Latest news with #GLOW
Time of India
17 hours ago
- Entertainment
- Time of India
Alison Brie to star in witness protection pilot
(Picture Courtesy: Facebook) Hollywood actor Alison Brie , best known for her role in Netflix series "GLOW", will feature in a witness protection pilot at FX. According to the entertainment news outlet Variety, the upcoming project hails from Hannah Fidell and Gina Welch. Both serve as writers, executive producers, and co-showrunners. Fidell will be directing. Initially announced in March 2023, it had David Chase serving as co-creator and executive producer, but he has reportedly exited the project. "A violent confrontation drives a high-end DC madame (Brie) to turn on her partner and enter witness protection in seaside Maine with her adolescent daughter," read the official logline. Brie's upcoming work is "Together", which is slated to hit the big screen on July 30. Directed by Michael Shanks, the horror film also stars Brie's husband, and actor Dave Franco in the lead role. PTI
Time of India
5 days ago
- Entertainment
- Time of India
Reacher Season 4 welcomes shocking cast changes, Christopher Rodriguez-Marquette joins in jaw-dropping twist
Amazon Prime Video's Reacher season 4 is undergoing a major cast change and Christopher Rodriguez-Marquette (Barry) has joined Reacher Season 4 opposite Alan Ritchson in a recasting, reports Deadline. Production for Reacher season 4 began earlier this month. Prime Video's hit action series Reacher is officially coming back with Season 4. The fans won't have to wait long, as the show has returned to filming a few months after Season 3's finale in March. ALSO READ: 'Didn't expect this much...': Squid Games Season 3 'heart wrenching' plot twist leaves fans devastated by Taboola by Taboola Sponsored Links Sponsored Links Promoted Links Promoted Links You May Like This may be of interest to you! Undo Reacher season 4 cast undergoes big change Reacher season 4 is based on Lee Child 's Jack Reacher anthology series, and follows its titular protagonist, an elite ex-military police major, as he travels across the United States, exposing conspiracies, corruption, and trafficking. According to media reports, Rodriguez-Marquette will play Jacob Merrick, a small-town policeman, replacing the one which is said to be meaty one this season — from Jay Baruchel . Jay was forced to quit the series to attend to a personal matter. Baruchel had only been announced as joining the cast a couple of weeks ago. Live Events Rodriguez-Marquette is best known for his role as Chris Lucado in HBO's Emmy-winning dark comedy series Barry. Many cast members changed from one season to the other, and Reacher Season 4 has recently announced new additions. However, shortly after the cast reveal, Deadline reports Jay Baruchel has been recast, and Christopher Rodriguez-Marquette will take over. ALSO READ: 'Pretty gay, dude': Trump's 'daddy' shirt ignites firestorm as MAGA world explodes, triggers massive backlash Season 4 will include a slate of new actors. Sydelle Noel (GLOW) is set to play Tamara Green, a detective with the Philadelphia police department, Agnez Mo (Pernikahan), who plays Lila Hoth, a young Indonesian woman who comes to Philly with her mother, Amisha Hoth (Levitating's Anggun), to track down her American biological father, and Kevin Corrigan (Law & Order: Organized Crime), who plays Detective Docherty, Tamara Green's partner. They were all cast as series regulars alongside Baruchel. Kevin Weisman (Suits: LA), Marc Blucas (My Life with the Walter Boys), and Kathleen Robertson (The Expanse) have been tapped for recurring guest roles in the upcoming series. Weisman will play Russell Plum, a freelance journalist based in Washington, D.C., who is investigating a suspected CIA Black Site. Blucas takes on the role of U.S. Congressman John Samson, with Robertson portraying his wife, Elsbeth Samson. ALSO READ: Indian-origin Zohran Mamdani faces shocking threat to US citizenship: Can Trump really deport him? The fourth season of the dramatic actioner adapts the 13th book in the global bestselling series, Gone Tomorrow. When a chance encounter with a distraught stranger on a train goes horribly wrong, Jack Reacher (Ritchson) is drawn into a complex and deadly game that pits him against ruthless foes from the highest echelons of power. The third season of Reacher debuted in February 2025 and quickly became the most watched returning series ever for Prime Video.
