Latest news with #BMP
Time of India
2 days ago
- Health
- Time of India
Hair Regrowth Without Transplant? New Molecular Approach Offers Hope
Mumbai: A team of scientists by mapping the complete molecular network of human hair, have identified several treatment procedures that can potentially eliminate the need for surgery or transplants for restoring hair growth. According to a recent study published in "Stem Cell Research & Therapy" integrating stem cell biology, gene therapy, and molecular signalling can potentially help to treat hair loss conditions like androgenetic alopecia (AGA) without the need of a transplant. The study co-authored by a multidisciplinary team from US and India, involving researchers of QR678, a hair regrowth formulation and The Esthetic Clinics (TEC) , suggest androgenetic alopecia (AGA)—the most common form of hair loss—not as an irreversible condition, but as a breakdown in regenerative signalling that can potentially be reversed.' Under the study, the researchers analysed five key molecular pathways—Wnt/β-catenin, Sonic Hedgehog (Shh), Bone Morphogenetic Protein (BMP), Notch, and AKT/MAPK—that collectively manage the hair follicle lifecycle. During their analysis, researchers found that in conditions like AGA, the communication between these aforementioned pathways breaks down, particularly with Wnt suppression and BMP overactivation, causing follicles to fall into dormancy. To correct such breakdowns the study outlined that gene-editing tools like CRISPR and stem cell therapies can help to correct misfiring signals, rebuild a supportive microenvironment. As per the researchers some of these treatments have already shown success in lab-grown tissue and animal models, and early clinical trials are expected to begin within the next two years. 'By mapping out the molecular misfires behind hair follicle dormancy, we now have a clearer pathway to develop therapies that don't just slow hair loss—but potentially reverse it by reawakening the body's own regenerative systems,' said Dr Michael Gold, dermatologist and founder of Gold Skin Care Center, USA. 'Hair follicles don't disappear; they go dormant due to disrupted cellular signals. By identifying how these signals fail—and how they can be restored—we move closer to resetting the system at a molecular level. It's a fundamental shift in how hair loss can be understood, and ultimately, reversed,' Dr Debraj Shome, senior author and Director at TEC, added. Scientists involved in the study suggest the global hair loss treatment market, valued around $4 billion (₹34,000 crore) available solutions includes only external therapies–-drugs, and treatment procedures—surgery, transplants. Whereas, the study's findings signal a space for exploring gene- and cell-based molecular therapies—a therapeutic domain that follows a completely different approach with differentiated targeting and treatment mechanisms.
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Business Standard
3 days ago
- Health
- Business Standard
Researchers map hair growth pathways for non-surgical hair restoration
Mumbai-based The Esthetic Clinics (TEC), in collaboration with QR678 Research, have co-authored a research paper that maps the complete molecular network governing human hair growth—potentially offering the clearest path yet to hair restoration without the need for surgery, medication, or transplantation. Shome added that the global hair transplant market is currently valued at $15.22 billion and is projected to reach $23.32 billion by 2030. Published in Stem Cell Research & Therapy, the paper was developed by a multidisciplinary team of researchers from India and the United States. It redefines androgenetic alopecia (AGA)—the most common form of hair loss. Significantly, the study is among the first to integrate stem cell biology, gene therapy, and molecular signalling into a unified therapeutic approach for treating AGA. 'For decades, we have treated hair loss as a cosmetic issue. This paper consolidates what we now understand about the biological breakdown behind it—and reframes baldness as a malfunction of the body's regenerative system,' said Debraj Shome, senior author and Director at TEC. The paper focuses on five main molecular pathways—Wnt/β-catenin, Sonic Hedgehog (Shh), Bone Morphogenetic Protein (BMP), Notch, and AKT/MAPK—that work together to control the hair follicle's growth cycle. In cases of AGA, this communication system breaks down—especially due to reduced Wnt activity and increased BMP signals—causing hair follicles to become inactive or dormant. The research proposes several therapeutic strategies to biologically 'reset' hair follicles, such as using stem cell therapies to restore a healthy follicle environment, among other approaches. The Esthetic Clinics noted that some of these approaches have shown results in lab-grown tissues and animal models, with early-stage clinical trials expected to begin within the next two years.
