Latest news with #Afrezza
Yahoo
7 hours ago
- Business
- Yahoo
MannKind Corporation (MNKD) Presented Inhaled Insulin Therapy At American Diabetes Association
MannKind Corporation (NASDAQ:MNKD) is one of the . MannKind Corporation (NASDAQ:MNKD) presented inhaled insulin therapy at the American Diabetes Association's 85th Scientific Sessions in Chicago, which was held from June 20 to June 23, 2025. Dr. Michael J. Haller of the University of Florida presented key results from the INHALE-1 Phase 3 clinical trial. This trial tested Afrezza, the company's inhaled insulin, in children and teens aged 4-17 with diabetes. The company highlighted several new studies at the meeting, including updates on inhaled insulin's benefits for children and adults with both type 1 and type 2 diabetes. Moreover, two other presentations discussed patient experiences and compared Afrezza to placebo in adults with type 2 diabetes. A close-up of a doctor's hand pressing on an inhaler, conveying the effect of the company's therapeutic products. Looking ahead, MannKind Corporation (NASDAQ:MNKD) plans to release full pediatric safety and efficacy data in the second quarter of 2025. The company aims to apply to expand Afrezza's use in children later in the year. MannKind Corporation (NASDAQ:MNKD) develops and sells inhaled therapies and delivery devices for serious endocrine and lung diseases. While we acknowledge the potential of MNKD as an investment, we believe certain AI stocks offer greater upside potential and carry less downside risk. If you're looking for an extremely undervalued AI stock that also stands to benefit significantly from Trump-era tariffs and the onshoring trend, see our free report on the best short-term AI stock. READ NEXT: 30 Stocks That Should Double in 3 Years and 11 Hidden AI Stocks to Buy Right Now. Disclosure: None. This article is originally published at Insider Monkey. Sign in to access your portfolio
Time Business News
10 hours ago
- Health
- Time Business News
Emerging Frontiers in Non-Insulin Treatments for Diabetes Mellitus
Non-insulin remedies for diabetes include drugs and treatments that help control blood sugar levels without using insulin, such as GLP -1 receptor agonist, SGLT 2 inhibitors, DPP -4 inhibitors, and lifestyle or device -based intervention. The market for these remedies is increasing due to the spread of growing global diabetes, an increase in demand for easy-to-use and low aggressive remedies, innovation in oral and injectable drug formulations, and weight loss compared to insulin, heart safety and better patients such as their additional benefits. Key Growth Drivers and Opportunities Rising Global Prevalence of Diabetes: The increasing global proliferation of diabetes, sedentary lifestyle, unhealthy diet and aging population are promoting considerable demand for effective and convenient treatment options. As more patients are diagnosed especially with type 2 diabetes there is a growing requirement of treatments managing blood sugar without complications of insulin use. Non-insulin therapy provides benefits such as weight loss and heart safety, such as oral administration, low side effects, and additional health benefits, making them a favorite option and accelerates their market growth. Challenges Non-insulin therapy for diabetes market faces many challenges, including high treatment costs, limited access to low and medium-income countries, and concerns on long-term security and side effects of new drug classes. Additionally, the patient may be affected by complex doses regimens or gastrointestinal side effects, and competition from insulin-based treatments remains stronger in some segments. Regulatory barriers and extensive clinical trials also slow down the introduction of innovative remedies. Innovation and Expansion IDF Establishes a Working Group to Examined New Type 5 Diabetes In April 2025, A working group to create formal diagnostic criteria and treatment guidelines for a type of diabetes associated with malnutrition that was officially designated as 'type 5 diabetes' during an international meeting of experts in India earlier this year was announced by IDF President Professor Peter Schwarz at the recent International Diabetes Federation (IDF) World Diabetes Congress 2025 in Bangkok, Thailand. Additionally, the working group will create educational modules to teach healthcare professionals and a worldwide research registry. Between 20 and 25 million individuals globally are thought to have type 5 diabetes, mostly in Asia and Africa. This discovery represents a turning point in our knowledge of diabetes and its impact on undernourished and lean adolescents and young adults in low- and middle-income (LMIC) nations. Cipla Takes Center Stage as CDSCO Authorized the Launch of Inhaled Insulin In December 2024, Following the Central Drugs Standard Control Organization's (CDSCO) approval of Cipla's exclusive distribution and marketing of Afrezza, an inhalation human insulin, in India, the company's stock will continue to be closely watched. Unlike existing insulins that