Daily Record
23-06-2025
- Entertainment
- Daily Record
Netflix fans issue 'brutal' warning about 'fantastic' new period drama
Netflix fans have been 'blown away' by one very popular period drama but viewers have warned it is not for the faint hearted. Following the popularity of historical dramas such as Bridgerton and The Buccaneers, viewers are keen for more period shows and American Primeval may be exactly what fans may need to fill that void. The Western miniseries dropped on Netflix in January this year, starring Friday Night Lights' Taylor Kitsch and GLOW actress Betty Gilpin. American Primeval is set against the backdrop of the Utah War in 1857, and tells the story of a mum and her son travelling across the brutal landscape that strips them of their freedom and pushes them towards savagery in the American West. Mum Sara, portrayed by Betty, is on the run with her son Devin, trying to escape their past life where she is wanted for the murder of her affluent husband, and is hoping to reunite her son with his father. The period drama is a blend of reality and fiction, with some characters inspired by real individuals who were all struggling to survive. The climatic episode, which depicts Mormon soldiers disguised as Natives attacking a group of pioneers, was based off a real event, The Mountain Meadows Massacre. The official synopsis reads: "Up is down, pain is everywhere, and innocence and tranquillity are losing the battle to hatred and fear. "Peace is the shrinking minority, and very few possess grace - even fewer know compassion. There's no safe haven in these wild lands, and only one goal matters: survival." Reddit users have been exchanging period drama recommendations and American Primeval appears to be a popular topic of conversation on the forum, the Express reports. One person suggested: "American Primeval - early America period piece, limited series, absolutely engrossing." Another echoed this sentiment with high praise, adding: "Based on an obscure true story... Gritty, with ultra-kinetic violence." However, several others have issued a warning about how "brutal" the series is. A Netflix fan who was left captivated by the show, shared: "Recently watched this on Netflix and it blew me away. Beautiful cinematography and a gritty and violent take on the wild west, this is just fantastic." Another enthusiastic viewer exclaimed: "This show was f***ing amazing," while someone else revealed their newfound fascination: "Love love love. For the first time we are seeing the story of the Mormons. Had no idea." The general consensus appeared to be hugely positive with remarks such as "Brutal show. Amazing," adding to the acclaim. Critics and audiences alike have all given American Primeval a thumbs up with a strong 72% rating on Rotten Tomatoes,. The positive feedback continued as someone said: "Much, much better than I was expecting. Saw all episodes straight through. Rather brutal." Another penned: "The limited series was excellent. I'm not a big fan of the genre but this series kept me engaged the entire way. It is well written and well cast." Join the Daily Record's WhatsApp community here an d get the latest news sent straight to your messages The accolades kept coming, with yet another noting: "Fast-paced and brutal, not for the faint of heart. Stunning cinematography and first class acting." In light of the show's success, the creators Peter Berg and Mark L Smith, have hinted at the possibility of expanding the universe with a prequel series. Berg revealed in an interview with The Hollywood Reporter: "We're talking about it right now. "That's the way we'd go if we do it. It would be a real big time jump to keep that crew going, but the idea of looking backwards is really interesting to me."
