Scientists crack the code on new vaccine for deadly plague bacteria
The announcement came from Tel Aviv University, which teamed up with the Israel Institute for Biological Research to create the mRNA-based vaccine, the first to protect against bacteria.
'In the study, we show that our mRNA vaccine provides 100% protection against pneumonic plague (a severe lung infection), which is considered the most dangerous form of the disease,' study co-lead Professor Dan Peer, director of the Laboratory of Precision NanoMedicine at Tel Aviv University, told Fox News Digital.
6 Illustration of the Yersinia pestis bacteria.
nobeastsofierce – stock.adobe.com
'Yersinia pestis, the causative agent of plague, is considered a highly lethal infectious bacterium, against which no approved vaccine exists.'
This bacterium is so lethal, even at small doses, that it's been classified as a 'Tier 1 select agent' by the CDC and is considered a 'potential bioterror weapon,' according to Peer.
'Within a week, all unvaccinated animals died, while those vaccinated with our vaccine remained alive and well,' the team reported, noting that a single dose provided full protection after two weeks.
The findings were published in the journal Science Advances.
Before this study, mRNA vaccines were only shown to protect against viruses, such as COVID-19, but not bacteria, according to Tel Aviv University's Dr. Edo Kon, who co-led the study.
'Until now, scientists believed that mRNA vaccines against bacteria were biologically unattainable,' said Kon in the announcement. 'In our study, we proved that it is, in fact, possible to develop mRNA vaccines that are 100% effective against deadly bacteria.'
6 A photo of Prof. Dan Peer, Dr. Inbal Hazan-Halefy, and Shani Benarroch.
Tel Aviv University
While vaccines for viruses trigger human cells to produce viral proteins, which then train the immune system to protect against them, that same method hasn't been effective for bacteria.
Instead, the scientists used a different method to release bacterial proteins that successfully created a 'significant immune response.'
'To enhance the bacterial protein's stability and make sure that it does not disintegrate too quickly inside the body, we buttressed it with a section of human protein,' they wrote.
'By combining the two breakthrough strategies, we obtained a full immune response.'
Dr. Jacob Glanville, CEO of Centivax, a San Francisco biotechnology company, reiterated the importance of the study.
6 Yersinia pestis vaccine vial and syringe.
iStock
'This is distinct from research in coronavirus, influenza and cancer, which have so far been driving mRNA vaccine applications,' Glanville, who was not part of the research team, told Fox News Digital.
The study shows how mRNA technologies can be rapidly applied to 'novel threat areas,' he confirmed.
'Following blowback from the mandates and rare but admittedly problematic side effects related to initial COVID-19 vaccines, mRNA as a platform has faced additional scrutiny to make sure that the next generation of vaccines to emerge from it has learned the lessons from the initial vaccines, and improved upon them,' Glanville told Fox News Digital.
'This research demonstrates yet another large application area for the technology.'
Potential limitations
6 Microscopic image of Yersinia pestis bacteria.
Getty Images
The primary limitation of the study, according to Peer, is that the vaccine's effectiveness was shown in mice.
'As with any pre-clinical study, it needs to be evaluated in a clinical study in order to assess its effectiveness in humans,' he told Fox News Digital.
In addition, the experimental mRNA vaccine is based on the 'lipid nanoparticle (LNP) mRNA vaccine platform' that was recently approved for COVID-19 vaccines, Peer noted, which requires 'cold chain logistics' (a supply chain that uses refrigeration).
'Nevertheless, extensive studies are performed in our lab, focusing on lipid formulation stability optimization that will enable room-temperature storage,' the researcher added.
Looking ahead
6 The primary limitation of the study, according to Peer, is that the vaccine's effectiveness was shown in mice.
motortion – stock.adobe.com
The goal is for this new technology to fast-track vaccines for bacterial diseases, according to the researchers. This could be particularly beneficial for pathogenic (disease-causing) and antibiotic-resistant bacteria.
'Due to excessive use of antibiotics over the last few decades, many bacteria have developed resistance to antibiotics, reducing the effectiveness of these important drugs,' said Peer.
'Consequently, antibiotic-resistant bacteria already pose a real threat to human health worldwide. Developing a new type of vaccine may provide an answer to this global problem.'
