
The opioid crisis' economic impact in Michigan
Why it matters: The cost burden falls unevenly across the country, with states in a belt stretching through Appalachia to New England typically having bigger caseloads and a higher cost per case.
Context: Opioid use disorder — defined as frequent opioid use and unsuccessful efforts to quit — is estimated to affect more than 6 million people in the United States, costing the nation an estimated $4 trillion last year, per health care consulting firm Avalere Health.
The cumulative economic burden on patients, including years of life lost and reduced quality of life, exceeded $3 trillion in 2024, Avalere estimated.
Zoom in: Michigan borders the states with the highest share of opioid misuse cases.
At $742,799, our average cost per case is slightly higher than the national average, per the analysis from Avalere, which used 2017 figures to project 2024 net costs.
Zoom out: Private businesses absorbed more than $467 billion in costs from lost productivity and health insurance costs, while the federal government bore about $118 billion in Medicare and other federal insurance costs, lost taxes and criminal justice expenses.
It cost state and local governments more than $94 billion, with about $42 billion of that going toward criminal justice costs.
What they're saying: Reports such as Avalere's help local officials across the state better understand the opioid crisis and how to address it with the state's $1.6 billion in opioid settlement funds, Joyce Fetrow, project director of the Northern Michigan Opioid Response Consortium, tells Axios.
Every dollar spent on recovery provides a 10% return, Fetrow says. Investment in recovery services leads more people to spend on housing, transportation and other needs instead of their addiction.
Follow the money: The projected cost of opioid use disorder in 2024 ranged from $419,527 per case in Idaho to more than $2.4 million in D.C.

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Examples of forward-looking statements include, among other things: statements regarding our confidence in future financial improvements, expectations about 2025 being a transition year, anticipated benefits from our strategic initiatives, potential optimization actions under review, our leadership transition and CEO search process, our expectations related to operating and financial results, our ability to efficiently exit unprofitable markets, our expectations regarding the Medicare Advantage environment, and our long-term opportunities and strategic growth plans and alignment with the macro environment, expected revenue, medical costs, net income and gross profit, total and average membership, Adjusted EBITDA, Medical Margin, geography entry costs and other financial projections and assumptions, including our fiscal year and second quarter 2025 guidance. Forward-looking statements reflect our current expectations and views about future events and are subject to risks and uncertainties that could significantly affect our future financial condition and results of operations. While forward-looking statements reflect our good faith belief and assumptions we believe to be reasonable based upon current information, we can give no assurance that our expectations or forecasts will be attained. Forward-looking statements are subject to known and unknown risks and uncertainties, many of which may be outside our control. 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Condensed Consolidated Statements of Operations In thousands, except per share data (unaudited) Three Months Ended June 30, Six Months Ended June 30, Revenues: Medical services revenue $ 1,392,039 $ 1,479,579 $ 2,921,918 $ 3,080,774 Other operating revenue 2,943 3,179 5,846 6,338 Total revenues 1,394,982 1,482,758 2,927,764 3,087,112 Expenses: Medical services expense 1,445,245 1,374,060 2,847,112 2,817,902 Other medical expenses 2,164 76,523 82,357 161,947 General and administrative 56,281 69,612 122,237 146,034 Depreciation and amortization 7,319 5,907 14,195 11,751 Total expenses 1,511,009 1,526,102 3,065,901 3,137,634 Income (loss) from operations (116,027 ) (43,344 ) (138,137 ) (50,522 ) Other income (expense): Income (loss) from equity method investments 5,412 9,955 18,084 15,639 Other income (expense), net 7,879 4,841 17,140 10,733 Interest expense (1,572 ) (1,697 ) (3,087 ) (2,981 ) Income (loss) before income taxes (104,308 ) (30,245 ) (106,000 ) (27,131 ) Income tax benefit (expense) (62 ) (417 ) (258 ) (284 ) Income (loss) from continuing operations (104,370 ) (30,662 ) (106,258 ) (27,415 ) Discontinued operations: Income (loss) before gain (loss) on sales — — — (518 ) Adjustments on sale of assets, net — — 14,000 (8,763 ) Total discontinued operations — — 14,000 (9,281 ) Net income (loss) (104,370 ) (30,662 ) (92,258 ) (36,696 ) Noncontrolling interests' share in (earnings) loss — (20 ) — (50 ) Net income (loss) per common