I met this incredibly intriguing guy at his goodbye party — he was moving to Europe. My uncle just invited me on a trip near where the guy lives. Should I contact him? Ask Lisi
She is constantly on a new diet: paleo, keto, vegan and tries every weight loss pill she can legally get her hands on. She is now on Ozempic and is in the best shape of her life. I am begging her to speak to a therapist in conjunction with a dietitian and nutritionist, to get her to maintain this weight and whatever healthy eating habits she is currently following.
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Time of India
3 hours ago
- Time of India
Ozempic and Wegovy may cut dementia risk by 45% and manage diabetes, study finds
Source: Reuters A groundbreaking study has revealed that GLP-1 receptor agonists—including popular weight-loss and diabetes drugs like Ozempic, Wegovy, and Mounjaro- may significantly reduce the risk of developing dementia. The analysis, conducted by Irish researchers and published in JAMA Neurology , involved data from over 164,000 participants and found that these medications reduced the risk of memory-robbing disorders by up to 45 per cent. These findings not only open new avenues for neurological protection but also position GLP-1 drugs as powerful tools in both metabolic and cognitive health management. Study links GLP-1 drugs like Ozempic and Mounjaro to lower dementia risk Researchers from the University of Galway reviewed 26 clinical trials involving 164,531 individuals—65% of whom were men, with an average age of 64. The participants were followed for an average of 31 months. The key discovery: patients taking GLP-1 agonists such as semaglutide (Ozempic, Wegovy) and tirzepatide (Mounjaro) were 45% less likely to develop dementia compared to those on other glucose-lowering medications. Dr. Catriona Reddin, senior study author, said, 'Our findings suggest that GLP-1 receptor agonists, in particular, may have a protective effect on brain health.' by Taboola by Taboola Sponsored Links Sponsored Links Promoted Links Promoted Links You May Like 5 Books Warren Buffett Wants You to Read In 2025 Blinkist: Warren Buffett's Reading List Undo How GLP-1 agonists may protect against dementia Although the exact mechanism remains under investigation, researchers propose several pathways through which GLP-1 medications could shield the brain: Reduced neuroinflammation: These drugs may lower inflammation in the brain, which is known to damage neurons and trigger dementia symptoms. Decrease in amyloid and tau proteins: GLP-1 agonists could suppress the accumulation of toxic proteins linked to Alzheimer's disease. Improved blood vessel health: They may reduce blood pressure and enhance blood flow, preventing vascular dementia. Neurogenesis stimulation: Early research suggests these drugs may promote neural growth in the hippocampus, the brain region essential for memory. GLP-1 drugs may help prevent both diabetes and dementia The new study aligns with earlier research from the University of Florida, which followed 400,000 Americans and reported a 33% lower risk of dementia among GLP-1 users compared to other treatments. This growing body of evidence supports the role of semaglutide and tirzepatide not only in treating type 2 diabetes and obesity but potentially in preventing cognitive decline. Professor Martin O'Donnell, Dean at the University of Galway, emphasised, 'With both diabetes and dementia rising, these findings have major public health implications.' Dementia and diabetes: Twin epidemics in the US The study arrives amid alarming trends: Over 8 million Americans currently live with dementia, with 500,000 new cases diagnosed each year. Diabetes now affects 38 million people in the US; around 12% of the population. According to the Alzheimer's Association, Alzheimer's rates have climbed 25 consecutive years. The intersection of these two epidemics highlights the urgency of therapies that can address both conditions simultaneously. Study highlights need for more GLP-1 brain health data While the findings are promising, researchers caution that more work is needed to confirm the results. Notable limitations include: Lack of data on dementia subtypes like Lewy body and vascular dementia Differences in study design and follow-up durations Unclear long-term cognitive outcomes for different age groups and genders Still, this analysis lays essential groundwork for future research into neurometabolic protection via GLP-1 therapies. Originally celebrated as breakthrough treatments for obesity and diabetes, these medications may now be poised to take on an even broader role in preventing neurodegenerative diseases. As Dr. Reddin concluded, 'This research marks a significant advancement in how we understand the brain benefits of diabetes medications.' This article is based on findings from a study published in JAMA Neurology (July 2024). While the research links GLP-1 drugs like Ozempic and Mounjaro to reduce dementia risk, it is observational and does not prove direct causation. Further studies are needed. Always consult a healthcare provider before making medication decisions. Also Read | 5 coffee routine habits that could be doing more harm than good, say experts
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Business Standard
