'The trial's been an overwhelming success because it has been the launchpad for us to consider what constitutes efficiency, and financial performance is double what it was before.' Slaughter added: 'If we're going to see it rolled out more substantially across different sectors, there should be incentives for early adopters, because we're creating the blueprint for the future.'