Latest news with #Gaucher
Yahoo
08-07-2025
- Health
- Yahoo
Cough Medicine May Protect Against Some of Parkinson's Worst Symptoms
An active ingredient in cough medicines since 1979 has shown promise as a treatment for neuropsychiatric symptoms in Parkinson's disease-related dementia. The drug, ambroxol, isn't approved for use in the US, Canada, or Australia, but it is commonly found in cough syrups and tablets from Europe. In a gold-standard phase 2 clinical trial, 22 participants with Parkinson's dementia who received a high daily dose of ambroxol for a year showed no worsening of key neuropsychiatric symptoms. Meanwhile, 25 patients who received the placebo displayed worsening symptoms, gaining an average of 3.73 points on an established neuropsychiatric score. Patients on ambroxol dropped an average of 2.45 points. Related: Both groups shared similar cognitive scores related to memory and language. But those taking ambroxol showed stabilization in symptoms like delusions, hallucinations, anxiety, irritability, apathy, and aberrant motor activity. Participants on ambroxol also experienced fewer falls. Though ambroxol was found to be safe, no clinically meaningful improvements in cognition were recorded. Yet there are reasons to remain optimistic. "Our goal was to change the course of Parkinson's dementia," says neurologist Stephen Pasternak from Western University in Canada. "This early trial offers hope and provides a strong foundation for larger studies." In the team's analysis, some participants carrying a high-risk GBA1 gene for Parkinson's showed improved cognitive performance on ambroxol. With a small sample size and no control group to compare outcomes to, the authors caution these results need to be followed up before drawing any conclusions. That said, high-risk GBA1 gene variants tend to result in lower activity of the enzyme Glucocerebrosidase (GCase), and this, in turn, is linked to more protein clumps in the brain, like Lewy bodies, which are associated with Parkinson's dementia. Recently, studies have found that ambroxol can significantly increase GCase activity. In the current trial, those taking the drug showed 1.5 times the amount of GCase activity. No serious adverse effects were reported by those taking ambroxol, although mild to moderate gastrointestinal issues were common and caused a few participants to drop out of the trial. The findings suggest that some of the more serious symptoms of Parkinson's disease may be managed by ambroxol if taken regularly at high doses. Because ambroxol can easily cross the blood-brain barrier, some scientists suspect the cough medicine can treat neurodegenerative conditions, like Parkinson's, Amyotrophic lateral sclerosis (ALS), Gaucher disease, neuroinflammation, or spinal cord injury. Whether that hypothesis proves to be true requires more clinical research. But the recent phase 2 trial on Parkinson's dementia gives scientists good reason to keep digging. "These findings suggest ambroxol may protect brain function, especially in those genetically at risk," says Pasternak. "It offers a promising new treatment avenue where few currently exist. If a drug like Ambroxol can help, it could offer real hope and improve lives." The study was published in JAMA Neurology. Scientists Finally Uncovered Where Gluten Reactions Start One Major Feature of Aging Might Not Be Universal After All Brain's Memory Center Never Stops Making Neurons, Study Confirms
North Wales Chronicle
04-07-2025
- Sport
- North Wales Chronicle
Jesse Evans digs deep for Grimes glory
Noel Meade's talented dual-purpose performer was unable to get involved when contesting the Copper Horse Stakes at Royal Ascot a fortnight ago but having previously impressed over hurdles at Ballinrobe, the nine-year-old was among the market principals for this Grade Three contest at 7-2. With 5-2 favourite Gaucher faltering on the run to the final flight, it was Barry Connell's veteran Enniskerry who looked most likely to emerge victorious after taking over the lead, but Jesse Evans dug deep on the run-in for Donagh Meyler and passed the post a half-length to the good. 'He's been great and has brought the owners all over the place and was in Ascot not so long ago. He's a yard favourite,' said Meyler. 'He's ground it out and is as tough as nails. He had a nice weight on the ratings and had match fitness on his side which definitely paid off there. 'He's toughed it out the whole way up the straight. I'm not sure what plans are but he's won a Graded race today and we'll celebrate that.' Meade was at Bellewstown, from where he told Racing TV: 'I'm absolutely thrilled – he's a little diamond. He's not very big, but he wears his heart on his sleeve and he rarely runs a bad race. 'Jumping helps him as he's a very slick jumper and he's a marvellous horse. He's won a lot of money – Flat, fences and hurdles.' On future plans, he added: 'I don't think he'd get home in the Galway Plate. We'll probably enter him in case the ground came up really good, but any time we've run him over further than two miles, it didn't work. 'I'd say it's unlikely we'll run him in the Plate and I don't think we'll run him in the Galway Hurdle again either. He's run well in it before, but he's at the top of the handicap and it would be very hard for him. 'If he went to Galway there's a chase there he might run in instead, but we'll see.'