are administered as injections, Afrezza is a rapid-acting insulin that is administered via inhalation. When taken at the start of a meal, Afrezza dissolves swiftly in the lungs when inhaled orally and immediately gets insulin into the circulation. Inventive Sparks, Expanding Markets Through R&D innovation, strategic alliances, and entry into developing markets, non-insulin treatment firms are propelling growth. They concentrate on creating safer, more efficient medications, utilizing digital technologies to assist patients, and obtaining authorization for more extensive therapeutic applications. The key players operating the Non-Insulin Therapies for Diabetes Market include AstraZeneca, Bristol-Myers Squibb, BoehringerIngelheim GmbH, Eli Lilly and Company, and others. About Author: Prophecy is a specialized market research, analytics, marketing and business strategy, and solutions company that offer strategic and tactical support to clients for making well-informed business decisions and to identify and achieve high value opportunities in the target business area. Also, we help our client to address business challenges and provide best possible solutions to overcome them and transform their business. TIME BUSINESS NEWS
Yahoo
11-07-2025
- Business
- Yahoo
Wells Fargo Maintains a Buy Rating on MannKind Corporation (MNKD), Sets a $9 PT
MannKind Corporation (NASDAQ:MNKD) is one of the . On May 8, Wells Fargo analyst Tiago Fauth maintained a Buy rating on MannKind Corporation (NASDAQ:MNKD) and set a price target of $9.00. A close-up of a doctor's hand pressing on an inhaler, conveying the effect of the company's therapeutic products. The rating was based on the company's promising growth potential and strategic advancements, as it is making notable progress in its MNKD-101 program, according to the analyst. With a majority of the expected sites activated and patients randomized, the interim analysis is set for mid-2026. The analyst expects the MNKD-101 program to advance in the second half of 2025. Fauth also reasoned that MannKind Corporation (NASDAQ:MNKD) has strong revenue growth, supported by a potential expansion of Afrezza into the pediatric market and Tyvaso DPI royalties. When combined with the market's focus on tangible revenue streams, these factors justify the analyst's optimistic rating. MannKind Corporation (NASDAQ:MNKD) is a biopharmaceutical company that develops and commercializes innovative therapeutic devices and products that address serious unmet medical needs for endocrine and orphan lung diseases. The company's pipeline and products include Afrezza, Pediatric Afrezza, V-Go, Tyvaso DPI, MNKD-101, MNKD-201, MNKD-301, and MNKD-501. While we acknowledge the potential of MNKD as an investment, we believe certain AI stocks offer greater upside potential and carry less downside risk. If you're looking for an extremely undervalued AI stock that also stands to benefit significantly from Trump-era tariffs and the onshoring trend, see our free report on the best short-term AI stock. READ NEXT: 30 Stocks That Should Double in 3 Years and 11 Hidden AI Stocks to Buy Right Now. Disclosure: None. This article is originally published at Insider Monkey. Error in retrieving data Sign in to access your portfolio Error in retrieving data Error in retrieving data Error in retrieving data Error in retrieving data
Time of India
26-06-2025
- Health
- Time of India
Inhaled insulin as good as injection for children at mealtime
London: Children with diabetes who inhaled their mealtime doses of insulin did just as well as those who injected insulin under the skin, researchers reported at the American Diabetes Association scientific meeting in Chicago. To regulate their blood sugar, patients with type 1 diabetes usually require an injection of a long-acting basal insulin once a day, plus additional injections of rapid-acting insulins at mealtimes. MannKind's inhaled insulin Afrezza is approved for use by adults but not yet for children, which prompted the study. The 230 children with type 1 diabetes, ages 4 to 17, who participated in the trial received either Afrezza at mealtimes, or their usual mealtime injections of insulin, for 26 weeks. Everyone continued to receive their basal insulin injections. Control of hemoglobin A1c, a marker of blood sugar control over the past several months, was comparable with the inhaled insulin and the injected insulin, the researchers found. Inhaled insulin was also associated with less weight gain and slightly higher child and parent preference scores. The inhaled formula did not have any adverse effects on patients' lungs, the researchers reported. "Inhaled insulin is the fastest acting insulin available and is a valuable alternative to injected analogue insulin," study leader Dr. Michael Haller of the University of Florida said in a statement. "Afrezza should be available as an option to all children and adults with type 1 diabetes." ONCE-WEEKLY INSULIN PROMISING FOR TYPE 2 DIABETES Eli Lilly's experimental once-weekly insulin efsitora was comparable to daily insulins