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India Today
42 minutes ago
- Health
- India Today
Endocrinologist Dr. Ambrish Mithal on the happy side-effects of weight-loss drugs
New-age weight-loss drugs are exploding the pharmaceutical market, offering better results than traditional medicines. Top endocrinologist Dr. Ambrish Mithal deconstructs the many facets, including side-effects, of these GLP-1 drugs in his recently published book The Weight Loss Revolution, in an episode of India Today's said that while the GLP-1 field -- drugs that belong to the class of GLP-1 targeting the same hormone in the body -- is just beginning to explode, there'll be many newer drugs with less and less side effects and easier to most cases have shown muscle loss as a prominent result of using GLP-1 medications like tirzepatide or semaglutide, Dr. Mithal explains that losing muscle is an accompanying factor to weight loss. "In the long run, if you're not following a healthy diet, you will end up with significant muscle loss. And this is not because of the weight-loss drugs. Whenever we lose weight, we also lose muscle. If you lose 10 kg, you've lost 2-3 kg of muscle. Now, if you want to preserve that, you have to ensure adequate protein and fibre in your diet. Along with that, you have to make sure that you're exercising regularly and that exercise should include strength training," Dr. Mithal also shared what many people experience loose skin after taking these medicines. "When you lose weight rapidly, you lose subcutaneous fat. Particularly in older people where skin tends to sag anyway. If you suddenly lose weight, don't hydrate yourself well, not eating the right kind of balanced diet, then you get that little sagging on the face which people have started calling Ozempic face. Before these drugs came into the market, anyone we put on a very strict diet or someone who had bariatric surgery would see similar results," he gastrointestinal side-effects, nausea, and vomiting, Dr. Mithal addressed concerns about thyroid cancer, highlighting that there's no evidence to link the also explained the "happy side-effects" of GLP-1 medications. Besides growing body of evidence suggesting how semaglutide is linked to Alzheimer's disease, Dr. Mithal said that the benefits of the drugs are moving beyond weight loss."The evidence that they might be helping Alzheimer's by helping obesity in the brain may actually be very exciting, and even for cardiac health, Parkinson's disease. Cardiac events are reduced. Fatty liver is reduced. Kidney disease progression is reduced. But the brain effects are particularly fascinating. Sleep apnea has also gone down," he said, adding that the drugs have also helped improve fertility outcomes in women with PCOS (Polycystic Ovary Syndrome).Currently, most GLP-1 drugs are injectable and expensive, limiting their access in India. However, new formulations and more research are on the way. Novo Nordisk's Wegovy and Eli Lilly's Mounjaro, two blockbuster fat-busting medicines, are set to gain ground in India to tackle the diabetes and obesity crisis."Remember, the GLP-1 field is just beginning to explode. There'll be many newer drugs with less and less side effects and easier to use," Dr. Mithal sayssaid.- EndsMust Watch
India Today
an hour ago
- Entertainment
- India Today
Kannappa box office Day 1: Vishnu Manchu's film outperforms Maa, F1 in India
Telugu devotional film, 'Kannappa', opened on a solid note at the domestic box office upon its release on June 27. The film has surpassed the Day 1 collection of Kajol's horror drama 'Maa', and Brad Pitt's 'F1' at the box office in India. 'Kannappa' is a film based on the legend of Kannappa, a staunch devotee of Lord to the tracking website, Sacnilk, the film earned Rs 9 crore nett at the domestic box office. While this isn't a huge number to start the theatrical run with, the film has been clocking in excellent occupancy in theatres. 'Kannappa' is expected to see an incline in numbers during the 'Maa' minted Rs 4.50 crore, half of what 'Kannappa' did on its first day at the box office. Brad Pitt's much-anticipated 'F1' collected Rs 5.25 crore in India. India Today reviewer, Sanjay Ponnappa, rated the film 2.5 out 5 stars and wrote, "Kannappa falters when it comes to direction, screenplay, and execution. Director Mukesh Kumar Singh, known for several mythological TV serials, brings the same melodramatic and slightly outdated touch to the film. The story and screenplay, written by Vishnu Manchu himself, add a fictional arc to the devotional tale we all know. Although the arc has interesting ideas, it suffers from poor execution in both writing and direction."Directed by Mukesh Kumar Singh, 'Kannappa' features an ensemble cast including Mohanlal, Akshay Kumar, Kajal Aggawarlal and Prabhas in cameo roles. The supporting roles include Mohan Babu, Sarathkumar, Brahmanandam, Brahmaji, Madhoo, Mukesh Rishi and Raghu Babu.'Kannappa' is jointly produced by AVA Entertainment and 24 Frames Factory.- EndsMust Watch
India Today
an hour ago
- Science
- India Today
Wake up Isro! You forgot to celebrate your own astronaut
