Latest news with #Howe
Daily Mirror
a day ago
- Business
- Daily Mirror
Alexander Isak holds private talks as Liverpool transfer decision edges closer
Alexander Isak has been linked with a mega-money transfer move to Liverpool this summer but Newcastle are hoping to quell interest by handing him a new long-term contract Newcastle manager Eddie Howe is relaxed amid suggestions that Liverpool are preparing to make a bid for star striker Alexander Isak. Magpies boss Howe has already held informal talks with Isak, 25, regarding his future and more detailed discussions are planned. The Sweden international has interest from a host of European giants including Liverpool, who are splashing the cash in the summer transfer window. The Reds have already spent a cool £185million on Florian Wirtz, Milos Kerkez and Jeremie Frimpong. Liverpool are also keen on signing Marc Guehi, as they aim to capitalise on their newfound status as Premier League champions. Anfield chiefs might not be done there either, with a bid for Isak understood to be a possibility as Darwin Nunez edges closer to joining Napoli. Newcastle have no intention of selling, though, and the Chronicle report that Howe could lead on new contract talks when his first-team squad return for pre-season training on July 7. It's been theorised that the imminent departures of CEO Darren Eales and sporting director Paul Mitchell from St James' Park have delayed negotiations. The report adds that Howe has been in contact with Isak over the summer break and he's calm about the situation. Despite the Swede's current contract not expiring until June 2028, Newcastle would be willing to hand him a new deal. Isak enjoyed his most prolific season in a black and white shirt last term, scoring 27 goals in all competitions. The Magpies' £63m club-record signing netted one of those at Wembley as Newcastle beat Liverpool in the Carabao Cup final in March and his form helped them secure a return to the Champions League. Howe has been on record admitting that Isak's situation is 'complex', with Newcastle needing to toe the line of financial fair play. Earlier this year, chief executive Eales - whose replacement, like Mitchell's, is yet to be confirmed - insisted that the club are under no pressure to sell their star players and directly referenced the 25-year-old. Should Liverpool make a bid for Alexander Isak? Have your say in the comments section. "They're all under long-term contracts. We have no intention at all of those players being moved on. We're not under the gun or anything like that," Eales said. "We've got an ownership that is ambitious and wants the best for the club. So from that perspective, it would be crazy for us to consider it. We're striving, as a club, to be at the top table. We want our best players here. I think it shows the value of Isak that they talk about him all the time. We're not looking to move any player on."
Miami Herald
5 days ago
- Business
- Miami Herald
Aspire Biopharma Holdings, Inc., Announces Last Patient Dosed in Phase 1 Clinical Trial of its Oral Transmucosal Fast-Acting High-Dose Aspirin Formulation
Enrollment Completed on Schedule; Topline Results Expected Mid Q3 2025 ESTERO, FL AND NEW YORK, NY / ACCESS Newswire / June 24, 2025 / Aspire Biopharma Holdings, Inc. (Nasdaq:ASBP) ("Aspire" or the "Company"), developer of a multi-faceted patent-pending drug delivery technology, today announced the last patient was dosed in its Phase 1 single-center clinical study of its oral transmucosal fast-acting high-dose aspirin formulation. Topline results from the study are anticipated by the middle of third quarter of 2025. "The successful completion of patient dosing in our Phase 1 trial is a noteworthy accomplishment. We are extremely grateful to the investigator and patients who participated in this study. Achieving this milestone on time and as planned per protocol also demonstrates the operational excellence of our team and clinical partners," said Michael Howe, Chief Executive Officer of Aspire. "We look forward to reporting initial safety and efficacy data in the third quarter, which will provide key insights into our formulation of high-dose aspirin and its potential as a fast-acting treatment option for suspected acute myocardial infarction. Following the receipt of the topline results, we plan to continue discussions with the FDA to ensure our path forward is well-aligned with regulatory expectations." Howe added, "We are eager to integrate the insights from this trial into our comprehensive development plan. We believe these trial results will also play a key role in our strategy to pursue potential partnership opportunities." Phase 1 Study Design The Phase 1 clinical trial, which is being conducted in the United States, compares the pharmacokinetic and pharmacodynamic characteristics of normal healthy adult volunteers after the administration of our sublingual dose of 162.5 mg aspirin powder with control healthy subjects given 162.5 mg oral aspirin (approximately two 81 mg aspirin tablets). The primary outcome measure will be plasma acetylsalicylic acid (ASA) concentration versus time data (pre-dose and up to 24 hours post-dose). The trial also measures Arachidonic acid (AA)-induced