in nearly a thousand adults with type 2 diabetes in three late-stage trials, researchers reported at the ADA meeting. The trials, which were designed to study patients at different stages of insulin use, each found efsitora to be just as effective as daily insulins for bringing HbA1c levels - a common measure of blood sugar over time - under control. "Once-weekly efsitora may offer a significant advancement for people with type 2 diabetes who need insulin by eliminating over 300 injections per year," Lilly's senior vice president of product development, Jeff Emmick, said in a statement. One trial, reported in The New England Journal of Medicine, involved patients with type 2 diabetes who were using insulin for the first time. A second trial in patients who had been using daily basal insulin degludec and a third trial in those who had been taking basal insulin glargine plus extra mealtime insulin doses were both reported in The Lancet. Efsitora "has the potential to facilitate and simplify insulin therapy , reducing the hesitation often associated with starting insulin to treat type 2 diabetes," Dr. Julio Rosenstock of University of Texas Southwestern Medical Center, who led one of the studies, said in a statement. People newly diagnosed with type 2 diabetes usually start treatment with oral medications, but roughly one-third of them will need to use insulin within 8 years of their diagnosis, according to an editorial in The Lancet. GENETICALLY ENGINEERED SKIN GRAFTS TREAT BLISTERING DISEASE Long-lasting wounds from a painful genetic skin disease can be healed with skin grafts genetically engineered from a patient's own cells, researchers reported in The Lancet. In severe dystrophic epidermolysis bullosa , or EB, the skin is so fragile the slightest touch - even from clothing - causes blistering and wounds, eventually leading to large, open lesions that never heal. "With our novel gene therapy technique, we successfully treated the hardest-to-heal wounds, which were usually also the most painful ones for these patients," study leader Dr. Jean Tang of Lucile Packard Children's Hospital Stanford in Palo Alto, California said in a statement. Severe dystrophic EB is caused by a defect in the gene for collagen VII, a protein that normally holds the skin together. As a result, the layers of the skin separate in response to even slight friction. To create the personalized skin grafts, doctors take a small biopsy sample of the patient's un-wounded skin and introduce a corrected version of the collagen VII gene to the skin cells. These cells are then grown into sheets of healthy skin. For the late-stage study, 11 patients with recessive dystrophic EB had a total of 43 wounds treated with grafts. For each treated wound, the researchers also identified a comparable "control" wound on the same patient that was managed with traditional measures. Six months later, 81% of treated wounds were at least half healed, compared with 16% of control wounds. Roughly two-thirds of treated wounds were at least three-quarters healed, compared with 7% of control wounds, and 16% of treated wounds had completely healed, compared with none of the control wounds. In addition, grafted areas had less pain, itching and blistering. The same research team had previously developed a gene therapy gel for treating smaller EB wounds. "I hope that if these patients are diagnosed as infants and start the gene therapy gel, maybe they won't develop big wounds," Tang said. "But if the gels don't work and a wound does expand, the skin graft therapy is the right treatment. The life arc of their disease will, I hope, be modified, with less suffering." An editorial published with the study notes that EB patients who participated in early-stage trials of the skin grafts still had decreased blistering and wounding, pain, and itch at grafted sites five years later. In April, the U.S. Food and Drug Administration granted Abeona Therapeutics approval for the skin grafts as an EB therapy. (To receive the full newsletter in your inbox for free sign up here)
Reuters
25-06-2025
- Health
- Reuters
Health Rounds: Inhaled insulin as good as injection for children at mealtime
June 25 (Reuters) - (This is an excerpt of the Health Rounds newsletter, where we present latest medical studies on Tuesdays and Thursdays. To receive the full newsletter in your inbox for free sign up here.) Children with diabetes who inhaled their mealtime doses of insulin did just as well as those who injected insulin under the skin, researchers reported at the American Diabetes Association, opens new tab scientific meeting in Chicago. To regulate their blood sugar, patients with type 1 diabetes usually require an injection of a long-acting basal insulin once a day, plus additional injections of rapid-acting insulins at mealtimes. MannKind's (MNKD.O), opens new tab inhaled insulin Afrezza is approved for use by adults but not yet for children, which prompted the study. The 230 children with type 1 diabetes, ages 4 to 17, who participated in the trial received either Afrezza at mealtimes, or their usual mealtime injections of insulin, for 26 weeks. Everyone continued to receive their basal insulin injections. Control of hemoglobin A1c, a marker of blood sugar control over the past several months, was comparable with the inhaled insulin and the injected insulin, the researchers found. Inhaled insulin was also associated with less weight gain and slightly higher child and parent preference scores. The inhaled formula did not have any adverse effects on patients' lungs, the researchers reported. 