Latest news with #EliLilly
Yahoo
4 hours ago
- Business
- Yahoo
Citi Expresses Optimism for Eli Lilly and Company (LLY)
Eli Lilly and Company (NYSE:LLY) is one of the 13 Best Long Term Growth Stocks to Invest in Right Now. On June 25, Citi reported that 'compelling' data shows that Eli Lilly and Company (NYSE:LLY) and Novo Nordisk (NVO) have turned obesity into a treatable disease from a lifestyle-based condition. The firm models more than $40 billion in obesity sales by 2030, well above the consensus estimates of $25 billion. Citi stated that as the obesity space evolves from injectables to convenient orals, such as orforglipron, the emergence of a 'dynamic' consumer-centric market is possible, and LillyDirect by Eli Lilly and Company (NYSE:LLY) is well-positioned to connect high consumer visibility for orforglipron with global access. In a research note, Citi further stated that it estimated penetration rates via income-based tiers for pricing and out-of-pocket costs in low- and mid-body mass index patients. The results place Eli Lilly and Company's (NYSE:LLY) consumer platform opportunity at $15B, which is not assumed in the firm's model. It thus believes that Eli Lilly and Company's (NYSE:LLY) is in a position to expedite access outside the US, employing a centralized out-of-pocket payment model instead of the traditional country-by-country launch. It contended that an 'income-based tiered pricing of orforglipron via LillyDirect could unlock unprecedented volume, all the while allowing it to maintain overall pricing power.' Eli Lilly and Company (NYSE:LLY) develops, manufactures, discovers, and sells pharmaceutical products. These products span oncology, diabetes, immunology, neuroscience, and other therapies. Investors are bullish on Eli Lilly and Company (NYSE:LLY) due to its in-demand GLP-1 drugs, used to treat diabetes and obesity, which are still in their early growth stages, and the company's strong financials. While we acknowledge the potential of LKQ as an investment, we believe certain AI stocks offer greater upside potential and carry less downside risk. If you're looking for an extremely undervalued AI stock that also stands to benefit significantly from Trump-era tariffs and the onshoring trend, see our free report on the best short-term AI stock. READ NEXT: The Best and Worst Dow Stocks for the Next 12 Months and 10 Unstoppable Stocks That Could Double Your Money. Disclosure: None. Sign in to access your portfolio
India Today
8 hours ago
- Health
- India Today
Endocrinologist Dr. Ambrish Mithal on the happy side-effects of weight-loss drugs
New-age weight-loss drugs are exploding the pharmaceutical market, offering better results than traditional medicines. Top endocrinologist Dr. Ambrish Mithal deconstructs the many facets, including side-effects, of these GLP-1 drugs in his recently published book The Weight Loss Revolution, in an episode of India Today's said that while the GLP-1 field -- drugs that belong to the class of GLP-1 targeting the same hormone in the body -- is just beginning to explode, there'll be many newer drugs with less and less side effects and easier to most cases have shown muscle loss as a prominent result of using GLP-1 medications like tirzepatide or semaglutide, Dr. Mithal explains that losing muscle is an accompanying factor to weight loss. "In the long run, if you're not following a healthy diet, you will end up with significant muscle loss. And this is not because of the weight-loss drugs. Whenever we lose weight, we also lose muscle. If you lose 10 kg, you've lost 2-3 kg of muscle. Now, if you want to preserve that, you have to ensure adequate protein and fibre in your diet. Along with that, you have to make sure that you're exercising regularly and that exercise should include strength training," Dr. Mithal also shared what many people experience loose skin after taking these medicines. "When you lose weight rapidly, you lose subcutaneous fat. Particularly in older people where skin tends to sag anyway. If you suddenly lose weight, don't hydrate yourself well, not eating the right kind of balanced diet, then you get that little sagging on the face which people have started calling Ozempic face. Before these drugs came into the market, anyone we put on a very strict diet or someone who had bariatric surgery would see similar results," he gastrointestinal side-effects, nausea, and vomiting, Dr. Mithal addressed concerns about thyroid cancer, highlighting that there's no evidence to link the also explained the "happy side-effects" of GLP-1 medications. Besides growing body of evidence suggesting how