3 hours ago
- Business Standard
CDMOs gear up for peptide boom amid rising demand for weight-loss drugs
As global demand for next-generation weight-loss and diabetes therapeutics surges, India's contract development and manufacturing organisations (CDMOs) are strategically positioning themselves to capture a bigger share of the peptide market, particularly in anticipation of key patent expiries such as that of semaglutide—a blockbuster GLP-1 receptor agonist. India is poised to play a critical role in the global manufacturing of GLP-1 drugs, driven by soaring demand for therapies like semaglutide and tirzepatide. The GLP-1 market is projected to exceed $150 billion by 2030. India's peptide CDMO market, currently estimated at around $80 million, is expected to grow at a CAGR of 14 per cent until 2030. Though the country currently accounts for just 3 per cent of the global peptide CDMO space—valued at $190 billion—the growth momentum is unmistakable, according to Nilaya Varma, Co-founder and Group CEO of Primus Partners. Top Indian players in the space include Glenmark, Cipla, Divi's Laboratories, Themis Medicare, Peptomer Therapeutics, Syngene International, and Sai Life Sciences. Semaglutide patent expiry fuels strategic activity Semaglutide, the active ingredient in drugs such as Ozempic and Wegovy, is owned and produced by Novo Nordisk and is set to go off-patent in India in March 2026. Leading pharmaceutical companies, including Dr Reddy's Laboratories, Sun Pharma, Cipla, Mankind Pharma, Natco Pharma, Lupin, and Biocon, are preparing to launch drugs in this category. These companies are investing in R&D, manufacturing capacity, and collaborations to compete in this rapidly growing market. Anthem Biosciences is experiencing a surge in inquiries for peptide active pharmaceutical ingredients (APIs), including those related to weight loss. 'Semaglutide can be produced through total synthesis or biosynthetic routes. Very few companies in India can manage biosynthetic production—and we are one of them,' said Ganesh Sambasivam, Promoter and Chief Scientific Officer at Anthem. While he declined to confirm whether semaglutide is in active production at Anthem, he hinted that it may be among the peptides currently in development. Syngene highlights technical edge in peptide trials Jayashree Aiyar, Chief Scientific Officer at Syngene International, sees opportunities not just in manufacturing, but also in preclinical and clinical development. 'We've already supported preclinical studies on semaglutide and recently helped a global pharma company with a bioequivalence study using pre-filled pens,' Aiyar said. These studies included developing and validating sensitive LC-MS/MS methods to measure semaglutide plasma levels—a significant technical challenge for peptides. Syngene's case study on semaglutide demonstrates the rigorous planning and execution required for clinical bioequivalence trials involving peptides. With gastrointestinal side effects common among test subjects, the company had to implement robust risk management and continuous patient support mechanisms. On the analytical front, it overcame complex challenges like autosampler carryover and low detection limits through custom-developed chromatography and mass spectrometry protocols. 'While we are not currently manufacturing GLP-1 APIs, we are well-equipped with peptide scale-up and fill–finish capabilities. We continue to invest in technologies to meet future market needs,' Aiyar added. Production and compliance challenges persist However, peptide manufacturing comes with its own set of challenges. 'There are production hurdles involving the availability of protected amino acids, coupling reagents, and advanced purification protocols, particularly for bulk APIs,' Varma noted. These challenges, combined with high utility costs and stringent environmental controls, add pressure to meet international compliance standards. Schemes such as the 2024 Production Linked Incentive (PLI) and Greenfield Bulk Drug Park initiatives are expected to ease some of these bottlenecks. While some CDMOs are already entrenched in the space, others are evaluating the landscape. Kashmik Formulations, for instance, is not currently working on semaglutide or related APIs, nor has it received client inquiries. However, the company sees the patent expiry of semaglutide as a potential inflection point. 'We're open to collaborations with larger players who can provide validated processes,' the company said in a statement. Diabetes burden drives urgency for scalable solutions The spike in demand is closely linked to a global epidemic of lifestyle diseases. Arushi Jain, Director at Akums Drugs & Pharmaceuticals, underscores this urgency. 'Over 100 million Indians are living with diabetes, underlining the need for scalable therapeutic solutions that address root causes such as obesity.' Akums is actively tracking developments in weight-loss APIs. As patents for semaglutide and similar molecules expire, Indian CDMOs are gearing up for a new wave of growth. Equipped with scientific expertise, evolving infrastructure, and an appetite for collaboration, the Indian peptide manufacturing ecosystem is emerging as a vital player in the global fight against obesity and metabolic diseases.
