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CyberArk, tech firm with US headquarters in Newton, bought for $25 billion

CyberArk, tech firm with US headquarters in Newton, bought for $25 billion

Boston Globe4 days ago
The deal is Chief Executive Officer Nikesh Arora's largest since taking the helm in 2018 and gives Palo Alto Networks a suite of identity security tools, which help users determine who should have certain access rights within an organization. These products can also be used with artificial intelligence programs, and will be in higher demand as more companies use AI agents to perform tasks, Bloomberg Intelligence analysts Mandeep Singh and Damian Reimertz said in a note.
Shares of CyberArk had gained 30% this year, giving it a market value of more than $21 billion. That increase includes the 13% jump on Tuesday. The stock was little changed before markets opened on Wednesday. Shares of Palo Alto fell 5.9%.
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Cybersecurity providers are becoming more acquisitive, with some looking to offer a full platform of products to customers that are seeking to save money by reducing vendors. Alphabet Inc. agreed to buy the cyber startup Wiz this year for $32 billion to add to its Google Cloud business. In April, Palo Alto announced plans to buy the startup Protect AI, which specializes in securing AI and machine learning applications and models.
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JPMorgan Chase & Co. advised Palo Alto and Qatalyst Partners advised CyberArk.
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New RADIOHEAD Study Validates Use of Guardant Reveal Tissue-Free Monitoring for Earlier Detection of Immunotherapy Response in Advanced Cancer
New RADIOHEAD Study Validates Use of Guardant Reveal Tissue-Free Monitoring for Earlier Detection of Immunotherapy Response in Advanced Cancer

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New RADIOHEAD Study Validates Use of Guardant Reveal Tissue-Free Monitoring for Earlier Detection of Immunotherapy Response in Advanced Cancer

The first readout from Guardant's research collaboration with the Parker Institute for Cancer Immunotherapy (PICI) shows Guardant Reveal detected responses to immunotherapy across multiple tumor types and identified non-responders up to 5 months earlier than standard methods Study shows Guardant Reveal's promise for confirming effective therapies earlier and optimizing treatment faster in patients with advanced cancer PALO ALTO, Calif., July 29, 2025--(BUSINESS WIRE)--Guardant Health, Inc. (Nasdaq: GH), a leading precision oncology company, today announced the first clinical readout from their collaboration in the RADIOHEAD study with the Parker Institute for Cancer Immunotherapy (PICI), a network of the largest concentration of immuno-oncology (IO) expertise in the world. The data, published today in Cancer Research Communications, a journal of the American Association for Cancer Research, found that Guardant Reveal successfully detected responses to immunotherapy across multiple solid tumor types in advanced stage cancer patients and identified non-responders more than three months—and in some cases nearly five months—before disease progression was visible by standard methods. Approximately 30% of patients with advanced-stage cancer receive immunotherapy treatment, with varying degree and duration of response. This study analyzed a large cohort of more than 500 patients with various advanced solid tumors, including lung, skin, head and neck, breast, GI, GU, and gynecologic cancers, receiving immunotherapy in a real-world setting to assess if blood-based monitoring could predict response accurately and faster than standard of care methods. The strong association found between long-term patient outcomes and changes in tumor fraction as measured with the tissue-free, methylation-based Guardant Reveal supports the use of blood-based monitoring to help predict treatment response and improve decision-making