Business Recorder
4 days ago
- Business
- Business Recorder
Finance Act 2025: BMP demands removal of ‘oppressive' clauses
LAHORE: The Federation of Pakistan Chambers of Commerce and Industry's Businessmen Panel (BMP) has strongly condemned the continuation of controversial fiscal amendments introduced under the Finance Act 2025, asserting that Saturday's successful shutter-down across Punjab and the rest of the country signals a deep rupture in the government's contract with the business community. Addressing the wave of frustration engulfing markets from Lahore to Faisalabad, Gujranwala, Sialkot and beyond, BMP Chairman Mian Anjum Nisar noted that this collective shutdown was not a routine protest—it was a definitive vote of no-confidence in the state's current economic direction. Traders, industrialists, wholesalers and retailers across Pakistan voluntarily ceased operations to register their dismay at the coercive new powers granted to tax officials under the revised law. Mian Anjum Nisar stated that Sections 37A and 37B of the Income Tax Ordinance—empowering tax officers with arrest and prosecution authority—violate the constitutional guarantees of fair treatment and due process. He said these clauses are more reflective of a police state than a participatory economy and have triggered panic throughout formal businesses already struggling with rising costs and limited liquidity. 'These measures were neither debated transparently nor tested through pilot phases. The sudden imposition of unchecked arrest powers, aggressive cash handling limits, and unrealistic digital compliance rules has pushed the entire business landscape into uncertainty,' Nisar warned. 'You cannot reform an economy by intimidating its engine. What the government has misjudged is the deep-rooted unity of Pakistan's trading and industrial community.' He pointed out that even law-abiding businesses with a clear tax history are now rethinking their operations due to the fear of misuse by the enforcement arms of the Federal Board of Revenue. Coupled with hasty implementation of SRO 350 and SRO 709, which mandate complex electronic invoicing and tracking requirements, the situation has left traders vulnerable to penalties without preparation. Anjum Nisar said the nationwide protest was not confined to any single region or sector. 'From mega industrial hubs in Lahore to small-town traders in central Punjab, the shutdown was absolute—and peaceful. This is not political agitation. It is a desperate but constitutional signal from those who have been pushed too far,' he said. BMP stated that instead of expanding the tax base through engagement, the government has opted for punitive actions that are alienating even registered taxpayers. 'This is not how you build trust. If every law-abiding businessperson starts to feel like a criminal, the tax system collapses under its own contradictions,' Nisar remarked. He expressed serious concern that the government's narrative continues to suggest that only a few sectors oppose the reforms. 'This strike disproved that myth. The unity seen across commercial centers in Punjab should be a wake-up call. We are talking about a total industry halt—a shutdown of production, supply chains, and sales from top to bottom,' he said. While acknowledging the establishment of a grievance redressal committee by FPCCI and the Ministry of Finance, BMP criticized the lack of urgency in addressing the issues. 'At this stage, verbal commitments are not enough. The government must issue written notifications immediately reversing or suspending the most dangerous aspects of these laws,' Nisar insisted. The Businessmen Panel emphasized that the business community has always been in favor of responsible reforms and progressive digitization. However, it cannot support a system that is imposed overnight, without education, infrastructure, or practical rollout plans. 'Pakistan's economy does not run on apps and directives. It runs on trust, predictability, and dialogue,' he added. He said BMP had repeatedly presented constructive suggestions, including timelines for documentation, gradual onboarding of digital systems, and protections against harassment. 'Unfortunately, the state continues to legislate from a distance, without consulting the very people who will bear the brunt of these policies,' Anjum Nisar lamented. He warned that if the Finance Act is not amended in the coming days, the economic consequences could extend beyond business closures to investment flight, job losses, and reduced exports. 'Pakistan's productive class cannot afford to operate in fear. We will not be spectators to our own collapse,' Nisar said. BMP reiterated its complete support for the constitutional right to protest and expressed pride in how peacefully and effectively the strike was observed across the country. 