logo
Reviewers Over 50 Swear By These 22 Hair Care Products

Reviewers Over 50 Swear By These 22 Hair Care Products

Buzz Feed13-05-2025
A moisturizing L'Oréal Paris in-shower hair treatment for those of you who don't have the time *or* the money to be sitting in a salon chair all day but still want some luscious-looking locks. Leave this lamellar water treatment in for 8 seconds, yes...8 seconds only, and rinse out for silkier, shinier, healthier-looking hair.
A splurge-worthy Sol de Janeiro hair and body mist — seems like everyone wants to get their hands on it. It comes in the same vanilla and caramel scent as the beloved Bum Bum Cream and might just have people telling you, "Ooooh, you smell so good!"
An air-dry leave-in curl cream made to enhance your natural curls and tame frizz. No need to damage your hair with hot styling tools, this blend of coconut oil and shea butter nourishes your locks and makes them smell great too!
An anti-humidity spray to give you that salon "wow" feeling at home, and for way cheaper. This fights off frizz and leaves you with silky-looking hair. FYI, this spray is heat activated, so it's ideal to use this on damp hair and blow-dry for best results.
A dandruff shampoo so you can finally get rid of those itchy, dry flakes once and for all. This is made with 1% ketoconazole, which gets to the ~root~ of the dandruff and makes sure that your scalp will look nice and clear.
A dry shampoo powder if your hair has been looking like it's been a while since wash day. Tap this on to say goodbye to greasy roots and make it look like your hair got a nice lil' refresh. Plus, this is TSA friendly, which makes it great for traveling.
K18 — it does a stellar job at restoring moisture and softness to hair that has been through a lot, whether it's from bleaching or just frequent hot tool use. Many reviewers say this leave-in reparative treatment is like "magic in a bottle!"
Or a budget-friendly collagen-coating hair treatment with collagen and ceramide 3 to treat hair that's been through intense heat or sun damage. Use this in between your shampoo and conditioner and leave it in for five minutes — soon enough, you'll have silky soft hair!
And a splurge-worthy bottle of Olaplex No. 3 that's totally worthy of all the hype since it'll help repair and strengthen your dry, damaged hair. After using this, you'll be telling all your friends, "Feel how soft my hair is!"
A detangling brush to help make dealing with knots and tangles a less painful part of your hair care routine. The flexible bristles glide through your hair and make sure there's no yanking, pulling, or tears.
A bottle of Fanola purple shampoo if your "bleach and tone" is looking yellow and brassy. This will help neutralize your color and bring back your blonde or gray locks.
A Chi automatic curling iron for those who are tired of putting so much effort into curling their hair or those who always find a way to accidentally burn their fingers on the hot barrel. This will automatically curl your hair, and the outer casing protects your fingers from any potential ouches!
Or a set of flexible curling rods that prove you don't always need a hot tool to give you the results you've been wishing for. You just wrap your hair around these soft rods, go to bed (they're comfortable enough to sleep in), and wake up with stunning curls!
An argan oil hair mask to give your hair that hair commercial-worthy shine and moisture you've been wanting. Your dry hair and split ends will thank you for buying this since its paraben- and sulfate-free formula will make your locks look oh-so-luscious.
A Mielle rosemary mint scalp oil that contains biotin and jojoba oil, which can help nourish your scalp and make hair look fuller and thicker. It's got over 74,000 5-star reviews, and people love how it smells, too!
A curl-activating cream to help reduce breakage and frizz for all you curly-haired folks. Whether you use this at night before bed or to style your mane in the morning, you'll see bouncy, defined curls like never before, thanks to the blend of vitamins and shea butter that nourishes and detangles.
A Revlon hot air brush because the Dyson Airwrap costs an arm and a leg and this round brush gives you the same, if not better, bouncy blowout results. This dries *and* styles at the same time, saving you some extra time in the morning!
Or a 3-in-1 hot tool that's got interchangeable heads so you can choose how much va-va-va-voom you want when blow-drying and styling your hair.
A scalp massager you can use in the shower to help exfoliate your head and make sure all that shampoo really gets into those roots.
A Verb hair oil because the only ghost here is the ghost of the person you were when you had frizzy hair and constant flyaways. This moringa-infused oil tames frizz, and reviewers with hair textures from straight to 4c love this because it makes their hair look shinier and feel softer.
A hair repair serum with argan oil, aloe vera, and vitamin E to make your hair shine like the star you are while keeping the frizz at bay. Reviewers love how lightweight this feels and that it doesn't leave their hair feeling super oily or greasy.
A color-depositing conditioner — great if you find yourself wanting a little color refresh when you're in between salon appointments. With every wash, your hair color will become more vibrant, and it'll save you the hassle of messing with at-home box dyes.
Orange background