'Inhaled insulin is the fastest acting insulin available and is a valuable alternative to injected analogue insulin,' study leader Dr. Michael Haller of the University of Florida said in a statement. 'Afrezza should be available as an option to all children and adults with type 1 diabetes.' ONCE-WEEKLY INSULIN PROMISING FOR TYPE 2 DIABETES Eli Lilly's (LLY.N), opens new tab experimental once-weekly insulin efsitora was comparable to daily insulins in nearly a thousand adults with type 2 diabetes in three late-stage trials, researchers reported at the ADA meeting. The trials, which were designed to study patients at different stages of insulin use, each found efsitora to be just as effective as daily insulins for bringing HbA1c levels - a common measure of blood sugar over time - under control. 'Once-weekly efsitora may offer a significant advancement for people with type 2 diabetes who need insulin by eliminating over 300 injections per year," Lilly's senior vice president of product development, Jeff Emmick, said in a statement. One trial, reported in The New England Journal of Medicine, opens new tab, involved patients with type 2 diabetes who were using insulin for the first time. A second trial, opens new tab in patients who had been using daily basal insulin degludec and a third trial, opens new tab in those who had been taking basal insulin glargine plus extra mealtime insulin doses were both reported in The Lancet. Efsitora 'has the potential to facilitate and simplify insulin therapy, reducing the hesitation often associated with starting insulin to treat type 2 diabetes," Dr. Julio Rosenstock of University of Texas Southwestern Medical Center, who led one of the studies, said in a statement. People newly diagnosed with type 2 diabetes usually start treatment with oral medications, but roughly one-third of them will need to use insulin within 8 years of their diagnosis, according to an editorial, opens new tab in The Lancet. Long-lasting wounds from a painful genetic skin disease can be healed with skin grafts genetically engineered from a patient's own cells, researchers reported in The Lancet, opens new tab. In severe dystrophic epidermolysis bullosa, or EB, the skin is so fragile the slightest touch – even from clothing - causes blistering and wounds, eventually leading to large, open lesions that never heal. 'With our novel gene therapy technique, we successfully treated the hardest-to-heal wounds, which were usually also the most painful ones for these patients,' study leader Dr. Jean Tang of Lucile Packard Children's Hospital Stanford in Palo Alto, California said in a statement. Severe dystrophic EB is caused by a defect in the gene for collagen VII, a protein that normally holds the skin together. As a result, the layers of the skin separate in response to even slight friction. To create the personalized skin grafts, doctors take a small biopsy sample of the patient's un-wounded skin and introduce a corrected version of the collagen VII gene to the skin cells. These cells are then grown into sheets of healthy skin. For the late-stage study, 11 patients with recessive dystrophic EB had a total of 43 wounds treated with grafts. For each treated wound, the researchers also identified a comparable "control" wound on the same patient that was managed with traditional measures. Six months later, 81% of treated wounds were at least half healed, compared with 16% of control wounds. Roughly two-thirds of treated wounds were at least three-quarters healed, compared with 7% of control wounds, and 16% of treated wounds had completely healed, compared with none of the control wounds. In addition, grafted areas had less pain, itching and blistering. The same research team had previously developed a gene therapy gel for treating smaller EB wounds. 'I hope that if these patients are diagnosed as infants and start the gene therapy gel, maybe they won't develop big wounds,' Tang said. 'But if the gels don't work and a wound does expand, the skin graft therapy is the right treatment. The life arc of their disease will, I hope, be modified, with less suffering.' An editorial published with the study notes that EB patients who participated in early-stage trials of the skin grafts still had decreased blistering and wounding, pain, and itch at grafted sites five years later. In April, the U.S. Food and Drug Administration granted Abeona Therapeutics (ABEO.O), opens new tab approval for the skin grafts as an EB therapy. (To receive the full newsletter in your inbox for free sign up here)
