Latest news with #KeckMedicine
Medscape
3 days ago
- Health
- Medscape
Alcohol-Related Liver Disease Increases Sharply
Significant liver fibrosis associated with heavy alcohol use rose more than twofold over roughly the past two decades in the US despite alcohol use rates holding steady, which might be explained by risk factors for alcohol-related liver injury in the population, researchers said. Those most likely to be heavy drinkers are women, adults aged 45 years or older, those living in poverty, and those with metabolic syndrome, the data showed. 'Alcohol-related liver disease is the main cause of liver-related death, and these results are a major wake-up call to the dangers of drinking,' lead investigator Brian Lee, MD, MAS, hepatologist and liver transplant specialist with Keck Medicine of University of Southern California, Los Angeles, said in a statement. The study was published online on July 23 in Clinical Gastroenterology and Hepatology . Call for Increased Awareness To gauge trends in advanced alcohol-related liver disease among heavy drinkers, Lee and colleagues mined data from the National Health and Nutrition Examination Survey (NHANES) spanning 1999-2020. The primary outcome was a high Fibrosis-4 (FIB-4) score (FIB-4 > 2.67 for those aged 65 years or younger and > 3.25 for those older than 65 years), which has previously been linked to a 25-fold higher risk for liver-related death. People with hepatitis B or C were excluded. Among 44,628 adults, 2474 were heavy drinkers — defined as at least 20 g/d for women and 30 g/d for men in the prior year. Among heavy drinkers, the prevalence of high FIB-4 — a marker of advanced liver scarring — increased more than twofold over time, from 1.8% in 1999-2004 to 4.3% in 2013-2020, vs an increase of 0.8%-1.4% among non-heavy drinkers. Notably, average alcohol intake stayed the same during the study period, the researchers said. Among heavy drinkers, the prevalence of metabolic syndrome rose from 26.4% in 1999-2004 to 37.6% in 2013-2020, the mean age increased, and a greater proportion was women or living in poverty — factors that can amplify susceptibility to alcohol's liver effects. Supplementary analyses restricting the cohort to adults aged 35-65 years or to pre-pandemic years (1999-2018) confirmed the same upward trends, with significant liver scarring tripling over 20 years. Limitations cited by the authors include the cross-sectional design of NHANES and reliance on self-reported alcohol intake, which can't capture fluctuations over time, and the use of FIB-4 as a surrogate for liver disease. Collectively, the data suggest that increasing morbidity and mortality due to alcohol-related liver disease 'may be related to a population more sensitized to the alcohol-related effects in the liver due to increased baseline risk factors,' the researchers wrote. The findings provide impetus for 'urgent awareness' of the contemporaneous risk for alcohol-related liver disease with heavy drinking and interventions to screen and treat risk factors, they added.
Los Angeles Times
5 days ago
- Health
- Los Angeles Times
Serious liver disease is up among heavy drinkers, even without more drinking
Serious liver disease is becoming more common among Americans who drink heavily, according to a new study from Keck Medicine of USC. It's not that more people are partying with alcohol. And it's not that the drinkers are having more drinks. It's that more of the people who drink regularly are becoming sick. Over the last two decades, the share of heavy drinkers who have advanced liver scarring jumped from 1.8% to 4.3%. For women, more than 1.5 drinks per night, on average, is considered heavy drinking. For men, it's 2 drinks. 'The fact that the risk not only increased but that it more than doubled — almost tripled — is really astonishing,' said Dr. Brian P. Lee, a liver transplant specialist at Keck Medicine of USC and lead author on the study. It was published in the journal Clinical Gastroenterology and Hepatology on Wednesday. Lee said he thinks patients might dramatically change their thinking and behavior if they had this information. The increase in illness was seen especially in women, older people and those with conditions like obesity or diabetes. Three USC researchers analyzed national health data from more than 44,000 adults surveyed between 1999 and 2020 in a well-known national heath study known as NHANES. Of those, 2,474 were heavy drinkers according to the definition of the National Institute on Alcohol Abuse and Alcoholism — 20 grams of alcohol per day for women and 30 grams for men, roughly the equivalent of 1.5 and 2 drinks. They found a more than twofold increase over the two decades in significant liver fibrosis, a condition where healthy liver tissue is replaced by stiff, fibrous tissue — like a sponge hardening into leather. If left unchecked, this can eventually lead to liver failure or cancer. By comparison, non-heavy drinkers saw a much smaller increase, from 0.8% to 1.4% over the same period. This rise in liver damage is especially troubling because many people don't realize anything is wrong until the disease is advanced. 