South Wales Argus
03-07-2025
- Sport
- South Wales Argus
Jesse Evans digs deep for Grimes glory
Noel Meade's talented dual-purpose performer was unable to get involved when contesting the Copper Horse Stakes at Royal Ascot a fortnight ago but having previously impressed over hurdles at Ballinrobe, the nine-year-old was among the market principals for this Grade Three contest at 7-2. With 5-2 favourite Gaucher faltering on the run to the final flight, it was Barry Connell's veteran Enniskerry who looked most likely to emerge victorious after taking over the lead, but Jesse Evans dug deep on the run-in for Donagh Meyler and passed the post a half-length to the good. 'He's been great and has brought the owners all over the place and was in Ascot not so long ago. He's a yard favourite,' said Meyler. 'He's ground it out and is as tough as nails. He had a nice weight on the ratings and had match fitness on his side which definitely paid off there. 'He's toughed it out the whole way up the straight. I'm not sure what plans are but he's won a Graded race today and we'll celebrate that.' Meade was at Bellewstown, from where he told Racing TV: 'I'm absolutely thrilled – he's a little diamond. He's not very big, but he wears his heart on his sleeve and he rarely runs a bad race. 'Jumping helps him as he's a very slick jumper and he's a marvellous horse. He's won a lot of money – Flat, fences and hurdles.' On future plans, he added: 'I don't think he'd get home in the Galway Plate. We'll probably enter him in case the ground came up really good, but any time we've run him over further than two miles, it didn't work. 'I'd say it's unlikely we'll run him in the Plate and I don't think we'll run him in the Galway Hurdle again either. He's run well in it before, but he's at the top of the handicap and it would be very hard for him. 'If he went to Galway there's a chase there he might run in instead, but we'll see.'
Leader Live
03-07-2025
- Sport
- Leader Live
Jesse Evans digs deep for Grimes glory
Noel Meade's talented dual-purpose performer was unable to get involved when contesting the Copper Horse Stakes at Royal Ascot a fortnight ago but having previously impressed over hurdles at Ballinrobe, the nine-year-old was among the market principals for this Grade Three contest at 7-2. With 5-2 favourite Gaucher faltering on the run to the final flight, it was Barry Connell's veteran Enniskerry who looked most likely to emerge victorious after taking over the lead, but Jesse Evans dug deep on the run-in for Donagh Meyler and passed the post a half-length to the good. 'He's been great and has brought the owners all over the place and was in Ascot not so long ago. He's a yard favourite,' said Meyler. 'He's ground it out and is as tough as nails. He had a nice weight on the ratings and had match fitness on his side which definitely paid off there. 'He's toughed it out the whole way up the straight. I'm not sure what plans are but he's won a Graded race today and we'll celebrate that.' Meade was at Bellewstown, from where he told Racing TV: 'I'm absolutely thrilled – he's a little diamond. He's not very big, but he wears his heart on his sleeve and he rarely runs a bad race. 'Jumping helps him as he's a very slick jumper and he's a marvellous horse. He's won a lot of money – Flat, fences and hurdles.' On future plans, he added: 'I don't think he'd get home in the Galway Plate. We'll probably enter him in case the ground came up really good, but any time we've run him over further than two miles, it didn't work. 'I'd say it's unlikely we'll run him in the Plate and I don't think we'll run him in the Galway Hurdle again either. He's run well in it before, but he's at the top of the handicap and it would be very hard for him. 'If he went to Galway there's a chase there he might run in instead, but we'll see.'
Glasgow Times
03-07-2025
- Sport
- Glasgow Times
Jesse Evans digs deep for Grimes glory
Noel Meade's talented dual-purpose performer was unable to get involved when contesting the Copper Horse Stakes at Royal Ascot a fortnight ago but having previously impressed over hurdles at Ballinrobe, the nine-year-old was among the market principals for this Grade Three contest at 7-2. With 5-2 favourite Gaucher faltering on the run to the final flight, it was Barry Connell's veteran Enniskerry who looked most likely to emerge victorious after taking over the lead, but Jesse Evans dug deep on the run-in for Donagh Meyler and passed the post a half-length to the good. 'He's been great and has brought the owners all over the place and was in Ascot not so long ago. He's a yard favourite,' said Meyler. 'He's ground it out and is as tough as nails. He had a nice weight on the ratings and had match fitness on his side which definitely paid off there. 'He's toughed it out the whole way up the straight. I'm not sure what plans are but he's won a Graded race today and we'll celebrate that.' Meade was at Bellewstown, from where he told Racing TV: 'I'm absolutely thrilled – he's a little diamond. He's not very big, but he wears his heart on his sleeve and he rarely runs a bad race. 'Jumping helps him as he's a very slick jumper and he's a marvellous horse. He's won a lot of money – Flat, fences and hurdles.' On future plans, he added: 'I don't think he'd get home in the Galway Plate. We'll probably enter him in case the ground came up really good, but any time we've run him over further than two miles, it didn't work. 'I'd say it's unlikely we'll run him in the Plate and I don't think we'll run him in the Galway Hurdle again either. He's run well in it before, but he's at the top of the handicap and it would be very hard for him. 'If he went to Galway there's a chase there he might run in instead, but we'll see.'