in cancer care. "Precise serial monitoring at the molecular level provides real value to oncologists and to patients using immunotherapy," said Craig Eagle, M.D., Chief Medical Officer at Guardant Health. "This study shows that Guardant Reveal has the potential to revolutionize how oncologists assess patient response, identifying earlier insights that can empower them to make informed decisions faster and improve patient outcome and quality of care." "Our RADIOHEAD study of Guardant Reveal in advanced stage cancers provides patients with a new caliber of precision monitoring in order to create better patient outcomes," said Tarak Mody, PhD, Chief Business Officer at PICI. "These findings exemplify PICI's commitment to forging mission-driven partnerships to bring cutting-edge technology into clinical practice, accelerate discoveries, and advance the development of curative immune therapies for patients." Key study findings include: Improved patient outcomes associated with any reduction in tumor fraction 75% lower risk of progression in patients with ≥80% decrease in tumor fraction Disease progression identified up to 5 months prior to standard of care methods The full manuscript in Cancer Research Communications is available here. About Guardant Health Guardant Health is a leading precision oncology company focused on guarding wellness and giving every person more time free from cancer. Founded in 2012, Guardant is transforming patient care and accelerating new cancer therapies by providing critical insights into what drives disease through its advanced blood and tissue tests, real-world data and AI analytics. Guardant tests help improve outcomes across all stages of care, including screening to find cancer early, monitoring for recurrence in early-stage cancer, and treatment selection for patients with advanced cancer. For more information, visit and follow the company on LinkedIn, X (Twitter) and Facebook. About RADIOHEAD The RADIOHEAD (Resistance Drivers for Immuno-Oncology Patients Interrogated by Harmonized Molecular Datasets) program is a pan-tumor, prospective cohort study of 1,070 immunotherapy-naïve patients receiving standard-of-care immune checkpoint inhibitor regimens. Conducted across 49 U.S. community oncology clinics, the study includes over 3,700 longitudinal blood samples collected at pretreatment, early on-treatment, and immune-related adverse event timepoints, with a focus on major immuno-oncology indications such as non-small cell lung cancer (~1,400 samples) and malignant melanoma (~500 samples). 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These statements are based on current expectations, forecasts and assumptions, and actual outcomes and results could differ materially from these statements due to a number of factors. These and additional risks and uncertainties that could affect Guardant Health's financial and operating results and cause actual results to differ materially from those indicated by the forward-looking statements made in this press release include those discussed under the captions "Risk Factors" and "Management's Discussion and Analysis of Financial Condition and Results of Operation" and elsewhere in its Annual Report on Form 10-K for the year ended December 31, 2024, and in its other reports filed with or furnished to the Securities and Exchange Commission. The forward-looking statements in this press release are based on information available to Guardant Health as of the date hereof, and Guardant Health disclaims any obligation to update any forward-looking statements provided to reflect any change in its expectations or any change in events, conditions, or circumstances on which any such statement is based, except as required by law. These forward-looking statements should not be relied upon as representing Guardant Health's views as of any date subsequent to the date of this press release. View source version on Contacts Investor Contact: Zarak Khurshidinvestors@ Media Contact: Meaghan Smithpress@