Geek Feed
20-06-2025
- Entertainment
- Geek Feed
Looks Like There's Hope for Mindhunter Fans After All
Netflix's Mindhunter managed to deliver two seasons before it got cancelled on Netflix, and while a lot of people cried for the series to come back, it looked like David Fincher had moved on. But as it turns out, there could be hope for the show after all. In a recent talk with CBR, Holt McCallany says he met with Fincher recently and says the series could come back in the form of a trilogy of films. He explains: 'I had a meeting with David Fincher in his office a few months ago, and he said to me that there is a chance that it may come back as three two-hour movies, but I think it's just a chance. I know there are writers that are working, but you know, David has to be happy with scripts.' While the series has managed to showcase several real-life serial killers, one big cliffhanger involves the BTK Killer who is shown committing his murders around the same time as the series; but it's ultimately more tragic when you realize that BTK was caught in 2005. For now, McCallany says that ' stars would all have to align' to get a new Mindhunter trilogy going on Netflix, but with Stranger Things ending, maybe Netflix could look back at one of their more popular shows soon. Besides Mindhunter , there have also been calls for a GLOW movie which I've also been campaigning for, but we'll just have to wait and see what happens. In the meantime, you can watch two excellent seasons of Mindhunter now streaming on Netflix.
Business Upturn
12-06-2025
- Business
- Business Upturn
Significant efficacy benefit of IMBRUVICA® (ibrutinib) plus venetoclax versus acalabrutinib plus venetoclax in frontline treatment of patients with chronic lymphocytic leukaemia suggested by indirect treatment comparison
Cross-study findings indicate significant clinical benefit of frontline fixed-duration ibrutinib plus venetoclax with improved likelihood of undetectable minimal residual disease and progression-free survival versus acalabrutinib plus venetoclax 1 Phase 2 CAPTIVATE long-term follow-up data further supports sustained efficacy and safety profile of fixed-duration ibrutinib plus venetoclax treatment in patients receiving frontline treatment for chronic lymphocytic leukaemia 2 Beerse, Belgium, June 12, 2025 (GLOBE NEWSWIRE) — Janssen-Cilag International NV, a Johnson & Johnson company, today announced new data from a matching-adjusted indirect comparison (MAIC) analysis assessing the efficacy of IMBRUVICA® (ibrutinib) in combination with venetoclax (I+V) vs acalabrutinib in combination with venetoclax (A+V) as fixed-duration (FD) treatments for adults with previously untreated chronic lymphocytic leukaemia (CLL).1 The data were featured in a poster presentation at the 30th European Hematology Association (EHA) Congress (Poster presentation #PF587) and reported that the I+V regimen yielded significantly better efficacy when compared to the A+V regimen.1 Patients treated with I+V were more likely to achieve disease clearance, as measured by undetectable minimal residual disease (uMRD) three months after the end of treatment (EOT+3), from both peripheral blood (PB) and bone marrow (BM).1 In addition to this, progression-free survival (PFS) significantly favoured I+V compared to A+V.1 'In the absence of head-to-head trials, clinicians need reliable tools to effectively compare treatment options and make the best possible choices for their patients,' said Talha Munir, M.D., Consultant in Clinical Haematology at St James's Hospital, Leeds, United Kingdom.