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Topflight Pharma Development Veteran Joins Synendos
Topflight Pharma Development Veteran Joins Synendos

Yahoo

time2 days ago

  • Health
  • Yahoo

Topflight Pharma Development Veteran Joins Synendos

Dr. George Garibaldi is named Chief Medical Officer (CMO) as Synendos transitions from Phase 1 into Phase 2 of its clinical development strategy Dr. George Garibaldi, MD BASEL, Switzerland, July 15, 2025 (GLOBE NEWSWIRE) -- Synendos Therapeutics ('Synendos'), the clinical-stage biotechnology company developing breakthrough therapies for neuropsychiatric disorders, announced today that it has named Dr. George Garibaldi, CMO. This appointment is particularly timely as the company moves towards Phase 2 clinical development of its lead drug asset SYT-510. Synendos CEO, Andrea Chicca said, "It's tremendous that Synendos can attract this calibre of talent and experience. George offers a nuanced clinical perspective on the urgent needs of the patients we are looking to help, combined with specific expertise in advancing transformative neuroscience therapies from concept to clinical adoption.' Dr. George Garibaldi is a psychiatrist and neuroscientist with more than 30 years of experience leading global clinical development programs in CNS disorders. His career spans leadership roles at Roche, Novartis and Janssen, where he oversaw the development of breakthrough treatments including Ocrevus® for primary progressive and relapsing remitting multiple sclerosis and Exelon® for Alzheimer's disease and Lewi body dementia. As co-founder of Noema Pharma, he spearheaded the in-licensing and advancement of shelved CNS assets, securing major venture funding and progressing them through pivotal clinical trials. Known for his strong beliefs in empowering patients, Dr. Garibaldi has published more than 100 peer-reviewed articles and has developed widely used clinician- and patient-reported outcome measures. He is a founder and past president of the International Society for CNS Clinical Trials and Methodology and is recognized by peers as a collaborative, strategic leader dedicated to advancing mental health and neuroscience therapeutics. 'Mental health and brain health have for far too long been underserved by traditional drug development models,' said Dr. Garibaldi. "Synendos is combining the pursuit of an innovative target with a commitment to rethinking how we design trials, measure outcomes and prioritize patient function. It's this willingness to be ahead of the curve with therapeutic innovation and a genuine patient focus that made me want to be part of the company.' He added, 'Society today recognizes that there is no health without mental health. We have the rare opportunity to chart our own path here. I am eager to lead this transformation and help this exceptional team advance the next generation of brain therapies that could truly change the lives of patients.' About SynendosSynendos is a clinical-stage, neuroscience company developing potentially breakthrough therapies for neuropsychiatric and other CNS disorders such as anxiety disorders, PTSD and other indications. We utilise the modulation of a new drug target in the endocannabinoid system (ECS) that enables restoration of the natural functioning of the brain. Synendos' lead drug candidate, SYT-510, belongs to a novel class of ECS modulators named Selective Endocannabinoid Re-uptake Inhibitors (SERIs). SERIs represent first-in-class, new chemical entities that modulate the ECS through a self-limiting mode of action (MoA) with the potential to deliver meaningful benefits to patients. This novel MoA has the potential to combine treatment of a range of symptoms with sustained efficacy in large patient populations together with the potential to address a key unmet need, that of chronic tolerability, allowing more patients to stay on treatment and regain an improved quality of life. For more information please contact: Synendos Therapeutics AG Simon Russell +41 79 138 5840 O Public Relations GmbHO'Patrick Wilson o@ 78 888 4332 A photo accompanying this announcement is available at in retrieving data Sign in to access your portfolio Error in retrieving data Error in retrieving data Error in retrieving data Error in retrieving data

Euro 2025: Netherlands ready to believe in miracles and win big against France to advance
Euro 2025: Netherlands ready to believe in miracles and win big against France to advance

Associated Press

time4 days ago

  • Sport
  • Associated Press

Euro 2025: Netherlands ready to believe in miracles and win big against France to advance

BASEL, Switzerland (AP) — Posed with the question 'Do you believe in miracles?' at the Women's European Championship, the Netherlands said it does. The Dutch likely must beat an in-form France by three clear goals on Sunday to reach the quarterfinals, needing to make up ground after a 4-0 beating by England. 'Miracles exist,' Netherlands coach Andries Jonker said in translated comments on Saturday. 'After a very heavy 4-0 defeat there is one thing you can do, rise up again.' The scenario in Group D is that France sits top on six points, and England is expected also to end on six points by beating Wales in the final round of games played at the same time on Sunday evening in Switzerland. That would leave just one Dutch path to finish runner-up to England in the standings — a big win over France to lift them in a three-way tiebreaker between the six-point teams. The decider would be goal difference for those three teams in games against each other while excluding their results against Wales. 'Remember Barcelona and Paris Saint-Germain,' Jonker said, citing the men's Champions League epic in 2017 that is known in soccer lore as 'La Remontada,' the comeback. Barcelona lost 4-0 in Paris in the first leg of the round of 16, then won 6-1 at home to advance. 'There is no other option,' added Jonker, once an assistant coach at Barcelona, but to deliver an unforgettable game and performance. France coach Laurent Bonadei saw no disrespect when told of Jonker's comments — and countered with humor. 'That's normal, that's his role,' Bonadei said of his counterpart's confidence, though noted his own team's threat after scoring six goals across its two wins so far. 'It's maybe not 3-0 that he needs to win, but 5-2 or 6-3,' said the France coach, whose team needs only a point to top the standings. 'It will be a beautiful game. I would prefer to be in our place than theirs.' Of course, if tournament debutant Wales was to stop England winning — not miraculous, though unlikely after losing to the Netherlands and 4-1 to France — then a win of any kind for the Dutch would be enough to advance. 'Wales is so eager to beat England,' said the Netherlands' veteran No. 10 Daniëlle van de Donk, who also was asked if she believed in miracles. 'I believe in our team,' van de Donk said in translated comments, 'and in football anything is possible.' ___ AP soccer:

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