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Indian Express
7 days ago
- Health
- Indian Express
‘If your hospital's doctor prescribed recombinant factor, that's what patient should get': HC pull up govt
Since 2023, 37-year old Mukul Gandhi, a hemophilia patient in Delhi, has been rushing to Jaipur to get a dose of recombinant factor drug. Exasperated, he, along with a few other hemophilia patients, moved the Delhi High Court last November. Eight months on, the Delhi government, on July 14, assured the HC that it will proactively ensure that adequate stock of recombinant factor injections are made available in the Capital's hospitals. It also directed the government 'to ensure that adequate numbers of haematologists are recruited and deployed in hospitals run by GNCTD to attend to the patients'. Gandhi was diagnosed at AIIMS New Delhi with hemophilia when he was three years old – a cut during his mundan ceremony had resulted in incessant bleeding. While crossing paths with others in a similar situation, his parents came to know of an NGO that ensures availability of fresh frozen plasma (FFP) for hemophilia patients, the prevalent therapy at the time. Over time, the more advanced therapy of recombinant factor, also known as Antihemophilic Factor (AHF), was introduced and made available as therapy for hemophilia patients in India. Speaking to The Indian Express, Gandhi said, 'Between 2013 and 2019, government hospitals in Delhi were administering recombinant factor therapy. However, after 2019, we started seeing irregular availability of recombinant factor – held to be scientifically more efficacious than plasma… Many government hospitals started seeing plasma-derived factors being made available instead.' 'We would also suffer side effects of the plasma therapy, such as nausea and nose bleed. By 2023, we started witnessing an acute shortage of the recombinant factor therapy in Delhi's government hospitals. Twice a week, I would take a bus from Dhaula Kuan to Jaipur, which was offering a variety of recombinant factor therapies. While the recombinant factor therapy is easily available in tier 2 and 3 cities such as Jaipur and Haridwar, it is not available in the National Capital,' he added. On July 14, the Delhi government, while admitting to have witnessed a supply shortage of the recombinant factor therapy, brought two experts to the HC – State Blood Cell officer Dr Seema Kapoor and Hemophilia in charge Dr Sunita Aggarwal at Lok Nayak Hospital. They impressed before Justice Datta that from their experience, they have seen 'no difference in efficacy between recombinant or plasma… techniques are so much developed that efficacy is same'. Justice Datta, however, countered, 'I would generally accept what you have to say. But the court's concern is only one, when doctors prescribe recombinant, it should be available… if your hospital's doctor has prescribed recombinant factor, then that's what the patient should get… The court isn't competent to get into this but only thing is if recombinant is prescribed it should be available.' The government then informed the HC that 'currently, there are adequate stocks of recombinant factor injections'. It went on to assure that 'proactive efforts shall continue to be made to ensure that there is adequate stock of recombinant factor injections in future as well'. However, Gandhi – represented by advocate Amit Khanna –pointed at other systemic issues faced by hemophilia patients. 'Most government hospitals in Delhi do not have hemophilia daycare centres and there is no dignity in the way we are treated. Hematologists are not available, which is essential since they will be the ones deciding on the dose, in accordance to the patients' age, weight and other factors. Instead, this is being done by general medicine doctors.' 'At Lok Nayak Hospital, my doses were not given according to my weight. After being administered a dose, they would ask me to come again in 12 hours for the next one. Given our condition which already makes us weak and prone to fatigue, this is harassment…,' said Gandhi, who works in a Delhi-based tendering company. Owing to hemophilia, which has caused internal bleeding over the years making his joints weak, Gandhi has 69% disability. He said that he was advised knee replacement surgery around five years ago but has been unable to consider the same in the absence of a steady supply of recombinant factor therapy. 'There have been instances where my knees got locked while crossing the road. Any surgery means I will require several doses of the recombinant factor… I have postponed the surgery as there is uncertainty over the availability of the drugs,' he added.