For four decades, India had been waiting in silence for its next big humanised space moment after the launch of Squadron Leader Rakesh Sharma. That moment finally came on June 25–26, 2025, as Group Captain Shubhanshu Shukla docked with the International Space science journalists celebrated this humongous achievement, his family watched with tears of joy, and parts of India witnessed the moment with pride. Something was missing - rather, someone was Indian Space Research Organisation, our very own Isro, was surprisingly mute. It wasn't just surprising for me to see Isro completely missing from the picture when it came to promoting its own astronaut. It was regularly covered the beat, I know how the Indian space agency functions - in silos and behind closed that's not all - access has been further restricted, media interactions are limited, and mission details are sometimes shared just days before launch on a website that still reminds you of the early years of the World Wide urgently needs to wake up to the harsh realities of modern media and public engagement, as its near-silent approach to celebrating Group Captain Shubhanshu Shukla's historic Axiom-4 mission starkly Shukla first Indian in International Space StationMoment of triumph for Group Captain 'Shux'#ISS #ShubhanshuShukla #ITVideo #Ax4 #Super6 | @Akshita_N @imsktripathi IndiaToday (@IndiaToday) June 26, 2025advertisementWhile Shukla's 14-day stint aboard the International Space Station marks a monumental leap for India's human spaceflight ambitions and directly supports the upcoming Gaganyaan mission, which he repeatedly said in his messages, Isro's muted communication strategy has severely blunted the buzz and national pride this achievement should have mission is a milestone not just for Shukla or the Indian Air Force, but for India's stature in the global space community, now effectively part of our soft launch to docking — everything you need to know about Axiom-4's journey to the International Space Station.#ITVideo #ShubhanshuShukla #Axiom4Mission | @Akshita_N @imsktripathi IndiaToday (@IndiaToday) June 25, 2025Yet, unlike the widespread fanfare and media saturation that accompanied Chandrayaan-3's triumphant lunar landing, Isro's promotional silence has left the public largely unaware or underwhelmed by this historic Indian Air Force and a few political leaders issued congratulatory messages, but Isro itself refrained from capitalising on the moment to build sustained excitement or public engagement. The first tweet, bare-bones in nature, came a day after Axiom-4 launched. Isro is yet to give a detailed breakdown of the scientific studies and experiments that have been sent, except for a couple of media interactions that were lined up by the Axiom team before strategic misstep risks undermining the momentum crucial for Gaganyaan, India's ambitious crewed spaceflight mission planned for 2027. Public enthusiasm and national pride are not mere vanity; they fuel political will, funding, and inspire the next generation of scientists and lessons Isro learned from Chandrayaan-3 - how to create a media spectacle that captivates the nation - appear squandered. The agency's failure to aggressively promote Shukla's mission reduces its impact to a footnote rather than a defining chapter in India's space Isro continues this low-key approach, it jeopardises not only the outreach and support for Gaganyaan but also risks ceding the narrative to foreign agencies and commercial space ambitions deserve a bold, confident media strategy that celebrates achievements loudly and widely. Otherwise, the nation's space program may struggle to capture the imagination and backing it critically time for Isro to wake up and own the media narrative is now - before the window for inspiring a billion hearts closes.(Sibu Tripathi heads the Science team at India Today Digital. He is a recipient of the prestigious Ramnath Goenka Excellence in Journalism award.)- Ends(Views expressed in this opinion piece are those of the author)Must Watch
India Today
7 hours ago
- Politics
- India Today
Trump warns Iran, says will absolutely bomb if uranium enrichment continues
25:35 India Today's Akshita Nandagopal explains the strategic significance of the Strait of Hormuz amid the West Asia conflict, US bombing of Iranian nuclear sites, Donald Trump's bid for a Nobel Peace Prize and the 50th anniversary of India's Emergency.
Time of India
10 hours ago
- Entertainment
- Time of India
Anupam Kher says he cried in front of Mahesh Bhatt after losing out on 'Saaransh': ‘I went to him and cursed'
Bollywood actor Anupam Kher recently shared a deeply personal story that shaped his journey in cinema. He revisited a turning point in his early career after being abruptly dropped from the 1984 film 'Saaransh'. Anupam Kher about confroting Mahesh Bhatt after losing Saaransh In an interview with India Today, Anupam noted that taking chances in both career and relationships helps an individual to reinvent and rediscover themselves. He emphasised the importance of forgiveness and moving on. 03:05 Aditya Roy Kapur's Singing Debut Leaves Fans Speechless | Metro In Dino Magic He described the crushing disappointment of being removed from the film just days before filming began. The blow left him so distraught that he contemplated leaving the city altogether. However, a moment of clarity led him to confront the situation head-on. 'I was on my way to VT station, planning to return to Delhi, Shimla, or Bombay. But I told myself – how can I leave without telling Mahesh Bhatt what I feel? So I went to him, cried, cursed, and said everything I had to. If I hadn't done that, I wouldn't be sitting here talking to you today. That moment changed me,' he stated. Anupam was initially signed for the movie, but later the studio decided that a newcomer could not play the role of a man in his 60s. They wanted an established actor. However, after Anupam's visit to Mahesh Bhatt and his emotional outburst, Mahesh told the makers that he needed Anupam in the movie Anupam Kher about Dino Kher admits that he did the right thing by opening up to Mahesh during that time. The actor emphasised that his upcoming film Metro... In Dino also revolves around the same theme – the importance of communication and speaking up. Dino release Metro... In Dino is set to hit cinemas on July 7. Directed by Anurag Basu , the film also features Aditya Roy Kapur , Sara Ali Khan, Konkona Sensharma, Fatima Sana Shaikh, Pankaj Tripathi, Neena Gupta, and Ali Fazal in key roles.