As Peer pointed out, the quick development of the COVID-19 vaccine was based on years of mRNA research for similar viruses.
6 The goal is for this new technology to fast-track vaccines for bacterial diseases, according to the researchers.
AP
'If tomorrow we face some kind of bacterial pandemic, our study will provide a pathway for quickly developing safe and effective mRNA vaccines.'
As this was a pre-clinical proof-of-concept study, Peer noted that several major milestones still need to be fulfilled before this vaccine could be considered for commercial rollout.
However, he believes that in an emergency situation, the vaccine could be scaled up and prepared in a 'relatively short time.'
Peer concluded, 'Beyond addressing the threat of plague outbreaks and potential bioterrorism, this study opens the door to developing mRNA vaccines against other antibiotic-resistant bacteria, offering a powerful new strategy to combat rising antimicrobial resistance and improve global pandemic preparedness.'
The study was supported by the European Research Council, the Israel Institute for Biological Research and the Shmunis Family Foundation.
Hashtags
Try Our AI Features
Explore what Daily8 AI can do for you:
Comments
No comments yet...
Related Articles
Yahoo
7 hours ago
- Yahoo
Unexpected medical issue grounds Isle Royale wolf-moose survey
A last-minute medical issue grounded researchers' annual wolf-moose survey on Isle Royale this past winter, marking yet another year that scientists have run into problems trying to count the animals on the remote island park. Isle Royale is a 134,000-acre (54,200-hectare) island in far western Lake Superior between Grand Marais, Minnesota, and Thunder Bay, Canada. The island, which doubles as a national park, offers scientists a rare chance to observe wolves and moose in their natural habitat, free from human influence. Researchers have conducted an annual survey of the island's wolf and moose population since 1958. Scientists from Michigan Tech University had planned to return to the island in January to conduct seven weeks of aerial surveys by ski-planes. Snow and bare branches make tracking easier from the air in winter, but the island lacks a land-based runway, forcing the scientists to use ski-planes that can land in the island's ice-covered harbors. The scientists released their annual report on Tuesday, but it does not include any new population estimates. The report notes that the researchers were not able to get into the air at all this winter because 'our usual aviation resources became unexpectedly unavailable due to extenuating circumstances and there was insufficient time to find a suitable alternative.' Michigan Tech spokesperson Hailey Hart explained in a telephone interview that the ski-plane pilot developed a last-minute medical issue and couldn't fly. The scientists were unable to find a replacement pilot. 'It was very sudden,' Hart said. 'It was a big bummer for them.' Researchers have experienced disruptions in three of the last five years they've attempted the survey. The COVID-19 pandemic forced them to cancel the survey in 2021, marking the first time since 1958 that population counts weren't conducted. They had to cut the survey short in February 2024 after weeks of unusually warm weather left the ice surrounding the island unsafe for ski-plane landings. The National Park Service suspended the researchers' work and ordered them to evacuate. Data the scientists gathered before they left showed the wolf population stood at 30 animals, down from 31 the previous year. The moose population stood at 840, down 14% from 2023. Most of Tuesday's report discusses observations a group of college students made on the island in the summer of 2024. They noted regular wolf sightings, observed a wolf chasing a moose and found the bones of a wolf that died a decade ago, well before the park service began relocating wolves to the island in 2018. The students also found the remains of 115 moose, including 22 believed to have died in 2024. Researchers believe wolves killed all but three of those moose. Hart said the scientists are planning another aerial survey next winter.