semaglutide is linked to Alzheimer's disease, Dr. Mithal said that the benefits of the drugs are moving beyond weight loss."The evidence that they might be helping Alzheimer's by helping obesity in the brain may actually be very exciting, and even for cardiac health, Parkinson's disease. Cardiac events are reduced. Fatty liver is reduced. Kidney disease progression is reduced. But the brain effects are particularly fascinating. Sleep apnea has also gone down," he said, adding that the drugs have also helped improve fertility outcomes in women with PCOS (Polycystic Ovary Syndrome).Currently, most GLP-1 drugs are injectable and expensive, limiting their access in India. However, new formulations and more research are on the way. Novo Nordisk's Wegovy and Eli Lilly's Mounjaro, two blockbuster fat-busting medicines, are set to gain ground in India to tackle the diabetes and obesity crisis."Remember, the GLP-1 field is just beginning to explode. There'll be many newer drugs with less and less side effects and easier to use," Dr. Mithal sayssaid.- EndsMust Watch
Indian Express
12 hours ago
- Health
- Indian Express
How GLP-1 drugs like semaglutide have revolutionised obesity treatment
Danish pharmaceutical giant Novo Nordisk launched its blockbuster weight-loss injectable semaglutide earlier this week, months after its competitor Eli Lilly's tirzepatide hit Indian markets — and nearly four years after these GLP-1 therapies took the United States by storm. The bottom line is this: these drugs have been shown to be extremely effective for weight-loss, helping people lose 15% to 20% of their body weight, equivalent to what they would otherwise lose with bariatric surgeries. Additionally, they have been found to be effective or are being studied for a host of other conditions, including cardiovascular diseases, kidney disease, non-alcoholic fatty liver disease, and obstructive sleep apnoea. It has also been reported that people on these drugs end up making significant dietary changes, consuming smaller, healthier meals. So how do these 'miracle drugs' work? How were they discovered? And what are other benefits of these drugs? Both semaglutide and tirzepatide belong to a new class of medicines called GLP-1 (glucagon-like peptide-1) receptor agonists. They are prescribed for the management of type-2 diabetes and obesity. These drugs mimic certain naturally-occurring gut hormones called incretins (GLP-1 is one such incretin) produced in the small intestine, and are hence also known as incretin mimicker. They work by: 🔴 improving the secretion of insulin that allows more of the glucose in the bloodstream to enter cells where it can be used for energy; 🔴 inhibiting the secretion of the hormone glucagon that stimulates the liver to release stored glucose into the bloodstream; 🔴 slowing down the emptying of the stomach so that the glucose levels in the bloodstream doesn't spike; and 🔴 reducing appetite by signalling to the brain that one is satiated. Semaglutide and tirzepatide both mimic the action of GLP-1. Tirzepatide additionally also mimics the action of another hormone called glucose-dependent insulinotropic polypeptide (GIP). While incretins were known as early as 1906, research into these gut hormones was overshadowed by the discovery of insulin in 1921. The substance produced by the pancreas has been used to manage diabetes for the past century. Interest in incretins was renewed in the 1960s after several studies showed that oral intake of glucose led to more insulin secretion than intravenously given glucose — demonstrating that the gut makes hormones that regulate insulin and glucose levels. GLP-1 became the first incretin to be discovered in 1986. Trials in the 1990s showed that GLP-1 infusion significantly increased insulin levels and lowered glucose levels in diabetic patients. But there was a problem: GLP-1 was not a very stable compound. This is where Novo Nordisk stepped in. While the pharma giant was primarily looking for a diabetes therapy, researchers believed GLP-1 drugs could also be used to treat obesity given that transplantation of some glucagon-producing tumours in animals caused profound anorexia. Novo Nordisk's first GLP-1 medicine was the daily-injectable liraglutide. Trial participants, however, experienced severe nausea, and when the doses were reduced, the efficacy suffered. But the trials found that nausea could be somewhat mitigated by starting at a lower dose and then gradually titrating up — a method still followed for both semaglutide and tirzepatide. The search for a once-weekly injectable eventually led to the discovery of