'The discipline and unity shown on July 20 have restored our belief that business owners can still come together for the nation's economic future. But that unity must now be respected—not ignored,' the chairman said. The Businessmen Panel demanded that the government issue official notifications to immediately withdraw Sections 37A and 37B, revise SRO 350 and SRO 709 with stakeholder input, and suspend punitive cash transaction rules until a proper mechanism is agreed upon. 'We are not seeking confrontation. We are demanding correction,' Mian Anjum Nisar said. 'If the government fails to act now, the business community will be forced to reconsider how—and whether—it continues to operate under such conditions.' Copyright Business Recorder, 2025
Associated Press
16-07-2025
- Business
- Associated Press
NeuralBase To Advance Development of AI Chatbot Platform With Integration of ChatGPT Technology
LAS VEGAS, NV - July 16, 2025 ( NEWMEDIAWIRE ) - NeuralBase AI Ltd. (OTC: NBBI), operating under its enterprise brand BMP AI and recognized as a growing innovator in enterprise artificial intelligence, today announced it is advancing the development of its intelligent chatbot platform. As part of this next phase, BMP AI plans to integrate advanced generative AI technology based on OpenAI's ChatGPT to enhance the platform's intelligence, adaptability, and user experience. This integration reflects NeuralBase's continued commitment to delivering conversational agents capable of natural, dynamic, and human-like interactions. Leveraging the capabilities of ChatGPT, the BMP AI platform aims to: ChatGPT is a product of OpenAI, and NeuralBase will be utilizing the technology under commercially available licensing through authorized API access. This integration does not constitute an endorsement or partnership, and all use is conducted in accordance with OpenAI's terms of use and ethical AI guidelines. 'This integration is a major milestone toward realizing our vision of adaptive, intelligent AI assistants,' said Vighnesh Dobale, CEO of NeuralBase. 'By building on ChatGPT's powerful language model, we're creating a more responsive, intuitive, and useful assistant for enterprise clients.' The BMP AI platform remains under active development. Planned iterations will target applications in fintech, customer service, and enterprise automation, where secure, scalable, and context-sensitive AI systems are increasingly in demand. NeuralBase maintains a strong commitment to transparency, privacy, and ethical AI design. As development progresses, the Company will continue to prioritize responsible deployment practices and data integrity. Additional information about NeuralBase AI Ltd. is available at or by visiting About NEURALBASE AI LTD. NeuralBase AI Ltd. (OTC: NBBI) is a publicly traded AI company focused on secure, scalable, and context-aware conversational systems and workflow automation. Through its BMP AI platform, currently in beta testing, the Company enables enterprises to streamline internal operations, enhance team collaboration, and improve productivity while maintaining compliance and data security. Legal Disclaimer and Forward-Looking Statements This press release contains forward-looking statements as defined under Section 27A of the Securities Act of 1933 and Section 21E of the Securities Exchange Act of 1934. These statements reflect current expectations, estimates, and projections of NeuralBase AI Ltd. (the 'Company' or 'NBBI') based on assumptions and current market conditions. Forward-looking statements may include terms such as 'aims,' 'anticipates,' 'expects,' 'intends,' 'plans,' 'believes,' 'may,' 'will,' 'could,' 'should,' and similar expressions. These statements relate, among other things, to the expected features and performance of the BMP AI platform; the timing and success of product development; potential industry applications; and overall strategic direction. All forward-looking statements are inherently subject to risks and uncertainties that may cause actual results to differ materially from those projected. NeuralBase AI Ltd. is a fully reporting company with the U.S. Securities and Exchange Commission (SEC) and files annual and quarterly reports, current reports, and other required disclosures. All public filings and disclosures may be reviewed at the SEC's EDGAR database at The Company trades on the OTC Markets under the ticker symbol NBBI. This press release is not, and should not be construed as, an offer to sell or a solicitation of an offer to buy any securities of NeuralBase AI Ltd. in the United States or in any other jurisdiction. Offers and sales of securities, if any, will be made only pursuant to an effective registration statement or valid exemption under the U.S. Securities Act of 1933, as amended. Investing in securities traded on the OTC Markets involves significant risk, including potential loss of principal, low liquidity, high volatility, and limited publicly available information. Shares traded on the OTC Markets may be more susceptible to market manipulation or price swings. Investors are strongly advised to conduct their own due diligence, consult a qualified investment advisor, and carefully review all SEC filings prior to making any investment decision. Media Contact: Vighnesh Dobale Chief Executive Officer [email protected] (727) 314-3717 View the original release on