San Francisco Chronicle
8 hours ago
- San Francisco Chronicle
Unexpected medical issue grounds Isle Royale wolf-moose survey
A last-minute medical issue grounded researchers' annual wolf-moose survey on Isle Royale this past winter, marking yet another year that scientists have run into problems trying to count the animals on the remote island park. Isle Royale is a 134,000-acre (54,200-hectare) island in far western Lake Superior between Grand Marais, Minnesota, and Thunder Bay, Canada. The island, which doubles as a national park, offers scientists a rare chance to observe wolves and moose in their natural habitat, free from human influence. Researchers have conducted an annual survey of the island's wolf and moose population since 1958. Scientists from Michigan Tech University had planned to return to the island in January to conduct seven weeks of aerial surveys by ski-planes. Snow and bare branches make tracking easier from the air in winter, but the island lacks a land-based runway, forcing the scientists to use ski-planes that can land in the island's ice-covered harbors. The scientists released their annual report on Tuesday, but it does not include any new population estimates. The report notes that the researchers were not able to get into the air at all this winter because 'our usual aviation resources became unexpectedly unavailable due to extenuating circumstances and there was insufficient time to find a suitable alternative.' Michigan Tech spokesperson Hailey Hart explained in a telephone interview that the ski-plane pilot developed a last-minute medical issue and couldn't fly. The scientists were unable to find a replacement pilot. 'It was very sudden,' Hart said. 'It was a big bummer for them.' Researchers have experienced disruptions in three of the last five years they've attempted the survey. The COVID-19 pandemic forced them to cancel the survey in 2021, marking the first time since 1958 that population counts weren't conducted. They had to cut the survey short in February 2024 after weeks of unusually warm weather left the ice surrounding the island unsafe for ski-plane landings. The National Park Service suspended the researchers' work and ordered them to evacuate. Data the scientists gathered before they left showed the wolf population stood at 30 animals, down from 31 the previous year. The moose population stood at 840, down 14% from 2023. Most of Tuesday's report discusses observations a group of college students made on the island in the summer of 2024. They noted regular wolf sightings, observed a wolf chasing a moose and found the bones of a wolf that died a decade ago, well before the park service began relocating wolves to the island in 2018. The students also found the remains of 115 moose, including 22 believed to have died in 2024. Researchers believe wolves killed all but three of those moose.
Scientific American
8 hours ago
- Scientific American
Pneumonic Plague Infections in Modern Times Show the Black Death Isn't Dead
Plague is often associated with Medieval history and the centuries-old Black Death epidemic, but a recent death in northern Arizona is a troublesome reminder of the flea-borne disease's lingering hold in parts of the world, including the U.S. Local health officials in Arizona's Coconino County, which includes the city of Flagstaff, confirmed late last week that a person there had died of pneumonic plague —a severe lung infection caused by Yersinia pestis, the bacterium behind the illness. Human infections and fatalities from plague are relatively rare in the U.S.; according to the Centers for Disease Control and Prevention, seven human cases are reported annually on average. Prior to the Arizona case, the most recent death was reported in 2021. Y. pestis arrived in port cities in the U.S. around 1900 and has since become endemic to rats and other rodents in western U.S. states including New Mexico, Arizona, Colorado, California, Oregon and Nevada. 'From a public health standpoint in the U.S., it's a scary thing that it's plague, and it's tragic that that this was a fatal case, but people need to remember that it's extremely rare,' says David Wagner, executive director of the Pathogen and Microbiome Institute at Northern Arizona University, who has studied plague for more than 25 years. 'Not to be flippant, but it's more important that you put your seat belt on going to the grocery store than it is to worry about plague in the western U.S.' On supporting science journalism If you're enjoying this article, consider supporting our award-winning journalism by subscribing. By purchasing a subscription you are helping to ensure the future of impactful stories about the discoveries and ideas shaping our world today. Scientific American spoke with Wagner about plague's signs and symptoms, and its persistence across time. [ An edited transcript of the interview follows. ] How do people get sick with plague? Plague is caused by the bacterium Y. pestis and is really a disease of rodents and their fleas. You have an infected rodent; a flea feeds on the blood of that rodent, and it picks up some Y. pestis. Then when the flea feeds on another rodent, it can pass along the Y. pestis. It's constantly cycling back and forth between rodents and fleas in nature; that's how it's been maintained for thousands of years in the environment around the world. What's the difference between bubonic and pneumonic plague? People call it the Black Death; they call it bubonic plague; they call it pneumonic plague—it's all the same disease, just different clinical manifestations. What stands apart [with the recent case is] that it's pneumonic plague. That's kind of rare, especially in the U.S. Pretty much all human cases, with a few