Scottish Sun
12 hours ago
- Scottish Sun
‘I'm fine with my kids hating me', says Angela Scanlon as she talks parenting fails, Ozempic and smartphone bans
Angela also opens up on why she'd feel lost without her mum friends and 'living vicariously' through Vicky Pattison RED ALERT 'I'm fine with my kids hating me', says Angela Scanlon as she talks parenting fails, Ozempic and smartphone bans Click to share on X/Twitter (Opens in new window) Click to share on Facebook (Opens in new window) ON TV and radio, Angela Scanlon may come across as quite carefree. But when it comes to parenting, she is definitely no-nonsense. 7 Angela Scanlon may come across as quite carefree but she is a no-nonsense parent Credit: Mark Hayman 7 Angela doesn't allow kids Ruby, seven, and Marnie, three, to have a smartphone The 41-year-old mum to Ruby, seven, and Marnie, three, with husband Roy Horgan, is one of a growing number of parents taking a hard line on not allowing her children smartphones. 'Ruby stamping her feet and telling me that her best mate has one does not mean I'm going to get her a phone if I believe that she is better off as a human without one,' Angela says. 'I'm OK with being the bad bitch. "I'm actually fine with her hating me if it makes sense in the long run for her not to have one. I'm still the parent.' Angela adds that she knows her own phone use impacts her. 'It's affected my concentration. "I will be reading a book and think: 'Oh, I've read three pages and have no idea what it said.' "There's a lack of regulation online and we are going to hand that to a child? "My plan is to hold off for as long as possible.' Her strong line on phones has forced her to change her own behaviour, too. Angela Scanlon lifts the lid on new Virgin Radio show & why she REFUSED to wear fake tan on Strictly 'I think our generation is justifying it because we love it. "I don't want to let it go. It's the conditioning. "You're going: 'Oh my god, how am I going to tell her she's not allowed it when I'm sitting there refreshing. "It requires us all to make changes.' Angela's firm but humorous approach to parenting made her the perfect first guest on our new parenting vodcast No Parental Guidance, which launches tomorrow. Hosted by parenting influencer Louise Boyce and comedian Hannah East, it will see guests from Made In Chelsea's Ollie Locke to presenter Konnie Huq spill on their challenges with raising kids. Angela and her three sisters grew up in County Meath, Ireland, and she never considered that there were things she would not be able to do as a girl. She's attempting to instil that attitude in her two young daughters. But raising independent, confident women can have its own issues. 'I read about how we are 'snowplough parenting' – basically going just in front of our kids and moving obstacles out of their way and clearing their path, because you don't want them to have any upset in life. 'MY GIRLS ARE FEISTY' "But you rob them of the opportunity to fall over and get up again and have the pride of overcoming something hard. "My girls are feisty and strong-willed, but then there can be challenges with that at the school gates when you are running late and they are full of emotion,' she laughs. 'That's the Irish in them, too. Honestly, the temper. . . But they are going to need it. "The world can be a difficult place for a woman, even now. "I like the idea of them being able to show their teeth every so often, and not in the traditional tits and teeth kind of way. "I mean show their fangs and sharpen their elbows.' The TV presenter explains how the boys in her daughter Ruby's football team almost forced her to quit playing. 'She's quite competitive and she's good at it. "There was an option to play on a mixed team, but after the trial she came home and said: 'No, I'm not going to do it.' "She said the boys were mean and wouldn't pass the ball to her or any of the other girls. 