'Liver disease is silent,' Lee said. 'Most people won't, even if they have [advanced liver scarring], have any symptoms at all.' Drinking patterns did not change much over the study period. But the health profiles of heavy drinkers did. Rates of metabolic syndrome — a cluster of conditions including obesity, diabetes, and high blood pressure — increased from 26% of people, to nearly 38%. Demographics shifted too: heavy drinkers became more likely to be women, people over the age of 45, and those living in poverty. 'We're showing with this study that the picture of the American drinker is changing dramatically,' Lee said. 'You have more women who are drinking heavily, more ethnic minorities who are drinking heavily, and these are groups that are known to have a higher sensitivity to alcohol in causing liver damage.' Other factors may also be at play, said Dr. Sammy Saab, medical director of the Pfleger Liver Institute at UCLA, who was not involved in the study. People could be consuming different types of drinks, or at different times. 'Have we moved away from beer, wine, to hard cocktails? Have we moved away from drinking with food, where the food absorbs some of the alcohol you consume, versus drinking without food where alcohol is better absorbed?' Saab asked. Then there are cultural changes, he said. 'In the old days, if you drank, you'd still have to drive home, but now we've got Uber, we have Lyft,' he said, which may remove some deterrents to heavy drinking. The current definition of heavy drinking in the U.S. may actually be too lenient, Lee said, especially compared to evolving global standards. Canada, for example, now advises no more than two drinks per week to minimize health risks. 'In the U.S. right now, we consider heavy drinking to be eight drinks or more per week for women and 15 or more for men — but that's quite high,' he said. 'We've shown in prior studies that you can develop liver disease at lower quantities than the U.S. threshold.' The study's findings highlight the need to rethink long-held assumptions about alcohol-related liver disease, and Lee hopes it can be used to develop more effective screening methods for early detection. The paper raises a lot of good questions, Saab said, serving as a call to action for researchers and clinicians to better understand this increase in alcohol-associated liver disease — and how to stop it.
Yahoo
14-07-2025
- Health
- Yahoo
Beyond melatonin: How doctors and sleep experts really recommend you overcome jet lag
Whether you're flying across the country or across the globe, that mind-melting, time-warping experience can leave even the most seasoned traveler wrestling with a serious case of jet lag. An honest-to-goodness (albeit temporary) sleeping disorder, jet lag strikes when your body's internal 24-hour clock (aka your circadian rhythm) gets completely out of sync with your new time zone. The result? You feel like you've sprinted directly into a wall of bone-deep fatigue and exhaustion. "Jet lag usually occurs when you travel across more than two time zones," says Dr. Joyce Adesina, a sleep medicine specialist with Keck Medicine of USC in Los Angeles. "So you're either experiencing some sort of insomnia or excessive daytime sleepiness because of this trip." But that's not all — other symptoms can include feeling disoriented, changes in appetite, digestive issues or shifts in your menstrual cycle. Headaches and irritability are also common. Even the idea of jet lag is enough to keep some would-be vacationers home: A 2024 survey discovered that one in five U.S. travelers would actually bow out of a trip if they thought jet lag was going to get the best of them. But there's no need to panic: There are plenty of expert-backed, scientifically-valid jet lag remedies to help nearly every traveler. Here's what you need to know — and how to get over jet lag. You know how you often feel tired, headachy and even a little disorientated during or immediately after a long flight? That's not jet lag; it's something called travel fatigue, and it strikes thanks to a combo of icks like low humidity, dehydration, low air pressure and sleep loss. Jet lag, on the other hand, occurs in the next few days after your flight. The symptoms are similar and often go hand in hand, so many people refer to the entire post-flight travel experience as jet lag. The severity of your jet lag is affected by several factors. Age: While everyone is susceptible to jet lag, research shows that people over the age of 60 experience circadian changes that can make it more difficult to recover from jet lag. Number of time zones: Generally, the more time zones you travel across, the longer it'll take to recover. There's actually a rough formula: Expect about one day of recovery for each time zone you cross. "If you are going from the West Coast to the East Coast of the United States, then it'll take about three days to adjust, since