Latest news with #Amish
News18
2 days ago
- Entertainment
- News18
The Chola Tigers by Amish to release on August 29
New Delhi, Jul 22 (PTI) Bestselling author Amish's upcoming book 'The Chola Tigers", the second installment in his Indic Chronicles, will hit the stands on August 29, announced publishing house Harper Collins India on Tuesday. The historical fiction, which builds on the world introduced in the author's 2020 bestseller 'Legend of Suheldev", is touted to be a 'thrilling historical saga of defiance, honour and redemption it celebrates the indomitable spirit of India". The book's cover was released by Tamil superstar Rajinikanth. ''The Chola Tigers' is an exhilarating story in which Emperor Rajendra Chola, the mightiest man of his era, orders a daring surgical strike on Ghazni in response to Sultan Mahmud's attack on the Somnath temple. 'This work of historical fiction is linked to my 2020 release 'Legend of Suheldev'. It is about a mission ordered by one of the greatest Tamilians ever, Emperor Rajendra Chola," Amish, author of 'Shiva Trilogy' and 'Ram Chandra Series', said in a statement. The plot unfolds around Mahmud of Ghazni's devastating attack on the revered Somnath temple, sparking response from the era's most powerful monarch, emperor Rajendra Chola as 'he summons a squad of defiant assassins to embark on a perilous quest and bring the fearsome enemy to his knees". According to the publisher, 'The Chola Tigers" explores the profound question: 'How far would you go to defend dharma and your country's honour?" 'The new novel is vintage Amish — a sweeping historical saga that is pacy, dramatic, simmering with political intrigue and personal vendetta, and heart-rending in its scenes of sacrifice and retribution. At its heart it masterfully explores the depths of human courage and resilience, and the indomitable spirit of a nation that refuses to be broken," said Poulomi Chatterjee, executive Publisher at HarperCollins India. Amish's previous books have sold more than 8 million copies and have been translated into 21 languages. PTI MG BK BK (This story has not been edited by News18 staff and is published from a syndicated news agency feed - PTI) view comments First Published: July 22, 2025, 17:30 IST Disclaimer: Comments reflect users' views, not News18's. Please keep discussions respectful and constructive. Abusive, defamatory, or illegal comments will be removed. News18 may disable any comment at its discretion. By posting, you agree to our Terms of Use and Privacy Policy.
Toronto Sun
2 days ago
- Health
- Toronto Sun
Allergies seem nearly impossible to avoid — unless you're Amish
Published Jul 22, 2025 • Last updated 11 minutes ago • 6 minute read Only 7% of Amish children had a positive response to one or more common allergens in a skin prick test, compared with more than half of the general U.S. population. Photo by Sarah L. Voisin / The Washington Post Reviews and recommendations are unbiased and products are independently selected. Postmedia may earn an affiliate commission from purchases made through links on this page. Whether triggered by pollen, pet dander or peanuts, allergies in this day and age seem nearly impossible to avoid. But one group appears virtually immune, a mystery to experts who study allergies. This advertisement has not loaded yet, but your article continues below. THIS CONTENT IS RESERVED FOR SUBSCRIBERS ONLY Subscribe now to read the latest news in your city and across Canada. Unlimited online access to articles from across Canada with one account. Get exclusive access to the Toronto Sun ePaper, an electronic replica of the print edition that you can share, download and comment on. Enjoy insights and behind-the-scenes analysis from our award-winning journalists. Support local journalists and the next generation of journalists. Daily puzzles including the New York Times Crossword. SUBSCRIBE TO UNLOCK MORE ARTICLES Subscribe now to read the latest news in your city and across Canada. Unlimited online access to articles from across Canada with one account. Get exclusive access to the Toronto Sun ePaper, an electronic replica of the print edition that you can share, download and comment on. Enjoy insights and behind-the-scenes analysis from our award-winning journalists. Support local journalists and the next generation of journalists. Daily puzzles including the New York Times Crossword. REGISTER / SIGN IN TO UNLOCK MORE ARTICLES Create an account or sign in to continue with your reading experience. Access articles from across Canada with one account. Share your thoughts and join the conversation in the comments. Enjoy additional articles per month. Get email updates from your favourite authors. THIS ARTICLE IS FREE TO READ REGISTER TO UNLOCK. Create an account or sign in to continue with your reading