Latest news with #Cushing's
Int'l Business Times
17-07-2025
- Business
- Int'l Business Times
Kelcie's Horse Treats Champions Thoughtful Innovation to Meet Equine Wellness
In the equestrian world, where horses are cherished partners, what they're fed particularly matters. Owners and trainers understand that a treat isn't a mere reward but a reflection of care, nutrition, and trust. Yet, the market for horse treats has long leaned toward the sugary side, relying on molasses and fillers that may be tasty but far from healthy. Kelcie's Horse Treats, a family-run brand, has emerged after recognizing this gap. Its mission is to create low-sugar, all-natural horse treats that animals and their caretakers can feel good about. Interestingly, the brand's story began with an encounter in a pub in a town in England. That's where Kelcie's founder and CEO, Kevin Nairne, a UK-based corporate professional with a career in IT, met Mary Elizabeth. She's a lifelong horsewoman whose family is deeply embedded in the professional show jumping community. From that moment, Kevin's life shifted. Marrying into a world of saddles, stalls, and showgrounds, he transitioned from technology to the tack room, driven by love and an unexpected passion for horses. The idea behind Kelcie's originated from Mary Elizabeth's observation of the lack of nutritious, clean treats in the market. "Many were loaded with sugar and additives," says Kevin. "They're unsuitable for horses that need to maintain optimal health and performance." The founder then brought his corporate mindset to the table and treated this realization like a business challenge. He formed a think tank of top grooms, veterinarians, and seasoned equestrians, asking one question: "What should the perfect horse treat look like?" The result was Kelcie's Pumpkin Spice Horse Treats. "Even the fussiest horses liked Kelcie's immediately," Kevin shares. "When we tested our first batch with our 25 horses at our home in Wellington, Florida, every single one of them, including the pickiest eater, devoured them instantly. In that moment, we knew we had made something special." The treats are made from 15 carefully selected natural ingredients. Pumpkin was chosen as the main ingredient because of its digestive qualities, turmeric for its anti-inflammatory properties, and anise were added to increase the palatability. Independently laboratory tested, the treats contain less than 9% (non-structural carbohydrates) sugar , making them ideal for horses with Cushing's and other sugar sensitivities. The treats undergo a unique extrusion process, which optimizes digestion and nutrient absorption, enhances shelf life, and prevents mold. Kelcie's Horse Treats Developed with sport horses in mind, Kelcie's products give every horse owner peace of mind, from spirited ponies to retired companions. "Our treats have no preservatives, no artificial additives, just fresh ingredients that are sourced and manufactured in the U.S. that support digestion, healthy coats, energy, and overall wellness," Kevin emphasizes. From its humble beginnings, Kelcie's took bold steps to establish itself. It partnered with a traveling showcase retailer to exclusively launch the brand at major US horse shows for several months. It put the treats directly in front of trainers, riders, and grooms at the heart of competitive circuits, resulting in immediate traction. Then the pandemic happened. While many businesses faltered, Kelcie's remained agile. Early traction and strong word of mouth carried the brand through. It shifted to online distribution and later secured a game-changing agreement with a leading distributor, allowing it to scale while preserving its handcrafted approach. Kevin's background in business was crucial. While he had no experience in equine nutrition at the start, his ability to build relationships, solve problems, and focus on quality helped Kelcie's grow. He brought the same attention to product development that he once applied to corporate solutions, insisting on nothing less than the best. Laura Kraut, a leading figure in international show jumping, whose Olympic pedigree speaks volumes, endorses Kelcie's personally , noting that even her most accomplished horses love the treats. That kind of recommendation doesn't come lightly. The reviews echo her sentiment. One shared: "She's a picky treat eater, which seems silly, but she enjoyed these [Kelcie's treats]. I was pleased with the ingredients, so it felt like a win-win." Another customer, writing about a rescue horse recovering from trauma, said, "I bought these for my sister's horse, Tamarindo, who is a rescue recovering from burns that previous owners inflicted on him. These treats have been great at gaining his trust while providing health benefits as well." With this reputation, it's hardly surprising that Kelcie's influence has expanded to the national stage. The brand has been named a participating sponsor for Wellington International, an event connected to Wellington's winter equestrian season, a prestigious event that attracts the best in the sport. Kelcie's aims to grow its legacy in the equestrian world. With a commitment to health, a personal story rooted in love and instinct, and a bold vision for what horses deserve, the brand continues to redefine how the industry thinks about horse treats.
