Latest news with #Age-RelatedMacular
Associated Press
30-06-2025
- Health
- Associated Press
Ashvattha Therapeutics Presents Positive Interim Phase 2 Results for Subcutaneous Migaldendranib Treatment for DME and Wet-AMD at 2025 MaculArt Meeting
Monthly subcutaneous migaldendranib shows favorable safety with sustained efficacy through 24 weeks in patients with DME and wet-AMD Novel subcutaneous delivery may offer a more patient-friendly alternative to intravitreal injections, with the potential to significantly reduce treatment burden REDWOOD CITY, Calif., June 30, 2025 (GLOBE NEWSWIRE) -- Ashvattha Therapeutics ('Ashvattha'), a clinical-stage company advancing a new class of nanomedicine therapeutics that traverse tissue barriers to selectively target and reprogram activated cells in regions of inflammation, today announced interim results from its ongoing Phase 2 study of subcutaneous (subQ) migaldendranib (MGB) for the treatment of diabetic macular edema (DME) and neovascular age-related macular degeneration (wet-AMD). The data were presented at the MaculArt Meeting, June 29 – July 1, 2025 in Paris. MGB represents a potential alternative to current standard of care, which requires patients to receive intravitreal injections every 4 to 12 weeks in a clinical setting. MGB is a first-in-class subcutaneously administered candidate being developed for convenient, at-home monthly treatment of DME and wet AMD, aiming to reduce treatment burden while avoiding systemic side effects. Unlike current anti-VEGF therapies that require repeated intravitreal injections directly into the eye, subcutaneously (subQ) administered MGB provides a unique mechanism of action of normalizing vascular endothelial growth factor (VEGF) expression in activated macrophages, microglia and retinal pigment epithelial cells in the retina. By reducing VEGF expression, MGB reduces the need for anti-VEGF intravitreal injections improving patient adherence. Key Phase 2 Interim Results (24-week data): Data presented in the presentation titled ' Subcutaneous Migaldendranib (MGB) for the Treatment of Neovascular Age-Related Macular Degenerations and Diabetic Macular Edema: Interim Results of Chronic Dosing Phase 2 Study' showed that subQ MGB demonstrated promising safety and tolerability in both DME and wet-AMD patients in the first 24 weeks of treatment. The study used more conservative supplement criteria compared to other recent clinical studies, with rescue anti-VEGF injections given when central subfield thickness increased above baseline, rather than the >75 μm increase from lowest value used in other studies. The interim analysis included 19 subjects who completed 24 weeks (11 wet AMD, 8 DME). Results: These interim results support MGB's potential in decreasing the need for supplemental intravitreal injections of anti-VEGF, suggesting a potential new treatment pathway for patients. End of study results will be presented at an upcoming conference. 'These results demonstrate a potential paradigm shift in the treatment of DME and wet-AMD patients,' said Jeff Cleland, PhD, CEO of Ashvattha Therapeutics. 'The interim Phase 2 data support the potential of subcutaneous MGB to offer patients a convenient, once-monthly alternative to frequent eye injections. By targeting inflammation and fluid accumulation in both eyes with a single systemic dose, we may be able to significantly reduce treatment burden and improve quality of life. We look forward to advancing this novel treatment for DME and wet-AMD and to bringing a new treatment forward for patients who need it most.' These data were also presented at the Clinical Trials at the Summit, June 21, 2025, in Las Vegas. About Ashvattha Therapeutics Ashvattha Therapeutics is advancing a new class of clinical-stage nanomedicine therapeutics that traverse tissue barriers to selectively target and reprogram activated cells only in regions of inflammation. Our targeted nanomedicine approach seeks to redefine precision medicine, empowering a new standard of care across ophthalmology, neurology, oncology, and inflammation. Ashvattha Therapeutics was founded by Kannan Rangaramanujam, Sujatha Kannan, and Jeff Cleland and incubated by Natural Capital. For more information, visit: Media ICR Healthcare [email protected] Investor Relations Aman Patel, CFA & Adanna G. Alexander, PhD ICR Healthcare [email protected]
Yahoo
20-05-2025
- Health
- Yahoo
Dry Age-Related Macular Degeneration Market Forecast 2025-2035 with Regional and Country-Level Analysis Featuring AstraZeneca, Astellas Pharma, Novartis, Apellis Pharmaceuticals, Alkeus Pharmaceuticals and More
