ICMR invites partners to launch and sell its new malaria vaccine
Called AdFalciVax, it is a recombinant vaccine, meaning parts of the genes that encode for targets are inserted into a cell, the target proteins are expressed, and then used to trigger an immune response.
Malaria is a parasitic infection transmitted by mosquitoes. While the current vaccine protects against the most common one that causes infection in humans called plasmodium falciparum, there are at least four other parasites from the same family known to cause infection in humans.
P. vivax is the other one that commonly causes malaria infections, especially in India. The others — p malariae, p ovale, and p knowlesi — cause fewer infections. While the pre-clinical studies have already shown positive indications, the company that collaborates with the ICMR will be responsible for further development, human clinical trials, and scale-up for commercial production.
The vaccine contains the genetic material of two targets — one for a major protein called CSP found on the surface of the malaria parasite and another for a combination of parts of two proteins that affect the pathogen's lifecycle.
'There are some key differences in the ICMR vaccine as compared to the other two currently in the market. One, this vaccine used the DNA for the whole CSP protein instead of just a few parts, meaning it is likely to produce a stronger immune response. Two, the other target that is used prevents the development of the p. falciparum in the mosquito's midgut during its lifecycle. What this essentially means is that it prevents the infection not only in the vaccinated person, but stops the further spread of the disease by disrupting the lifecycle of the pathogen even when it has already been picked up by a mosquito from an infected person for further transmission,' said Dr Subhash Singh, project manager for development of the vaccine.
Senior scientist Dr Susheel Singh and director Dr Sanghamitra Pati were part of the development process. The pre-clinical validation was done in collaboration with ICMR-National Institute of Medical Research and the National Institute of Immunology.
Anonna Dutt is a Principal Correspondent who writes primarily on health at the Indian Express. She reports on myriad topics ranging from the growing burden of non-communicable diseases such as diabetes and hypertension to the problems with pervasive infectious conditions. She reported on the government's management of the Covid-19 pandemic and closely followed the vaccination programme.
Her stories have resulted in the city government investing in high-end tests for the poor and acknowledging errors in their official reports.
Dutt also takes a keen interest in the country's space programme and has written on key missions like Chandrayaan 2 and 3, Aditya L1, and Gaganyaan.
She was among the first batch of eleven media fellows with RBM Partnership to End Malaria. She was also selected to participate in the short-term programme on early childhood reporting at Columbia University's Dart Centre. Dutt has a Bachelor's Degree from the Symbiosis Institute of Media and Communication, Pune and a PG Diploma from the Asian College of Journalism, Chennai. She started her reporting career with the Hindustan Times.
When not at work, she tries to appease the Duolingo owl with her French skills and sometimes takes to the dance floor. ... Read More
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