there is a three-hour difference. If you are going across seven time zones, it will take a week," says Bryce Mander, PhD, an associate professor of psychiatry and human behavior at the University of California, Irvine, School of jet lag affects everyone differently. "There are some people who travel one time zone, and that really bothers them. It really is very disruptive to their entire routine, to their sleep, to when they feel good. And there are other people who can travel for four or five hours, and it's not a big deal for them," says Jamie Zeitzer, PhD, co-director of the Stanford Center for Sleep and Circadian Sciences. Destination: Your body's natural clock actually runs slightly longer than 24 hours, which means it's easier to stretch your day out than to compress it. That's why traveling west (where you "gain" time) feels more natural than traveling east (where you "lose" time), according to research. Sleep before travel: If your sleep is not great in the days leading up your flight, you're at a higher risk of getting jet lag after traveling. First, the bad news: You can't eliminate jet lag completely. However, that doesn't mean you're destined for fatigue-fueled travel. "There are essentially two cues that can help you swing your circadian rhythm and soften the effects of jet lag," says Dr. Sam Kashani, an assistant clinical professor of sleep medicine at David Geffen School of Medicine at UCLA. "One is bright light exposure, and the other is strategically timed melatonin." The timing of each is key to your jet lag recovery. Light is your secret weapon for beating jet lag because it directly controls your circadian rhythm. Here's how it works: Light exposure suppresses melatonin, the hormone your body naturally releases about one to three hours before bedtime. By strategically timing when you get light, you can actually shift your internal clock. The key is matching your light exposure to your travel direction. The exact timing will depend on how many time zones you're crossing and your desired sleep schedule at your destination, but here's the gist, according to Kashani: Evening light usually helps you adapt to a later time zone after traveling west, whereas first-thing morning light can help you adjust to an earlier time zone after traveling east. If it's not sunny or bright outside when you're trying to make these adjustments? Adesina recommends considering a light box for boosting exposure ... or sunglasses when you need to avoid light. Light directly affects the melatonin your body releases — and since melatonin is what signals sleepiness, taking melatonin supplements at strategic times may also help shift your internal clock. "For jet lag, you must take melatonin across multiple days at low doses —1 to 3 milligrams or less — at least three hours before [your desired] bedtime, and after you take it, you need to stay awake until your desired bedtime," says Mander. (Some experts even suggest taking melatonin a few days before your trip.) That said, melatonin is not a sleeping pill. Instead, melatonin can improve certain symptoms of jet lag, like alertness, and reduce daytime sleepiness, but it might not help shorten the time it takes for jet-laggers to fall asleep. Remember, if you're considering taking any supplements or medication to help with your jet lag, consult your doctor first. (Learn which melatonin supplement might be right for you.) The easiest way to figure out your light exposure and melatonin timing is to use a jet lag calculator, such as the one on says Kashani. Use the tool to start shifting your schedule before, after or during your flight. The calculator considers factors including your departure and arrival locations, flight times and your typical sleep and wake schedule. You can also choose whether to incorporate melatonin into your adjustment plan. There's also an option to include melatonin as part of your adjustment plan. Another option is the Timeshifter app, favored by Mander, that formulates a personalized jet-lag recovery plan, that includes advice on when to abstain from caffeine and when to sneak in a cat nap. There are other ways you can get over jet lag. You can get a jump start on adjusting your circadian rhythm by gradually shifting your sleep schedule at home a few days before your flight. Traveling east? Hit the sack 30 minutes earlier each night until you're one to two hours ahead. If you're traveling west, do the opposite — go to bed 30 minutes later. "Since it takes a number of days to adjust to a new time zone based on how many time zones you cross, if you're going on a short trip, try to stay on your home time zone [schedule] to minimize jet lag," says Mander. The reason? Shifting to a new time zone on a brief getaway means you'll be more jet lagged coming home than you would have been had you stayed on your home time zone. No matter how much you want to devour that in-flight meal, think about what time it is where you're heading before you do, says Rebecca Robbins, PhD, an assistant professor of medicine at