Try Our AI Features

Explore what Daily8 AI can do for you:

Comments

No comments yet...

Related Articles

If You Think Real Beauty Results Only Happen When You Spend Tons Of Money, These 39 Items Are Here To Prove You Wrong
If You Think Real Beauty Results Only Happen When You Spend Tons Of Money, These 39 Items Are Here To Prove You Wrong

Buzz Feed

time6 days ago

  • Buzz Feed

If You Think Real Beauty Results Only Happen When You Spend Tons Of Money, These 39 Items Are Here To Prove You Wrong

A Physicians Formula Butter Glow & Go Stick offering a luxuriously creamy, easy-to-apply formula that glides on skin to give you that "just returned from a week-long tropical vacation" glow. The double-ended applicator comes with two colors that can be used as contour, bronzer, blush, eyeshadow, and lip color. So many uses and for so little money, despite being comparable to the $46 Charlotte Tilbury Beach Stick. Monday Haircare Dry Shampoo that works just as well as more expensive competitors to absorb oil and add volume, with the added bonus of keratin to strengthen and protect against humidity. Oh, and the floral scent is definitely a compliment magnet! Amazing they don't charge more for all these benefits... La Roche-Posay Effaclar gel made with adapalene, an over-the-counter retinoid that can help minimize the appearance of pores, attack blackheads and whiteheads, and regulate skin cell turnover. Clear skin is possible, even without a pricey prescription — just check out this review pic! L'Oréal Paris BB Cream, a green-tinted formula that combats redness through the power of color theory. It doesn't stop there — it also works to even complexion, hydrate with vitamin E, and set the perfect stage for you to apply your makeup on. Turns out you don't have to drop $50+ on Dr Jart+'s Cicapair Color Correcting Cream! An ultra-affordable E.l.f. color corrector that comes in a ton of shades to help counteract different types of discoloration, like redness and dark spots. Mix and match to create the perfect foundation for the rest of your makeup routine. A lightweight gel cream from Nivea with powerful Q10 that helps plump, firm, and moisturize skin in as little as two weeks with consistent use. One reviewer found success with this when expensive neck creams from department stores and Sephora fell flat. Hawaiian Tropic's SPF 30 Mineral Powder Sunscreen Brush offering some light coverage (and extra sun protection on top of your normal sunscreen) that won't weigh you down on hot days. Most intriguing: Reviewers are using this on their scalp and hairline because YES scalp burns can happen and NO we're not putting goopy sunscreen in our hair. It's also wayyy cheaper than the $69 Colorescience version. Jergens Natural Glow tanning lotion — a classic because it gives you a gradual, just-got-back-from-vacation glow after just a few uses. It's easier to use than more expensive brands that risk getting streaky *and* it's formulated with elastin to help your skin feel firmer. E.l.f.'s Hydrating Core Lip Shine in the "Ecstatic" shade, which reviewers say works as a very good, affordable replacement for Clinique's "Black Honey," the $25 "universal shade" that has a Shakira-level of fame and adoration. This $7 alternative is nonsticky, moisturizes with vitamin E, and melts onto your lips like buttah. A Revlon volcanic face roller way easier to use than those disposable blotting pads. You just roll the volcanic stone over any oily or greasy areas on your face and then pop it in your bag for later. A portable spa treatment if you think about it. Gold Bond's firming neck and chest cream to pamper your décolletage with some special skincare attention. The glycerin and aloe hydrate while the salicylic acid gently exfoliates, leaving firmer, softer skin. After seeing these impressive results, I have to thank Gold Bond for not charging double. An SPF 50 Airy Sunstick Smoothing Bar that works like a giant lip balm for your face. It's nonsticky, glides on clear, works nicely as a primer, and is so easy to apply (check out the curved shape), you may actually remember to reapply for once. Plus, it's cheaper than the Supergoop version. A Wet n Wild lipstick formulated with vitamins A and E and macadamia for silky smooth color. Reviewers are shocked at the quality considering the price: a single dollar. Nothing at the dollar store even costs that little! Some reviewers have even compared it to MAC. 