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National Geographic
2 days ago
- Health
- National Geographic
This underdiagnosed vein disorder affects 4 in 10 Americans
A nurse practitioner examines a patient with chronic venous insufficiency (CVI), a vascular condition in which damaged leg veins impair blood flow back to the heart. CVI can lead to symptoms such as swelling, skin changes, and venous ulcers if left untreated. Photograph by Michael Macor, The San Francisco Chronicle via Getty Images From tingly legs to bulging veins, these warning signs may point to chronic venous insufficiency—a widespread circulatory issue doctors say is on the rise. Swelling, aching calves, tingling, or bulging veins might seem like everyday discomforts, but they could point to a hidden problem in your circulatory system. A surprisingly common yet underrecognized condition called chronic venous insufficiency is behind a growing number of cases—and scientists say it's far more widespread than most people realize. Here are five things to know about this painful and underdiagnosed vascular disorder. What is chronic venous insufficiency? Chronic venous insufficiency (CVI) occurs when the valves in your leg veins become weak or damaged and begin leaking. 'Because veins carry blood back to the heart, these leaky valves can allow blood to flow backward or pool in the leg,' says Raul Guzman, division chief of vascular surgery and endovascular therapy at Yale School of Medicine, New Haven Hospital. Over time, this backward flow and pooling increases pressure within the veins, leading to inflammation and damage to surrounding tissues. Left unchecked, the condition can trigger a chain reaction that affects both the skin's surface and the deeper structures of the leg. Early signs and symptoms of CVI Early signs of CVI can be as subtle as a tight feeling in your calves, cramping, or especially heavy or tired legs after a long day. But as the condition progresses, symptoms often intensify and include 'pain or discomfort in the leg, swelling, and skin damage,' explains Guzman. The skin may take on a discolored or leathery appearance, become itchy or cracked, and develop slow-healing wounds or ulcers. (Scientists are unraveling the mysteries of pain.) Due to the pooling blood, varicose and bulging veins are another hallmark sign, though not everyone with CVI has them. Left untreated, CVI can lead to increased venous pressure, more serious conditions, and even blood clots. Who is most at risk for CVI? Despite its low profile, chronic venous insufficiency affects an estimated 40 percent of Americans, according to the Society for Vascular Surgery. It's especially common in women over 50 and those who are pregnant. But men aren't immune, particularly if they lead a sedentary lifestyle or are living with obesity. It's also prevalent in individuals with a history of deep vein thrombosis or other venous diseases. 'We know that there is a hereditary component to CVI,' says Guzman. (Why heart attacks are rising in young adults—and what to watch out for.) Smoking and high blood pressure can also contribute to the condition. So can jobs that require prolonged standing or sitting because 'may cause blood to pool in the legs, increasing pressure on your veins,' says Marie Robert, a surgical pathologist at Yale School of Medicine, New Haven Hospital. Why CVI is often misdiagnosed One of the biggest challenges with CVI is that its symptoms are frequently misinterpreted. Swollen legs may be attributed to aging or fluid retention. Varicose veins are often seen as purely cosmetic, and skin changes may be mistaken for eczema or unrelated irritation. But ignoring these signs can allow the condition to worsen, Guzman says—sometimes even resulting in irreversible damage. That's why it's essential to consult a healthcare provider, such as a vascular specialist, if even minor symptoms persist or worsen. Robert says that a simple physical exam and either an magnetic resonance angiogram (MRA) or ultrasound are usually all that are needed to determine whether CVI is present and what treatment may be required. The good news is that CVI is highly treatable, especially when caught early. Doctors often begin with conservative approaches, such as suggestions to elevate your legs above your heart during the day and using compression garments to improve blood flow. 'The first method of treatment involves the use of elastic compression stockings,' says Guzman. (The ability to reverse damage to your lungs and heart is tantalizingly close.) Lifestyle changes, such as weight loss, improving diet, regular exercise, and avoiding prolonged periods of sitting or standing, are also frequently recommended. All such recommendations 'help ease swelling, improve circulation, and relieve symptoms,' says Robert. Medications such as blood thinners or diuretics may also be prescribed to reduce swelling or improve blood flow. 'And there are several surgical procedures and more advanced medical interventions that can be performed,' adds Guzman. These include sclerotherapy (an injected solution that causes the affected veins to collapse and fade), vein stripping, angioplasty and stents, endovenous ablation (a minimally invasive procedure using heat or laser to close off the affected veins), or surgical removal of malfunctioning veins. 'Use of these treatments depends on the location of the involved veins and the degree of the problem,' says Guzman. As awareness of chronic venous insufficiency grows, so do opportunities for earlier detection and more effective management. 'For many people, CVI is annoying and uncomfortable—but not usually life-threatening,' says Robert. 'It's a condition that can be helped by a variety of lifestyle changes and mild interventions.'