The Hindu
15-07-2025
- Health
- The Hindu
Understanding cell signals could change the way hair loss is treated, study finds
A study titled 'Pathophysiological Mechanisms of Hair Follicle Regeneration and Potential Therapeutic Strategies' published in Stem Cell Research & Therapy (2025) explains how hair loss, especially androgenetic alopecia (AGA), is caused by problems in the body's natural hair growth signals -- not just hormones or ageing. The review focuses on five important biological pathways -- Wnt/β-catenin, Sonic Hedgehog (Shh), BMP, Notch, and AKT/MAPK that help control when hair grows, falls and regrows. Study highlights The study found that in people living with AGA, the signals that help hair grow (like Wnt and Shh) are blocked, while signals that stop growth (like BMP and TGF-β) are more active. This leads to smaller, weaker hair follicles that stop producing hair over time. 'These signals work together like a team,' Debraj Shome, co-founder and director at The Esthetic Clinics and Depti Bellani, senior manager medical affairs and research at QR678 and lead authors of the study explain. 'To fix the problem, we need to focus on all of them -- not just one.' Current treatments like minoxidil (topical solution that works by increasing blood flow to the scalp and extending the hair's growth phase) and finasteride (oral medication that reduces the production of dihydrotestosterone (DHT), a hormone that contributes to hair follicle miniaturisation and hair loss) can slow down hair loss or help with some regrowth, but they do not treat the real reason why follicles stop working. The study highlights new types of treatments that are being tested, such as small molecules that can restart growth signals, stem cell therapy and gene editing. Formulations such as QR678, developed by the authors' research team, are also part of this new approach. Shift in hair loss treatment Experts say this could mark a big shift in how hair loss is treated. Instead of just covering up the symptoms, future treatments may be able to restart the hair follicle's natural growth process. However, the study also warns that activating these signals too much, especially Wnt or AKT -- can be risky and must be done carefully. With over 50% of men and 25% of women affected by AGA by the age of 50, the authors say it's time to look at hair loss not just as a cosmetic problem, but as a health issue that can be treated by understanding how the body's regenerative systems work. 'This isn't just about growing hair,' they said. 'It's about waking up the body's natural repair systems and helping hair follicles work the way they're meant to.' The authors also stress the importance of collaboration across medical specialties to move this research forward. Since hair loss is linked to hormonal changes, immune responses, and genetic factors, a combined approach involving dermatologists, endocrinologists, geneticists, and regenerative medicine experts is essential. 'Personalised treatment plans based on each person's biological profile will likely give better results,' the authors note. They add that wider clinical trials, safety studies and shared research efforts will be key to turning these scientific findings into real, effective therapies for patients. Various forms of hair loss and regenerative medicine The study also points out that other forms of hair loss, such as scarring alopecia, autoimmune types like alopecia areata and hair loss caused by chemotherapy are linked to similar problems in the body's regenerative signalling systems. This suggests that the same scientific approach could help treat a wider range of hair loss conditions. The authors say that the hair follicle is more than just a cosmetic structure, it functions like a mini-organ and offers valuable insight into how tissues heal, how the immune system protects certain cells, and how stem cells behave. By studying hair follicles, researchers can also learn more about the body's broader ability to repair itself, making hair loss an important area of focus in regenerative medicine.