Los Angeles Times
21-07-2025
- Business
- Los Angeles Times
Fuel Your Week with Factor: The Best Factor Promo Codes and Discounts Right Now
Looking for a convenient way to eat healthy, delicious meals without spending hours of meal-prepping in the kitchen? Factor (Factor 75) delivers chef-prepared, ready-made meals right to your door. I have personally used Factor where I chose Carb Conscious and High Protein (30g+ of protein) meals. The process of choosing my meals and the introductory prices were hard to beat! Whether you're a busy professional, a student, or just looking to simplify your weeknight dinners, I know you'll enjoy them as much as I did. Save money with the latest Factor promo codes and discount below! If you're new to Factor, customers can score an unbeatable deal: $130 off your first order plus free shipping. Additionally, new customers also receive 20% off their next four boxes after the first order. This is the perfect way to try out Factor's ever-changing menu risk-free and see how easy healthy and convenient eating can be. Just use the promo code (GO130FREE) at checkout. With a busy school or work schedule, students and recent grads can enjoy exclusive savings on Factor meal plans. If you're a student, you can get 65% off your first box and 15% off your next 51 boxes when you verify through Student Beans. Graduates aren't left out either – get a 65% discount on your first box with Grad Beans. Factor takes care of the meals while you handle the studies. Factor proudly supports military members and healthcare workers with special discounts. Factor's Hero Discount provides 55% off the first order for military members, veterans, first responders, doctors, and nurses. Both groups can also receive 15% off 51 meal boxes. Simply verify your status to access these generous savings and enjoy nutritious, ready-made meals delivered to your door. Sign up for Factor's newsletter and you'll receive 50% off and free shipping on your first order – a great intro into the brand. You can also save up to 50% with Factor's bundle offers, making it easy to stock up on your favorite meals at a lower price where the more you buy the cheaper each meal becomes. Factor also offers referral credits where referring a friend gives them $40 off their first order and you earn $40 towards your next box. And if you're looking for a unique gift, Factor's gift cards let you share the convenience and nutrition with friends and family. No matter your lifestyle or budget, Factor makes it simple to eat well and save money. Factor frequently updates their promotions and offers deals for both new and existing customers throughout the year. Use these Factor promo codes and discounts to help you achieve your fitness goals or to just save you time in the kitchen. When you get signed up, you may add the proper promo code after the 'Do you have a discount code?' prompt. Subsequently, you may also add the Factor coupon code at checkout before payment. What types of meals does Factor provide? Factor provides many types of meals depending on your goals or preferences. They offer Calorie Smart (550 cal or less per meal), High Protein (at least 30g of protein or more per meal), Keto (high percentage of fat and lower carbs), Flexitarian (balanced between veggies and protein), Low Carb, Fiber Filled, GLP-1 Support (high protein and low in calorie), and Vegan & Veggie. All Factor meals arrive fully cooked and only need to be reheated before eating. How long do these meals last in the fridge? Once the meals have been delivered, they will last 7 days in the refrigerator. Are the meals frozen? All Factor meals are prepared fresh and delivered in an insulated box, cooled by gel packs. Once you receive your package, put them in the fridge immediately. Do not keep them in the transit box. Do you deliver to all of the USA? Factor delivers to all 48 contiguous states, except Hawaii and Alaska.