platelet aggregation over 8 hours after dosing and Serum thromboxane B2 (TxB2) over 8 hours after dosing, both of which are valuable for documenting Aspire's sublingual high-dose aspirin's rapid impact on cardiac events. Following completion of this trial, Aspire plans to submit a section 505(b)(2) NDA seeking approval to market the high-dose aspirin product. About the Aspire Targeted Oral Delivery Platform Aspire's technology delivers a soluble, fast-acting granular or powder formulation which has been developed by using our patent-pending methodology, and "trade secret" process. The technology's new mechanism of action allows for rapid sublingual absorption and entry into the bloodstream of drugs and other substances. The benefits of "rapid absorption" are to provide rapid impact in more precise quantities. About Aspire Biopharma, Inc. Headquartered in Estero, Fl., Aspire Biopharma has developed a disruptive technology that can deliver supplements and drugs rapidly and precisely. For more information, please visit Safe Harbor Statement Certain statements made in this communication are "forward-looking statements" within the meaning of the safe harbor provisions of the United States Private Securities Litigation Reform Act of 1995. Forward-looking statements may generally be identified by the use of words such as "estimate," "projects," "expects," "anticipates," "forecasts," "plans," "intends," "believes," "seeks," "may," "will," "would," "should," "future," "propose," "potential," "target," "goal," "objective," "outlook" and variations of these words or similar expressions (or the negative versions of such words or expressions) are intended to identify forward-looking statements. These forward-looking statements include, but are not limited to, statements regarding the financial position, business strategy and the plans and objectives of management for future operations. These statements are based on various assumptions, whether or not identified in this communication, and on the current expectations of Aspire's management and are not predictions of actual performance. These forward-looking statements are provided for illustrative purposes only and are not intended to serve as and must not be relied on by any investor as a guarantee, an assurance, a prediction or a definitive statement of fact or probability. These forward-looking statements are not guarantees of future performance, conditions or results, and involve a number of known and unknown risks, uncertainties, assumptions and other important factors, many of which are outside the control of the parties, that could cause actual results or outcomes to differ materially from those discussed in the forward-looking statements. The Company undertakes no obligation to update these statements for revisions or changes after the date of this release, except as required by law. Aspire Biopharma Holdings, Inc. Contact TraDigital IRKevin McGrath+1-646-418-7002kevin@ SOURCE: Aspire Biopharma Holdings, Inc.
North Wales Live
20-06-2025
- Business
- North Wales Live
QVC slashes Ninja's 'perfect' pizza oven by £110 beating Amazon for BBQ season
As the summer season draws near, garden parties and outdoor dinners become the order of the day. Enjoying the sunshine with delectable food in the company of friends and family is a cherished tradition. One essential that most people crave during this time is pizza, but ordering takeaway for the whole family can be quite costly. This is why pizza ovens are fast becoming a must-have item in gardens and homes. However, finding the right one that won't empty your wallet can be a challenge. Fortunately, shoppers are in luck as they can now purchase the Ninja Artisan Pizza Oven with Cover from QVC for a discounted price of £219.95, down from its original price of £324.98. This deal is even cheaper than what's offered on the Ninja website (£229.99) and Amazon (£229). Moreover, new QVC shoppers can enjoy an extra £5 off with the code FIVE4U, bringing the total cost down to £214.95. The Ninja pizza oven allows shoppers to whip up delicious 12-inch pizzas in just a matter of minutes. It's electric, so there's no need for flames or gas - simply plug it in and start cooking. With five pizza settings such as Thin Crust, New York and Deep Dish, shoppers can perfect their favourite style every time. The package even includes a pizza peel, stone, and a cover to keep it safe outdoors, reports the Mirror. But this oven isn't just for pizza, as shoppers can also use it to bake bread, air fry meals, and prove dough - all in the great outdoors. It heats up to 370 degrees and can accommodate a full meal, like chicken wings or chips. There's even a window so customers can watch their food as it cooks. Its simple controls make it easy to use and it's ideal for gardens, patios or balconies. For those in the market for a pizza oven, but not quite sold on what's offered, there's the Ooni Koda 12 Gas-Powered Pizza Oven at Argos for £299, featuring instant gas ignition, reaching cooking temperatures in 15 minutes, and capable of blasting pizzas to perfection in just 60 seconds with an impressive 500 degrees. Alternatively, bargain hunters can consider the Outdoor Pizza Oven from Vonhaus, priced at £129.99, which is portable, whips up 12-inch pizzas, hits the mark with temperatures up to 350 degrees within 15 minutes, and also doubles as a smoker for meats, fish, or veggies. On the other hand, the ninja pizza oven from QVC has garnered a sterling 4.7 out of 5 star rating from users. Feedback includes rave reviews such as: "So quick and easy and the pizzas were lovely. Perfectly cooked everytime Also tried the air fryer function and it was to the usual NINJA standard too." Further praise comes from a satisfied customer who expressed: "Very impressed, exceeded expectations. Big enough for a 12 inch pizza but small enough to easily move. The oven heats up fairly quickly, but then retains the heat if making several pizzas." An additional happy buyer remarked: "Exactly as expected. Feels solid, makes you feel confident it can produce the desired heat, safely and with ease!". However, some customers did voice concerns, with one noting: "One thing I would say is that the pizza was a bit too dark for me and I've heard others say the same." Another customer was full of praise, remarking: "Amazing! Made gluten free from frozen bases and normal ones from fresh bases and they were the best pizzas we have had in a long time! Toppings - less is more for sure! Really impressed - 3 pizzas in under 15 mins!".
South Wales Argus
12-06-2025
- Sport
- South Wales Argus
A look at the longevity of Premier League managers
Frank had been the top flight's second longest-serving manager, having been appointed nearly seven years ago in October 2018. Here, the PA news agency looks at the new-look top five. Pep Guardiola, Manchester City PEP 💬 From day one, I felt incredible love and respect with all my assistants and coaches here. If I did not feel that I wouldn't be here. — Manchester City (@ManCity) November 22, 2024 Appointed: July 1, 2016 Guardiola's famed intensity has previously led to earlier than expected departures from Barcelona and Bayern Munich, with a sabbatical year in between, but at City he has put down roots – signing a contract extension last season to take his reign beyond a decade. He has won six league titles and the 2022-23 Champions League among his 14 major trophies with the club but will go into the new campaign seeking a response to a season of dramatic under-performance. Mikel Arteta, Arsenal Arsenal's impressive performances under Mikel Arteta have not been rewarded by trophies (Bradley Collyer/PA) Appointed: December 22, 2019 Premier League runners-up three years in a row, Arsenal's manager now also assumes second spot in these rankings from Frank. The Spaniard will reach six years at the helm just before Christmas but despite consistent strong performances, has only the 2019-20 FA Cup to show for his time in charge and will be desperate to finally add a league title. Marco Silva, Fulham Marco Silva celebrates a win (Bradley Collyer/PA) Appointed: July 1, 2021 Scott Parker's departure following relegation in 2021 led Fulham to turn to Silva and his has been a successful reign, winning the Championship title in his first season before finishing 10th, 13th and then 11th in the top flight. Silva was also linked with Spurs before Frank's appointment but looks set to lead the Cottagers into a fifth season. Eddie Howe, Newcastle Newcastle have been able to finally celebrate trophy success again under Eddie Howe (Owen Humphreys/PA) Appointed: November 8, 2021 The man to finally bring silverware to St James' Park after a wait of 56 years, Howe was appointed shortly after the Saudi-backed takeover of the club in 2021 – though not before Steve Bruce was allowed to remain in charge of his boyhood club for his 1,000th game in management. Second-bottom and winless at the time, Howe's Magpies finished 11th and have since been fourth, seventh and fifth in his three full seasons in charge. Unai Emery, Aston Villa Unai Emery has brought the good times back to Villa Park (Nigel French/PA) Appointed: November 5, 2022 Appointed almost a year after Howe, Emery also instigated a swift turnaround. Villa were outside the relegation zone on alphabetical order alone, ahead of Southampton, when he took over but finished seventh and then fourth the following season. A run to the Champions League quarter-finals ensued, beating Bayern Munich along the way before losing to eventual champions Paris St Germain, alongside a sixth-placed league finish. One extreme to the other Thomas Frank goes from the second longest-serving manager at a Premier League club to the newest! He spent 6 years and 7 months at Brentford before moving to Spurs 🤝 — Premier League (@premierleague) June 12, 2025 Frank goes from one of the longest-serving Premier League managers to one of eight in post for less than a year. Prior to the Dane's appointment, the shortest reign belonged to David Moyes – though in a curious quirk, Moyes is also the Premier League manager who has spent longest with his current club thanks to a previous 11-year spell at Everton between 2002 and 2013. Two more managers will hit the two-year mark early next month – Bournemouth's Andoni Iraola on July 1 and Daniel Farke three days later with newly-promoted Leeds. Fabian Hurzeler has his one-year anniversary at Brighton this coming Sunday.