Harvard Medical School and sleep scientist at Brigham and Women's Hospital in Boston. "This will help you make good decisions while you're traveling, like maybe forgoing a meal that's being served on the plane and getting something at the airport instead." Keep that mentality when on the ground too. "It's always best to eat on the schedule of your destination," says Adesina. That means don't eat lunch at breakfast time or vice versa. All those cues help you reset your internal clock." Beyond food, be careful with caffeine. Adesina recommends avoiding caffeine after midday in the time zone of your new destination. And since both caffeine and alcohol can disrupt sleep, consider sticking to water on long flights. One key for mitigating jet lag is to arrive at your destination as rested and relaxed as possible, which can be tricky with air travel. That's why Robbins suggests bringing familiar comfort items from home on your flight — things like a cozy shawl, a trusted eye mask or earplugs you've already tested at home, noise-canceling headphones and a high-quality travel pillow. These small touches can make a real difference in your travel experience. Research supports this approach: A small study of competitive cricket players found that better sleep quality during flights (with fewer disruptions) helped with jet lag recovery. If you can swing it, consider booking a seat with more leg room. (Those cricket players snoozed well in business class.) Zeitzer, who once flew business class to Korea, agrees: "I have to say, jet lag is a lot less bad when you're flying business class. You have all this physical space. You have mental space. You're eating better. You're more relaxed." The only downside? "Now that I know how good the other half has it, when I have to fly economy to Korea, the jet lag is worse!" While not worrying about jet lag is easier said than done, mindset can make a difference. "The more you worry about it, the worse that it's going to be," says Zeitzer. He says to look for ways to reduce that anxiety to make it easier for you to travel. Plan your strategy: Use Sleepopolis jet lag calculator or the Timeshifter app to determine when to get light and/or how much melatonin to take before, during and after your flight. Start shifting early: Try adjusting your wake time and bedtime in the days prior to your travel. The jet lag calculator or app can help. Get your melatonin: Talk to your health care provider about possibly taking a low-dose melatonin supplement, like Thorne Melaton-3, our pick for the best overall melatonin supplement. Pack comfort items: Stash items in your carry-on bag that help you feel relaxed such as a travel pillow, earplug or eye mask. Consider Travelrest's Nest Ultimate Memory Foam Travel Pillow, Loop Quiet 2 earplugs and the Nidra Deep Rest Eye Mask. Watch what you consume: Try to avoid alcohol and caffeine, which can mess up sleep. And drink plenty of water to stay hydrated. Eat strategically: Start eating on your new schedule as soon as possible, which means you'll need to be mindful of the time airplane meals are served. And when you are eating during travel, have light meals to help avoid digestive issues. Stay comfortable: Make sure to stretch, move about the cabin and engage in relaxing activities on board, says Mander. Use your comfort items to help you relax. Get the right light: Again, turn to your jet lag calculator or app to determine the best times to get light. Use a light box or wear sunglasses if needed. (Try Ray-Ban Wayfarers or Quay After Hours sunglasses.) Settle in smart: Take a shower once you arrive and a quick 20-minute nap if needed — only if it's at least eight or more hours before your planned bedtime. Eat and drink on schedule: Have meals according to the new time zone. Get plenty of water to stay hydrated. Take melatonin, if planned: Follow your calculator or app guidance for timing — and your health care provider's advice. Exercise outdoors: The fresh air and natural light exposure can help adjust your internal clock, Robbins suggests. Keep it simple for short trips: If your trip is brief, consider staying on your home time zone schedule. Stay positive: Worrying about jet lag doesn't help. Try to relax and enjoy your trip! Joyce Adesina, MD, sleep medicine specialist with Keck Medicine of USC Sam A. Kashani, MD, assistant clinical professor of sleep medicine at David Geffen School of Medicine at UCLA Bryce Mander, PhD, associate professor of psychiatry and human behavior at the University of California, Irvine, School of Medicine Rebecca Robbins, PhD, assistant professor of medicine at Harvard Medical School and sleep scientist at Brigham and Women's Hospital in Boston Jamie Zeitzer, MD, co–director of the Stanford Center for Sleep and Circadian Sciences and professor of psychiatry and behavioral sciences sleep medicine at Stanford University Our health content is for informational purposes only and is not intended as professional medical advice. Consult a medical professional on questions about your health.