share, basic and diluted Continuing operations $ (0.25 ) $ (0.07 ) $ (0.25 ) $ (0.07 ) Discontinued operations $ — $ — $ 0.03 $ (0.02 ) Weighted average shares outstanding Basic and diluted 413,836 411,271 413,388 409,152 Expand agilon health, inc. Condensed Consolidated Statements of Cash Flows In thousands (unaudited) Six Months Ended June 30, 2025 2024 Cash flows from operating activities: Net income (loss) $ (92,258 ) $ (36,696 ) Adjustments to reconcile net income (loss) to net cash used in operating activities: Depreciation and amortization 14,195 11,751 Stock-based compensation expense 32,101 35,116 Loss (income) from equity method investments (18,084 ) (15,639 ) Distributions of earnings from equity method investments — 3,340 Adjustments on sale of assets, net (14,000 ) 3,784 Other noncash items (3,107 ) (837 ) Changes in operating assets and liabilities: 14,081 (67,312 ) Net cash provided by (used in) operating activities (67,072 ) (66,493 ) Cash flows from investing activities: Purchase of property and equipment (7,099 ) (6,451 ) Purchase of intangible assets (9,717 ) (17,893 ) Investment in loans receivable and other (1,000 ) (9,742 ) Investments in marketable securities (60,154 ) (12,006 ) Proceeds from maturities of marketable securities and other 125,339 115,747 Net cash provided by (used in) investing activities 47,369 69,655 Cash flows from financing activities: Proceeds from (payments for) equity issuances, net (2,741 ) 1,345 Repayments of long-term debt — (2,500 ) Net cash provided by (used in) financing activities (2,741 ) (1,155 ) Net increase (decrease) in cash, cash equivalents and restricted cash and equivalents (22,444 ) 2,007 Cash, cash equivalents and restricted cash and equivalents, beginning of period 193,860 114,329 Cash, cash equivalents and restricted cash and equivalents, end of period $ 171,416 $ 116,336 Expand agilon health, inc. Key Operating Metrics In thousands (unaudited) GROSS PROFIT (LOSS) Three Months Ended June 30, Six Months Ended June 30, 2025 2024 2025 2024 Total revenues $ 1,394,982 $ 1,482,758 $ 2,927,764 $ 3,087,112 Medical services expense (1,445,245 ) (1,374,060 ) (2,847,112 ) (2,817,902 ) Other medical expenses (1) (2,164 ) (76,523 ) (82,357 ) (161,947 ) Gross profit (loss) $ (52,427 ) $ 32,175 $ (1,705 ) $ 107,263 Expand ____________________________________ (1) Represents physician compensation expense related to surplus sharing and other care management expenses that help to create medical cost efficiency. Includes costs in geographies that are in implementation and are not yet generating revenue and investments to grow existing markets. For the three months ended June 30, 2025 and 2024, costs incurred in implementing geographies were $0.2 million and $18,000, respectively. For the six months ended June 30, 2025 and 2024, costs incurred in implementing geographies were $(1.0) million and $0.6 million, respectively. Expand ____________________________________ (1) Represents direct geography entry costs, including investments to develop and expand our platform and costs in geographies that are in implementation and are not yet generating revenue and investments to grow existing markets. (2) Includes transaction-related costs. Expand Our platform support costs, which include regionally-based support personnel and other operating costs to support our geographies, are expected to decrease over time as a percentage of revenue as our physician partners add members and our revenue grows. Our operating expenses at the enterprise level include resources and technology to support payor contracting, clinical program development, quality, data management, finance, and legal and compliance functions. ____________________________________ (1) Gross profit (loss) is defined as total revenues less medical services expense and other medical expenses. Expand ADJUSTED EBITDA Three Months Ended June 30, Six Months Ended June 30, 2025 2024 2025 2024 Net income (loss) (1) $ (104,370 ) $ (30,662 ) $ (92,258 ) $ (36,696 ) (Income) loss from discontinued operations, net of income taxes — — (14,000 ) 9,281 Interest expense 1,572 1,697 3,087 2,981 Income tax expense (benefit) 62 417 258 284 Depreciation and amortization 7,319 5,907 14,195 11,751 Severance and related costs 119 868 644 3,283 Stock-based compensation expense 15,381 18,207 32,101 35,116 EBITDA adjustments related to equity method investments (2) 4,366 1,404 11,209 5,306 Other (3) (7,782 ) (668 ) (18,002 ) (5,082 ) Adjusted EBITDA $ (83,333 ) $ (2,830 ) $ (62,766 ) $ 26,224 Expand ____________________________________ (1) Includes direct geography entry costs, including investments to develop and expand our platform and costs in geographies that are in implementation and are not yet generating revenue and investments to grow existing markets. For the three months ended June 30, 2025 and 2024, (i) $0.2 million and $18,000, respectively, are included in other medical expenses