The Herald Scotland
12-07-2025
- The Herald Scotland
El Chapo's son pleads guilty in connection with running Sinaloa Cartel
Guzman's guilty plea in Chicago comes at a point where the level of violence the Chapitos unleashed continues to dominate Sinaloa. Mexican authorities recently found twenty bodies, including several that were decapitated and four that were left hanging from a bridge over a highway. They appeared to be victims of a turf war between the Chapitos and rival Sinaloa faction La Mayiza. Authorities hope Guzman Lopez's plea deal will help pave the way to further prosecution of the Chapitos and the Sinaloa cartel as a whole, experts say. It's unclear what information "El Raton" or "the Mouse" as he is known has agreed to share. "This is obviously a hugely symbolic case for the United States, U.S. prosecutors have made the Chapitos a top priority for years," said Parker Asmann, a Sinaloa Cartel expert with organized crime research group InSight Crime. "Securing his cooperation could mean they could undermine the drug trade and attack corruption in Mexico they want to target." Guzman Lopez admitted to four charges: two stemming from an indictment in Illinois and two from an indictment out of New York. The charges included international drug trafficking and engaging in a criminal enterprise. The judge delayed sentencing to a later date, but prosecutors and defense attorneys said Guzman Lopez could potentially face life in prison and have to forfeit $80 million.


Al Etihad
11-07-2025
- Politics
- Al Etihad
Son of Mexico's 'El Chapo' pleads guilty in US drugs case: report
12 July 2025 00:12 NEW YORK (AFP)A son of Mexican drug kingpin Joaquin "El Chapo" Guzman pleaded guilty to narcotics charges in a Chicago court Friday, US media said, part of a deal he struck with prosecutors in return for a reduced "El Raton," or "The Mouse," Ovidio Guzman signed a deal dated June 30 indicating he would enter a guilty plea to avoid a jury trial and a potentially harsher sentence had he been guilty plea was formalised during a hearing in a Chicago court after months of negotiation with the justice department -- the first time one of El Chapo's sons has inked a deal with Guzman, 35, is accused of conspiring in a continuing criminal enterprise, importing and distributing fentanyl, laundering money, and using formal guilty plea, reported by the local CBS2 broadcaster, will likely result in a far shorter prison term than the life sentence given to his father El Chapo following a high-profile trial held in could offer US authorities "valuable information" about the cartel and its protectors, Mike Vigil, former head of operations for the Drug Enforcement Administration, told lawyers and prosecutors did not respond to requests for Guzman gained prominence in October 2019 when Mexican authorities detained him -- only to release him later on orders from then president Andres Manuel Lopez Obrador amid a standoff between law enforcement and gang Guzman was recaptured in January 2023, while Lopez Obrador was still in office, and later extradited to the United authorities accuse Ovidio and his three brothers of leading Los Chapitos, a faction of the Sinaloa Cartel designated by the administration of US President Donald Trump as a global "terrorist" father, one of the world's most infamous drug traffickers, is serving a life sentence in a US United States alleges Ovidio Guzman and his associates trafficked fentanyl into the country, where the opioid epidemic is linked to tens of thousands of Sinaloa cartel is one of six Mexican drug trafficking groups that Trump has designated as terrorist son, Joaquin Guzman Lopez, was arrested after arriving in the United States last July on a private plane with cartel co-founder Ismael "El Mayo" Zambada, who claimed he had been arrests sparked cartel infighting that has left more than 1,200 people dead and 1,400 missing in Sinaloa state, located in northwestern Mexico. In its aggressive policy against drug cartels, the Trump administration announced additional sanctions against Los Chapitos in June for fentanyl trafficking and increased the reward to $10 million for each of the fugitive brothers.


