This Rare Amazon Scorpion's Venom Can Kill Breast Cancer Cells, Say Scientists
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Since extracting venom is impractical, scientists used Heterologous Expression to insert the gene into yeast, enabling large-scale production of the cancer-killing molecule
In a groundbreaking discovery, Brazilian scientists have identified a molecule in the venom of the rare Amazon scorpion, Brotheas amazonicus, that shows promise in the treatment of breast cancer. This molecule, named BamazScplp1, has the remarkable ability to target and destroy cancer cells without harming normal cells in the body.
Researchers at the University of São Paulo have drawn comparisons between BamazScplp1 and the traditional chemotherapy drug Paclitaxel, noting that initial lab tests demonstrate similar efficacy in eradicating breast cancer cells.
BamazScplp1 is classified within the serine protease enzyme group, which is known for breaking down proteins and potentially disrupting the life cycle of cancer cells. The scientists observed that the molecule induces cancer cell death through necrosis, a process typically harmful to the body but potentially effective in eliminating tumours in cancer treatment.
Given the impracticality of extracting venom directly from scorpions, the research team employed a biotechnological method known as Heterologous Expression. This technique involves inserting the relevant gene into a microorganism, such as yeast, to produce the molecule in large quantities.
Professor Elian Arantes, the lead researcher, highlighted the use of the yeast Pichia pastoris, which is widely recognised in the biotech industry for its efficiency. This innovation allows for the mass production of BamazScplp1 without harming animals.
Breast cancer remains the most common cancer among women worldwide and is the second leading cause of cancer-related deaths, according to the World Health Organization (WHO). In 2022, there were 2.3 million new cases and approximately 670,000 deaths attributed to breast cancer. Projections indicate that by 2050, these figures could rise to 3.2 million new cases and over 1 million deaths annually.
The discovery of BamazScplp1 brings new hope in the fight against breast cancer. While the research is still in its preliminary stages, with extensive animal testing and clinical trials yet to come, the scientific community is optimistic about its potential. If BamazScplp1 proves to be as effective and safe in humans as it is in the lab, it could revolutionise the treatment of breast cancer.
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June 25, 2025, 18:39 IST
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