Latest news with #HCR™
Business Wire
5 days ago
- Business
- Business Wire
Molecular Instruments® Continues RNA Imaging Leadership with Next-Generation miRNA/siRNA Detection and Clinical-Grade Ready-to-Use Kits
LOS ANGELES--(BUSINESS WIRE)--Molecular Instruments® (MI), the inventor of the HCR™ platform, today announced key enhancements to its HCR™ Gold and HCR™ Pro product lines. These upgrades include next-generation chemistry for high-specificity detection of small RNA targets—including microRNAs (miRNAs) and small interfering RNAs (siRNAs)—and the introduction of a new ready-to-use, prefilled dispenser format for automated assay workflows. 'With small RNA detection and ready-to-use dispensers, HCR™ Pro and HCR™ Gold are setting a new standard for clinical-grade workflows." Share Together, these advances represent a pivotal development in delivering clinical-grade RNA imaging performance with seamless, high-throughput usability. Next-Generation HiFi Chemistry Unlocks Small RNA Detection Both HCR™ Gold and HCR™ Pro now incorporate next-generation HCR™ HiFi architecture, enabling robust detection of small RNAs such as miRNA and siRNA with built-in automatic background suppression, allowing for unmatched signal-to-background performance. Researchers can now visualize and quantify low-abundance, short-length targets with the same confidence as typical transcripts—driving new biological insights across both foundational research and translational discovery. Prefilled Dispensers Support Scalable, Clinical-Grade Performance Additionally, MI has begun shipping HCR™ Pro kits in a fully prefilled dispenser format for the DISCOVERY ULTRA automated research platform. This ready-to-use packaging eliminates manual reagent preparation, streamlining setup and minimizing variability between users and runs. By simplifying the workflow and enhancing reproducibility, these prefilled kits mark a critical milestone on the path toward scalable, clinical-grade molecular imaging. 'These upgrades are a major step forward in our vision to make high-performance bioimaging effortless and with the highest levels of precision,' said Dr. Aneesh Acharya, Chief Commercial Officer at Molecular Instruments. 'With small RNA detection and ready-to-use dispensers, HCR™ Pro and HCR™ Gold are setting a new standard for clinical-grade workflows.' The prefilled format is now available for an initial automation platform, with broader compatibility in development. To learn more or place an order, visit About Molecular Instruments Molecular Instruments® ( is a company powering the future of bioimaging through the development of clinical-grade molecular detection technologies. The company offers automated and manual chromogenic and fluorescent in situ hybridization (ISH) assays that seamlessly integrate with existing immunohistochemistry (IHC) and immunofluorescence (IF) workflows. With thousands of users globally, MI is establishing the field standard for RNA detection and supporting applications from academic research to drug development and diagnostics.
Yahoo
16-06-2025
- Business
- Yahoo
Molecular Instruments Launches HCR™ Pro RNA-ISH for Manual Workflows, Enabling Extreme-Sensitivity RNA Imaging in an Accessible Format
LOS ANGELES, June 16, 2025--(BUSINESS WIRE)--Molecular Instruments® (MI), inventor of the HCR™ technology, today announces the launch of HCR™ Pro RNA-ISH for manual workflows, expanding the unmatched performance and versatility of the HCR™ imaging platform by enabling extreme-sensitivity RNA imaging with chromogenic or fluorescent staining in an accessible and flexible format tailored for hands-on research applications. HCR™ Pro RNA-ISH integrates enzymatic signal amplification to enable extreme-sensitivity RNA imaging for the most demanding targets/samples when signal-to-background is at an absolute premium. For example, the assay facilitates rapid scanning of a low-expression target in a highly-autofluorescent sample over a large field-of-view at low magnification. "HCR™ products are known for redefining what's possible for RNA imaging in challenging contexts," said Cameron Earl, Director of Product Management at Molecular Instruments. "HCR™ Pro has already elevated that standard on the leading automated platforms. Now we're excited to offer the extreme sensitivity of HCR™ Pro RNA-ISH to researchers using manual assays on the full gamut of sample types from whole-mount embryos to ultrathick brain slices." HCR™ Pro RNA-ISH pioneers entirely protease-free workflows in tissue sections, preserving sample morphology and maintaining protein target integrity, enabling seamless compatibility with existing immunohistochemistry (IHC)/immunofluorescence (IF) assays. The assay employs HCR™ HiFi Probes available from MI's Infinite Catalog for any target RNA in any organism across the tree of life with no design fee and backed by the HCR™ HiFi Probe Promise. Chromogenic staining offers the convenience of brightfield microscopy and the option of archival staining. Fluorescent staining offers the convenience of spectrally distinct channels for multiplex RNA-FISH/IF workflows. Learn more about manual HCR™ Pro RNA-ISH. About Molecular Instruments Molecular Instruments® ( develops and synthesizes molecular kits powered by the breakthrough HCR™ imaging platform for applications in academic research, drug development, synthetic biology, and clinical pathology and diagnostics. View source version on Contacts Media Contact:Joyce YooAssociate Director of Marketingjoyce@
Business Wire
16-06-2025
- Science
- Business Wire
Molecular Instruments Launches HCR™ Pro RNA-ISH for Manual Workflows, Enabling Extreme-Sensitivity RNA Imaging in an Accessible Format
LOS ANGELES--(BUSINESS WIRE)--Molecular Instruments® (MI), inventor of the HCR™ technology, today announces the launch of HCR™ Pro RNA-ISH for manual workflows, expanding the unmatched performance and versatility of the HCR™ imaging platform by enabling extreme-sensitivity RNA imaging with chromogenic or fluorescent staining in an accessible and flexible format tailored for hands-on research applications. HCR™ Pro RNA-ISH enables extreme-sensitivity RNA imaging with chromogenic or fluorescent staining in an accessible and flexible format. HCR™ Pro RNA-ISH integrates enzymatic signal amplification to enable extreme-sensitivity RNA imaging for the most demanding targets/samples when signal-to-background is at an absolute premium. For example, the assay facilitates rapid scanning of a low-expression target in a highly-autofluorescent sample over a large field-of-view at low magnification. 'HCR™ products are known for redefining what's possible for RNA imaging in challenging contexts,' said Cameron Earl, Director of Product Management at Molecular Instruments. 'HCR™ Pro has already elevated that standard on the leading automated platforms. Now we're excited to offer the extreme sensitivity of HCR™ Pro RNA-ISH to researchers using manual assays on the full gamut of sample types from whole-mount embryos to ultrathick brain slices.' HCR™ Pro RNA-ISH pioneers entirely protease-free workflows in tissue sections, preserving sample morphology and maintaining protein target integrity, enabling seamless compatibility with existing immunohistochemistry (IHC)/immunofluorescence (IF) assays. The assay employs HCR™ HiFi Probes available from MI's Infinite Catalog for any target RNA in any organism across the tree of life with no design fee and backed by the HCR™ HiFi Probe Promise. Chromogenic staining offers the convenience of brightfield microscopy and the option of archival staining. Fluorescent staining offers the convenience of spectrally distinct channels for multiplex RNA-FISH/IF workflows. Learn more about manual HCR™ Pro RNA-ISH. About Molecular Instruments Molecular Instruments® ( develops and synthesizes molecular kits powered by the breakthrough HCR™ imaging platform for applications in academic research, drug development, synthetic biology, and clinical pathology and diagnostics.