experience. Access articles from across Canada with one account Share your thoughts and join the conversation in the comments Enjoy additional articles per month Get email updates from your favourite authors Don't have an account? Create Account Despite the increasing rate of allergic diseases, both in industrialized and in developing countries, the Amish remain exceptionally – and bafflingly – resistant. Only 7% of Amish children had a positive response to one or more common allergens in a skin prick test, compared with more than half of the general U.S. population. Even children from other traditional farming families, who still have lower rates of allergic disease than nonfarm children, are more allergic than the Amish. In fact, one Amish community living in northern Indiana is considered one of the least allergic populations ever measured in the developed world. 'Generally, across the country, about 8 to 10% of kids have asthma. In the Amish kids, it's probably 1 to 2%,' said Carole Ober, chair of human genetics at the University of Chicago. 'A few of them do have allergies, but at much, much lower rates compared to the general population.' This advertisement has not loaded yet, but your article continues below. Now, Ober and other researchers are trying to discover what makes Amish and other traditional farming communities unique, in the hopes of developing a protective treatment that could be given to young children. For instance, a probiotic or essential oil that contains substances found in farm dust, such as microbes and the molecules they produce, could stimulate children's immune systems in a way that prevents allergic disease. 'Certain kinds of farming practices, particularly the very traditional ones, have this extraordinary protective effect in the sense that, in these communities, asthma and allergies are virtually unknown,' said Donata Vercelli, a professor of cellular and molecular medicine at the University of Arizona. 'The studies that have been done in these farming populations are critical because they tell us that protection is an attainable goal.' Your noon-hour look at what's happening in Toronto and beyond. By signing up you consent to receive the above newsletter from Postmedia Network Inc. Please try again This advertisement has not loaded yet, but your article continues below. The Amish are members of a Christian group who practice traditional farming – many live on single-family dairy farms – and use horses for fieldwork and transportation. As of 2024, around 395,000 Amish live in the United States, concentrated mostly in Pennsylvania, Ohio and Indiana. Over the past century, the incidence of allergic diseases – including hay fever (allergic rhinitis), asthma, food allergies and eczema – has increased dramatically. Hay fever, or an allergic reaction to tree, grass and weed pollens, emerged as the first recognized allergic disease in the early 1800s, climbing to epidemic levels in Europe and North America by 1900. The 1960s saw a sharp increase in the prevalence of pediatric asthma, a condition in which the airways tighten when breathing in an allergen. From the 1990s onward, there has been an upswing in the developed world in food allergies, including cow's milk, peanut and egg allergies. This advertisement has not loaded yet, but your article continues below. Urbanization, air pollution, dietary changes and an indoor lifestyle are often cited as possible factors. The 'hygiene hypothesis' – first proposed in a 1989 study by American immunologist David Strachan – suggests that early childhood exposure to microbes protects against allergic diseases by contributing to the development of a healthy immune system. The study found that hay fever and eczema were less common among children born into larger families. Strachan wondered whether unhygienic contact with older siblings served as a protection against allergies. Subsequent findings have given support to the hygiene hypothesis, such as that children who grow up with more household pets are less likely to develop asthma, hay fever or eczema. Perhaps even more beneficial than having older siblings or pets, however, is growing up on a farm. (More than 150 years ago, hay fever was known as an 'aristocratic disease,' almost wholly confined to the upper classes of society. Farmers appeared relatively immune.) This advertisement has not loaded yet, but your article continues below. This 'farm effect' has been confirmed by studies on agricultural populations around the world, including in the United States, Europe, Asia and South America. But even among farming communities, the most pronounced effect appears to be in the Amish. In a study of 60 schoolchildren by Ober, Vercelli and their colleagues, the prevalence of asthma was four times lower in the Amish as compared with the Hutterites, another U.S. farming community with a similar genetic ancestry and lifestyle. The prevalence of allergic sensitization – the development of antibodies to allergens and the first step to developing an allergy – was six times higher in the Hutterites. The researchers first ruled out a genetic cause; in fact, an analysis showed that the Amish and Hutterite children were remarkably similar in their ancestral roots. Instead, the main difference between these two populations seemed to be the amount of exposure as young children to farm animals or barns. This advertisement has not loaded yet, but your article continues below. 