semaglutide. This also proved to be much more effective than liraglutide for weight loss: those on semaglutide lost up to 15% of their body weight compared to 5% on liraglutide. This led to further clinical trials to look into the drug's weight loss effects. While it was already seeing off-label use for this purpose, semaglutide finally received approval for obesity management from the US regulator in 2021. In addition to the 15% average weight loss, trials with semaglutide have demonstrated its ability to reduce the risk of major cardiovascular events (such as heart attacks and strokes) by 20%, and the risk of all-cause mortality by 19%. Studies have shown a 69% reduction in heart failure events. There is also evidence that the drug can resolve fatty buildup in the liver in 63% of patients and improve liver fibrosis — the hardening of liver tissue due to fatty deposits — in 37% of cases. Tirzepatide, which uses an additional target gastric inhibitory polypeptide (GIP), has been shown to lead to a weight-loss of up to 20% of the body weight. The medicine was also approved for the treatment of obesity-related obstructive sleep apnoea — a condition where a person's breathing stops and starts while they sleep. Trials have also shown that it can improve lipid profile, and demonstrated a 20% reduction in the risk of cardiovascular as well as all cause death. 'There is no doubt that the medicines are effective for kidney and heart conditions. There is also evidence that has emerged about fatty liver disease. But, what I am most excited about are the happy neurological side effects. There seems to be some evidence to show that the medicines are associated with lower risk of Alzheimer's and other dementia,' Dr Ambrish Mithal, chairman of endocrinology and diabetes at Max Healthcare, told The Indian Express. He added: 'Importantly, these drugs have reduced cravings in people. They are not only eating smaller meals but also healthier ones. Sweet cravings have gone down. There is also evidence to show that it helps with alcohol addiction.' Bolstered by the success of semaglutide and tirzepatide, several other drugs are now in the pipeline. 'There are a lot of drugs that are in the pipeline, including drugs with once-a-month dosing instead of every week and very effective oral pills,' Dr Mithal said. Trials are ongoing for drugs such as retatrutide that uses three targets: GLP-1RA and GIP used by its predecessor tirzepatide along with glucagon. There is also CagriSema that uses two targets GLP-1 RA and a new Amylin receptor agonist. Oral GLP-1 drugs such as orforglipron and danulipron may soon be available as well. Two other drugs, which use two targets GLP-1 RA and glucagon — Survodutide and Mazdutide are also in phase 3 clinical trials. Anonna Dutt is a Principal Correspondent who writes primarily on health at the Indian Express. She reports on myriad topics ranging from the growing burden of non-communicable diseases such as diabetes and hypertension to the problems with pervasive infectious conditions. She reported on the government's management of the Covid-19 pandemic and closely followed the vaccination programme. Her stories have resulted in the city government investing in high-end tests for the poor and acknowledging errors in their official reports. Dutt also takes a keen interest in the country's space programme and has written on key missions like Chandrayaan 2 and 3, Aditya L1, and Gaganyaan. She was among the first batch of eleven media fellows with RBM Partnership to End Malaria. She was also selected to participate in the short-term programme on early childhood reporting at Columbia University's Dart Centre. Dutt has a Bachelor's Degree from the Symbiosis Institute of Media and Communication, Pune and a PG Diploma from the Asian College of Journalism, Chennai. She started her reporting career with the Hindustan Times. When not at work, she tries to appease the Duolingo owl with her French skills and sometimes takes to the dance floor. ... Read More
Yahoo
12 hours ago
- Business
- Yahoo
Why This Weight Loss Drug Company's Stock Surged Today