Dublin, May 20, 2025 (GLOBE NEWSWIRE) -- The "Dry Age-Related Macular Degeneration Market - A Global and Regional Analysis: Focus on Region and Country Analysis - Analysis and Forecast, 2025-2035" report has been added to dry age-related macular degeneration market is witnessing substantial growth, driven by a range of key factors. One of the primary drivers is the aging global population, as age is the most significant risk factor for developing dry age-related macular degeneration. With an increasing number of elderly individuals, the demand for effective treatments and diagnostic tools is on the rise. Additionally, advancements in retinal imaging technologies, such as optical coherence tomography (OCT) and fundus photography, are enabling earlier detection and more precise monitoring of disease progression, driving market the growing focus on precision medicine and genetic testing is enhancing the ability to tailor treatments to individual patients, thus improving clinical outcomes. The increasing awareness of eye health and the rising adoption of preventive measures, such as lifestyle changes and regular eye screenings, are also stimulating demand. Moreover, the improvement in healthcare infrastructure in emerging markets and the availability of specialized training for ophthalmologists are fuelling the adoption of innovative AMD treatment options. The combination of these drivers is poised to continue supporting the growth of the dry AMD the positive growth trajectory, several challenges continue to impact the global dry age-related macular degeneration market. One of the primary challenges is the high cost of treatment and diagnostic technologies can be a significant barrier. Innovative treatments, especially in the realm of gene therapy, stem cell therapy, and advanced imaging technologies, come with high development and implementation costs. This can limit access to effective therapies in low- and middle-income regions, where healthcare infrastructure may be less developed and resources are lack of effective treatments for the advanced stages of dry AMD. While there are interventions to manage early stages, such as nutritional supplements and lifestyle modifications, there is no cure or approved treatment that can significantly reverse the damage once it progresses to advanced dry AMD or geographic atrophy. This limitation has restricted the market potential for advanced therapies and treatment the dry age-related macular degeneration market continues to evolve, several emerging trends are expected to significantly influence its future trajectory. The increasing development of innovative treatments, such as gene therapies, retinal implants, and biologic agents targeting disease progression, is poised to provide new hope for patients. Furthermore, advancements in diagnostic technologies, including high-resolution imaging and artificial intelligence-driven tools for early detection, will allow for more precise monitoring and intervention. With the aging global population, particularly in regions with a higher prevalence of AMD, the demand for cost-effective, easy-to-administer, and efficient treatment options will continue to rise. Additionally, increased focus on the role of lifestyle modifications, such as diet and supplements, will shape prevention strategies, offering a holistic approach to managing age-related macular conclusion, the global dry age-related macular degeneration market is expected to experience steady growth, driven by advancements in therapeutic interventions, heightened awareness, and a focus on early detection. As research and development in this space continue to progress, key stakeholders, including pharmaceutical companies, healthcare providers, and researchers, will play a critical role in improving treatment outcomes and patient quality of life. The market's expansion, coupled with continued innovation, will empower patients with better management tools, reducing the long-term burden of the condition and preserving vision for millions around the Topics Covered1. Global Dry Age-Related Macular Degeneration Markets: Industry Outlook1.1 Introduction1.2 Market Trends1.3 Regulatory Framework1.4 Epidemiology of Dry AMD1.5 Clinical Trial Analysis1.6 Market Dynamics1.6.1 Impact Analysis1.6.2 Market Drivers1.6.3 Market Challenges1.6.4 Market Opportunities2. Global Dry Age-Related Macular Degeneration Market, by Region, $Million, 2023-20352.1 North America2.1.1 Key Findings2.1.2 Market Dynamics2.1.3 Market Sizing and Forecast2.1.3.1 North America Dry Age-Related Macular Degeneration Market, by Country2.1.3.1.1 U.S.2.2 Europe2.2.1 Key Findings2.2.2 Market Dynamics2.2.3 Market Sizing and Forecast2.2.3.1 Europe Dry Age-Related Macular Degeneration Market, by Country2.2.3.1.1 Germany2.2.3.1.2 U.K.2.2.3.1.3 France2.2.3.1.4 Italy2.2.3.1.5 Spain2.3 Asia Pacific2.3.1 Key Findings2.3.2 Market Dynamics2.3.3 Market Sizing and Forecast2.3.3.1 Asia Pacific Dry Age-Related Macular Degeneration Market, by Country2.3.3.1.1 Japan3. Global Dry Age-Related Macular Degeneration Market: Competitive Landscape and Company Profiles3.1 Key Development and Strategies3.1.1 Mergers and Acquisitions3.1.2 Synergistic Activities3.1.3 Business Expansions and Funding3.1.4 Product Launches and Approvals3.1.5 Other Activities3.2 Company Profiles3.2.1 AstraZeneca3.2.2 Astellas Pharma3.2.3 Novartis AG3.2.4 Apellis Pharmaceuticals3.2.5 Alkeus Pharmaceuticals3.2.6 Belite Bio3.2.7 Aviceda Therapeutics3.2.8 Cognition Therapeutics3.2.9 Annexon Biosciences3.2.10 Lineage Cell Therapeutics4. Research MethodologyFor more information about this report visit About is the world's leading source for international market research reports and market data. We provide you with the latest data on international and regional markets, key industries, the top companies, new products and the latest trends. 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