👀 L'Oreal Paris Bright Reveal — a new dark spot correcting rinse-off treatment that aims to be like a professional peel in a bottle. The blue gel uses 25% AHA, BHA, and PHA to chemically exfoliate and help reveal brighter, smoother skin. Expect compliments with words like glowing, radiant, and wellness influencer. A Curél moisture spray when you want to boost your routine with a hit of ceramides — a key ingredient for helping your skin's moisture barrier. Spritz it on your face, body, or over makeup for a hydrating refresh. Despite the chichi packaging, you're more likely to find this affordable gem at your local drugstore than at a department store. Garnier SkinActive Micellar Cleansing Water, which has a place in an astounding amount of medicine cabinets (56,000+ positive ratings on Amazon!) because it gently (but effectively!) removes dirt, excess oil, and even waterproof makeup without drying out your skin and hurting your budget. You don't even need to rinse with water — just apply and wipe off. A Vanicream cleanser for when you just want something super gentle, simple, and effective. It costs less than $10 and, without any fanfare, cleanses and removes makeup. It's a great option for sensitive skin — no drying or irritation here. I have since sworn off fancy cleansers because this does the job better than anything else! A beloved Maybelline "Fit Me" matte foundation that has over 40 shades so you're sure to find the perfect match. This oil-free, breathable, lightweight formula gives you buildable coverage and a fancy matte finish you normally don't get outside of Sephora. Or TirTir cushion foundation promising up to 72 hours of buildable coverage to help hide redness, blemishes, dark circles, and other unwanted discoloration. The oval-shaped puff makes it easy to get this heavenly product in every nook and cranny for a seamless satin finish. As a bonus, it's made with red propolis extracts that have antimicrobial properties. Reviewers are saying this a great swap for Dior! Ogx Argan Oil of Morocco Curl-Defining Cream for curls so bouncy you'll be jumping for joy (and to show them off). The argan oil-boosted formula moisturizes and tames frizz while adding a level of volume and shine you'd normally expect from a much higher price point. Or Lottabody Wrap Me Curl Mousse, a whipped-cream-like delight that defines curls, moisturizes with shea and coconut oil, and tackles frizz all for UNDER $5. The foam makes it super easy to distribute throughout your hair, and the heavenly scent will make you feel like you're on a tropical vacation. Bio-Oil made with vitamin E, chamomile, and lavender oil to moisturize your face and body, and help improve the appearance of scars, stretch marks, dark spots, and more. One reviewer loves using it in place of a pricey serum! L.A. Colors metallic nail polish that somehow costs less than $2, yet still provides a striking shine you normally have to pay 5–10 times the amount to achieve. At that price point, I'm shocked it works at all, let alone WELL! Peach Slices nose pore patches offering an overnight solution for stubborn open pimples. Just wash your face, exfoliate, and pop one on before bed. The hydrocolloid bandage will soak up gunk from your pores without drying your skin. Normally, you'd have to book a facial for these kinds of results! A cruelty-free Essence Lash Princess lengthening mascara that's lightweight, won't transfer, doesn't smudge, and lasts all day — oh and makes your eyelashes look like tall, beautiful skyscrapers. Why Essence only charges $5 for such an S-tier mascara