Yahoo
11-07-2025
- Business
- Yahoo
Crinetics Pharmaceuticals to Report Second Quarter 2025 Financial Results on August 7, 2025
SAN DIEGO, July 11, 2025 (GLOBE NEWSWIRE) -- Crinetics Pharmaceuticals, Inc. (Nasdaq: CRNX) today announced that it will report second quarter 2025 financial results on Thursday, August 7, 2025 after the market closes. Company management will host a conference call at 4:30 p.m. ET to discuss financial results and provide a business update. Conference Call & Webcast Thursday, August 7 @ 4:30 p.m. ET Domestic: 1 833-470-1428 International: 1 404-975-4839 Access Code: 899803 Webcast: Participants can use the dial-in numbers above OR access the live webcast via a direct link (HERE) or by visiting the Events section of the Crinetics website. To ensure a timely connection, it is recommended that participants connect at least 15 minutes prior to the scheduled start of the call. The webcast will be archived on the Investor Relations section of About Crinetics Pharmaceuticals Crinetics Pharmaceuticals is a clinical stage pharmaceutical company focused on the discovery, development, and commercialization of novel therapeutics for endocrine diseases and endocrine-related tumors. Crinetics' lead development candidate, PALSONIFY (paltusotine), is the first investigational once-daily, oral, selective somatostatin receptor type 2 (SST2) nonpeptide agonist that is in clinical development for acromegaly and carcinoid syndrome associated with neuroendocrine tumors. Atumelnant is currently in development for congenital adrenal hyperplasia and ACTH-dependent Cushing's syndrome. All of the company's drug candidates are orally delivered, small molecule, new chemical entities resulting from in-house drug discovery efforts, including additional discovery programs addressing a variety of endocrine conditions such as hyperparathyroidism, polycystic kidney disease, Graves' disease (including thyroid eye disease), diabetes, obesity and GPCR-targeted oncology indications. Investors:Gayathri DiwakarHead of Investor Relationsgdiwakar@ (858) 345-6340 Media: Natalie BadilloHead of Corporate Communications nbadillo@ (858) 345-6075
Time of India
16-06-2025
- Health
- Time of India
Not just sugar: The long-term impacts of Type2 diabetes you cannot afford to ignore
In the blur of busy mornings, endless to-do lists, and late-night dinners, it is easy to brush off the little things—like feeling more tired than usual, needing a second glass of water more often, or barely noticing that a tiny wound is taking its time to heal. These moments slip by unnoticed, folded into the rhythm of everyday life. But sometimes, it is in these small shifts that the body starts to whisper—subtle signs that something deeper may be unfolding beneath the surface. One of the most quietly persistent conditions that often begins this way is diabetes. Common, yes—but far from simple. It affects how the body manages blood sugar, often due to problems with insulin, the hormone that helps move glucose into our cells. When this process falters, sugar builds up in the blood, leading to long-term health issues if left unchecked. There are three main types of diabetes: Type 1 , which usually starts in childhood and needs insulin treatment for life Gestational diabetes , which happens during pregnancy and may go away after child birth Type 2 diabetes , the most common form which often develops in adults and is linked to lifestyle, diet and heredity. But it can also result from secondary causes such as chronic pancreatitis, Cushing's syndrome, or prolonged use of medications like steroids. Prevalence of Type 2 diabetes is rising sharply in India due to shifting lifestyles, poor diets, physical inactivity, and rising obesity. According to the Indian Council of Medical Research (ICMR), over 101 million 1 people currently live with diabetes, and another 136 million 2 are pre-diabetic. The WHO estimates that around 77 million 3 Indian adults specifically have Type 2 diabetes, placing the country among those with the highest global burden. Yet despite these numbers, the condition often develops quietly, with subtle early signs that are easy to overlook. Recognising these signals early is crucial, as the real challenge lies not just in diagnosis, but in preventing the serious long-term risks Type 2 diabetes can bring. To better understand the often-missed signs and why early screening is critical—especially for younger individuals with a family history—we spoke to Dr. Ajay Agarwal , Senior Director, Fortis Hospital, Noida. ' Some early signs include non-specific symptoms like increased thirst, frequent urination, and persistent hunger—even after meals. These form the classic triad of diabetes and should raise concern, particularly in those over 35, ' he said. ' Other indicators may be recurrent urinary infections, visual issues, slow-healing wounds, fatigue, and low energy. ' He stressed that early detection