5 Reasons Alphabet Is the Smartest Stock to Buy Right Now
5 Reasons Alphabet Is the Smartest Stock to Buy Right Now

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5 Reasons Alphabet Is the Smartest Stock to Buy Right Now

Key Points Alphabet's business continues to showcase its strength. Google Cloud recently gained a new customer. The stock is dirt cheap compared to its peers. 10 stocks we like better than Alphabet › Alphabet (NASDAQ: GOOG) (NASDAQ: GOOGL) is one of the few big tech stocks that doesn't fetch a massive premium to the market. As a result, many investors may be attracted to it. However, buying a stock just because it's cheap isn't a smart idea. Plenty of stocks are cheap for good reasons. Still, I think Alphabet is an excellent buy at this price point, and I have five reasons to support this view. 1. Google Search revenue is rising The biggest reason why shares of Alphabet trade at a discount to its peers is that the market is worried about its base business collapsing. While there are several brands underneath its umbrella, the biggest is Google Search. The theory is that Google Search won't be able to compete against various generative AI services. If more people use generative AI than Search, Alphabet's revenue will tumble and drag its profits down with it. While several people seem to hold that opinion, and there is some evidence Google is very slowly losing some users to generative AI, it hasn't affected its results. In the second quarter, Search's revenue rose 12% year over year. That's an acceleration from the previous quarter's 10% growth. Clearly, Google Search is doing quite well, and the central argument to the bear case isn't supported by the financial results. 2. AI Search Overviews bridge the gap Just because generative AI challenges Google doesn't mean that it's ignoring it. Instead, it has embraced generative AI and offers AI Search Overviews at the top of its results. Management says that this has become a very popular feature and has been used by over 2 billion people in 40 languages. While Alphabet may see some defectors to generative AI platforms, its AI Search Overviews could provide enough of a generative AI experience to maintain the vast majority of its user base. Furthermore, management has stated that Overviews has around the same monetization as a regular Google Search, so it isn't losing out on a ton of revenue, either, with this integration. 3. Google Cloud is gaining momentum Another key part of the Alphabet investment thesis is the growth of Google Cloud, its cloud computing wing that allows its clients to rent high-powered computing devices over the internet to run workloads. Google Cloud has been gaining momentum recently, and even captured one of the most important clients in the world: OpenAI, the maker of ChatGPT, one of the leading generative AI models. Although Google has a competing model, Gemini, it remains neutral in the cloud computing market and allows other models to be used. This neutrality was attractive to OpenAI, and it trusts Google enough to run its workloads on its servers. This is a huge client win for Google Cloud and showcases its overall strength 4. Google Cloud's finances are improving Google Cloud had an excellent first quarter, with revenue rising 32% year over year. Furthermore, the segment's operating margins are rapidly improving, with a 21% margin in the second quarter, up from 11% year over year. As Google Cloud continues to grow faster than the rest of the company and operating margins improve, this segment will become a much larger part of the Alphabet investment thesis. Cloud computing has powerful tailwinds, including traditional workload migration and AI workload growth. This segment will continue growing rapidly, and over the next decade, will become a key part of the overall company's finances. 5. The stock is dirt cheap Circling back to the top, Alphabet's stock is unbelievably cheap right now. It trades at less than 20 times forward earnings, which is significantly cheaper than the broader market, as measured by the S&P 500, which trades for 24 times forward earnings. Most of the big tech stocks trade in the high 20s range of forward price-to-earnings (P/E), all the way up to the high 30s. This either makes Alphabet undervalued or the other group overvalued. Regardless, it's an excellent buy now and is a great way to ensure that you're not overpaying for a big tech stock. Should you buy stock in Alphabet right now? Before you buy stock in Alphabet, consider this: The Motley Fool Stock Advisor analyst team just identified what they believe are the for investors to buy now… and Alphabet wasn't one of them. The 10 stocks that made the cut could produce monster returns in the coming years. Consider when Netflix made this list on December 17, 2004... if you invested $1,000 at the time of our recommendation, you'd have $624,823!* Or when Nvidia made this list on April 15, 2005... if you invested $1,000 at the time of our recommendation, you'd have $1,064,820!* Now, it's worth noting Stock Advisor's total average return is 1,019% — a market-crushing outperformance compared to 178% for the S&P 500. Don't miss out on the latest top 10 list, available when you join Stock Advisor. See the 10 stocks » *Stock Advisor returns as of July 29, 2025 Keithen Drury has positions in Alphabet. The Motley Fool has positions in and recommends Alphabet. The Motley Fool has a disclosure policy. 5 Reasons Alphabet Is the Smartest Stock to Buy Right Now was originally published by The Motley Fool Sign in to access your portfolio

Alphabet Has a Brilliant Fallback Plan on AI Even if Search Is Disrupted
Alphabet Has a Brilliant Fallback Plan on AI Even if Search Is Disrupted

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Alphabet Has a Brilliant Fallback Plan on AI Even if Search Is Disrupted