Daily Mirror
04-07-2025
- Daily Mirror
TikTok star 'murdered Marine' before dancing in videos to footage from the news
Joshua Guzman and Marko Cinan have been accused of shooting 'devoted father' and 'beloved fiancee' Anthony Sanders at a mall in Houston, Texas, in front of his son and partner A TikToker accused of murdering a Marine veteran in a parking garage allegedly posted a video of himself to the social media dancing to rap music as coverage of the incident played in the background. Joshua Guzman, 22, is one of two men who have been charged with the murder of Anthony Sanders, a 30-year-old Marine veteran who was shot to death in front of his fiancee and their toddler son in the garage of the Galleria Mall in Houston, Texas. Charges were levelled against Guzman and 23-year-old Marko Cinan after the former's mother passed police a TikTok video allegedly showing him dancing to news coverage of the incident while lip-syncing to rap songs. In one of several videos created by Guzman, who boasts 50,000 followers on TikTok, the 22-year-old can allegedly be seen lip syncing along Cinan to the song "Graffiti" by rapper YoungBoy Never Broke Again. The song includes the lyrics: "I got locked in that cell and they ain't let me out." Guzman reportedly turned himself in to police on June 30, days after Cinan was charged on June 25, with his attorney, Romy Kaplan, telling local media he claimed to have been approached with a knife, arguing the case was one of "self-defence". Mr Kaplan: "Somebody approached him not once, but twice, with a knife, but also possibly a gun." He added: "We cooperated with HPD. "We met with HPD already for voluntary surrender, so everything that's been done has been forthright and honest, and I look forward to vigorously defending his rights." But Ronyel Sanders, Mr Sanders' mother, claimed to have been on a phone call with her son when he was shot, telling local NBC News affiliate station KRPC that he was "protecting his son and his fiancée" at the time. A GoFundMe page set up in the wake of Mr Sanders' death describes the man as a "devoted father" and "beloved fiancee". A statement posted to the site reads: "Anthony Sanders was abruptly taken away from us, leaving behind shattered hearts and unfinished dreams due to the senseless act of murder." "Anthony was a devoted father, beloved fiancé to Selena, cherished son, nephew, cousin, and brother whose kindness warmed every heart around him. "His greatest joy was his precious baby boy and his beautiful fiancée, Selena—the family he passionately worked to support. In the wake of this profound loss, Anthony's grieving mother humbly invites anyone who wishes to support the family to donate, especially for Selena, whose care and well-being are now a priority."


Hindustan Times
04-07-2025
- Hindustan Times
Who is Justin Guzman? TikToker arrested for Marine's murder in Texas
A TikTok user shot and killed a Marine veteran, Anthony Sanders, in front of the man's baby and fiancée in Texas. He later posted about it on his TikTok page, according to New York Post report. Justin Guzman turned himself in to Houston police on Monday. He was charged in the killing of 30-year-old Anthony Sanders, a Marine veteran,(Instagram) The incident unfolded on June 3, 2025, inside a parking garage near the Galleria Mall on Westheimer Road around 5 pm, according to local media reports. Who is Justin Guzman ? Justin Guzman, 22, turned himself in to Houston Police on Monday. He was charged in the killing of 30-year-old Anthony Sanders, a Marine veteran, last month, as per KPRC. Guzman, a Tik Toker made lip-sync, dancing videos on his primary account that has over 130,000 followers before it got banned. Later, he started operating another account @guzmanhimself1, where he garnered 52,000 followers as of July 1, 2025. During a court hearing on Monday, Sanders' parents, both Army veterans, showed a TikTok video where Guzman danced in front of a TV news report about the shooting, according to KHOU. 'We're here for justice. Justice for Anthony and also to stand for what he stood for as a person,' Sanders' father, Frank Sanders, told the outlet. 'This was uncalled for.' Guzman blocked Anthony Sanders's car On June 3, Sanders had a confrontation with Guzman and Marko Cinan, 23, in the Galleria Mall parking garage. Reports said they had insulted Sanders' fiancée in the mall elevator where she worked. After the argument, Sanders tried to drive away with his fiancée and their 10-month-old son, but Guzman reportedly 'brake-checked' him and blocked his car with his own. Sanders got out of his car to deal with the situation, but he was shot ten times while his fiancée and baby stayed inside the car. Royal Sanders said she was thankful her son stepped out of the vehicle before the shots were fired. 'Because had he not stepped out, the baby was in the car, the fiancée was in the car,' she told KHOU at the courthouse Monday. Police detained Guzman, Cinan, and a third man soon after the shooting, but they were later released. Cinan turned himself in on June 25 and was booked into the Harris County Jail. Guzman's lawyers claimed he acted in self-defense and said Sanders had pulled out a knife during the argument, according to the Financial Express. But police said they found no weapon on Sanders or at the scene. Guzman was being held on a $750,000 bond Guzman was being held on a $750,000 bond. Cinan, who already had a criminal record, was being held on a $1 million bond, according to Law and Crime. Both men appeared in several TikTok videos on Guzman's account, which had over 50,000 followers. In some of the videos, they made gun-like gestures with their hands and pretended to shoot at the camera.