'The Hutterite kids and pregnant moms don't go into the animal barns. Kids aren't really exposed to the animal barns until they're like 12 or so, when they start learning how to do the work on the farm,' Ober said. 'The Amish kids are in and out of the cow barns all day long from an early age.' When analyzing samples of Amish and Hutterite house dust, they found a microbial load almost seven times higher in Amish homes. Later experiments showed that the airways of mice that inhaled Amish dust had dramatically reduced asthmalike symptoms when exposed to allergens. Mice that inhaled Hutterite dust did not receive the same benefit. Now, Ober and Vercelli are beginning to identify the protective agents in Amish dust that prevent allergic asthma. In 2023, their analysis of farm dust found proteins that act like delivery trucks, loaded with molecules produced by microbes and plants. When these transport proteins deliver their cargo to the mucus that lines the respiratory tract, it creates a protective environment that regulates airway responses and prevents inflammation. This advertisement has not loaded yet, but your article continues below. 'We don't really talk about the hygiene hypothesis as much anymore because we now understand that it's not really about how hygienic you're living,' said Kirsi Järvinen-Seppo, director of the Center for Food Allergy at the University of Rochester Medical Center. 'It's more like a microbial hypothesis, since beneficial bacteria that colonize the gut and other mucosal surfaces play a significant role.' During the first year or two of life, a baby's immune system is rapidly developing and highly malleable by environmental stimuli, such as bacteria. Some experts believe that exposing young children to certain types of beneficial bacteria can engage and shape the growing immune system in a way that reduces the risk of allergic diseases later in life. Farm dust contains a hodgepodge of bacteria shed from livestock and animal feed that isn't harmful enough to cause illness, but does effectively train the immune system to become less responsive to allergens later in life. This advertisement has not loaded yet, but your article continues below. In 2021, Järvinen-Seppo and her colleagues compared the gut microbiomes of 65 Old Order Mennonite infants from a rural community in New York with 39 urban/suburban infants from nearby Rochester. Like the Amish, the Old Order Mennonites follow a traditional agrarian lifestyle. Almost three-fourths of Mennonite infants in the study were colonized with B. infantis, a bacterium associated with lower rates of allergic diseases, in contrast to 21% of Rochester infants. 'The colonization rate is very low in the United States and other Western countries, compared to very high rates in Mennonite communities, similar to some developing countries,' Järvinen-Seppo said. 'This mirrors the rates of autoimmune and allergic diseases.' These clues about the origin of the farm effect represent a step toward the prevention of allergic diseases, Järvinen-Seppo says. This advertisement has not loaded yet, but your article continues below. Whatever form the treatment takes, the impact on prevention of allergic diseases, which affect millions of people worldwide and reduce quality of life, could be enormous, experts say. 'I don't know that we can give every family a cow. … But we are learning from these time-honored and very stable environments what type of substances and exposures are needed,' Vercelli said. 'Once we know that, I don't think there will be any impediment to creating protective strategies along these lines.' Read More For more health news and content around diseases, conditions, wellness, healthy living, drugs, treatments and more, head to – a member of the Postmedia Network. Sunshine Girls Sunshine Girls World Celebrity Canada
Business Standard
2 days ago
- Entertainment
- Business Standard
HarperCollins India is delighted to announce the forthcoming publication of The Chola Tigers: Avengers of Somnath
