‘Combat Cocktail': How America Overmedicates Veterans
The VA's own guidelines say no data support drug combinations to treat PTSD. The Food and Drug Administration warns that combining certain medications such as opioids and benzodiazepines can cause serious side effects, including death.
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Yahoo
23 minutes ago
- Yahoo
Lysoway Therapeutics Awarded Grant from The Michael J. Fox Foundation to Advance TRPML1 Agonist to Treat Parkinson's Disease
CAMBRIDGE, Mass., August 06, 2025--(BUSINESS WIRE)--Lysoway Therapeutics, Inc., a biopharmaceutical company developing small molecule modulators of lysosomal ion channels, today announced that it has received a research grant from The Michael J. Fox Foundation for Parkinson's Research (MJFF). Support comes from MJFF's Parkinson's Disease Therapeutics Pipeline Program, which focuses on candidates with strong potential to slow or halt disease progression or alleviate burdensome symptoms for those living with Parkinson's disease. Lysoway Therapeutics funding of $2.93 million will support the preclinical and translational development of Lysoway's novel, highly brain-penetrant small molecule TRPML1 agonist. The study aims to investigate whether activating TRPML1 by a novel, small molecule modulator, will enhance the lysosomal membrane calcium ion channel to restore lysosomal function and help with clearance of alpha-synuclein, the protein that is linked to the disease. "We are honored to receive this generous grant from The Michael J. Fox Foundation," said Valerie Cullen, PhD, Principal Investigator and SVP of Research and Translation at Lysoway. "TRPML1 is a high value target due to its pivotal role in sensing and responding to cellular stress. By activating this ion channel, we can engage multiple beneficial pathways that restore autophagy/lysosomal homeostasis and bolster cellular resilience. Our lead development candidate is both orally bioavailable and highly brain-penetrant, offering strong potential to modify disease progression in Parkinson's Disease." Yongchang Qiu, PhD, Founder and Chief Executive Officer of Lysoway Therapeutics, added "This funding underscores growing confidence in TRPML1 as a compelling target for Parkinson's disease. It will allow us to accelerate development of our lead TRPML1 agonist and to establish key biomarkers for target engagement, with the goal of initiating first-in-human clinical trials early next year." About Lysoway Therapeutics, in Cambridge, MA, Lysoway Therapeutics is a leader in developing therapeutically viable lysosomal ion channel modulators. The company is advancing a pipeline of small molecule activators targeting these channels to treat neurodegenerative diseases. Learn more at View source version on Contacts Media contact: Info@
Newsweek
25 minutes ago
- Newsweek
Potato Salad Recall Map Shows New Warning Issued in 5 States
Based on facts, either observed and verified firsthand by the reporter, or reported and verified from knowledgeable sources. Newsweek AI is in beta. Translations may contain inaccuracies—please refer to the original content. Hans Kissle is recalling its Red Potato Bliss Salad due to an undeclared wheat allergen discovered in a labeling error. Newsweek reached out to the company for comment via phone on Tuesday night and left a voicemail. Why It Matters Numerous recalls have been initiated this year due to the potential of damaged products, foodborne illness, contamination and undeclared food allergens. Millions of Americans experience food sensitivities or allergies every year. According to the U.S. Food and Drug Administration (FDA), the nine "major" food allergens in the U.S. are eggs, milk, fish, wheat, soybeans, Crustacean shellfish, sesame, tree nuts and peanuts. People with a wheat allergy could experience a "serious or life-threatening allergic reaction if they consume these products," the FDA warns. What To Know In the alert, the FDA says that 66 units of the potato salad are being recalled because of the mislabeling issue. The product is packaged in a 16-ounce container that is clear and has a white lid. The product's UPC Code number is 036217673706 and has a use-by date of August 20, 2025. The container says, "Hans Kissle Tri Color Twist Pasta Salad" while the top says, "Hans Kissle Red Bliss Potato Salad," the FDA says. There have been no reported illnesses or adverse reactions as it relates to this recall as of Tuesday, the FDA says. The recalled potato salads were distributed to Stop & Shop retail locations in five states, the alert notes. Below is a map showing the affected states, which include New York, New Jersey, Rhode Island, Connecticut and Massachusetts. What People Are Saying The FDA in the alert, in part: "The recall was initiated after it was discovered that 66 containers of Tricolor Twist Pasta Salad were mislabeled with the incorrect top label. While the front label correctly identifies the product, the top label misrepresents it as Red Bliss Potato Salad. The actual product contains wheat, which is not declared on the top label." In an email to Newsweek in January, the FDA said: "Most recalls in the U.S. are carried out voluntarily by the product manufacturer and when a company issues a public warning, typically via news release, to inform the public of a voluntary product recall, the FDA shares that release on our website as a public service. The FDA's role during a voluntary, firm-initiated, recall is to review the recall strategy, evaluate the health hazard presented by the product, monitor the recall, and as appropriate alert the public and other companies in the supply chain about the recall." It added: "The FDA provides public access to information on recalls by posting a listing of recalls according to their classification in the FDA Enforcement Report, including the specific action taken by the recalling company. The FDA Enforcement Report is designed to provide a public listing of products in the marketplace that are being recalled." Additional information on recalls can be found via the FDA's Recalls, Market Withdrawals, & Safety Alerts. What Happens Next Consumers are advised to return the recalled product to the original place of purchase for a full refund, the FDA says. People with additional questions may contact the company via phone at 978-556-4500 from 8 a.m. to 5 p.m. ET weekdays.
CBS News
25 minutes ago
- CBS News
Hennepin County commissioners mull taking over HCMC in effort to keep hospital open
Changes could be coming at the Twin Cities metro area's largest trauma hospital. At a packed meeting Tuesday, Hennepin County commissioners said they will have to take extreme measures to make sure it stays open. Hennepin County Medical Center (HCMC) takes patients who don't have insurance. Officials believe it has caused an annual debt of tens of millions of dollars. Even though HCMC is considered a county hospital, it has been run by the medical care group Hennepin Healthcare. HCMC's workers work for Hennepin Healthcare. Over the last couple of years, a group of appointed business and medical community volunteers have been overseeing the budget they admit is tricky. "We are facing a structural financial crisis at this hospital because we take care of patients who don't have insurance or are underinsured," said Mohamed Omar, chief operations officer and board chair. "That is why this hospital is in financial trouble, it's not because of mismanagement." But some county commissioners have questions and want to take back financial oversight. They are the ones who pay for the deficit. WCCO obtained data showing the hospital had $38 million in debt last year, which was picked up by property taxes. Commissioner Jeffrey Lunde is voting yes to taking back control. He says the deficit could mean raising property taxes to help cover the deficit. "Our commitment is to keep that hospital open, but there needs to be changing," said Lunde. "I think what you are seeing by the board, saying that we need to step in, we've hit the moment that it is the final buck." Dozens at the committee meeting backed that idea, including a Hennepin Healthcare nurse who believes the path they are on is not working and they need redirection. The committee voted to push the change to a final vote that they say will help the system. Lunde says if the change goes through on Aug. 12, HCMC will continue to accept patients without insurance.