Yahoo
03-06-2025
- Business
- Yahoo
Molecular Instruments and Alpenglow Biosciences Partner to Advance 3D RNA Imaging in Intact Biological Samples
LOS ANGELES & SEATTLE, June 03, 2025--(BUSINESS WIRE)--Molecular Instruments® (MI), the inventor of the innovative HCR™ platform, and Alpenglow Biosciences, a leader in 3D light-sheet microscopy, are excited to announce a partnership that enables high-resolution, three-dimensional RNA imaging in intact biological specimens. By integrating MI's HCR™ Gold RNA-FISH assay with Alpenglow's 3Di™ Hybrid Open-Top Light-Sheet (HOTLS) fluorescent microscope, researchers gain access to a powerful, accessible workflow for visualizing molecular expression patterns in 3D while preserving the native architecture of their samples. This collaboration merges two state-of-the-art technologies into a seamless imaging solution. HCR™ Gold RNA-FISH provides highly specific and sensitive labeling of RNA targets in any sample, including thick tissues and whole-mount specimens. Additionally, the HCR™ platform's small DNA-based amplification reagents enable deep sample penetration and produce strong signals with minimal background, ensuring robust results even in challenging samples. Complementing this, Alpenglow's 3Di™ HOTLS system generates high-resolution 3D reconstructions across a broad range of sample sizes and formats, transforming labeled samples into rich, spatially resolved datasets. Alpenglow further enhances these insights with cutting-edge data processing and AI-driven analysis, enabling a deeper understanding of complex biological systems. "HCR™ products have long enabled researchers to see deeper – delivering gold-standard performance in thick and complex samples, from whole-mount embryos to cleared tissues," said Dr. Aneesh Acharya, Chief Commercial Officer at Molecular Instruments. "We pioneered protease-free sample preparation to preserve fine structure, and now, with Alpenglow, we're entering a new era: democratizing 3D molecular imaging for the translational community. By combining the precision of HCR™ Gold with the power of open-top light-sheet microscopy, we're opening a window into intact biology – making it possible to explore molecular organization in its native context, at scale." "We are excited to work with the team at Molecular Instruments," said Nick Reder, MD and CEO of Alpenglow Biosciences. "With their high-quality HCR™ Gold reagents and ability to penetrate deep tissue, along with our 3Di Instrument, we will bring a powerful new tool to customers seeking to understand the underlying biology of their tissue specimens with labeling of RNA targets. These tools working together will help researchers and drug development scientists to unlock insights within the tissue to help accelerate their scientific programs." Together, the two platforms eliminate the limitations of conventional 2D histology, which often relies on thin tissue sections and can obscure key biological context. This integrated approach empowers researchers to explore intact samples – such as embryos, organoids, and other delicate 3D structures – without disrupting their morphology. In doing so, scientists can uncover spatial patterns and cellular interactions that would otherwise be lost in serial sections. Designed for modern workflows, HCR™ Gold is fully compatible with tissue clearing and automation, ensuring reproducible, scalable performance across large studies. Alpenglow's 3Di™ HOTLS enhances this capability with a versatile imaging system that supports scan volumes up to 12.5 cm by 7 cm and features a 1 cm working distance – delivering high-throughput, adaptive imaging across diverse research applications. This joint solution is especially impactful in fields such as developmental biology, neuroscience, and immunology – areas where understanding molecular organization in 3D is critical to advancing scientific discovery. By combining the precision of HCR™ Gold with the advanced imaging capabilities of 3Di™ HOTLS, MI and Alpenglow Biosciences are offering deeper insights into complex systems and setting a new standard in molecular profiling. About Molecular Instruments Molecular Instruments® ( is a company powering the future of bioimaging through the development of clinical-grade molecular detection technologies. The company offers automated and manual chromogenic and fluorescent in situ hybridization (ISH) assays that seamlessly integrate with existing immunohistochemistry (IHC) and immunofluorescence (IF) workflows. With thousands of users globally, MI is establishing the field standard for RNA detection and supporting applications from academic research to drug development and diagnostics. About Alpenglow Biosciences Alpenglow Biosciences is a 3D spatial biology company focused on accelerating drug development and improving clinical diagnostics with AI-enabled 3D imaging technology. Their platform solution provides new spatial biology insights with greater accuracy by non-destructively digitizing entire tissues. Alpenglow partners with pharmaceutical companies to bring better therapeutics to market faster through greater understanding of mechanism of action, efficacy & toxicology, and clinical trial enrollment using their patented platform. See what you've been missing at View source version on Contacts Media Contact: Joyce YooAssociate Director of Marketingjoyce@ Steve PembertonSVP Commercial Developmentmedia@ Error in retrieving data Sign in to access your portfolio Error in retrieving data Error in retrieving data Error in retrieving data Error in retrieving data