PRNewswire New Delhi [India], July 22: Scheduled for release on 29 August 2025, The Chola Tigers is the second book in Amish's Indic Chronicles, after the bestselling Legend of Suheldev. A thrilling historical saga of defiance, honour and redemption it celebrates the indomitable spirit of India. When the ruthless tyrant Mahmud of Ghazni destroys the sacred temple of Somnath, the greatest ruler of the time, Emperor Rajendra Chola, summons a squad of defiant assassins to embark on a perilous quest and bring the fearsome enemy to his knees. This historical fiction title builds on the world introduced in the 2020 bestseller Legend of Suheldev, which garnered widespread appreciation from readers and went on to become a bestseller. Pacy and action-packed, The Chola Tigers, explores the profound question: How far would you go to defend dharma and your country's honour? On the occasion of the book's announcement, Amish, author, says, "The Chola Tigers is an exhilarating story in which Emperor Rajendra Chola, the mightiest man of his era, orders a daring surgical strike on Ghazni in response to Sultan Mahmud's attack on the Somnath temple. This work of historical fiction is linked to my 2020 release Legend of Suheldev. It is about a mission ordered by one of the greatest Tamilians ever, Emperor Rajendra Chola. And it is a great honour that the cover of this book was released by one of the greatest Tamilians alive and an Indian treasure, Rajinikanth ji." Poulomi Chatterjee, Executive Publisher -- HarperCollins India, adds, "Amish has brilliantly reimagined our beloved legends and epics, and episodes from medieval Indian history, for millions of people across the country to enjoy afresh. The new novel is vintage Amish--a sweeping historical saga that is pacy, dramatic, simmering with political intrigue and personal vendetta, and heart-rending in its scenes of sacrifice and retribution. At its heart it masterfully explores the depths of human courage and resilience, and the indomitable spirit of a nation that refuses to be broken. It's going to keep readers spellbound until the final page, and we can't be happier to publish it!" ABOUT THE CHOLA TIGERS The place will be of their choosing. The time will be of their choosing. But the Indians will have their vengeance. 1025 CE, India. Mahmud of Ghazni believes he has crushed the spirit of Bharat--the Shiva Linga at the Somnath temple lies shattered and thousands are dead. But among the ashes of destruction, an oath is taken. Five people--a Tamil warrior, a Gujarati merchant, a devotee of Lord Ayyappa, a scholar-emperor from Malwa, and the most powerful man on Earth, Emperor Rajendra Chola--resolve to undertake a perilous quest and strike at the heart of the invader's kingdom. From the grandeur of the Chola Empire to the shadows of Ghazni's bloodstained court, The Chola Tigers is the scintillating story of a fierce retaliation. A story of unity forged through pain, of courage born from despair, and of vengeance that becomes Dharma. ABOUT THE AUTHOR Amish is a 1974-born, IIM (Kolkata)-educated banker-turned-author. The success of his debut book, The Immortals of Meluha (Book 1 of the Shiva Trilogy), encouraged him to give up his career in financial services to focus on writing. Besides being an author, he is also a broadcaster, the founder of a video gaming company, a film producer and a former diplomat with the Indian government. Amish is passionate about history, spirituality and philosophy, finding beauty and meaning in all world religions. His books have sold more than 8 million copies and have been translated into 21 languages. His Shiva Trilogy is the fastest-selling and his Ram Chandra Series the second-fastest-selling book series in Indian publishing history. His books in The Indic Chronicles, which are based on medieval Indian history, are also blockbuster bestsellers. You can connect with Amish here: ABOUT HARPERCOLLINS INDIA HarperCollins India publishes some of the finest writers from the Indian subcontinent and around the world, publishing approximately 200 new books every year, with a print and digital catalogue of more than 2000 titles across 10 imprints. Its authors have won almost every major literary award including the Man Booker Prize, JCB Prize, DSC Prize, New India Foundation Award, Atta Galatta Prize, Shakti Bhatt Prize, Gourmand Cookbook Award, Publishing Next Award, Tata Literature Live!, Gaja Capital Business Book Prize, BICW Award, Sushila Devi Award, Sahitya Akademi Award and Crossword Book Award. HarperCollins India also represents some of the finest publishers in the world including Harvard University Press, Gallup Press, Oneworld, Bonnier Zaffre, Usborne, Dover and Lonely Planet. HarperCollins India is also the recipient of five Publisher of the Year Awards - in 2021 and 2015 at the Publishing Next Industry Awards, and in 2021, 2018 and 2016 at Tata Literature Live. HarperCollins India is a subsidiary of HarperCollins Publishers.