Key Points In its second-quarter earnings release, Alphabet raised its 2025 capital spending guidance by $10 billion. The spending is to serve demand from AI cloud customers. Google Cloud has become a go-to choice for most AI startups. 10 stocks we like better than Alphabet › Google Search parent Alphabet (NASDAQ: GOOG) (NASDAQ: GOOGL) is the cheapest stock in the Magnificent Seven, and you might scratch your head about why when looking at its financials. Last quarter, revenue grew 14%, with earnings per share up 22%. Yet the stock trades at 19.5 times this year's earnings estimates, a lower-than-market multiple. The reason is that investors fear what the advent of artificial intelligence (AI) will do to Google Search activity, and whether Alphabet's biggest cash cow will come under threat. Last quarter's numbers show that isn't happening, fortunately. But it doesn't necessarily mean disruption will never happen. Yet even if Search growth peters out, it seems Alphabet has another AI fallback plan: Google Cloud. Google Cloud is seeing massive AI-powered growth Even if Search gets disrupted to some degree -- though I don't believe that will happen quickly -- it appears Alphabet's Google Cloud unit could make up the then some. Last quarter, Google Cloud grew revenue 32% to $13.6 billion, accelerating from the prior quarter's 28% growth, while operating margins widened tremendously, nearly doubling from 11.3% to 20.7% over the course of the year. It should also be noted that of the $3.3 billion in incremental revenue relative to last year, $1.65 billion fell to operating profits, so Google Cloud is making operating margins above 50% on every incremental dollar of cloud revenue. Google Cloud's backlog also surged 18% sequentially -- good for a 72% annualized rate -- and 38% year over year to $106 billion. That's higher than the current revenue growth rate, suggesting the unit could continue to accelerate, or at least keep up its current high growth rates for a while. There is such hot demand for Google's cloud infrastructure and such high returns on its assets that management decided to increase its capital expenditure plan for 2025 from $75 billion to $85 billion. And why not? The company is clearly seeing huge demand for Cloud services, and very profitable demand at that. If a business is earning such high returns on incremental investments, it should invest all that it can. Google Cloud is becoming a platform of choice for AI start-ups While Alphabet doesn't break down cloud growth by cohort, it's likely that a big reason for the strong Cloud growth is demand from premier AI unicorns. On the second-quarter conference call with analysts, CEO Sundar Pichai said: "We also offer the industry's widest range of TPUs [tensor processing units] and GPUs [graphics processing units], along with storage and software built on top. That's why nearly all gen-AI unicorns use Google Cloud." Indeed, Google Cloud's AI unicorn customer list is impressive, encompassing the cream of the crop in AI talent today: Safe Superintelligence (co-founded by Ilya Sutskever, an OpenAI co-founder and former Google Brain researcher) Physical Intelligence (founded by a cohort that includes former Google DeepMind researchers) Anthropic Thinking Machines Lab (founded by Mira Murati, former chief technology officer of OpenAI) World Labs (founded by Fei-Fei Li, a Stanford professor known as "the godmother of AI") OpenAI, per a recent Google Cloud deal announced in June. This isn't a comprehensive list, and Google also has big enterprise customers, including Apple. It's also encouraging that two of the biggest AI model builders, OpenAI and Anthropic, still choose to run workloads on Google Cloud despite their primary relationships being with other cloud providers and major investors Microsoft and Amazon, respectively. Why has Google become such a destination for AI start-ups? While that discussion would be long and highly technical, the attraction appears to be based on a combination of factors. First, Google was the first cloud company to begin designing its own AI chips, or "tensor processing units," back in 2014, in order to power its artificial intelligence research experiments more cost-effectively. On that subject, Google is the tech giant that has been studying AI seriously for the longest time. Although OpenAI was the first to unveil ChatGPT and assumed the lead in AI chatbots, before that, Google had been the monopolistic center of AI research. Google researchers invented "transformers" technology, the main innovation that catapulted AI technology to the next level over the past eight years or so. It appears that Google's legacy position at the forefront of AI research -- even though it was initially caught off-guard by ChatGPT in late 2022 -- has informed its knowledge of AI infrastructure, paving the way for Google Cloud's recent success. Google Cloud can pick up the slack Over the course of a year, Google Cloud's operating profit rose 141%, going from 4.3% of total operating income to 9.1%. Given that Google is accelerating investments and appears to have an accelerating cloud backlog, look for that percentage of profits to increase quickly. Over time, if Search growth slows or even declines, Google's own AI service based on its Gemini large language model (LLM) could pick up the slack. But even if that doesn't happen, it appears there's a good chance that the next big AI breakout could be one of Google Cloud's AI unicorn customers. That would lead to growth in Google Cloud profits, offsetting a slowing or decline in Search. And if Alphabet is able to ward off the threat to Search, the stock will look like one of the biggest bargains on Wall Street, with its cloud business playing a huge part. Should you invest $1,000 in Alphabet right now? Before you buy stock in Alphabet, consider this: The Motley Fool Stock Advisor analyst team just identified what they believe are the for investors to buy now… and Alphabet wasn't one of them. The 10 stocks that made the cut could produce monster returns in the coming years. Consider when Netflix made this list on December 17, 2004... if you invested $1,000 at the time of our recommendation, you'd have $624,823!* Or when Nvidia made this list on April 15, 2005... if you invested $1,000 at the time of our recommendation, you'd have $1,064,820!* Now, it's worth noting Stock Advisor's total average return is 1,019% — a market-crushing outperformance compared to 178% for the S&P 500. Don't miss out on the latest top 10 list, available when you join Stock Advisor. See the 10 stocks » *Stock Advisor returns as of July 29, 2025 Billy Duberstein has positions in Alphabet, Amazon, Apple, and Microsoft. The Motley Fool has positions in and recommends Alphabet, Amazon, Apple, and Microsoft. The Motley Fool recommends the following options: long January 2026 $395 calls on Microsoft and short January 2026 $405 calls on Microsoft. The Motley Fool has a disclosure policy. Alphabet Has a Brilliant Fallback Plan on AI Even if Search Is Disrupted was originally published by The Motley Fool Error in retrieving data Sign in to access your portfolio Error in retrieving data Error in retrieving data Error in retrieving data Error in retrieving data

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