is beyond me, but we're all grateful. Or E.l.f Lash Xtndr Tubing Mascara, which creates tubing around your lashes to make them appear longer, thicker, and darker. The lightweight "extensions" won't smudge or weigh down your actual lashes and — best of all — they fall right off when you wash your face. Priceless! An Elizavecca collagen coating hair protein treatment that takes your dry, tired hair and turns it into the silky-soft locks you've always wanted. Just apply it to wet hair after shampooing, wait five minutes, rinse, and wonder why other, pricier hair treatments (like Olaplex!) don't work this well. A tube of Roc retinol night cream possibly imbued with time traveler magic, because it will feel like you're turning back the hands of time when you go to sleep each night. OK, maybe it won't be that dramatic, but the shea butter and squalane will hydrate, and the retinol will work hard to smooth and possibly reverse some signs of aging. This reviewer says it's a great alternative to prescription retinol. L'Oreal Lumi Glotion that's a lotion, glowy foundation base, and highlighter all in one bottle. Over 30,000 5-star happy customers love how effective this vacation-in-a-bottle is, despite the low price. Some reviewers even compare it to the pricey Drunk Elephant Sunshine Drops! A high shine lip gloss from L.A. Colors providing a splashy shine so bright, you might blind people with your smile. The luxurious, vanilla-scented color has shea butter for moisture, isn't sticky, and costs less than a cup of coffee (even a cheap one from the corner store)! Nyx's Pore Filler Targeted Stick that's basically Photoshop's blurring tool, but IRL. Apply it like a giant tube of face lip balm to help smooth and reduce the appearance of pores. It's under $8, which is certainly less than an Adobe subscription. Mielle's Rosemary Mint strengthening oil, a TikTok-hall-of-famer that almost 80,000 5-star reviews confirm is worth the hype. The biotin-infused serum can help strengthen hair and encourage new growth, leaving hair feeling healthier and fuller. Reviewers say it's helped with everything from receding hairlines to sparse eyebrows — who knew something so effective was just sitting on a drugstore shelf this whole time? An E.l.f. hydrating grip primer that reviewers say is a comparable swap for Milk's Hydro Grip primer. The cooling gel uses hyaluronic acid to help hydrate and smooth your face and clings to makeup so you can enjoy full coverage all day long. L'Oréal Paris Collagen Daily Face Moisturizer who has been clearly cheating off Charlotte Tilbury's test paper. Like the Magic Cream, this cheaper alternative absorbs quickly and seals in moisture for smoother, plumper skin. A Nyx liquid eyeliner, with a precision tip and long-lasting, ultra-pigmented color, capable of serving just as dramatic looks as Kat Von D or Stila, at less than HALF the price. L'Oréal Paris Elvive 8 Second Wonder Water bringing you silkier hair in just eight seconds. On top of a wave of hydration, it also adds shine and decreases frizz and static. Reviewers note it's a close match to a certain Redken product, but for way cheaper. "Glow Up!" Vitamin C Face Serum powerful enough to help reduce dark spots, brighten skin, and give you an overall glowy makeover. Despite having superstar ingredients like 3-O ethyl ascorbic acid for radiance and hyaluronic acid, aloe vera, and vitamin E for supreme hydration, this miracle formula costs less than $10. STEP AWAY from the C-Firma. Catrice "Instant Awake" Under Eye Brightener to expertly conceal and brighten dark circles under your eyes just as well as the $33 Becca version. The lightweight, color-adapting formula is designed to blend seamlessly — check the drastic difference in the review photo! An under-$10 Mielle rosemary mint strengthening edge gel you can count on to keep your hairstyle in place *without* flakiness. The formula is enriched with biotin, coconut oil, and babassu oil to help prevent breakage, hydrate, and add shine.