Yahoo
2 days ago
- Entertainment
- Yahoo
HarperCollins India is delighted to announce the forthcoming publication of The Chola Tigers: Avengers of Somnath
A scintillating new novel by the bestselling author of the Shiva Trilogy and the Ram Chandra series- Amish The cover of The Chola Tigers was revealed by Indian cinema's superstar and living legend Rajinikanth, along with the author Amish, in a private ceremony in Chennai. NEW DELHI, July 22, 2025 /PRNewswire/ -- Scheduled for release on 29 August 2025, The Chola Tigers is the second book in Amish's Indic Chronicles, after the bestselling Legend of Suheldev. A thrilling historical saga of defiance, honour and redemption it celebrates the indomitable spirit of India. When the ruthless tyrant Mahmud of Ghazni destroys the sacred temple of Somnath, the greatest ruler of the time, Emperor Rajendra Chola, summons a squad of defiant assassins to embark on a perilous quest and bring the fearsome enemy to his knees. This historical fiction title builds on the world introduced in the 2020 bestseller Legend of Suheldev, which garnered widespread appreciation from readers and went on to become a bestseller. Pacy and action-packed, The Chola Tigers, explores the profound question: How far would you go to defend dharma and your country's honour? On the occasion of the book's announcement, Amish, author, says, "The Chola Tigers is an exhilarating story in which Emperor Rajendra Chola, the mightiest man of his era, orders a daring surgical strike on Ghazni in response to Sultan Mahmud's attack on the Somnath temple. This work of historical fiction is linked to my 2020 release Legend of Suheldev. It is about a mission ordered by one of the greatest Tamilians ever, Emperor Rajendra Chola. And it is a great honour that the cover of this book was released by one of the greatest Tamilians alive and an Indian treasure, Rajinikanth ji." Poulomi Chatterjee, Executive Publisher — HarperCollins India, adds, "Amish has brilliantly reimagined our beloved legends and epics, and episodes from medieval Indian history, for millions of people across the country to enjoy afresh. The new novel is vintage Amish—a sweeping historical saga that is pacy, dramatic, simmering with political intrigue and personal vendetta, and heart-rending in its scenes of sacrifice and retribution. At its heart it masterfully explores the depths of human courage and resilience, and the indomitable spirit of a nation that refuses to be broken. It's going to keep readers spellbound until the final page, and we can't be happier to publish it!" ABOUT THE CHOLA TIGERS The place will be of their choosing. The time will be of their choosing. But the Indians will have their vengeance. 1025 CE, India. Mahmud of Ghazni believes he has crushed the spirit of Bharat—the Shiva Linga at the Somnath temple lies shattered and thousands are dead. But among the ashes of destruction, an oath is taken. Five people—a Tamil warrior, a Gujarati merchant, a devotee of Lord Ayyappa, a scholar-emperor from Malwa, and the most powerful man on Earth, Emperor Rajendra Chola—resolve to undertake a perilous quest and strike at the heart of the invader's kingdom. From the grandeur of the Chola Empire to the shadows of Ghazni's bloodstained court, The Chola Tigers is the scintillating story of a fierce retaliation. A story of unity forged through pain, of courage born from despair, and of vengeance that becomes Dharma. ABOUT THE AUTHOR Amish is a 1974-born, IIM (Kolkata)-educated banker-turned-author. The success of his debut book, The Immortals of Meluha (Book 1 of the Shiva Trilogy), encouraged him to give up his career in financial services to focus on writing. Besides being an author, he is also a broadcaster, the founder of a video gaming company, a film producer and a former diplomat with the Indian government. Amish is passionate about history, spirituality and philosophy, finding beauty and meaning in all world religions. His books have sold more than 8 million copies and have been translated into 21 languages. His Shiva Trilogy is the fastest-selling and his Ram Chandra Series the second-fastest-selling book series in Indian publishing history. His books in The Indic Chronicles, which are based on medieval Indian history, are also blockbuster bestsellers. You can connect with Amish here: ABOUT HARPERCOLLINS INDIA HarperCollins India publishes some of the finest writers from the Indian subcontinent and around the world, publishing approximately 200 new books every year, with a print and digital catalogue of more than 2000 titles across 10 imprints. Its authors have won almost every major literary award including the Man Booker Prize, JCB Prize, DSC Prize, New India Foundation Award, Atta Galatta Prize, Shakti Bhatt Prize, Gourmand Cookbook Award, Publishing Next Award, Tata Literature Live!, Gaja Capital Business Book Prize, BICW Award, Sushila Devi Award, Sahitya Akademi Award and Crossword Book Award. HarperCollins India also represents some of the finest publishers in the world including Harvard University Press, Gallup Press, Oneworld, Bonnier Zaffre, Usborne, Dover and Lonely Planet. HarperCollins India is also the recipient of five Publisher of the Year Awards – in 2021 and 2015 at the Publishing Next Industry Awards, and in 2021, 2018 and 2016 at Tata Literature Live. HarperCollins India is a subsidiary of HarperCollins Publishers. 