'So I said: 'OK, so do you like football? You can decide if you want to go back. 7 Angela prides herself on raising independent, confident women, like her and her sisters Credit: Mark Hayman 7 Angela, who studied business at Technological University Dublin, also runs her own jewellery company Credit: Mark Hayman "But if I loved something and a boy wouldn't let me do it, I don't think I would let him stop me. "You are good at football. This is going to happen in life. "People are going to not pass the ball to you. You're going to have to fight. "This is a really important lesson. I'll leave you to make the choice.' 'She came back saying: 'I thought about it and you're right. I want to do it. "I don't think boys should take football away from me.'' Looking at Angela's Instagram, you might imagine she has the juggle that is being a working mum nailed. She laughs at the very idea. 'It's a s**t show,' she admits. 'Ruby said the other day: 'I can't do football because I told you my football boots are too small and you threw them out.' "I'm thinking: 'It's 8.50am. I can't get you new football boots right this second.' I have found the most brilliant bunch of women who are there throughout. I really depend on them Angela Scanlon 'I have lowered the expectations of myself and embraced the chaos.' While school WhatsApp groups often get a bad rap, Angela says she would be lost without hers. She says: 'I'm always asking: 'Is there a parent-teacher meeting I'm supposed to be at? When is the cake sale?' "But I have found the most brilliant bunch of women who are there throughout. I really depend on them. "I've made some unbelievable lifelong friends.' And as a person in the public eye, does she feel the pressure to look impeccable at the school gates? 'Ah, come on,' she says laughing. 'Look at me [pointing at her bare face]. "It's too exhausting. I have enough to do. "I really like the separation. When I go on the school run, I'm a mum. "There has been the odd time I've done a pick-up after a photo shoot and I'm all made up and everyone is like: 'Oooh'. "But that is not my normal.' However, away from her mum pals, there's another friendship that has blossomed – with Vicky Pattison. They met on a panel show and launched a podcast together called Get A Grip. 'I LIVE VICARIOUSLY THROUGH HER' 'I've known her for seven years. "There was an easy chemistry between us that you don't get all the time with work. "I messaged her and said: 'I'm doing a podcast and I think we should do it as a duo.' "She said: 'That's right up my wheelhouse,' which I had to Google to check she was saying yes. 'I can't do her accent and she wouldn't dare do mine. "I really have to tune into her when she's full Geordie. "She said 'bairn' for the first time and I was like: 'What does that mean?' "But I think it's great we have two heavily accented women who are reflective of the listeners. "The podcast is like a woman's group chat and we go all over the place with our topics. "I thought it was an Irish thing to go between the light and shade, but she's got that ability, too.' Angela, who has been married to Roy, a 45-year-old entrepreneur, for 11 years, has been offering tips to new wife Vicky, who tied the knot with Ercan Ramadan last August. 'There's marital and baby chat and all sorts, because we're at very different stages, I suppose. "I live vicariously through her and she taps me for tips. 7 Angela has been married to entrepreneur Roy Horgan for 11 years 7 Angela met Vicky Pattison on a panel show and they launched a podcast together called Get A Grip "I don't know that she should be taking them, but I'm happy to offer!' The pair also have talked about their struggles, too – Vicky has shared her journey with premenstrual dysphoric disorder (PMDD) and Angela has opened up about her 15-year battle with anorexia and bulimia. She previously told Fabulous: 'I want my girls to be healthy and I try to impress that on them. "It's tricky, because I don't remember when I was growing up and in the grip of it, having very many points of reference of people who had been there and come through it. 'I speak about it because what you want in those moments is a sense of hope, like: 'You can get to the other side and have a great life.' She says now: 'PMDD was something that I was quite ignorant about, and that's when you realise there is real power and impact in sharing those stories and not shamefully hiding them. "And it might not be PMDD or an eating disorder, but there will be things people can relate to and a sense of 'you are not alone'.' As someone who has grown up with an eating disorder, does she worry about the rise of Ozempic, where there are women who are smaller than average lying to get it? 