PHQ-3: A Quick, Yet Still Effective Depression Screen
PHQ-3: A Quick, Yet Still Effective Depression Screen

Medscape

time6 days ago

  • Medscape

PHQ-3: A Quick, Yet Still Effective Depression Screen

A shortened version of the commonly used nine-item Patient Health Questionnaire (PHQ-9) may offer clinicians a quicker yet still effective way to screen for depressive symptoms, new research suggested. The PHQ-3 only includes items 1 (about interest), 2 (about depressed mood), and 6 (about self-esteem or failure) from the PHQ-9. In a survey study of more than 96,000 US adult participants, the PHQ-3 had 98% sensitivity and 76% specificity for predicting at least moderate or greater depressive symptoms. Additionally, it was 'highly correlated' with the full PHQ-9 and noninferior to a recently validated four-item version for effectiveness — and it yielded a sensitivity of more than 90% across all ages, races, and ethnicities. Lead study author Roy H. Perlis, MD, vice chair of research in the Department of Psychiatry at Mass General Brigham, Boston, said the investigators wanted to determine the shortest version of the PHQ-9 that could still be effective — and found that the PHQ-3 hit the 'sweet spot' they were looking for. 'We let the data tell us what the constellation of symptoms are that best predict overall severity and how well they do at identifying depression. It's a way we might be able to get the maximum amount of information in the shortest amount of time,' Perlis told Medscape Medical News. However, he noted that he's not yet ready to recommend the PHQ-3 for widespread use in clinical practice. 'I want to see further studies in clinical settings. But I think we made a good start towards showing it did well in a big, general sample of US adults,' Perlis said. The findings were published online on July 21 in JAMA Network Open . Shorter Attention Spans 'The PHQ-9 was not intended as a tool to diagnose depression. It's just a way to start the conversation; and although it's not perfect, it is useful,' Perlis noted. The original patient-reported PHQ was a screen for depression as well as for anxiety, eating disorders, alcohol misuse, and somatization. The version with a nine-item depression scale (PHQ-9) became widely used to screen for depression plus related symptoms, such as fatigue and troubled sleep. However, the length has become burdensome to some patients, especially those who prefer to use phone apps rather than printed out forms. 'Faced with a long list of survey questions, some individuals may be tempted to speed through or to not respond at all,' the investigators wrote. At the recent American Psychiatric Association annual meeting, clinicians in the audience at several sessions mentioned their patients have been complaining that the PHQ-9 is too long and that they prefer data to be delivered in smaller 'chunks.' Perlis said that attitude was a big motivator for their study. 'We're in an era where we have shorter attention spans and people want things very quickly,' he said. 'Personally, I would always rather have the PHQ-9. The question we were trying to answer was: Can we ask fewer questions if we don't have the time or the space to ask about nine [items] and do almost as well?' Perlis reported. The research assessed data from four waves of an online survey conducted from November 2023 to July 2024. In the first wave, they identified the optimal questionnaire items to be included. The four waves had a total of 96,234 participants (57% women; mean age, 47.3 years). Of these, 68% were White individuals, 13% were Black individuals, 10% were Hispanic or Latino individuals, 5% were Asian, and 4% were classified as 'other.' In the full patient population, 26% had moderate or greater depressive symptoms, as measured by a PHQ-9 score ≥ 10. Follow-Up Is Key After examining shortened versions of the PHQ-9 that ranged from including just one item up to eight items, the PHQ-3 with items 1 (interest), 2 (depressed mood), and 6 (self-esteem or failure) was deemed to be the 'optimal' version. It had a sensitivity of 0.98 (95% CI, 0.97-0.98) and a specificity of 0.76 (95% CI, 0.75-0.76) for moderate or greater depressive symptoms. Across all subgroups except participants aged 65 or older, the sensitivity for the PHQ-3 was > 0.94. For that subgroup, it was 0.93. The PHQ-3 was also noninferior to previously reported sensitivity and specificity of the PHQ-Depression-4 in the whole study group and in all subgroups. The area under the receiver operating characteristic curve (AUROC) for predicting moderate or greater depressive symptoms was 0.83 for the PHQ-3. The AUROC for the PHQ-9 was 0.84. 'While a shortened scale cannot capture the full range of the PHQ-9, it may facilitate more widespread and efficient investigation of psychiatric symptoms in general population samples when participant burden and/or data collection expense must be minimized,' the investigators wrote. Overall, Perlis said the PHQ-3 could be a possible first-step screening tool, with more questions added as needed. 'What's most important is that people are screening for depression and, if someone screens positive, that they're following up with a more comprehensive evaluation and offering treatment if it's indicated,' he said. 'It's really about figuring out who needs follow-up.' Menu of Options? In an accompanying editorial, Kurt Kroenke, MD, Regenstrief Institute Indianapolis, noted that the study had 'numerous strengths,' including its large and diverse study population but also several limitations. First, criteria for calculating sensitivity and specificity was not a structured psychiatric interview, which is what was used in the past to evaluate two- and nine-item PHQs. Also, because the researchers pulled from a general population sample, future studies should focus on actual patients from both primary care and psychiatric settings, Kroenke suggested. He noted that in addition to the various shortened PHQs, the two-item and four-item versions of the Patient-Reported Outcomes Measurement Information System have shown benefit. 'Clinicians and researchers looking for ultrashort depression measures now have a menu from which to choose, which is good since one size may not fit all purposes,' Kroenke wrote. 'Expanded use of brief screeners to increase detection of depression has the potential to decrease the burden of the most prevalent mental disorder worldwide,' he added.

