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Al-Ahram Weekly
11-07-2025
- Sport
- Al-Ahram Weekly
Wrestling: Egyptian Olympic medallist Mohamed ‘Kesho' Ibrahim retires - Omni sports
Egyptian Olympic bronze medallist Mohamed 'Kesho' Ibrahim announced his retirement from Wrestling on Friday after a career of dazzling highs and disruptive setbacks. 'After many years of toil, challenges and victories … I have decided to officially announce my retirement,' the 27-year-old wrote in an emotional post on social media. 'Wrestling was more than a sport – it was my life, my passion and my support in the hardest times.' Kesho has not announced any reasons behind this decision, which seems premature, but he has been under the radar since his return from a disappointing campaign in the Paris Olympics. Ibrahim burst onto the global stage in Tokyo, taking bronze in the 67 kg class with a last-gasp win over 2018 world champion Artem Surkov of Russia. The medal ended Egypt's nine-year wrestling drought and drew instant comparisons with Gaber, the Athens 2004 gold-medallist he idolised. He became the 8th Egyptian wrestler to claim an Olympic medal. The road to a second Olympic podium proved turbulent. A dispute with the Egyptian Wrestling Federation sidelined him for about 18 months after Tokyo. He returned in 2023, crashed out in the round of 32 at the world championships and scraped into Paris 2024 by taking bronze at a last-chance qualifier in May. In Paris, his campaign unravelled early with a round-of-16 defeat by Azerbaijan's Hasrat Jafarov. Controversy followed when French police detained him in August 2024 over an allegation that he groped a woman in a bar. Prosecutors dropped the case for lack of evidence, but Egypt's Olympic Committee (EOC) suspended him for breaching team rules by failing to return to camp that night. 'Thank you to every coach who helped me, every teammate who stood by me, and every fan who cheered,' Ibrahim said, adding that wrestling 'taught me to be a man before a champion.' Nicknamed 'The Tank' for his stocky power, Mohamed 'Kesho' Ibrahim took up wrestling at five and rose quickly through Egypt's age-group ranks, piling up nearly 20 continental medals. Guided by the example of his idol Karam Gaber – the 2004 Olympic champion and 2012 silver-medallist – he became the first Egyptian, Arab or African to secure an Olympic berth via the senior world championships when a fifth-place finish in 2019 punched his ticket to Tokyo. Besides his Tokyo medal, Ibrahim won a host of titles, including back-to-back U-23 world titles (2018, 2019), African Championship golds in 2020 and 2023, and the 2024 All-Africa Games crown. (For more sports news and updates, follow Ahram Online Sports on Twitter at @AO_Sports and on Facebook at AhramOnlineSports.) Follow us on: Facebook Instagram Whatsapp Short link:
Medscape
23-06-2025
- Health
- Medscape
Multitasking ctDNA Helps Guide Lymphoma Treatment
Circulating tumor DNA (ctDNA) is gaining ground as an important multitasking tool in the frontline treatment of diffuse large B-cell lymphoma (DLBCL), with key novel applications that include identifying genetic subtypes and guiding the escalation or de-escalation of chemotherapy, new research has shown. 'We have demonstrated that a PET/ctDNA-guided approach in frontline DLBCL is feasible in a multicenter setting,' said first author Anastasios Stathis, MD, of the Clinic of Hematology, Oncology Institute of Southern Switzerland, EOC, Bellinzona, Switzerland, in presenting the findings at the 18th International Conference on Malignant Lymphoma (ICML) 2025 in Lugano, Switzerland. 'The allocation of patients and treatment based on the combined results of PET and ctDNA is operationally successful,' he said. The findings are from the preliminary results of the phase 2 SAKK 38/19 trial, which focuses on the goal of identifying patients with key MCD genetic subtypes that are known to respond poorly to the standard of care of R-CHOP (rituximab + cyclophosphamide, doxorubicin hydrochloride [hydroxydaunomycin], vincristine [Oncovin], prednisone) chemotherapy, and who may be more successfully treated with the addition of a Bruton tyrosine kinase inhibitor such as acalabrutinib. 'The most important aspect of this study is the novelty of using ctDNA as a tool to identify a genetic subtype of DLBCL prior to treatment for the purpose of treating that cohort differently precision medicine,' said Mark Roschewski, MD, a senior clinician with the Center for Cancer Research, National Institutes of Health in Bethesda, Maryland, who was a discussant for the study, in comments to Medscape Medical News . Importantly, there are currently no diagnostic assays available to identify the genetic details of a tumor in DLBCL prior to therapy, which can be so crucial in determining a treatment plan, Roschewski explained. 'We know a lot about the complexity of DLBCL genetics, but the information is not actionable because it is such a challenge to get that information prior to therapy,' he said. 'As such, this information is only available after therapy is over and mostly only reported in clinical trials.' For the study, conducted at 16 sites in Switzerland and 3 in Italy, the authors were able to utilize ctDNA to identify patients with the MCD subtype because of its ability to detect the two mutations known to be present in MCD: MYD88 and CD79B . Among 230 treatment-naive patients with CD20-positive DLBCL screened for the trial, 194 patients (88.2%) had detectable ctDNA, and 35 (15.9%) had the MYD88 and/or CD79B mutations. Importantly, the turnaround time for the genetic profiling with ctDNA results among 124 patients in the full analysis set (after screening failures and other exclusions) was only 9 days, and the median time to start treatment was just 15 days. 