* 'The matching-adjusted indirect comparison data presented at EHA suggests that ibrutinib plus venetoclax may offer meaningful clinical advantages over acalabrutinib plus venetoclax with patients more likely to achieve higher rates of undetectable minimal residual disease, three months after treatment. This may translate into more time in remission and longer progression-free survival – outcomes that matter deeply to both patients and the healthcare professionals who treat them.' Patients who met the AMPLIFY inclusion criteria from both the Phase 3 GLOW (NCT03462719) and Phase 2 CAPTIVATE (NCT02910583) studies were included in this analysis, and, after matching and balancing the treatment cohorts, comparative analyses between the trials suggested that I+V significantly reduced the risk of progression or death by 47 percent when compared to patients treated with A+V (hazard ratio [HR]: 0.53; 95 percent confidence interval [CI]: 0.33-0.85; p =0.0085).1,3,4,5 The results also suggested that patients treated with I+V were almost twice (95 percent CI: 1.47-2.41; p <0.0001) and 2.4 times (95 percent CI: 1.78-3.12; p <0.0001) more likely to achieve uMRD than A+V at EOT+3, in PB and BM, respectively.1 The GLOW and CAPTIVATE FD cohorts were based on individual patient-level data with a median follow-up of approximately 4.5 years, while the A+V cohort used aggregate level data from the AMPLIFY study with a median follow-up of approximately 3.4 years.1 Results from final analysis of CAPTIVATE Long-term follow-up results from the Phase 2 CAPTIVATE study data were presented as a poster at the American Society of Clinical Oncology (ASCO) 2025 Annual Meeting (Poster presentation #219) and will also be presented as an encore oral presentation at EHA 2025 (Oral presentation #S156).6 The data reinforced the durable clinical benefit of frontline I+V.2 Phase 2 CAPTIVATE results demonstrated patients in the I+V FD cohort displayed a clinically meaningful PFS and overall survival (OS) vs the MRD-guided cohort.2 After a median follow-up of 68.9 months, the 5.5-year PFS and OS rates for all treated patients were 66 percent (95 percent CI: 58-72) and 97 percent (95 percent CI: 93-99), respectively.2 Additionally, the 5.5 year PFS rate in patients who achieved uMRD in the PB at the EOT was 71 percent (95 percent CI: 60-80).2 Furthermore, 1-year PFS and OS rates from the start of retreatment (with single-agent ibrutinib or FD I+V) were both 100 percent, whilst 2-year PFS and OS rates from the start of retreatment were 91 percent and 96 percent, respectively.2 No new safety signals were observed during the CAPTIVATE study since the previous follow-up, with COVID-19, diarrhoea and hypertension being the most frequently reported adverse events (AEs).2 In the total pooled CAPTIVATE population, 32 percent (n=64/202) of patients had progressive disease following 5.5 years of follow-up.2 Of the 53 patients with available samples, none had acquired resistance-associated mutations in BTK or PLCG2 .2 'The final analysis of CAPTIVATE highlights how ibrutinib continues to raise the bar in the treatment of chronic lymphocytic leukaemia, with durable minimal residual disease response, extended treatment-free intervals, and a tolerable safety profile,' said Ester in't Groen, EMEA Therapeutic Area Head Haematology, Johnson & Johnson Innovative Medicine. 'With the longest follow-up of any oral fixed-dose regimen, ibrutinib is setting a new standard for what patients and clinicians can expect from targeted therapies. We remain committed to advancing science in complex blood cancers and improving outcomes across the cancer care landscape.' 'The updates presented at EHA add to the growing body of evidence in support of ibrutinib, the most extensively studied Bruton's tyrosine kinase inhibitor, as the standard of care in the frontline treatment of chronic lymphocytic leukaemia,' said Jessica Vermeulen, Vice President, Lymphoma & Leukemia Disease Area Stronghold Leader, Johnson & Johnson Innovative Medicine. 'Offering patients not only more time, but also the option for treatment-free remissions continues to be our goal and we are proud of the incredible contribution ibrutinib has made since its first European approval in 2014.' About the MAIC analysis The objective of this analysis was to compare the progression-free survival (PFS) and undetectable minimal residual disease (uMRD) data from the fixed-duration (FD) ibrutinib + venetoclax (I+V) cohorts from the Phase 3 GLOW (NCT03462719) and Phase 2 CAPTIVATE (NCT02910583) studies against the Phase 3 AMPLIFY (NCT03836261) data.1 In absence of prospective head-to-head trials investigating different Bruton's tyrosine kinase inhibitors (BTKis) plus B-cell lymphoma 2 (Bcl-2) strategies, this study utilised matching-adjusted indirect comparison (MAIC) to obtain useful insights on comparative efficacy.1 Individual patient data from the FD I+V cohorts of the GLOW and CAPTIVATE studies were pooled and compared to aggregate published Intent-to-Treat (ITT) data of the acalabrutinib plus venetoclax (A+V) arm of the AMPLIFY study.1,3,4,5 A MAIC was performed following method published by Signorovitch et al. and guidelines from the National Institute for Health and Care Excellence (NICE).1,7 Patients who did not meet the inclusion criteria of AMPLIFY were excluded from the I+V pooled cohort to establish the I+V patient population for analysis.1 The remaining I+V patients were then reweighted so that the average baseline characteristics of the pooled I+V cohort matched those of the A+V patients in AMPLIFY.1 The reweighted outcomes from I+V were then compared to the reported outcomes for A+V using indirect treatment comparison.1 Relative effects were quantified using relative risk (RR) and hazard ratios (HR) with 95 percent confidence intervals.1 There are potential sources of bias that cannot be accounted for in MAIC, that should be considered when interpreting such data. Specifically, in this comparison, the measurement of progression was stricter in GLOW and CAPTIVATE, requiring computer or magnetic imaging regardless of suspected progression and the median follow-up was longer in I+V population.1 Both may have biased the PFS results in favour of A+V.1 Additionally, AMPLIFY reported multicolour flow cytometry use but with no details on the number of colours and comparability is assumed with the 8-colour assay used in I+V studies.1 As in any non-randomised comparison there may be additional unreported clinically important prognostic patient baseline characteristics which cannot be accounted for.1 For example, Cumulative Illness Rating Scale score data was not collected in CAPTIVATE and therefore could not be used in matching.1 About CAPTIVATE The Phase 2 CAPTIVATE study ( NCT02910583 ) evaluated previously untreated adult patients with chronic lymphocytic leukaemia (CLL), who were 70 years or younger, including patients with high-risk disease, in two cohorts with combined median age of 60 years: a minimal residual disease (MRD)-guided cohort (n=43) and an FD cohort (n=159; median age).2,4,8 Patients in the FD cohort received three cycles of ibrutinib lead-in followed by 12 cycles of I+V (oral ibrutinib [420 mg/d]; oral venetoclax [five-week ramp-up to 400 mg/d]) and the primary endpoint was complete response rate.4 In the MRD cohort, after completion of three cycles ibrutinib lead-in followed by 12 cycles I+V, patients with confirmed uMRD were randomly assigned to double-blind treatment with placebo, or continuous ibrutinib.4 The primary endpoint was one-year disease-free survival.4 About the GLOW study The GLOW study ( NCT03462719 ) is a randomised, open-label, Phase 3 trial that evaluated the efficacy and safety of frontline, FD I+V versus chlorambucil plus obinutuzumab in adult patients with CLL who are (a) ≥65 years old, or (b) 18-64 years old with a Cumulative Illness Rating Scale score of greater than six or creatinine clearance less than 70 mL/min, who had active disease requiring treatment per the International Workshop on CLL criteria.3 About ibrutinib Ibrutinib is a once-daily oral medication that is jointly developed and commercialised by Janssen Biotech, Inc. and Pharmacyclics LLC, an AbbVie company.9 Ibrutinib blocks the Bruton's tyrosine kinase (BTK) protein, which is needed by normal and abnormal B-cells, including specific cancer cells, to multiply and spread.10 By blocking BTK, ibrutinib may help move abnormal B-cells out of their nourishing environments and inhibits their proliferation.11 Ibrutinib is approved in more than 100 countries and has been used to treat more than 325,000 patients worldwide.12 There are more than 50 company-sponsored clinical trials, including 18 Phase 3 studies, over 11 years evaluating the efficacy and safety of ibrutinib.10,13 In October 2021, ibrutinib was added to the World Health Organization's Model Lists of Essential Medicines (EML), which refers to medicines that address global health priorities and which should be available