The QWINT Program: Once-Weekly Insulin Efsitora
The QWINT Program: Once-Weekly Insulin Efsitora

Medscape

time7 days ago

  • Medscape

The QWINT Program: Once-Weekly Insulin Efsitora

This transcript has been edited for clarity. Akshay Jain, MD: Greetings from Chicago. I'm Akshay Jain, endocrinologist from Vancouver, Canada. Joining us at the ADA 85th Scientific Sessions today, we've got a very special guest, Dr Athena Philis-Tsimikas, who is the corporate vice president at Scripps in San Diego. Welcome. Athena Philis-Tsimikas, MD: Thank you so much. Happy to be here. Jain: Dr Philis-Tsimikas is one of the lead investigators of the QWINT trial, looking at new basal insulin efsitora alfa. What do you think is the need to have another new insulin? Philis-Tsimikas: It's a good question, because we have so many amazing new drugs that have come out and that we're seeing here at the ADA this year. Despite that, we know that there are over 800 million people with diabetes across the world, just recently published, and that means that there's still going to be many people that require insulin. We know that about 50%-25% of people will still, at some point, require insulin. I do think that insulin remains relevant, and we need to have new ways to deliver and really make it easier for people to take insulin. Jain: That makes sense. Despite all the new medications, insulin's not going anywhere. It's still going to be the backbone for many people requiring optimal diabetes management. Tell us about the QWINT program. What are the studies talking about, and what are they evaluating? Philis-Tsimikas: The QWINT programs are interesting and exciting. You said it's a basal insulin, but it's actually a once-weekly basal insulin. As opposed to the once daily that we've had for a long time and newer once dailies that were longer, this now takes us even longer. Insulin efsitora was tested in the QWINT trials. It was tested in people naive to insulin, people already on insulin, and in type 1 diabetes— so both type 2 and type 1 diabetes — and looking to see if it was noninferior to daily basal insulin and even if it was superior. Jain: That's great. What did the study show? Philis-Tsimikas: I was the lead author on QWINT-3, which was a basal insulin switch trial. For people already coming in on basal insulin, we switched them to go to either efsitora or degludec. At the end of 26 weeks, we showed that it was noninferior. They had a lowering of their A1c from about 7.8% down to about 7%. It was noninferior. They did not show superiority, but what an amazing finding to know that you could take insulin just once a week and still get your A1c down to just below 7%. Jain: Remarkable ability to drop the injection burden, going from 365 shots a year to just 52 shots a year. That's really uplifting. Where I work in Canada, we've got access to insulin icodec, which is a once-weekly insulin, and that is also helping improve patient outcomes. We are moving forward with our ability to give basal insulin with fewer shots. In your studies, were there any patient reported outcomes that were evaluated? Philis-Tsimikas: There were. We did look at satisfaction questionnaires. Satisfaction questionnaires came out better for those who were on once-weekly insulin efsitora. In addition, we also looked at patient safety, so we wanted to make sure that, while you're getting to those better A1cs, do you really have no difference in hypoglycemia? It did show that — for combined nocturnal, both level 2 and level 3 outcomes — there was no difference in terms of the hypoglycemia rates. Jain: That's a really important thing. One very interesting thing that I saw at the presentation yesterday on the QWINT-1 study is that they looked at level 1 hypoglycemia. Do you want to share some of the results with our audience about that? Philis-Tsimikas: Sure. QWINT-1 was a very interesting study because it gave a fixed dose of this basal once-weekly