and (ii) $4.2 million and $4.8 million, respectively, are included in general and administrative expenses. For the six months ended June 30, 2025 and 2024, (i) $(1.0) million and $0.6 million, respectively, are included in other medical expenses and (ii) $10.8 million and $15.3 million, respectively, are included in general and administrative expenses. (2) Includes elimination of certain administrative services provided by agilon health, inc. to equity method investments. (3) Includes interest income, transaction-related costs and elimination of certain administrative services provided by agilon health, inc. to equity method investments. Expand agilon health, inc. Supplemental Financial Information In thousands (unaudited) Three Months Ended June 30, 2025 Six Months Ended June 30, 2025 Medicare Advantage (Consolidated) CMS ACO Models (Unconsolidated) Medicare Advantage (Consolidated) CMS ACO Models (Unconsolidated) Medical services revenue $ 1,392,039 $ 434,806 $ 2,921,918 $ 848,271 Other operating revenue 2,943 — 5,846 — Total revenues 1,394,982 434,806 2,927,764 848,271 Medical services expense (1,445,245 ) (401,902 ) (2,847,112 ) (753,755 ) Other medical expenses (2,164 ) (17,848 ) (82,357 ) (54,090 ) Gross profit (loss) (52,427 ) 15,056 (1,705 ) 40,426 Other operating revenue (2,943 ) — (5,846 ) — Other medical expenses 2,164 17,848 82,357 54,090 Medical margin $ (53,206 ) $ 32,904 $ 74,806 $ 94,516 Expand Certain of our operations are not consolidated for the period presented because we do not have the ability to control certain activities due to another party's control of the entities' board of directors. Although revenues of the unconsolidated operations are not recorded as revenues by us, income (loss) from equity method investments is nonetheless a significant portion of our overall earnings. See Note 14 to the Condensed Consolidated Financial Statements in the Quarterly Report on Form 10-Q for the period ending June 30, 2025 for additional discussion on our equity method investments. In addition to providing results that are determined in accordance with GAAP, we present Medical Margin and Adjusted EBITDA, which are non-GAAP financial measures. We define Medical Margin as medical services revenue after medical services expense is deducted. Medical services expense represents costs incurred for medical services provided to our members. As our platform matures over time, we expect Medical Margin to increase in absolute dollars. However, Medical Margin per member per month (PMPM) may vary as the percentage of new members brought onto our platform fluctuates. New membership added to the platform is typically dilutive to Medical Margin PMPM. We believe this metric provides insight into the economics of our capitation arrangements as it includes all medical services expense directly associated with our members' care. We define Adjusted EBITDA as net income (loss) adjusted to exclude: (i) income (loss) from discontinued operations, net of income taxes, (ii) interest expense, (iii) income tax expense (benefit), (iv) depreciation and amortization, (v) stock-based compensation expense, (vi) severance and related costs, and (vii) certain other items that are not considered by us in the evaluation of ongoing operating performance. We reflect our share of Adjusted EBITDA for equity method investments by applying our actual ownership percentage for the period to the applicable reconciling items on an entity-by-entity basis. Gross profit (loss) is the most directly comparable GAAP measure to Medical Margin. Net income (loss) is the most directly comparable GAAP measure to Adjusted EBITDA. We believe Medical Margin and Adjusted EBITDA help identify underlying trends in our business and facilitate evaluation of period-to-period operating performance of our operations by eliminating items that are variable in nature and not considered by us in the evaluation of ongoing operating performance, allowing comparison of our recurring core business operating results over multiple periods. We also believe Medical Margin and Adjusted EBITDA provide useful information about our operating results, enhance the overall understanding of our past performance and future prospects, and allow for greater transparency with respect to key metrics we use for financial and operational decision-making. We believe Medical Margin and Adjusted EBITDA or similarly titled non-GAAP measures are widely used by investors, securities analysts, ratings agencies, and other parties in evaluating companies in our industry as a measure of financial performance. Other companies may calculate Medical Margin and Adjusted EBITDA or similarly titled non-GAAP measures differently from the way we calculate these metrics. As a result, our presentation of Medical Margin and Adjusted EBITDA may not be comparable to similarly titled measures of other companies, limiting their usefulness as comparative measures.