'These timelines clearly show the operational feasibility of such an approach,' Stathis said. Overall, in the full analysis set, 72.6% of patients had advanced disease (stages III-IV), and 64.5% had extra-nodal involvement. With 96 patients excluded due to screening failure, 124 patients were included in the full analysis, and all that were found to have MYD88 and/or CD79B mutations (27; 21.8%) were assigned to receive frontline therapy with acalabrutinib plus six cycles of R-CHOP in a group allocated as cohort A. Treatment Escalation, De-Escalation Of the remaining 97 patients who did not have the mutations, all were started on two cycles of R-CHOP and then evaluated with ctDNA and PET to guide treatment escalation or de-escalation on the basis of one of three treatment strategies corresponding to their ctDNA/PET results. Overall, 6.5% of patients (n = 8) were found to be PET and ctDNA-positive after the two cycles and were therefore allocated to escalation of therapy to four more R-CHOP cycles plus acalabrutinib, followed by 2 months of acalabrutinib (cohort B). About 30.6% of patients (n = 38) were ctDNA and PET-negative and therefore had their therapy de-escalated, receiving only two more R-CHOP cycles plus two rituximab doses (cohort C). About 36.5% of patients (n = 44) were either PET or ctDNA-positive after the two cycles and were allocated to receive four more R-CHOP cycles (cohort D). Preliminary Results Preliminary results including PET and ctDNA responses show that at the end of therapy, the majority of patients remained ctDNA-negative (79.8% overall), with 7.3% ctDNA-positive and data missing on 12.9% of patients. Having detectable ctDNA at baseline significantly correlated with factors including the International Prognostic Index (IPI), bulky disease, and PET imaging parameters that indicated a poorer prognosis, including higher metabolic tumor volume (MTV) and total lesion glycolysis (TLG). While the numbers were small, higher PET scores (indicative of worse prognosis) at the end of treatment (Deauville 4 or 5) correlated with ctDNA positivity, with the ctDNA positivity rate of only 2.6% among 78 patients with lower Deauville scores of 1-3. Notably, ctDNA negativity at the end of two cycles of R-CHOP showed only a nonsignificant trend in being associated with end-of-treatment negative PET scores. The only factors found to be predictors of positive PET imaging at the end of treatment included high baseline MTV and TLG ( P = .013 and P = .026, respectively), with no association between baseline ctDNA, IPI, or other factors. Further commenting on the study during his discussion at the meeting, Roschewski agreed that the discrepancies with ctDNA and PET scan results were a limitation. 'We need to have more information on to understand why was there such a discordance in things that we typically think go in the same direction,' he said. However, 'the quantitative level of baseline ctDNA in the study correlated quite nicely with tumor burden as measured by PET scan high-risk features such as IPI.' 'But using it in a more nuanced way, this also was one of the first trials that showed us that you could actually risk stratify the patients based on the mutation profiling from ctDNA, and that was successful in 88% of the patients, and the turnaround time was only 9 days.' Roschewski noted that key additional studies are also looking at the addition of acalabrutinib to R-CHOP through different trial designs, including the ESCALADE trial, and a study Roschewski and his own team are also conducting looking at molecular profiles of patients who do and do not respond to acalabrutinib. Ultimately, 'the main barrier to precision medicine in large lymphoma remains genetic heterogeneity, and we need to continue to find novel ways to overcome that barrier,' he said.
Time of India
18-06-2025
- Business
- Time of India
Interpol notice against couple for investment fraud
Panaji: A Red Corner Notice through Interpol, based on a request by the Goa police, has been issued against fraud accused Myron Rodrigues and his wife Deepali Parab. Both have been booked by the economic offences cell (EOC) police station, Panaji, for defrauding several investors. Myron and Deepali have been named prime accused in the fraud and offences had been registered against them under the Goa Protection of Interests of Depositors Act. A chargesheet in the matter was filed on Feb 25 this year before the principal district and sessions court, Margao, by EOC. Earlier, to help apprehend Myron, a Blue Corner Notice had been issued, but he could not be apprehended. A Red Corner Notice was published on May 19 by Interpol. The crime branch has also already filed two chargesheets in this case against the two accused. More chargesheets are likely soon against a third accused, Sunita Rodrigues. Myron and Deepali allegedly cheated people, mostly from the Salcete taluka, to the tune of over Rs 100 crore under the pretext of offering lucrative returns on their investments in the share market. The EOC added five more names in connection with another case involving directors of real estate companies. by Taboola by Taboola Sponsored Links Sponsored Links Promoted Links Promoted Links You May Like 5 Books Warren Buffett Wants You to Read In 2025 Blinkist: Warren Buffett's Reading List Undo On Aug 11, 2023, the EOC received a complaint from Ivon Suresh Joaquim Almeida, a resident of Navelim, Salcete, against Myron and Deepali, both residents of Kirbhat, Nuvem. The couple was accused of duping and cheating the complainant to the tune of over Rs 36 lakh under the pretext of investing his money in the share market, by offering lucrative returns, and misappropriating the complainant's money for their own use. Subsequently, on Aug 30, 2023, the EOC registered another first information report after receiving more complaints against the same accused for duping and cheating investors to the tune of over Rs 20 crore.