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Yahoo
3 days ago
- Health
- Yahoo
Allergies seem nearly impossible to avoid — unless you're Amish
Whether triggered by pollen, pet dander or peanuts, allergies in this day and age seem nearly impossible to avoid. But one group appears virtually immune, a mystery to experts who study allergies. Despite the increasing rate of allergic diseases, both in industrialized and in developing countries, the Amish remain exceptionally - and bafflingly - resistant. Only 7 percent of Amish children had a positive response to one or more common allergens in a skin prick test, compared with more than half of the general U.S. population. Even children from other traditional farming families, who still have lower rates of allergic disease than nonfarm children, are more allergic than the Amish. Subscribe to The Post Most newsletter for the most important and interesting stories from The Washington Post. In fact, one Amish community living in northern Indiana is considered one of the least allergic populations ever measured in the developed world. 'Generally, across the country, about 8 to 10 percent of kids have asthma. In the Amish kids, it's probably 1 to 2 percent,' said Carole Ober, chair of human genetics at the University of Chicago. 'A few of them do have allergies, but at much, much lower rates compared to the general population.' Now, Ober and other researchers are trying to discover what makes Amish and other traditional farming communities unique, in the hopes of developing a protective treatment that could be given to young children. For instance, a probiotic or essential oil that contains substances found in farm dust, such as microbes and the molecules they produce, could stimulate children's immune systems in a way that prevents allergic disease. 'Certain kinds of farming practices, particularly the very traditional ones, have this extraordinary protective effect in the sense that, in these communities, asthma and allergies are virtually unknown,' said Donata Vercelli, a professor of cellular and molecular medicine at the University of Arizona. 'The studies that have been done in these farming populations are critical because they tell us that protection is an attainable goal.' The Amish are members of a Christian group who practice traditional farming - many live on single-family dairy farms - and use horses for fieldwork and transportation. As of 2024, around 395,000 Amish live in the United States, concentrated mostly in Pennsylvania, Ohio and Indiana. Over the past century, the incidence of allergic diseases - including hay fever (allergic rhinitis), asthma, food allergies and eczema - has increased dramatically. Hay fever, or an allergic reaction to tree, grass and weed pollens, emerged as the first recognized allergic disease in the early 1800s, climbing to epidemic levels in Europe and North America by 1900. The 1960s saw a sharp increase in the prevalence of pediatric asthma, a condition in which the airways tighten when breathing in an allergen. From the 1990s onward, there has been an upswing in the developed world in food allergies, including cow's milk, peanut and egg allergies. Urbanization, air pollution, dietary changes and an indoor lifestyle are often cited as possible factors. The 'hygiene hypothesis' - first proposed in a 1989 study by American immunologist David Strachan - suggests that early childhood exposure to microbes protects against allergic diseases by contributing to the development of a healthy immune system. The study found that hay fever and eczema were less common among children born into larger families. Strachan wondered whether unhygienic contact with older siblings served as a protection against allergies. Subsequent findings have given support to the hygiene hypothesis, such as that children who grow up with more household pets are less likely to develop asthma, hay fever or eczema. Perhaps even more beneficial than having older siblings or pets, however, is growing up on a farm. (More than 150 years ago, hay fever was known as