NZ Herald
17-07-2025
- Business
- NZ Herald
On the Up: Power pricing start-up Factor secures $3m, signs first customer across the Tasman
The Wellington-based pair say Factor is delivering a suite of tools – with AI in the mix – that automate what has traditionally been a clunky, spreadsheet-based pricing process for energy retailers, distribution networks and other energy tech companies. 'Simon and I have been working together for a decade. We were part of the founding team at Flick Electric,' Venning-Bryan says, name-checking the upstart electricity retailer that began its life selling power at wholesale rates plus a margin. Flick was sold to Z in 2018 for $46m. Z, in turn, sold Flick to Meridian in May for $70m. 'I was CMO [chief marketing officer] there and Simon was CTO [chief technology officer].' After Flick was sold to Z, Venning-Bryan and Pohlen left to help scale up Flux Federation, Meridian's in-house effort to create billing software (last month, Meridian announced plans to cull 53 jobs from Flux as it entered an outsourcing deal with British firm Kraken). 'In the course of that work, we got to understand the commercial and industrial sector more deeply. We could see there was an opportunity in forecasting and pricing. 'The crux of the problem is that when a utility – and this is globally true – has to provide a price for a commercial customer, which could be anyone from an office building through to a factory through to a farm, those prices are bespoke. They don't come off a generic price book like they might for residential. 'So what happens is they go to a back office pricing team, who almost always use a combination of SQL [database] queries and spreadsheets to come up with a price. It can take a few days or even a few weeks.' And things are getting more complicated as corporate power customers add solar panels to some of their rooftops, and maybe install EV chargers – and in Fonterra's case, electric milk truck chargers – and other points of complexity amid greater electrification. The rise of AI offered the opportunity to quickly gather pricing from legacy systems without power companies having to rip them out. 'We interviewed 30 utilities in 15 markets to validate our own thinking about that opportunity,' Venning-Bryan says. Max Factor To outsiders, coming from a tiny market might seem a disadvantage. But Venning-Bryan says offshore utilities are gobsmacked by the lengths the start-up has had to go to grapple with New Zealand's multi-player market, which has 27 networks. Their pitch: if they can make it work here, they can make it work anywhere. 'We cut our teeth in New Zealand, one of the world's most complex energy markets, with dozens of distribution networks and no standardised meter data format. We built Factor to handle that, and in doing so we built something market-agnostic. That's why we're ready to scale globally,' Venning-Bryan says. Pohlen says Factor can be set up using natural language queries, thanks to technology that builds on Amazon Web Service's Chronos LLM (large language model). Factor has 10 staff, mostly AI experts and data scientists. The new funding will be used in part to expand the team, including sales and marketing roles. Icehouse Ventures chief executive Robbie Paul says Factor's ability to apply modern software design and AI to deeply entrenched industry problems is what drew his attention. 'Just when you think software and AI has eliminated all inefficiencies, in walk great entrepreneurs like Jessica Venning-Bryan and Simon Pohlen optimising a colossal industry like energy,' Paul says. Factor is Icehouse's second early-stage investment announced this week. The firm has raised $16m toward its target $30m for its new Seed Fund IV. Chris Keall is an Auckland-based member of the Herald's business team. He joined the Herald in 2018 and is the technology editor and a senior business writer.


Dublin Live
17-06-2025
- Entertainment
- Dublin Live
Thousands of fans to head to Dun Laoghaire for Ukulele Hooley 2025
Our community members are treated to special offers, promotions and adverts from us and our partners. You can check out at any time. More info Dun Laoghaire will be abuzz this with thousands of enthusiasts from Ireland and beyond gathering for the renowned Ukulele Hooley. Now in its 14th year, the event boasts an impressive line-up of international and local ukulele talent, taking place from Saturday, August 23 to Sunday, August 24. As Europe's longest-running ukulele festival, the Hooley promises a financial boost for the charming south Dublin seaside town, offering a fun-filled weekend of entertainment for fans. The highlight of the two-day celebration is the free concert in the People's Park, Dun Laoghaire, on Sunday, August 24, which draws in thousands of enthusiasts. The 2025 Hooley, supported by Dun Laoghaire Rathdown County Council, will feature an array of fan-favourite attractions, including: Workshops, with a special session for kids The UKE Factor competition Saturday Afternoon Stage at Eblana Cabana Flash Mob The Bus Busk Open Mic The Big Concert and Jam in the People's Park This year's Hooley will showcase ukulele performers from the USA, Poland, Italy, the UK, and a wealth of homegrown talent. Organiser Niall Carty said: "I can promise a bigger and better festival this year. It's a very unique music event that bring people together through the sheer joy that the ukulele brings. "We want everyone to be a part of this extraordinary experience. This is a free, family focussed, fun event that has grown into an internationally recognised celebration of the humble ukulele which is now one of the most popular instruments in Ireland." Cathaoirleach of Dun Laoghaire Rathdown County Council, Cllr Jim Gildea, added: "We are delighted to welcome the return of Ukulele Hooley to Dún Laoghaire this August. Now in its 14th year, the festival has become a vibrant celebration of music, community, and creativity that draws visitors from all over the world. Dun Laoghaire-Rathdown County Council is proud to support this joyful and inclusive event, which brings such positive energy and international attention to our beautiful town." Further information on the festival can be found at Join our Dublin Live breaking news service on WhatsApp. Click this link to receive your daily dose of Dublin Live content. We also treat our community members to special offers, promotions, and adverts from us and our partners. If you don't like our community, you can check out any time you like. If you're curious, you can read our Privacy Notice. For all the latest news from Dublin and surrounding areas visit our homepage.