and affordable for all.14 Ibrutinib was first approved by the European Commission (EC) in 2014, and approved indications to date include:10 As a single agent or in combination with rituximab or obinutuzumab or venetoclax for the treatment of adult patients with previously untreated CLL As a single agent or in combination with bendamustine and rituximab (BR) for the treatment of adult patients with CLL who have received at least one prior therapy As a single agent for the treatment of adult patients with relapsed or refractory (RR) mantle cell lymphoma (MCL) As a single agent for the treatment of adult patients with Waldenström's macroglobulinaemia (WM) who have received at least one prior therapy, or in first line treatment for patients unsuitable for chemo-immunotherapy. In combination with rituximab for the treatment of adult patients with WM For a full list of adverse events and information on dosage and administration, contraindications and other precautions when using ibrutinib please refer to the Summary of Product Characteristics . About Chronic Lymphocytic Leukaemia CLL is typically a slow-growing blood cancer of the white blood cells.15 The overall incidence of CLL in Europe is approximately 4.92 cases per 100,000 persons per year and it is about 1.5 times more common in men than in women (based on individuals diagnosed 2000-2002).16 CLL is predominantly a disease of the elderly, with a median age of 72 years at diagnosis.17 While patient outcomes have dramatically improved in the last few decades, the disease is still characterised by consecutive episodes of disease progression and the need for therapy.18 Patients are often prescribed multiple lines of therapy as they relapse or become resistant to treatments.19 About Johnson & Johnson At Johnson & Johnson, we believe health is everything. Our strength in healthcare innovation empowers us to build a world where complex diseases are prevented, treated, and cured, where treatments are smarter and less invasive, and solutions are personal. Through our expertise in Innovative Medicine and MedTech, we are uniquely positioned to innovate across the full spectrum of healthcare solutions today to deliver the breakthroughs of tomorrow, and profoundly impact health for humanity. Learn more at . Follow us at . Janssen-Cilag International NV, Janssen Pharmaceutica NV, Janssen-Cilag Limited, Janssen Biotech, Inc., and Janssen Research & Development, LLC are Johnson & Johnson companies. Cautions Concerning Forward-Looking Statements This press release contains 'forward-looking statements' as defined in the Private Securities Litigation Reform Act of 1995 regarding product development and the potential benefits and treatment impact of daratumumab. The reader is cautioned not to rely on these forward-looking statements. These statements are based on current expectations of future events. If underlying assumptions prove inaccurate or known or unknown risks or uncertainties materialise, actual results could vary materially from the expectations and projections of Johnson & Johnson. Risks and uncertainties include, but are not limited to: challenges and uncertainties inherent in product research and development, including the uncertainty of clinical success and of obtaining regulatory approvals; uncertainty of commercial success; competition, including technological advances, new products and patents attained by competitors; challenges to patents; changes in behaviour and spending patterns of purchasers of health care products and services; changes to applicable laws and regulations, including global health care reforms; and trends toward health care cost containment. A further list and descriptions of these risks, uncertainties and other factors can be found in Johnson & Johnson's most recent Annual Report on Form 10-K, including in the sections captioned 'Cautionary Note Regarding Forward-Looking Statements' and 'Item 1A. Risk Factors,' and in Johnson & Johnson's subsequent Quarterly Reports on Form 10-Q and other filings with the Securities and Exchange Commission. Copies of these filings are available online at or on request from Johnson & Johnson. Johnson & Johnson does not