'It is terrifying, because there was that very singular ideal of beauty that we all grew up with. "Now, you have people in the public eye of all shapes and sizes and colours and creeds. "It's healthy for people to be able to see themselves reflected on screen. Transparency provides relief for people and honesty allows for people to give themselves a goddamn break Angela Scanlon "Anything that's trying to corral us towards being the same as everybody else is not good. 'But, ultimately, the issue is actually less about the choices people are making, it's more about the judgment. "We all feel that we're allowed to tear people apart for whatever their choices are. 'We chatted about the Kardashians' surgery on the podcast and if they should be transparent. "Some people come out and tell you they've done it. "And one part of the camp will go: 'Isn't that great? They're being honest.' "And the other part will go: 'They shouldn't be doing it in the first place,' or 'They shouldn't be forcing it down our throats.'' She adds that she feels honesty is also key when it comes to how people portray parenting. 'Like with celebrity parents when they pretend they don't have help. "And you are thinking: 'Oh my god, how does she do that? And why does her hair look OK? "And why are the kids doing activities on a full crafting table and they've got their five-a-day and a f**king packed lunch and their runners are clean, when I can barely get them into the car and out the door.' "Transparency provides relief for people and honesty allows for people to give themselves a goddamn break.' 7 Angela and pro partner Carlos Gu on Strictly Come Dancing in 2023 Credit: BBC Angela has recently landed a new weekend slot on Virgin Radio, allowing her to be a more present mum. 'I'm on Saturdays 10am-1pm. It's certainly more conducive to life as a working mother. I can do the swimming drop and go to work. "It's more sociable, too. I'll be able to have a Friday-night wine with the mums to take the edge off a hard week!' As well as her busy showbiz career – which included starring on Strictly Come Dancing in 2023 – Angela, who studied business at Technological University Dublin, also runs her own jewellery company, FRKL, creating earrings, bracelets, charms and stackable necklaces in her own style. 'I feel very lucky to be able to do it, but it's hard . "I studied business, so I've always had that desire to create something. "I'm enjoying building FRKL and I'm hoping it's maybe something Ruby will take over. 'I like for her to realise that I do things that aren't just shiny things on telly, that actually there's a lot of quite dull day-to-day stuff and that hard work is really the only way. "I also think it's important for them to know I'm making a choice to go to work versus staying at home, because I'm going to something I love. "Otherwise, they're like: 'Oh my god, she's leaving to do something she hates. What does that say about us?' "So I really try to be transparent with them. "Honesty, that's my secret of parenting - and buying them new football boots, even if it's two days after the fact." Get A Grip hosted by Angela Scanlon and Vicky Pattison, is available on all podcast platforms. IN THE MAKE-UP CHAIR WITH ANGELA What are your skincare heroes? I love Tatcha The Dewy Skin Cream. It's lush. What are your make-up essentials? I have multiple concealers, as I don't really wear foundation. Nars is gorgeous. I've got a Trish McEvoy one for under-eyes and a Becca one that's been discontinued. Any beauty hacks? I bought a mouth guard as I realised I clenched my jaw, and it's relaxed my whole face. What do you splurge on? I got a Dermalux LED Phototherapy device. I'll lie with it on and have a little meditation. Any budget buys? Weleda Skin Food is incredible. Who is your celebrity beauty icon? Cate Blanchett– I like a woman to look like herself. Unlock even more award-winning articles as The Sun launches brand new membership programme - Sun Club.
