Latest news with #Caucasian
Indian Express
15 hours ago
- Health
- Indian Express
Revolutionising disease's treatment: Twin study identifies novel risk genes, molecular subtypes in thyroid cancer among Indians
In a significant leap for cancer research and precision medicine, a twin Indian study has decoded the complex genetic architecture of thyroid cancer — one of the most common endocrine malignancies. Researchers from Tata Memorial Centre and the Department of Genetics, University of Delhi, South Campus, have shed new light on how thyroid cancer behaves in Indian patients, identifying novel risk genes and molecular subtypes that could revolutionise diagnosis and treatment. Both the studies were published back-to-back in 'JCO Global Oncology.' The research is spearheaded by graduate student Vaishakhi Trivedi under the mentorship of Dr Kumar Prabhash and Dr Amit Dutt. 'Our work not only adds data to global cancer databases — it also redefines what is known about thyroid cancer in the Indian population,' Professor Dutt said. The first study concerns papillary thyroid cancer (PTC), which accounts for 80-85 per cent of all thyroid cancer cases in India. This is considered treatable. The team analysed DNA from 100 Indian patients and found mutations in the DUOX2 gene found in nearly nine per cent of cases. 'This gene, previously known for its role in thyroid hormone production, now appears to be a genetic red flag for recurrence and poor prognosis. This is the first time DUOX2 has been implicated as a predisposing factor in PTC. It offers an opportunity for early detection and potentially life-saving interventions,' Prof Dutt said. The study even identified two different subtypes associated with aggressive cancer and high recurrence. The BRAF-RAS-driven subtype makes up 62 per cent of cases and is identified by mutations that are often tied to more aggressive tumour behaviour. The iBR (Independent of BRAF-RAS) subtype is a newly-defined category. 'This group lacks traditional mutations but shows alarming signs of treatment resistance and high recurrence. It is marked by alterations in genes like SMAD4 and TG — a previously uncharted territory for thyroid oncologists,' said Dr Prabhash. This dual classification signals a new era of care where treatments are tailored to the patient's genetic profile rather than a one-size-fits-all approach. While PTC is common and often curable, anaplastic thyroid cancer (ATC) is its deadly cousin — rare, fast-moving and resistant to nearly every treatment in the book. In a separate study, the research team examined 68 samples and found mutations in the THRA gene in 11 per cent of Indian patients with ATC. This is in sharp contrast to Caucasian datasets. 'THRA, a gene tied to thyroid hormone signalling, appears to be a key player in cellular plasticity or the process by which cancer cells morph, lose their identity and become more aggressive. THRA mutations are like flipping the switch. They make the cancer harder to kill but they also give us a target. That's a rare silver lining,' Dr Prabhash explained. These findings offer practical methods of how thyroid cancers are diagnosed, treated and managed in Indian patients. 'Patients with DUOX2 mutations could be monitored proactively, much like BRCA testing in breast cancer. This may help in diagnosing aggressive PTC and ATC early and prevent a relapse,' Prof Dutt said. Researchers also added that therapies that restore THRA function may finally give ATC patients a fighting chance. 'We need a personalised roadmap for thyroid cancer. With the promise of advanced tools like CRISPR gene editing and small-molecule inhibitors, these discoveries could soon migrate from the lab bench to the bedside,' the researchers said. 'Genetic profiling should be as routine as a biopsy,' said Vaishakhi Trivedi. 'We have the science. Now we need the systems to support it.' Anuradha Mascarenhas is a journalist with The Indian Express and is based in Pune. A senior editor, Anuradha writes on health, research developments in the field of science and environment and takes keen interest in covering women's issues. With a career spanning over 25 years, Anuradha has also led teams and often coordinated the edition. ... Read More
Hindustan Times
a day ago
- Automotive
- Hindustan Times
Bubba Wallace wins Brickyard 400: Why the NASCAR victory in Indianapolis is historic