undertake to update any forward-looking statement as a result of new information or future events or developments. *Talha Munir, M.D., Consultant in Clinical Haematology at St James's Hospital, Leeds, United Kingdom, has provided consulting, advisory, and speaking services to Janssen-Cilag International NV; he has not been paid for any media work. 1 Munir T, et al., Cross-Study Comparison of Ibrutinib in Combination with Venetoclax (I+V) vs Acalabrutinib in Combination with Venetoclax (A+V) in Subjects with Previously Untreated Chronic Lymphocytic Leukemia (CLL). Poster presentation at 2025 European Hematology Association (EHA) Congress; June 12–15, 2025. [Poster PF587]. 2 Ghia P, et al. Final Analysis of Fixed-Duration Ibrutinib + Venetoclax for Chronic Lymphocytic Leukemia (CLL)/Small Lymphocytic Lymphoma (SLL) in the Phase 2 CAPTIVATE Study. Oral presentation at 2025 European Hematology Association (EHA) Congress; June 12–15, 2025. [Oral S156]. 3 A Study of the Combination of Ibrutinib Plus Venetoclax Versus Chlorambucil Plus Obinutuzumab for the First-line Treatment of Participants With Chronic Lymphocytic Leukemia (CLL)/Small Lymphocytic Lymphoma (SLL) (GLOW). Available at: Last accessed: June 2025. 4 Ibrutinib Plus Venetoclax in Subjects With Treatment-naive Chronic Lymphocytic Leukemia /Small Lymphocytic Lymphoma (CLL/SLL) (CAPTIVATE). Available at: Last accessed: June 2025. 5 Study of Acalabrutinib (ACP-196) in Combination With Venetoclax (ABT-199), With and Without Obinutuzumab (GA101) Versus Chemoimmunotherapy for Previously Untreated CLL (AMPLIFY). Available at: Last accessed: June 2025. 6 Ghia P, et al. Final Analysis of Fixed-Duration Ibrutinib + Venetoclax for Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma in the Phase 2 CAPTIVATE Study. Poster presentation at 2025 American Society of Clinical Oncology (ASCO) Annual Meeting; May 30–June 3, 2025. [Poster #219]. 7 Signorovitch JE, et al. Matching-adjusted Indirect Comparisons: A New Tool for Timely Comparative Effectiveness Research. Value Health, 2012; 15: 940-947. 8 Jacobs R, et al., Outcomes in High-risk Subgroups After Fixed-Duration Ibrutinib + Venetoclax for Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma: Up To 5.5 years of Follow-up in the Phase 2 CAPTIVATE Study. Poster presentation at 2024 European Hematology Association (EHA) Hybrid Congress; June 13–16, 2024. [Poster P675]. 9 European Medicines Agency. IMBRUVICA Summary of Product Characteristics. April 2025. Available at: Last accessed: June 2025. 10 Turetsky A, et al. Single cell Imaging of Bruton's tyrosine kinase using an Irreversible Inhibitor. Sci Rep. 2014; 4: 4782. 11 de Rooij MF, et al. The Clinically Active BTK Inhibitor PCI-32765 targets B-cell Receptor- and Chemokine-controlled Adhesion and Migration in Chronic Lymphocytic Leukemia. Blood. 2012; 119(11): 2590-2594. 12 J&J Data on File (RF-465355). Patients Treated on Imbruvica Worldwide. May 2025. 13 Pollyea DA, et al. A Phase I Dose Escalation Study of the Btk Inhibitor PCI-32765 in Relapsed and Refractory B Cell Non-Hodgkin Lymphoma and Use of a Novel Fluorescent Probe Pharmacodynamic Assay. Blood. 2009; 114(22): 3713. 14 World Health Organization. WHO Prioritizes Access to Diabetes and Cancer Treatments in New Essential Medicines Lists. Available at: Last accessed: June 2025. 15 American Cancer Society. What is Chronic Lymphocytic Leukemia? Available at: Last accessed: June 2025. 16 Sant M, et al. Incidence of Hematologic Malignancies in Europe by Morphologic Subtype: Results of the HAEMACARE project. Blood. 2010; 116:3724–34. 17 Eichhorst B, et al. Chronic Lymphocytic Leukaemia: ESMO Clinical Practice Guidelines for Diagnosis, Treatment and Follow-up Ann Oncol. 2021; 32(1): 23-33. 18 Moreno C. Standard Treatment Approaches for Relapsed/refractory Chronic Lymphocytic Leukemia after Frontline Chemoimmunotherapy. Hematology Am Soc Hematol Educ Program. 2020; 2020: 33-40. 19 Bewarder M, et al. Current Treatment Options in CLL. Cancers (Basel). 2021;13(10): 2468. CP-523458 June 2025 Disclaimer: The above press release comes to you under an arrangement with GlobeNewswire. Business Upturn takes no editorial responsibility for the same.