Yahoo
11-06-2025
- Business
- Yahoo
Largo Announces $10 Million Factoring Facility to Accelerate Receivables and Support Working Capital
All dollar amounts expressed are in thousands of U.S. dollars unless otherwise indicated. Monetizes accounts receivable from vanadium product sales to support near-term working capital Initial facility of up to $10 million, with potential expansion to $30 million subject to customer and credit approvals TORONTO, June 11, 2025--(BUSINESS WIRE)--Largo Inc. ("Largo" or the "Company") (TSX: LGO) (NASDAQ: LGO) today announces that its wholly owned subsidiary, Largo Resources USA ("LUSA"), has entered into a non-recourse factoring facility dated June 10, 2025 (the "Facility") with a well-established third-party factoring company (the "Factor") for the sale of certain accounts receivable. Under the terms of the Facility, LUSA may sell eligible accounts receivable to the Factor for receipts of up to $10 million. The Factor will advance 85% of the invoice value, with commission rates ranging from 0.51% for invoices up to 30 days, to 1.37% for those up to 90 days, depending on customer payment terms. All factored invoices are on a non-recourse basis, with the Factor assuming credit risk. The Company is working with the Factor to establish similar receivables purchase facilities for Largo Inc. and Largo Commodities Trading Ltd., which is expected to increase the overall size of the Facility, subject to the inclusion of additional customers and credit approvals. The Facility has an initial term of two years, and the Factor may terminate it with 90 days' prior written notice or immediately in the event of default. Daniel Tellechea, Interim CEO of Largo stated: "This Facility allows us to access liquidity more quickly by monetizing receivables tied to vanadium shipments, which can take between 30 and 90 days to convert to cash. Improving working capital efficiency is a necessary step as we work through our operational turnaround plan." He continued: "This Facility is expected to better align cash inflows with expenditures and ensures we have additional flexibility to support day-to-day operations while continuing our efforts to stabilize production and improve sales." CIRQUE Capital, Inc. acted as the Company's financial advisor and arranger in connection with the Facility and will receive certain custodial fees pursuant to the terms of the Facility. About Largo Largo is a globally recognized supplier of high-quality vanadium and ilmenite products, sourced from its world-class Maracás Menchen Mine in Brazil. As one of the world's largest primary vanadium producers, Largo produces critical materials that empower global industries, including steel, aerospace, defense, chemical, and energy storage sectors. The Company is committed to operational excellence and sustainability, leveraging its vertical integration to ensure reliable supply and quality for its customers. Largo is also strategically invested in the long-duration energy storage sector through its 50% ownership of Storion Energy, a joint venture with Stryten Energy focused on scalable domestic electrolyte production for utility-scale vanadium flow battery long-duration energy storage solutions in the U.S. Largo's common shares trade on the Nasdaq Stock Market and on the Toronto Stock Exchange under the symbol "LGO". For more information on the Company, please visit Cautionary Statement Regarding Forward-looking Information: This press release contains "forward-looking information" and "forward-looking statements" within the meaning of applicable Canadian and United States securities legislation. Forward-looking information in this press release includes, but is not limited to, statements with respect to the timing and amount of estimated future production and sales; the future price of commodities; costs of future activities and operations, including, without limitation, the effect of inflation and exchange rates; the effect of tariffs; the effect of unforeseen equipment maintenance or repairs on production; the ability to produce high purity V2O5 and V2O3 according to customer specifications; the extent of capital and operating expenditures; the ability of the Company to make improvements on its current short-term mine plan; and the impact of global delays and related price increases on the Company's global supply chain and future sales of vanadium products. The following are some of the assumptions upon which forward-looking information is based: that general business and economic conditions will not change in a material