The Herald Scotland
12-06-2025
- Sport
- The Herald Scotland
A look at the longevity of Premier League managers
Pep Guardiola, Manchester City PEP 💬 From day one, I felt incredible love and respect with all my assistants and coaches here. If I did not feel that I wouldn't be here. — Manchester City (@ManCity) November 22, 2024 Appointed: July 1, 2016 Guardiola's famed intensity has previously led to earlier than expected departures from Barcelona and Bayern Munich, with a sabbatical year in between, but at City he has put down roots – signing a contract extension last season to take his reign beyond a decade. He has won six league titles and the 2022-23 Champions League among his 14 major trophies with the club but will go into the new campaign seeking a response to a season of dramatic under-performance. Mikel Arteta, Arsenal Arsenal's impressive performances under Mikel Arteta have not been rewarded by trophies (Bradley Collyer/PA) Appointed: December 22, 2019 Premier League runners-up three years in a row, Arsenal's manager now also assumes second spot in these rankings from Frank. The Spaniard will reach six years at the helm just before Christmas but despite consistent strong performances, has only the 2019-20 FA Cup to show for his time in charge and will be desperate to finally add a league title. Marco Silva, Fulham Marco Silva celebrates a win (Bradley Collyer/PA) Appointed: July 1, 2021 Scott Parker's departure following relegation in 2021 led Fulham to turn to Silva and his has been a successful reign, winning the Championship title in his first season before finishing 10th, 13th and then 11th in the top flight. Silva was also linked with Spurs before Frank's appointment but looks set to lead the Cottagers into a fifth season. Eddie Howe, Newcastle Newcastle have been able to finally celebrate trophy success again under Eddie Howe (Owen Humphreys/PA) Appointed: November 8, 2021 The man to finally bring silverware to St James' Park after a wait of 56 years, Howe was appointed shortly after the Saudi-backed takeover of the club in 2021 – though not before Steve Bruce was allowed to remain in charge of his boyhood club for his 1,000th game in management. Second-bottom and winless at the time, Howe's Magpies finished 11th and have since been fourth, seventh and fifth in his three full seasons in charge. Unai Emery, Aston Villa Unai Emery has brought the good times back to Villa Park (Nigel French/PA) Appointed: November 5, 2022 Appointed almost a year after Howe, Emery also instigated a swift turnaround. Villa were outside the relegation zone on alphabetical order alone, ahead of Southampton, when he took over but finished seventh and then fourth the following season. A run to the Champions League quarter-finals ensued, beating Bayern Munich along the way before losing to eventual champions Paris St Germain, alongside a sixth-placed league finish. One extreme to the other Thomas Frank goes from the second longest-serving manager at a Premier League club to the newest! He spent 6 years and 7 months at Brentford before moving to Spurs 🤝 — Premier League (@premierleague) June 12, 2025 Frank goes from one of the longest-serving Premier League managers to one of eight in post for less than a year. Prior to the Dane's appointment, the shortest reign belonged to David Moyes – though in a curious quirk, Moyes is also the Premier League manager who has spent longest with his current club thanks to a previous 11-year spell at Everton between 2002 and 2013. Two more managers will hit the two-year mark early next month – Bournemouth's Andoni Iraola on July 1 and Daniel Farke three days later with newly-promoted Leeds. Fabian Hurzeler has his one-year anniversary at Brighton this coming Sunday.