exceptions, are acquired from the environment—from the bite of an infected flea. If there isn't a rodent host for that flea to feed on, it will look for other mammals to feed on. And if humans happen to be in proximity, it will feed on humans and can transmit Y. pestis. If the immune system doesn't stop Y. pestis at the source of the flea bite, it will migrate through your lymphatic system to your closest major lymph node. So let's say I was bit on my wrist; then the bacteria would go to that lymph node in my underarm and start to reproduce there. And that mass swelling, that swollen lymph node, is called a bubo—that's why it's called bubonic plague. These days, it's a dead end because there's not flea-borne transmission from one human to another. It just stops there with the treatment or death of that individual. Left untreated, though, bubonic plague can get down into your lungs via the bloodstream. That's called secondary pneumonic plague. Those individuals, then, via cough or direct contact, can spread plague person-to-person, and that's called primary pneumonic plague. What people might not know is that plague has been endemic throughout the western U.S. in rodent populations for more than 100 years. Someone could also get pneumonic plague from an animal—for example, if they were handling an infected animal and that animal coughed. Sometimes hunters in Central Asia will kill [infected] ground squirrels, and when they're skinning them can inhale particles. People also talk about septicemic plague, and that means it's gotten into your bloodstream, and that typically also arises from bubonic plague. You could also get [septicemic plague] directly if you had cuts on your hands and were handling rodents without gloves. Can pets get infected or transmit plague to humans? Pets, especially free-roaming ones, may come into contact with dead rodents that have died of plague. Fleas can hop onto pets, which then bring them into the home. This is pretty rare because there are so few [human] cases in the U.S., but that is something we think about. Flea and tick collars are a good idea. If animals do get sick, most of the evidence shows that dogs fight off the infection and can create antibodies against Y. pestis. Cats are more susceptible and can quickly become sick and actually can progress to pneumonic plague. It's super, super rare, but that's a possible way for humans to be exposed to pneumonic plague. What are the symptoms and treatment? With bubonic plague, typically people develop a fever, headache, chills and fatigue, and then they'll get those swollen lymph nodes called buboes. It typically takes a few days to manifest because it sort of starts off in stealthy mode inside the body to try and avoid the immune system. Plague is easily treated with many different types of antibiotics, as long as it's caught in time. If untreated, bubonic plague mortality rates may be somewhere between 30 to 60 percent, depending on the situation. Pneumonic plague, left untreated, is almost always fatal. So diagnostics become really important. The challenge is that many physicians in the U.S. have never seen plague. The symptoms are a bit common to other things, so rapid testing in the lab can help. Where is plague typically found in the U.S. and around the world? What people might not know is that plague has been endemic throughout the western U.S. in rodent populations for more than 100 years. It just so happened that a lot of the rodent host species in Central Asia, where it evolved, were quite similar to some of the ground squirrels that we have here in the U.S. It was first reported in native ground squirrels in California in 1908 and was in human populations before then. And then it spread really rapidly to the east and just sort of stopped at the western edge of North Dakota, South Dakota, Nebraska, Kansas, Oklahoma and Texas. It's a bit of a mystery why; the rodent diversity and climate changes quite a bit in [that region]. I'm also currently working on plague with colleagues in Madagascar, which has more human plague cases than any other country —around 75 percent of the global [case] total. It has hundreds to thousands of cases every year, with quite a few deaths. How has it persisted over the years? We don't have a good handle on which rodents are actually maintaining it in the U.S. So we've been going out and collecting plague-infected fleas from prairie dogs for more than 25 years because it's our window into plague activity. Prairie dogs are ground squirrels that live in dense colonies, so they're very conspicuous. If the prairie dogs die off, we go out and collect fleas from their burrows. We take a piece of white flannel, breathe on it to bait it with carbon dioxide, and then put it down the burrows. The fleas will hop on, and then we take them back to our laboratory and freeze them to kill them. Then we can study the Y. pestis DNA directly from those fleas. We're very careful when we do this, and we talk with our physicians here at Northern Arizona University. Every year we review the symptoms and they give us a prescription for antibiotics. Then we do what we call fever watch, where we take our temperature before we go out. The prairie dogs can't be maintaining it because they're just so susceptible—it'll just wipe out a whole colony when it gets in. And so there's other rodents out there maintaining plague, but it's still a bit of a mystery in the western U.S. How has it become less dangerous? There were three great historical plague pandemics, and it's estimated that maybe 250 million people died [total]. But we don't have those large pandemics anymore because we have hygiene, which controls rat populations in cities—and then, most importantly, we have antibiotics.