helps prevent serious complications such as kidney disease, retinopathy, and neuropathy , and also makes management simpler. ' While prediabetes can often be reversed with lifestyle changes, full-blown diabetes usually requires multiple medications, which can reduce compliance. Early diagnosis enables easier, more cost-effective treatment and significantly improves long-term outcomes. ' Type 2 diabetes develops gradually and so do its complications. While these health risks may take years to surface, being aware of them early and managing blood sugar effectively, for example, by regularly monitoring at home with a good quality glucometer machine can greatly reduce their impact. Here are some common long-term health concerns linked to unmanaged Type 2 diabetes: Cardiovascular health : Diabetes can increase the risk of heart attacks, strokes, and peripheral artery disease by damaging blood vessels over time. Kidney failure : Chronic high blood sugar can silently lead to end-stage kidney disease, often requiring dialysis or transplant. Nerve damage (Neuropathy) : Starts with numbness or pain in feet and hands and may lead to digestive problems, sexual dysfunction, and even 'silent' heart attacks. Vision loss : Diabetic retinopathy is now one of the leading causes of blindness. Amputations : Poor circulation and nerve damage may cause ulcers and infections that go unnoticed—making diabetes the top cause of non-traumatic limb loss. Other risks : These include cognitive decline, increased risk of infections, and severe fatty liver disease. On the long-term impact of unmanaged diabetes, Dr. Agarwal added, ' Chronic high blood sugar acts like a systemic poison, silently damaging blood vessels and nerves. The complications—from heart disease to kidney failure and diabetic foot—can be life-altering. Prevention of complications starts with early control of Diabetes. ' The good news is that monitoring today doesn't need to be complicated or painful. With the availability of gentle lancing devices, smart glucometer machines , and user-friendly digital tools , people can track their sugar levels easily from home. Highlighting the critical role of monitoring, Dr. Agarwal shared, ' Consistent glucose blood sugar monitoring using RBS (random blood sugar) charting and 3-monthly HbA1c testing is key. It keeps patients motivated and in control, while also giving doctors valuable insights into patients' glycemic profile. ' He further explained the evolving approach in clinical practice, ' We now recommend a 7-point blood sugar profile for many patients, which involves checking blood sugar levels before and after meals, as well as at bedtime. It's great information for the doctor and helps us tailor the treatment. ' Emphasising how monitoring directly informs risk assessment, Dr. Agarwal added, ' A newly diagnosed diabetic with an HbA1c of 10 worries me far more than someone with well-managed diabetes for 20 years and an HbA1c of 7. Regular and structured self-monitoring of blood glucose (SMBG) helps us catch before they escalate. ' Because Type 2 diabetes develops slowly and its complications even more so, prevention and timely care are our most powerful allies. This is where lifestyle plays a crucial role. Eating balanced meals, staying active, maintaining a healthy weight, and blood sugar monitoring regularly—even when asymptomatic—can significantly delay or prevent diabetes. ' Lifestyle changes like losing 5–7% body weight, eating whole foods with fewer refined carbs, and exercising 150 minutes a week can dramatically reduce insulin resistance, ' says Dr. Agarwal. ' In people with a family history of diabetes, these habits, combined with regular monitoring with a glucometer machine at home, can delay or prevent diabetes altogether ', he added. On the importance of early screening, especially for younger adults, Dr. Agarwal stresses, ' For adults in their 30s and 40s with a family history, screening is non-negotiable—even if they feel fine. A simple HbA1c test every 1–3 years can detect issues early. And regardless of results, adopting preventive habits is essential. I would also highlight women with gestational diabetes as a key group. Continuous glucose monitoring and Oral Glucose Tolerance Testing during pregnancy—once at the first consultation and again between 24–28 weeks—can help avoid dangerous complications .' Living with or working to prevent Type 2 diabetes is not about living in fear, but about understanding, care, and the quiet power of small, steady steps. It is a journey shaped not by perfection, but by progress. A journey that begins with staying curious about your health, asking questions, and making mindful choices each day. By approaching this path with patience and compassion, you not only support your own well-being but also create space for a healthier tomorrow for those around you. References - India, there are estimated,developing diabetes in near future).