an 'aristocratic disease,' almost wholly confined to the upper classes of society. Farmers appeared relatively immune.) This 'farm effect' has been confirmed by studies on agricultural populations around the world, including in the United States, Europe, Asia and South America. But even among farming communities, the most pronounced effect appears to be in the Amish. In a study of 60 schoolchildren by Ober, Vercelli and their colleagues, the prevalence of asthma was four times lower in the Amish as compared with the Hutterites, another U.S. farming community with a similar genetic ancestry and lifestyle. The prevalence of allergic sensitization - the development of antibodies to allergens and the first step to developing an allergy - was six times higher in the Hutterites. The researchers first ruled out a genetic cause; in fact, an analysis showed that the Amish and Hutterite children were remarkably similar in their ancestral roots. Instead, the main difference between these two populations seemed to be the amount of exposure as young children to farm animals or barns. 'The Hutterite kids and pregnant moms don't go into the animal barns. Kids aren't really exposed to the animal barns until they're like 12 or so, when they start learning how to do the work on the farm,' Ober said. 'The Amish kids are in and out of the cow barns all day long from an early age.' When analyzing samples of Amish and Hutterite house dust, they found a microbial load almost seven times higher in Amish homes. Later experiments showed that the airways of mice that inhaled Amish dust had dramatically reduced asthmalike symptoms when exposed to allergens. Mice that inhaled Hutterite dust did not receive the same benefit. Now, Ober and Vercelli are beginning to identify the protective agents in Amish dust that prevent allergic asthma. In 2023, their analysis of farm dust found proteins that act like delivery trucks, loaded with molecules produced by microbes and plants. When these transport proteins deliver their cargo to the mucus that lines the respiratory tract, it creates a protective environment that regulates airway responses and prevents inflammation. 'We don't really talk about the hygiene hypothesis as much anymore because we now understand that it's not really about how hygienic you're living,' said Kirsi Järvinen-Seppo, director of the Center for Food Allergy at the University of Rochester Medical Center. 'It's more like a microbial hypothesis, since beneficial bacteria that colonize the gut and other mucosal surfaces play a significant role.' During the first year or two of life, a baby's immune system is rapidly developing and highly malleable by environmental stimuli, such as bacteria. Some experts believe that exposing young children to certain types of beneficial bacteria can engage and shape the growing immune system in a way that reduces the risk of allergic diseases later in life. Farm dust contains a hodgepodge of bacteria shed from livestock and animal feed that isn't harmful enough to cause illness, but does effectively train the immune system to become less responsive to allergens later in life. In 2021, Järvinen-Seppo and her colleagues compared the gut microbiomes of 65 Old Order Mennonite infants from a rural community in New York with 39 urban/suburban infants from nearby Rochester. Like the Amish, the Old Order Mennonites follow a traditional agrarian lifestyle. Almost three-fourths of Mennonite infants in the study were colonized with B. infantis, a bacterium associated with lower rates of allergic diseases, in contrast to 21 percent of Rochester infants. 'The colonization rate is very low in the United States and other Western countries, compared to very high rates in Mennonite communities, similar to some developing countries,' Järvinen-Seppo said. 'This mirrors the rates of autoimmune and allergic diseases.' These clues about the origin of the farm effect represent a step toward the prevention of allergic diseases, Järvinen-Seppo says. Whatever form the treatment takes, the impact on prevention of allergic diseases, which affect millions of people worldwide and reduce quality of life, could be enormous, experts say. 'I don't know that we can give every family a cow. … But we are learning from these time-honored and very stable environments what type of substances and exposures are needed,' Vercelli said. 'Once we know that, I don't think there will be any impediment to creating protective strategies along these lines.' Related Content Family adopts a shelter dog — then learns he's the father of their late dog Can the Fed stay independent? Trump-era adviser may put it to the test. The Hubble telescope zooms in on the galaxy next door Solve the daily Crossword