Investors are optimistic about the initiation of a phase 3 trial for a weight loss drug from Viking Therapeutics. The real value in the biopharmaceutical company may lie in the oral formulation of the drug. 10 stocks we like better than Viking Therapeutics › Shares in biopharmaceutical company Viking Therapeutics (NASDAQ: VKTX) were up by 6.3% at 12:30 a.m. ET today. The move likely stems from the market digesting the previous day's news that Viking had initiated a phase 3 trial of its most promising program in its pipeline, namely VK2375, a treatment for metabolic disorders, including obesity. There are probably two key reasons why the market likes the initiation of a phase 3 trial: VK2375 is a dual GLP-1/GIP receptor agonist similar to Eli Lilly's blockbuster weight loss drug Zepbound. Viking is developing VK2375 in both subcutaneous (under the skin) and oral formulations. The subcutaneous phase 3 trial is currently underway, while the phase 2 oral dosing trial results are expected to be released later this year. For reference, Novo Nordisk also offers a highly successful weight loss drug, Wegovy, a GLP-1 receptor agonist. While Viking Therapeutics, with a $3.2 billion market capitalization, will face challenges in competing with Eli Lilly's Zepbound unless it can demonstrate superior efficacy in the phase 3 trial, the real value in the business may lie in the oral formulation. There are obvious convenience and accessibility advantages to an oral formulation over a subcutaneous one, and a successful phase 2 trial may encourage a much larger pharmaceutical company to consider acquiring the company to take it through phase 3. As such, look out for the phase 2 results later in the year. In addition, note that Novo Nordisk has submitted to the FDA for approval of an oral formulation of Wegovy , and Eli Lilly recently reported positive results in a phase 3 trial for an oral GLP-1 agonist, orforglipron. All this means that the field is getting crowded. Before you buy stock in Viking Therapeutics, consider this: The Motley Fool Stock Advisor analyst team just identified what they believe are the for investors to buy now… and Viking Therapeutics wasn't one of them. The 10 stocks that made the cut could produce monster returns in the coming years. Consider when Netflix made this list on December 17, 2004... if you invested $1,000 at the time of our recommendation, you'd have $687,731!* Or when Nvidia made this list on April 15, 2005... if you invested $1,000 at the time of our recommendation, you'd have $945,846!* Now, it's worth noting Stock Advisor's total average return is 818% — a market-crushing outperformance compared to 175% for the S&P 500. Don't miss out on the latest top 10 list, available when you join . See the 10 stocks » *Stock Advisor returns as of June 23, 2025 Lee Samaha has no position in any of the stocks mentioned. The Motley Fool recommends Novo Nordisk and Viking Therapeutics. The Motley Fool has a disclosure policy. Why This Weight Loss Drug Company's Stock Surged Today was originally published by The Motley Fool Erreur lors de la récupération des données Connectez-vous pour accéder à votre portefeuille Erreur lors de la récupération des données Erreur lors de la récupération des données Erreur lors de la récupération des données Erreur lors de la récupération des données
Daily Mail
16 hours ago
- Health
- Daily Mail
ANNE ASHWORTH asks if it's worth investing in weight-loss drugs
There is a bottomless appetite for news about weight-loss drugs. We cannot hear enough about the celebrities, politicians and tycoons – including Elon Musk, Boris Johnson, Sharon Osbourne and Oprah Winfrey – who have used Ozempic or Mounjaro. In Britain, such has been the increase in uptake of these GLP-1 drugs that supermarket sales are shrinking. Sometimes this kind of coverage can have a wider message for investors. Public figures' reliance on 'fat jabs' underlines the forecast that the global market for these products could grow from the current $30billion (£22.4billion) to more than $150billion by the end of the decade, as millions seek a route out of obesity. So could you add weight to your portfolio by taking a slice of Eli Lilly, the US maker of Mounjaro, which is now being prescribed by GPs? Or should you opt for Novo Nordisk, the Danish giant that produced blockbuster brands Ozempic and Wegovy? An opportunity could lie in the weakness of shares of these ground-breaking businesses. Over the past year, Eli Lilly is down 13 per cent and Novo Nordisk has tumbled by 53 per cent. Will James, manager of the Guinness European Equity Income Fund, says: 'Novo Nordisk has been in the eye of the storm of late and its fall from grace has been impressive.' The two companies are battling not only against each other, but also with rival start-ups against a tense political background in the US. This is the largest market for weight-loss drugs, but US health secretary Robert F Kennedy Jr is not a fan. He wants to drive down the cost of all drugs. But he also believes that overeating is not the prime cause of obesity. He said: 'American kids did not suddenly get gluttonous and