NDTV
29-05-2025
- Health
- NDTV
9 Causes For Puffiness In The Face
Facial puffiness can be unsettling, whether it greets you in the mirror first thing in the morning or lingers throughout the day. While occasional puffiness is usually harmless, persistent swelling may signal an underlying issue. The face can appear bloated due to various factors including dietary habits, allergies, fluid retention, or even medical conditions. According to the American Academy of Dermatology, changes in the skin or facial volume can often reflect internal health imbalances. Identifying the cause of facial puffiness is key to finding the right solution and restoring your natural glow. Here are 9 common causes you should know about. Causes for facial puffiness Facial puffiness is not just a cosmetic concern, it can be your body's way of asking for attention. Let's look at the top nine culprits behind that bloated or swollen look. 1. Excessive salt intake Consuming too much sodium causes your body to retain water, especially around the eyes and cheeks. This leads to a puffy appearance, especially in the morning. 2. Allergies Allergic reactions can cause inflammation in the face, especially around the eyes and lips. Common triggers include pollen, pet dander, and certain foods or skincare products. 3. Poor sleep quality Lack of restful sleep or irregular sleep cycles can lead to facial swelling and dark circles. Fluid tends to pool under the eyes when lying down too long or not sleeping well. 4. Alcohol consumption Alcohol dehydrates the body and causes inflammation. This can lead to water retention and noticeable swelling in the face, especially the next day after drinking. 5. Hormonal fluctuations Changes in hormones during menstruation, pregnancy, or menopause can result in water retention, which contributes to puffiness in the face. 6. Sinus issues Sinus congestion or infections can lead to swelling in the cheeks, under-eye area, and forehead due to fluid buildup and inflammation. 7. Dehydration Ironically, not drinking enough water can cause your body to hold onto fluids. This results in a swollen look, especially around the eyes and mouth. 8. Medical conditions Conditions like hypothyroidism, Cushing's syndrome, or kidney disease can lead to persistent puffiness due to fluid imbalance or hormonal dysfunction. 9. Facial infections or inflammation Localised infections such as cellulitis or dental abscesses can cause one side of the face to swell, often accompanied by pain or redness. Facial puffiness isn't always just a beauty concern, it may be a subtle cue from your body. While occasional swelling is common, persistent puffiness warrants attention. Monitoring your diet, hydration, and health habits can make a big difference. If symptoms persist, consult a healthcare provider to rule out any underlying condition and receive appropriate treatment. Your face reflects your health, listen closely. Disclaimer: This content including advice provides generic information only. It is in no way a substitute for a qualified medical opinion. Always consult a specialist or your own doctor for more information. NDTV does not claim responsibility for this information.
Newsweek
29-05-2025
- Entertainment
- Newsweek
WWE Superstar Omos Reveals Medical Condition That Nearly Killed Him
Based on facts, either observed and verified firsthand by the reporter, or reported and verified from knowledgeable sources. Newsweek AI is in beta. Translations may contain inaccuracies—please refer to the original content. WWE star Omos, renowned for his towering 7'3" presence, recently shared the story of a life-altering medical condition that was discovered by chance during his college years. He credits the diagnosis with saving his life. In a revealing interview on Insight With Chris Van Vliet, Omos detailed his journey from assuming his rapid growth was normal to facing a critical health crisis. Omos explained his incredible size was never just simple genetics. He recalled being six feet tall by age 11 and shooting up to 6'7" by 13, which he initially thought was just a significant growth spurt. It wasn't until he was playing college basketball in the United States that a doctor's keen observation led to an urgent intervention. Omos recounted the doctor, Dr. Vesely, contacting the university president: "He goes, 'Hey, my name is Dr. Vesely. I saw one of your players, Jordan Omogbehin. By the size of his hands, the size of his jaw, and facial features, I think he might have acromegaly. You need to check him as soon as possible.'" More news: WWE News: Steve Austin Reveals Real-Life Vince McMahon Confrontation Though Omos initially thought it might be a joke, the warning proved gravely serious. An MRI revealed devastating news. "They pull out the MRI and say, 'You have a pituitary tumor. If you don't take it out, either you're going to go blind, or you're going to have a heart attack.' INGLEWOOD, CALIFORNIA - APRIL 02: (L-R) Brock Lesnar wrestles Omos during WrestleMania Goes Hollywood at SoFi Stadium on April 02, 2023 in Inglewood, California. INGLEWOOD, CALIFORNIA - APRIL 02: (L-R) Brock Lesnar wrestles Omos during WrestleMania Goes Hollywood at SoFi Stadium on April 02, 2023 in Inglewood, my body was producing so much growth hormone, it was enlarging my heart. They said, 'We need to get this fixed now,'" Omos shared. He learned he had an unprecedented combination of rare conditions. "It's kind of similar to what Andre the Giant had. It's called acromegaly. Big Show has it as well," Omos explained. "But mine is kind of unique because I have acromegaly, I also have gigantism, and I have partial Cushing's disease. It was the first time in endocrine history that a patient had all three." His case was so unique it was documented in a medical journal. Even today, Omos requires ongoing medical management. "I have to be on meds to stop me from growing, because I still grow. I don't grow this way anymore [taller], but I still grow sideways... So I take medication to stop my body from using the growth hormones so I don't get any bigger." Despite these lifelong challenges, he reports feeling well. "I'm pain-free. I feel great," Omos stated, before underscoring the gravity of the early diagnosis: "But if the doctor hadn't caught it when he did—I would've been dead." He gives full credit to the observant physician: "Shout out to Dr. Vesely. He pretty much saved my life." More WWE News: For more on WWE, head to Newsweek Sports.