insulin at intervals of every 4 weeks. If you needed an incremental increase, it increased from 100 to 150, to 250, up to 400. Despite having this fixed-dose adjustment, there was no increase in the level 1 or the level 2/level 3 combined hypoglycemia episodes. It's interesting because in all the other trials of once-weekly insulin, level 1 with icodec and efsitora, both were slightly more elevated in those groups. It's very interesting that in the fixed-dose implementation we did not see that difference. Jain: I think that's remarkable. The safety is very important. It's paramount. Also, it gives more confidence to primary care, especially those who are a little shy of starting insulin. Now, one thing that I'd love to talk to you about is the loading dose concept. This is not something that one is aware of when you are using daily basil insulin. Can you tell us about the need for doing this loading and what exactly the loading entails? Philis-Tsimikas: Right, absolutely. This was found in both the icodec and the efsitora studies that we did. Because this has a very long half-life and it takes a while to get up to a steady state, we do need to give a one-time only starting dose. With efsitora, it was three times what the calculated weekly dose was. You take your daily dose, multiply it by seven to get your weekly dose, and then by three for that one-time starting dose. Icodec was similar in that you had to take it times seven, but then one and a half times, so you gave a 50% extra dose. That starting dose allows you to get up a little bit faster so that you don't run higher blood sugars during that first 2-3-week time period. Jain: That's excellent. The other very interesting thing that I saw about the QWINT-1 study was that 76% of individuals were able to get to a dose with this fixed-dose regimen without requiring more than 400 units a week. It doesn't require too much for that flexible dosing aspect. Do you want to share a little bit more about that? Philis-Tsimikas: I think that was absolutely an interesting part. The fact that you can manage the majority of patients with just this one insulin injection once a week without having to then further titrate in a very detailed way that can be difficult for the patient and the provider, right? So, 76% of the time is remarkable. Jain: I think one thing to also note is that, as clinicians, we are always aware that it's a marathon, not a sprint, right? Sooner or later, as long as you're up-titrating, you'll get to the target range. With the QWINT-1 protocol, for the first month, you're continuing to stay on 100 units. I think it's important to reassure the patients that we will be going up in a gradual manner, so that they're not too worried that the sugar's not coming down that quickly. Philis-Tsimikas: Absolutely. If you think about it, for someone who's insulin naive, that's where they've been running. It might not even make a difference for them. Jain: Exactly. Philis-Tsimikas: For someone who's been on insulin that we're switching over, that might make a little bit of a difference but certainly not for that insulin-naive population. Jain: Any final pearls of wisdom that you want to give to our audience? Philis-Tsimikas: Maybe just that for our patients who were on the study, they were all incredibly happy to be able to convert over to this once-weekly dose. Many did not want to stop, and they're all looking forward to seeing when once-weekly insulin will be available — in the United States, at least. I know you are lucky to have it in Canada and other places in Europe. We're looking forward to it in the United States as well. Jain: Thank you so much for joining us, Dr Philis-Tsimikas. Philis-Tsimikas: Thank you so much.

DOWNLOAD THE APP

Get Started Now: Download the App

Ready to dive into a world of global content with local flavor? Download Daily8 app today from your preferred app store and start exploring.
app-storeplay-store