Yahoo
10-07-2025
- Health
- Yahoo
How Hearing Aids Could Help You Live Longer, According To Science
A new study suggests that hearing aids and cochlear implants can help people feel more connected and even live longer lives. Adults using hearing aids and implants were better able to engage in group conversations and that they were more at ease in noisy or challenging listening environments. This can have an effect on overall mortality, too, researchers said. Hearing loss is a super common side effect of getting older, with an estimated 1 in 3 adults between the ages of 65 and 74 experiencing it, per Johns Hopkins Medicine. Despite this stark data, many older folks are hesitant to use hearing aids. Now, new research suggests that investing in a hearing aid can do a whole lot more than just help you hear what's going on around you—it could actually help you feel more connected to the people you interact with and even live longer. This was the major takeaway from the study, which was published in JAMA Otolaryngology – Head & Neck Surgery. And while the leap from using a hearing aid to living longer seems like a stretch, doctors who treat hearing loss say otherwise. 'It's not just about hearing better, it's about keeping the brain active and staying connected,' says Janet Choi, MD, MPH, study co-author and an otolaryngologist with Keck Medicine of USC. So, what's behind this connection? Dr. Choi and other hearing specialists break it down. Meet the experts: Janet Choi, MD, MPH, study co-author and an otolaryngologist with Keck Medicine of USC; Robert J. Macielak, MD, an otolaryngologist at The Ohio State University Wexner Medical Center; Meaghan P. Reed, AuD, clinical director of audiology at Massachusetts Eye and Ear For the study, Dr. Choi and her fellow researchers analyzed data from 65 previously published studies that featured data on more than 5,000 people. They specifically looked at how hearing aids and cochlear implants impacted participants' social quality of life, how they felt about the impact of their hearing loss on social situations, and how lonely they felt. The researchers discovered that adults who used hearing devices like hearing aids felt more socially connected and less limited in social situations. They also reported feeling like they were better able to engage in group conversations and that they were more at ease in noisy or challenging listening environments. This scientific analysis follows a 2024 study by Choi that found that adults with hearing loss who use hearing aids have an almost 25 percent lower risk of mortality. About one in three older adults have hearing loss, according to the National Institute on Aging (NIA). The odds of developing hearing loss also increases with age, per the NIA. There are a few reasons why hearing loss is linked to longevity. 'Hearing is deeply connected to how we engage with the world,' Dr. Choi explains. 'When people lose their hearing, they often withdraw socially, which can lead to poor quality of life, social isolation, even earlier cognitive decline.' Hearing loss can even have an indirect impact on health. 'Many with untreated hearing loss may fear visiting physicians or struggle to understand medical instructions and treatment plans, which can lead to delaying or avoiding necessary medical care,' says Meaghan P. Reed, AuD, clinical director of audiology at Massachusetts Eye and Ear. The social isolation and reduced mental stimulation that comes with hearing loss are also known risk factors for cognitive decline, Reed says. 'Studies indicate that individuals with untreated hearing loss are at a significantly higher risk of developing dementia and other cognitive impairments,' she says. 'Additionally, untreated hearing loss often increases healthcare costs and living expenses, adding financial stress. Together, these factors contribute to a decline in overall health and quality of life, which can ultimately reduce lifespan and longevity.' The best way to know if you need a hearing aid is to get your hearing tested, says Robert J. Macielak, MD, an otolaryngologist at The Ohio State University Wexner Medical Center. But he also says there are certain signals that suggest it may be time to schedule that test. 'Signs that you should get your hearing tested include difficulty hearing in loud environments or on the phone, having trouble hearing children's voices, or if you find that you need to lip read to understand conversation,' Dr. Macielak says. It's also important to listen to the people around you, Choi says. 'Loved ones often notice the changes before you do,' she says. Reed says you have a few options if you think you need to get your hearing checked. 'Online hearing screening apps are available and are sometimes used by over-the-counter hearing aids to help set their devices,' she says. 'These apps can also be useful for monitoring hearing over time, but they are not comprehensive tests.' Your general practitioner can also do a basic hearing test, but these are usually a quick pass/fail assessment versus an in-depth evaluation, Reed says. From there, you may be referred to a hearing specialist for a more detailed look at what's going on. 'With the availability of over-the-counter hearing aids, there are now more options than ever to get support,' Dr. Choi says. 'I encourage anyone experiencing signs of hearing difficulty to start with a hearing test. You may be surprised by the range of effective solutions available.' You Might Also Like Jennifer Garner Swears By This Retinol Eye Cream These New Kicks Will Help You Smash Your Cross-Training Goals
Newsweek
09-07-2025