Bubba Wallace became the first Black driver to win on Indianapolis Motor Speedway's 2.5-mile oval on Sunday. The 31-year-old managed to go through a late rain delay, two overtimes, and fuel concerns to hold off Kyle Larson in the Brickyard 400. This was the third NASCAR Cup victory of Wallace's career was also his biggest. It snapped a 100-race winless streak that dated to 2022 at Kansas. Bubba Wallace celebrates after winning the NASCAR Cup Series Brickyard 400 at Indianapolis Motor Speedway(Getty Images via AFP) Wallace also won at Talladega in 2021. It's his first win at one of NASCAR's four crown jewel races. As soon as he crossed the finish line, the 31-year-old exclaimed: 'Unbelievable.' His final gap was 0.222 seconds. Read More: Belgian Grand Prix 2025: McLaren's Oscar Piastri wins, teammate Lando Norris comes second Larson trailed by 5.057 seconds with 14 laps to go, but the gap was down to about three seconds with six remaining when the yellow flag came out because of rain. The cars rolled to a stop on the pit lane with four to go, giving Wallace about 20 additional minutes to think and rethink his restart strategy. 'Bubba Wallace is now the 2nd black driver to achieve a major win at Indianapolis Motor Speedway. The first was Lewis Hamilton at F1's last race in 2007,' one person celebrated Wallace's win on X, platform formerly known as Twitter. Read More: Aaron Rodgers to extend his time with the Steelers? What we know about his plans to retire Bubba Wallace has a multiracial background with both African American and Caucasian ancestry. Born William Darrell Wallace Jr on October 8, 1993, in Mobile, Alabama, he is the son of Darrell Wallace Sr, an entrepreneur of Caucasian descent, and Desiree Wallace, who is African American. This heritage has shaped his identity as the first full-time African American driver in the Cup Series since Wendell Scott in the 1960s and 1970s, a milestone he achieved in 2018 with Richard Petty Motorsports.
New York Post
3 days ago
- Business
- New York Post
Former employee sues Major League Soccer for discrimination
Major League Soccer executives undermined a black marketing director after he complained that they gave a promised promotion to a white colleague — then fired him, he claimed in a lawsuit. Cedric Shine, who began at MLS in December 2022 as a brand marketer, was fired in May after months of poor treatment from top bosses at the soccer league, he said in a July 18 Manhattan Supreme Court lawsuit. Shine, 41, said he was told he was about to be given a new job as senior director of marketing for the league when new direct supervisors were installed in February. 3 Cedric Shine was hired by Major League Soccer in 2022. Cedric D. Shine/ LinkedIn But days later, the new bosses reversed course, he said in court papers. 'The decision to block Shine's promotion came mere weeks after Shine's new supervisors terminated one of the few Black Directors in the Marketing Department, Justin Cox,' according to the lawsuit. The higher level job was instead given to 'a Caucasian MLS Marketing Director,' Shine said in the legal filing. When he complained to MLS' human resources department about the move, 'and its racial implications,' Shine was promoted 'over his supervisors' objections' — triggering a 'campaign of retaliation against him,' he claimed. Bosses berated him, lied about him showing up late for work, slashed his marketing budget and would abruptly leave events he organized, leaving MLS corporate partners and MLS executives 'in attendance to question why marketing leadership was leaving the event and reflected extremely poorly on Shine,' he said in the litigation. 3 Shine claims he was the target of retaliation at work. Cedric D. Shine/ Instagram Questioning 'their views' on his performance 'would be frowned upon' and that he 'would be seen as someone who lacks the ability to accept constructive criticism,' bosses allegedly told Shine, he claimed in court papers. When other officials and MLS higher-ups ignored his complaints of retaliation, 'Shine attempted to schedule a meeting with MLS Deputy Commissioner Gary Stevenson, who oversaw the leadership team that had been retaliating against Shine.' Instead of a meeting with Stevenson, Shine was fired, according to the lawsuit. 3 Shine said his bosses lied about him arriving late for work. Cedric D. Shine/ Instagram 'As a proximate result of MLS' conduct, Shine has been adversely affected in his employment and career, emotional well-being, the quality of his life and in his normal life's pursuits, and Shine believes MLS' conduct … has and will continue to have a negative effect upon him.' Shine is seeking unspecified damages. The league, which has instituted anti-racism campaigns in the wake of several high profile incidents, denied Shine's accusations. 'Shine's allegations of retaliation have no merit and the League intends to vigorously defend the recently filed lawsuit,' MLS said in a statement, adding the league is committed 'to providing an equitable and inclusive environment.'