Yahoo
10-06-2025
- General
- Yahoo
When are STAAR results released 2025? How Texas high school students can check
High school students in the Lone Star State can now view their STAAR results from this spring. On Tuesday, the Texas Education Agency (TEA) released end-of-course assessment data from the State of Texas Assessments of Academic Readiness (STAAR). While students begin taking STAAR exams in third grade, the high school-level tests are subject-specific and typically taken after a student completes the corresponding course. While the STAAR results for students in grades three through eight aren't available yet, those for high school students are. Here's how to check them. People are also reading: Texas, Austin high school students gained in math, declined in English on STAAR test The spring 2025 results for the STAAR End-of-Course (EOC) assessments were released on Tuesday, June 10. TEA provides the following steps to view a student's STAAR scores: Log in to your district's parent portal. Click the link to your district's parent portal page to access STAAR results. Learn more about the STAAR results, including how each test question was answered, and find personalized resources to support learning at home. At the beginning of the next school year, STAAR results can be discussed with teachers to determine the best ways to support learning and academic growth. STAAR results can be viewed via the Texas Assessment site or at The District Family Portal uses a Single Sign-On (SSO) requiring the student's unique access code, date of birth, and first name. More on STAAR: Bill to eliminate STAAR, reshape Texas school testing on path to legislative death The STAAR results for students in grades three through eight will be available on Tuesday, June 17, according to TEA. This article originally appeared on Austin American-Statesman: STAAR test results: How to view Spring 2025 Texas high school scores
Yahoo
03-06-2025
- Climate
- Yahoo
Allegan County: Damage from storms is $2.2 million
ALLEGAN, Mich. (WOOD) — Allegan County's emergency management agency says its preliminary assessment has estimated some $2.2 million in damage caused by the severe storm that spawned two tornadoes in the county last week. NWS confirms 2 tornadoes in Allegan County on Thursday The county's Emergency Operations Center put together the preliminary assessment to submit to the office of Gov. Gretchen Whitmer, who may decide whether to issue a state emergency or disaster declaration. If issued, a state or federal disaster declaration would open up access to resources for recovery. The county already declared a local state of emergency. The EOC says it found $440,000 in direct expenses and damage to local government property that fall under Michigan State Police administrative rules for possible reimbursement. Allegan County community reacts to state of emergency The National Weather Service has confirmed two EF1 tornadoes touched down in Allegan County on the night of May 15. One was in the Martin area and the other was near the Sandy Pines campground. As of Wednesday, the EOC said it was not aware of any federal financial assistance for businesses or residents with property damage. It advised people to contact their insurance company. Additional resources may be available by calling 211 or through the American Red Cross, which is reachable at (733.27677). The tornado that marched through Martin sent trees crashing down, damaged some homes and knocked out power for days. 'Trees across the road,' street commissioner Rick Martin said. 'You couldn't go in or out of Martin at 11 p.m., 12 p.m.' He estimated cleanup costs at $250,000 — but said it will end up being less than that because neighbors, people who grew up there, friends and family have stepped up. Neighbor David Cheeseman said he saw it firsthand. 'In the middle of the night, neighbors were out helping clean things up,' Cheeseman said. 'The whole town's been that way. I've always liked it here, but now I love it.' Cheeseman planted a tree before he even closed on his Martin home 20 years ago. It has grown taller and taller as the years have passed and as he built a life there. Now, that special tree will soon come down after it was rocked by the tornado. 'It was 30 feet tall until Thursday night,' he said. Cheeseman said the governor declaring a disaster and offering access to more resources for recovery could be helpful. 'There are people that are going to need help for sure,' he said. While the street commissioner also said the extra help would be beneficial, he again praised his community. 'Any help that comes along, we're not going to turn it down by any means,' he said. 'But the community here has cleaned it up. You talk to anybody, it's family. It's just the way it is.' Crews are trying to finish cleanup before Monday's annual Memorial Day parade through Martin, which includes veterans, the high school band and tractors. It's a priority for the village to keep the parade on. 'It's a goal of the (department of public works), the village of Martin to have this to make sure life goes on,' the street commissioner said. Copyright 2025 Nexstar Media, Inc. All rights reserved. This material may not be published, broadcast, rewritten, or redistributed.