Business Wire
03-06-2025
- Business
- Business Wire
Molecular Instruments and Alpenglow Biosciences Partner to Advance 3D RNA Imaging in Intact Biological Samples
LOS ANGELES & SEATTLE--(BUSINESS WIRE)--Molecular Instruments® (MI), the inventor of the innovative HCR™ platform, and Alpenglow Biosciences, a leader in 3D light-sheet microscopy, are excited to announce a partnership that enables high-resolution, three-dimensional RNA imaging in intact biological specimens. By integrating MI's HCR™ Gold RNA-FISH assay with Alpenglow's 3Di™ Hybrid Open-Top Light-Sheet (HOTLS) fluorescent microscope, researchers gain access to a powerful, accessible workflow for visualizing molecular expression patterns in 3D while preserving the native architecture of their samples. Experience a new era of 3D molecular imaging — HCR™ Gold RNA-FISH meets Alpenglow's 3Di™ light-sheet system to reveal RNA expression in intact tissues with stunning clarity. This collaboration merges two state-of-the-art technologies into a seamless imaging solution. HCR™ Gold RNA-FISH provides highly specific and sensitive labeling of RNA targets in any sample, including thick tissues and whole-mount specimens. Additionally, the HCR™ platform's small DNA-based amplification reagents enable deep sample penetration and produce strong signals with minimal background, ensuring robust results even in challenging samples. Complementing this, Alpenglow's 3Di™ HOTLS system generates high-resolution 3D reconstructions across a broad range of sample sizes and formats, transforming labeled samples into rich, spatially resolved datasets. Alpenglow further enhances these insights with cutting-edge data processing and AI-driven analysis, enabling a deeper understanding of complex biological systems. 'HCR™ products have long enabled researchers to see deeper – delivering gold-standard performance in thick and complex samples, from whole-mount embryos to cleared tissues,' said Dr. Aneesh Acharya, Chief Commercial Officer at Molecular Instruments. 'We pioneered protease-free sample preparation to preserve fine structure, and now, with Alpenglow, we're entering a new era: democratizing 3D molecular imaging for the translational community. By combining the precision of HCR™ Gold with the power of open-top light-sheet microscopy, we're opening a window into intact biology – making it possible to explore molecular organization in its native context, at scale.' 'We are excited to work with the team at Molecular Instruments,' said Nick Reder, MD and CEO of Alpenglow Biosciences. 'With their high-quality HCR™ Gold reagents and ability to penetrate deep tissue, along with our 3Di Instrument, we will bring a powerful new tool to customers seeking to understand the underlying biology of their tissue specimens with labeling of RNA targets. These tools working together will help researchers and drug development scientists to unlock insights within the tissue to help accelerate their scientific programs.' Together, the two platforms eliminate the limitations of conventional 2D histology, which often relies on thin tissue sections and can obscure key biological context. This integrated approach empowers researchers to explore intact samples – such as embryos, organoids, and other delicate 3D structures – without disrupting their morphology. In doing so, scientists can uncover spatial patterns and cellular interactions that would otherwise be lost in serial sections. Designed for modern workflows, HCR™ Gold is fully compatible with tissue clearing and automation, ensuring reproducible, scalable performance across large studies. Alpenglow's 3Di™ HOTLS enhances this capability with a versatile imaging system that supports scan volumes up to 12.5 cm by 7 cm and features a 1 cm working distance – delivering high-throughput, adaptive imaging across diverse research applications. This joint solution is especially impactful in fields such as developmental biology, neuroscience, and immunology – areas where understanding molecular organization in 3D is critical to advancing scientific discovery. By combining the precision of HCR™ Gold with the advanced imaging capabilities of 3Di™ HOTLS, MI and Alpenglow Biosciences are offering deeper insights into complex systems and setting a new standard in molecular profiling. About Molecular Instruments Molecular Instruments® ( is a company powering the future of bioimaging through the development of clinical-grade molecular detection technologies. The company offers automated and manual chromogenic and fluorescent in situ hybridization (ISH) assays that seamlessly integrate with existing immunohistochemistry (IHC) and immunofluorescence (IF) workflows. With thousands of users globally, MI is establishing the field standard for RNA detection and supporting applications from academic research to drug development and diagnostics. About Alpenglow Biosciences Alpenglow Biosciences is a 3D spatial biology company focused on accelerating drug development and improving clinical diagnostics with AI-enabled 3D imaging technology. Their platform solution provides new spatial biology insights with greater accuracy by non-destructively digitizing entire tissues. Alpenglow partners with pharmaceutical companies to bring better therapeutics to market faster through greater understanding of mechanism of action, efficacy & toxicology, and clinical trial enrollment using their patented platform. See what you've been missing at