- Health
- Newsweek
Herpes Virus Could Help Treat Advanced Cancer
Based on facts, either observed and verified firsthand by the reporter, or reported and verified from knowledgeable sources. Newsweek AI is in beta. Translations may contain inaccuracies—please refer to the original content. While it may give billions of people worldwide painful cold sores, a common virus could be harnessed to provide a much-need new cancer treatment. This is the conclusion of a study by researchers with Keck Medicine at the University of Southern California, who have shown in early clinical trials that a genetically modified version of herpes simplex virus type 1 (HSV-1) can be used against advanced melanoma. Melanoma is a form of skin cancer that originates in the cells that give our skin its pigment. In its advanced form, however, it spreads to other sites in the body. "These findings are very encouraging because melanoma is the fifth most common cancer for adults—and about half of all advanced melanoma cases cannot be managed with currently available immunotherapy treatments," said paper author and oncologist Dr. Gino Kim In of Keck Medicine in a statement. "The survival rate of untreatable advanced melanoma is only a few years, so this new therapy offers hope to patients who may have run out of options to fight the cancer." Stock image of a doctor inspecting a patient's mole for skin cancer, Stock image of a doctor inspecting a patient's mole for skin cancer, Wavebreakmedia/iStock / Getty Images Plus In their study, In and colleagues recruited 140 patients with advanced melanoma that either did not respond—or was no longer responding—to immunotherapy. Each participant had multiple tumors, some of which were "superficial," in that they were located on or just beneath the skin, while others were located deeper in the body, such as in organs like the liver or lungs. "Unlike other immunotherapy drugs, RP1 is an 'intratumoral' therapy that is injected directly into melanoma tumors," In told Newsweek. Both deep and superficial tumors were treated with a modified version of HSV-1 in combination with the immunotherapy agent, nivolumab (which helps the immune system's T-cells fight tumors), every two weeks for up to 16 weeks in total. If the patients appeared to be responding to the treatment, they then continued receiving nivolumab every four weeks for up to two years. The modified HSV-1 virus used in the study is named "RP1." It is designed to specifically target and destroy cancerous tumors while also stimulating the body's white blood cells to seek and destroy other cancer cells across the entire body. Unlike its natural predecessor, RP1 does not cause herpes. The U.S. Food and Drug Administration approved RP1 for review in patients with advanced melanoma that was not responding to immunotherapy in January this year. By the trial's end, the team found that tumors had shrunk by at least 30 percent in one-third of the patients—while nearly one-in-six saw their tumors disappear completely. "Importantly, RP1 was very well tolerated with approximately 90 percent of patients having only mild side effects, such as fatigue, fever and flu-like symptoms," noted In. An artist's impression of the herpes simplex virus. An artist's impression of the herpes simplex virus. Artur Plawgo/iStock / Getty Images Plus Comparing the outcomes of both tumors that were directly treated and those that were not, the team found that uninjected tumors shrank and/or disappeared just as frequently. "This result suggests that RP1 is effective in targeting cancer throughout the entire body and not just the injected tumor," said In. This, she continued, "expands the potential effectiveness of the drug, because some tumors may be more difficult or impossible to reach." In added that—while it is too early to tell if the positive outcomes stay permanent—she is optimistic about RP1 therapy's potential. She explained: "I believe that oncolytic viruses will open up an important new approach to fighting cancer in some patients in the near future." Stock image of melanoma cells seen through a microscope. Stock image of melanoma cells seen through a microscope. Dlumen/iStock / Getty Images Plus With the first two phases of the clinical trial now complete, the researchers are now moving to confirm their findings in a larger, global population of more than 400 trial patients. Keck Medicine will once again serve as one of the sites for this next trial. Patients interested in participating are encouraged to contact Keck Medicine Oncology Clinical Research Program Manager, Sandy Tran, by email. The clinical trials are being sponsored by the biotechnology company Replimune, which manufactures RP1 as well as other viral-based cancer therapies. As the mechanism of RP1's action is not specific to melanoma, the researchers say that the treatment may also have potential in treating other cancer types. Do you have a tip on a health story that Newsweek should be covering? Do you have a question about melanoma treatment? Let us know via health@ Reference Gino In, Michael Wong, Joseph Sacco, Eva Muñoz Couselo, Dirk Schadendorf, Georgia Beasley, Jiaxin Niu, Bartosz Chmielowski, Trisha Wise-Draper, Mohammed Milhem, Tawnya Bowles, Katy Tsai, Celeste Lebbe, Caroline Gaudy-Marqueste, Adel Samson, Junhong Zhu, Marcus Viana, Jeannie Hou, & Caroline Robert. (2025). Response analysis for injected and non-injected lesions and of the safety and efficacy of superficial and deep/visceral RP1 injection in the registrational cohort of anti–PD-1–failed melanoma patients of the IGNYTE trial. 2025 ASCO Annual Meeting.