lazy – something is poisoning them.' Kennedy points the finger at the food companies. Although his assertions may not have any basis in fact, firms in this industry are already concerned about the impact of fat jabs on eating habits. The consultancy company Kantar says that lower supermarket sales have coincided with increased uptake of GLP-1 treatments. A year ago, 2.3 per cent of UK households had one member using GLP-1. It now stands at 4.1 per cent. NOVO NORDISK A bet on Novo Nordisk is a gamble on a corporate comeback. Almost exactly a year ago, the shares – priced in DKK, or Danish krone – were at their peak of Kr.1,208, against Kr.441. The pharmaceutical giant, set up a century ago, was greater in size than the Danish economy, and had become what James describes as 'the flag bearer for Europe's sometimes-doubted ability to innovate'. Today, Novo Nordisk looks more vulnerable than all-conquering. So much so that the activist hedge fund Parvus Asset Management has been amassing a stake, presumably to force a shake-up. Also pressing for change is the largest shareholder, the Novo Foundation. This follows the unseating in May of Novo Nordisk's chief executive Lars Fruergaard Jorgensen, only the fifth person to have held this role in the company's history. His departure was spurred by Eli Lilly's rapid seizure of market share in the US, where Mounjaro is the most-prescribed drug. Novo Nordisk remains the global leader, however. The problems began last year when Novo Nordisk could not satisfy demand for its drugs, leading to a damaging surge in 'compounding'. Under this arrangement, pharmacies can mix cheap copycat versions of drugs: the customers of US online telehealth companies, such as Hims & Hers Health, proved to be more than keen on 'Ozempic dupes'. The situation was exacerbated by the poor performance in a trial of new weight-loss treatment CagriSema. But Novo Nordisk is trying to shift the perception of the drug with its additional cardiovascular benefits. Meanwhile, Amycretin, another new-generation drug, appears to be delivering results superior to Mounjaro. Amycretin is administered as a once-weekly injection and a daily pill. A few months ago there may have been speculation that Novo Nordisk could turn out to be the pharmaceutical equivalent of MySpace – the pre-eminent social media site that sank into obscurity when Facebook emerged. However, in recent weeks the pessimism surrounding the company has lessened. James says: 'This is a high-quality, high-return business with an impressive track record of success and improving people's lives.' The shares are on a p/e ratio (a guide to value) of 17 times earnings. At the height of Novo Nordisk's hype, this was 40 times. This upbeat assessment is shared by brokers. In the past few days, Barclays, Deutsche, JP Morgan and UBS have reiterated their 'buy' recommendations. ELI LILLY Eli Lilly might be best known for Mounjaro, but its pipeline includes cancer and diabetes drugs and products for Alzheimer's and Crohn's disease. Established in 1876, it has also just snapped up the gene-editing start-up Verve Therapeutics for $1.3billion as a way to expand beyond weight-loss drugs, while making the most of its expertise in this area. If approval is forthcoming, Eli Lilly plans to launch Orforglipron, a once-a-day pill, next year. This represents considerable progress for a business once most-closely associated with the anxiety medication Prozac, which is no longer manufactured. The scope of Eli Lilly's range evidently inspires confidence, since 17 of the 29 analysts that follow the company rate the shares a buy with an average target price of $951, against the current $780. Putting some money into Eli Lilly and Novo Nordisk makes sense if you are diversifying your portfolio this summer and want to invest in innovation. However, both Novo Nordisk and Eli Lilly face huge competition, with about 150 rival products in development. Not all are guaranteed immediate success. This week, for example, shares in the US pharmaceutical company Amgen slipped by 6 per cent on news that its MariTide weight-loss injectable caused vomiting. Novo Nordisk is one of the top ten holdings at the giant Fundsmith fund. However, its portfolio no longer includes the drinks group Diageo, in a wider shift triggered by the impact of weight-loss drugs. Companies such as Associated British Foods, McDonald's, Mondelez, Nestle, PepsiCo, Tate & Lyle and Unilever are aware of the need to adapt as consumers move away from alcohol, confectionery, fizzy drinks and snacks. They must shape up for the fat-jab age – or face investors' ire.