adverse manner; demand for, and stable or improving price of V2O5 and other vanadium products, ilmenite and titanium dioxide pigment; receipt of regulatory and governmental approvals, permits and renewals in a timely manner; that the Company will not experience any material accident, labour dispute or failure of plant or equipment or other material disruption in the Company's operations at the Maracás Menchen Mine or relating to Largo Clean Energy, specially in respect of the installation and commissioning of the EGPE project; the availability of financing for operations and development; the availability of funding for future capital expenditures; the ability to replace current funding on terms satisfactory to the Company; the ability to mitigate the impact of heavy rainfall; the reliability of production, including, without limitation, access to massive ore, the Company's ability to procure equipment, services and operating supplies in sufficient quantities and on a timely basis; that the estimates of the resources and reserves at the Maracás Menchen Mine are within reasonable bounds of accuracy (including with respect to size, grade and recovery and the operational and price assumptions on which such estimates are based); the accuracy of the Company's mine plan at the Maracás Menchen Mine; that the Company's current plans for ilmenite can be achieved; the Company's ability to protect and develop its technology; the Company's ability to maintain its IP; the competitiveness of the Company's product in an evolving market; the Company's ability to attract and retain skilled personnel and directors; the ability of management to execute strategic goals; that the Company will enter into agreements for the sales of vanadium, ilmenite and TiO2 products on favourable terms and for the sale of substantially all of its annual production capacity; and receipt of regulatory and governmental approvals, permits and renewals in a timely manner. Forward-looking statements can be identified by the use of forward-looking terminology such as "plans", "expects" or "does not expect", "is expected", "budget", "scheduled", "estimates", "forecasts", "intends", "anticipates" or "does not anticipate", or "believes", or variations of such words and phrases or statements that certain actions, events or results "may", "could", "would", "might" or "will be taken", "occur" or "be achieved", although not all forward-looking statements include those words or phrases. In addition, any statements that refer to expectations, intentions, projections, guidance, potential or other characterizations of future events or circumstances contain forward-looking information. Forward-looking statements are not historical facts nor assurances of future performance but instead represent management's expectations, estimates and projections regarding future events or circumstances. Forward-looking statements are based on our opinions, estimates and assumptions that we considered appropriate and reasonable as of the date such information is stated, subject to known and unknown risks, uncertainties and other factors that may cause the actual results, level of activity, performance or achievements of Largo to be materially different from those expressed or implied by such forward-looking statements, including but not limited to those risks described in the annual information form of Largo and in its public documents filed on and available on from time to time. Forward-looking statements are based on the opinions and estimates of management as of the date such statements are made. Although management of Largo has attempted to identify important factors that could cause actual results to differ materially from those contained in forward-looking statements, there may be other factors that cause results not to be as anticipated, estimated or intended. There can be no assurance that such statements will prove to be accurate, as actual results and future events could differ materially from those anticipated in such statements. Accordingly, readers should not place undue reliance on forward-looking statements. Largo does not undertake to update any forward-looking statements, except in accordance with applicable securities laws. Readers should also review the risks and uncertainties sections of Largo's annual and interim MD&A which also apply. Trademarks are owned by Largo Inc. View source version on Contacts For further information, please contact: Investor Relations Alex GuthrieDirector, Investor Relations+1.416.861.9778aguthrie@ Sign in to access your portfolio