Time of India
3 days ago
- Entertainment
- Time of India
Meet Lauren Cosgrove, the woman behind the NHL star T.J. Oshie's success
In the action-packed world of the NHL, Timothy Leif "T.J." Oshie stands out as a fan-favorite right winger for the Washington Capitals. With a career that spans Olympic fame, a Stanley Cup win, and over a decade in professional hockey, T.J. Oshie has made headlines for his on-ice brilliance; but away from the spotlight. Another star has been quietly supporting him every step of the way; his wife, Lauren Cosgrove. View this post on Instagram A post shared by ColorsTV (@colorstv) A love story that started in North Dakota Lauren Cosgrove was born on October 24, 1990, in Missouri. She studied at the University of North Dakota, where she first met Timothy Leif Oshie in 2011 through mutual friends. The two began dating shortly after their first meeting. And their connection grew strong over the years. By February 2014, the couple was engaged, and just over a year later, in July 2015. They got married right after T.J. was traded from the St. Louis Blues to the Washington Capitals. The timing marked a fresh chapter in both their personal and professional lives. The family behind the NHL jersey Lauren Cosgrove may not be a public figure in the traditional sense, but she has a strong presence on Instagram. With over 200,000 followers, her account gives fans a behind-the-scenes look at their life off the rink featuring adorable family moments, parenting highs and lows, and celebrations big and small. by Taboola by Taboola Sponsored Links Sponsored Links Promoted Links Promoted Links You May Like Villas For Sale in Dubai Might Surprise You Villas In Dubai | Search Ads Get Rates Undo The couple now has four children. Lauren's role as a mother and partner has been a steadying force in T.J. Oshie's life; providing emotional balance throughout the ups and downs of his NHL career. FAQs How did Timothy Leif Oshie meet Lauren Cosgrove? They met in 2011 through mutual friends while Lauren was attending the University of North Dakota. When did T.J. Oshie and Lauren Cosgrove get married? In July 2015. Is Lauren Cosgrove active on social media? Yes, she is active on Instagram. And here she shares family updates and personal moments. What is Lauren Cosgrove's background? She is from Missouri, of Caucasian ethnicity. And is reported to be Christian. She attended the University of North Dakota. Lauren Cosgrove is an American citizen of Caucasian ethnicity, and she is believed to follow Christianity. Although she keeps her professional life private, she is widely admired by hockey fans and families across the NHL community for being supportive, grounded, and authentic. Also Read: Back in play? NHL ban wobbles as Carter Hart draws offers after WJC trial verdict For real-time updates, scores, and highlights, follow our live coverage of the India vs England Test match here. Catch Rani Rampal's inspiring story on Game On, Episode 4. Watch Here!
News18
4 days ago
- News18
Missing For Nine Months, Woman Found Alive Near Death Valley In Colorado
Last Updated: Further details about the circumstances surrounding her disappearance remain unknown. Kelsey Pittman, a North Carolina resident, has been found alive in Colorado after being missing for nine months. She was last seen near California's Death Valley National Park before disappearing without a trace. After months of extensive search efforts, she was finally located on July 22. The Inyo County Sheriff's Office confirmed the news in an official Facebook post, stating, 'The Inyo County Sheriff's Office is relieved to announce that [Kelsey Pittman] has been located alive in the state of Colorado." However, further details about the circumstances surrounding her disappearance and where she spent her time during the nine months remain unknown. Pittman, aged 33, was first reported missing by her mother in November 2024 after she was unable to contact her. Concerned for her daughter's safety, her mother reached out to local authorities for assistance. In February 2025, the Inyo County Sheriff's Office received a report of a suspicious, abandoned vehicle located near The Pads, or Slab City, an area often frequented by campers and located close to Death Valley National Park. Upon investigation, it was confirmed that the white 2009 Chevrolet HHR found at the site was registered to Pittman. A check of the vehicle's licence plates confirmed it was from North Carolina. On July 2, the department released an update stating that, despite their continued and rigorous efforts, the investigation had not yielded results. Pittman was described as a 'Caucasian female who is 5 feet 5 inches tall and weighs 130 pounds." She is noted to have blond or brownish-blond hair. While Pittman has now been found, the Sheriff's Office has chosen not to disclose the specifics of her discovery, including how and where she was located in Colorado. The decision was made in order to respect the privacy of both Pittman and her family. Get breaking news, in-depth analysis, and expert perspectives on everything from geopolitics to diplomacy and global trends. Stay informed with the latest world news only on News18. Download the News18 App to stay updated! view comments First Published: Disclaimer: Comments reflect users' views, not News18's. Please keep discussions respectful and constructive. Abusive, defamatory, or illegal comments will be removed. News18 may disable any comment at its discretion. By posting, you agree to our Terms of Use and Privacy Policy.
