Latest news with #HCR™Pro
Business Wire
6 days ago
- Business
- Business Wire
Molecular Instruments® Continues RNA Imaging Leadership with Next-Generation miRNA/siRNA Detection and Clinical-Grade Ready-to-Use Kits
LOS ANGELES--(BUSINESS WIRE)--Molecular Instruments® (MI), the inventor of the HCR™ platform, today announced key enhancements to its HCR™ Gold and HCR™ Pro product lines. These upgrades include next-generation chemistry for high-specificity detection of small RNA targets—including microRNAs (miRNAs) and small interfering RNAs (siRNAs)—and the introduction of a new ready-to-use, prefilled dispenser format for automated assay workflows. 'With small RNA detection and ready-to-use dispensers, HCR™ Pro and HCR™ Gold are setting a new standard for clinical-grade workflows." Share Together, these advances represent a pivotal development in delivering clinical-grade RNA imaging performance with seamless, high-throughput usability. Next-Generation HiFi Chemistry Unlocks Small RNA Detection Both HCR™ Gold and HCR™ Pro now incorporate next-generation HCR™ HiFi architecture, enabling robust detection of small RNAs such as miRNA and siRNA with built-in automatic background suppression, allowing for unmatched signal-to-background performance. Researchers can now visualize and quantify low-abundance, short-length targets with the same confidence as typical transcripts—driving new biological insights across both foundational research and translational discovery. Prefilled Dispensers Support Scalable, Clinical-Grade Performance Additionally, MI has begun shipping HCR™ Pro kits in a fully prefilled dispenser format for the DISCOVERY ULTRA automated research platform. This ready-to-use packaging eliminates manual reagent preparation, streamlining setup and minimizing variability between users and runs. By simplifying the workflow and enhancing reproducibility, these prefilled kits mark a critical milestone on the path toward scalable, clinical-grade molecular imaging. 'These upgrades are a major step forward in our vision to make high-performance bioimaging effortless and with the highest levels of precision,' said Dr. Aneesh Acharya, Chief Commercial Officer at Molecular Instruments. 'With small RNA detection and ready-to-use dispensers, HCR™ Pro and HCR™ Gold are setting a new standard for clinical-grade workflows.' The prefilled format is now available for an initial automation platform, with broader compatibility in development. To learn more or place an order, visit About Molecular Instruments Molecular Instruments® ( is a company powering the future of bioimaging through the development of clinical-grade molecular detection technologies. The company offers automated and manual chromogenic and fluorescent in situ hybridization (ISH) assays that seamlessly integrate with existing immunohistochemistry (IHC) and immunofluorescence (IF) workflows. With thousands of users globally, MI is establishing the field standard for RNA detection and supporting applications from academic research to drug development and diagnostics.
Yahoo
16-06-2025
- Business
- Yahoo
Molecular Instruments Launches HCR™ Pro RNA-ISH for Manual Workflows, Enabling Extreme-Sensitivity RNA Imaging in an Accessible Format
LOS ANGELES, June 16, 2025--(BUSINESS WIRE)--Molecular Instruments® (MI), inventor of the HCR™ technology, today announces the launch of HCR™ Pro RNA-ISH for manual workflows, expanding the unmatched performance and versatility of the HCR™ imaging platform by enabling extreme-sensitivity RNA imaging with chromogenic or fluorescent staining in an accessible and flexible format tailored for hands-on research applications. HCR™ Pro RNA-ISH integrates enzymatic signal amplification to enable extreme-sensitivity RNA imaging for the most demanding targets/samples when signal-to-background is at an absolute premium. For example, the assay facilitates rapid scanning of a low-expression target in a highly-autofluorescent sample over a large field-of-view at low magnification. "HCR™ products are known for redefining what's possible for RNA imaging in challenging contexts," said Cameron Earl, Director of Product Management at Molecular Instruments. "HCR™ Pro has already elevated that standard on the leading automated platforms. Now we're excited to offer the extreme sensitivity of HCR™ Pro RNA-ISH to researchers using manual assays on the full gamut of sample types from whole-mount embryos to ultrathick brain slices." HCR™ Pro RNA-ISH pioneers entirely protease-free workflows in tissue sections, preserving sample morphology and maintaining protein target integrity, enabling seamless compatibility with existing immunohistochemistry (IHC)/immunofluorescence (IF) assays. The assay employs HCR™ HiFi Probes available from MI's Infinite Catalog for any target RNA in any organism across the tree of life with no design fee and backed by the HCR™ HiFi Probe Promise. Chromogenic staining offers the convenience of brightfield microscopy and the option of archival staining. Fluorescent staining offers the convenience of spectrally distinct channels for multiplex RNA-FISH/IF workflows. Learn more about manual HCR™ Pro RNA-ISH. About Molecular Instruments Molecular Instruments® ( develops and synthesizes molecular kits powered by the breakthrough HCR™ imaging platform for applications in academic research, drug development, synthetic biology, and clinical pathology and diagnostics. View source version on Contacts Media Contact:Joyce YooAssociate Director of Marketingjoyce@
Business Wire
16-06-2025
- Science
- Business Wire
Molecular Instruments Launches HCR™ Pro RNA-ISH for Manual Workflows, Enabling Extreme-Sensitivity RNA Imaging in an Accessible Format
LOS ANGELES--(BUSINESS WIRE)--Molecular Instruments® (MI), inventor of the HCR™ technology, today announces the launch of HCR™ Pro RNA-ISH for manual workflows, expanding the unmatched performance and versatility of the HCR™ imaging platform by enabling extreme-sensitivity RNA imaging with chromogenic or fluorescent staining in an accessible and flexible format tailored for hands-on research applications. HCR™ Pro RNA-ISH enables extreme-sensitivity RNA imaging with chromogenic or fluorescent staining in an accessible and flexible format. HCR™ Pro RNA-ISH integrates enzymatic signal amplification to enable extreme-sensitivity RNA imaging for the most demanding targets/samples when signal-to-background is at an absolute premium. For example, the assay facilitates rapid scanning of a low-expression target in a highly-autofluorescent sample over a large field-of-view at low magnification. 'HCR™ products are known for redefining what's possible for RNA imaging in challenging contexts,' said Cameron Earl, Director of Product Management at Molecular Instruments. 'HCR™ Pro has already elevated that standard on the leading automated platforms. Now we're excited to offer the extreme sensitivity of HCR™ Pro RNA-ISH to researchers using manual assays on the full gamut of sample types from whole-mount embryos to ultrathick brain slices.' HCR™ Pro RNA-ISH pioneers entirely protease-free workflows in tissue sections, preserving sample morphology and maintaining protein target integrity, enabling seamless compatibility with existing immunohistochemistry (IHC)/immunofluorescence (IF) assays. The assay employs HCR™ HiFi Probes available from MI's Infinite Catalog for any target RNA in any organism across the tree of life with no design fee and backed by the HCR™ HiFi Probe Promise. Chromogenic staining offers the convenience of brightfield microscopy and the option of archival staining. Fluorescent staining offers the convenience of spectrally distinct channels for multiplex RNA-FISH/IF workflows. Learn more about manual HCR™ Pro RNA-ISH. About Molecular Instruments Molecular Instruments® ( develops and synthesizes molecular kits powered by the breakthrough HCR™ imaging platform for applications in academic research, drug development, synthetic biology, and clinical pathology and diagnostics.
