Latest news with #Klotho
Yahoo
25-06-2025
- Health
- Yahoo
Protein Breakthrough Could Extend Healthy Lifespan, Study Finds
A protein called Klotho, when boosted, helps mice live longer and age healthier, offering a potential new path for anti-aging treatments in humans, according to a groundbreaking study from the Universitat Autònoma de Barcelona (UAB). Published in Molecular Therapy and led by Professor Miguel Chillón, the study found that a specific form of Klotho, known as secreted Klotho (s-KL), improved muscle strength, bone health, and brain function in treated mice. These mice lived 15–20% longer than untreated peers, reaching the human equivalent of about 70 years with greater physical and mental vitality. Klotho is known to combat inflammation and oxidative stress, key drivers of aging. Unlike other forms of the protein, s-KL circulates freely in the body without disrupting systems like calcium metabolism, making it a safer candidate for therapies. 'If we can find a viable delivery method, s-KL could make a significant contribution to improving people's quality of life,' the researchers said, per The Brighter Side of News. 'It could help build the healthiest society possible.' Using gene therapy with adeno-associated viruses (AAV9), scientists delivered s-KL through the bloodstream and directly into the brain, targeting areas critical for muscle and memory. Three groups of mice were treated: one at six months (young adulthood), another at 12 months (middle age), and a control group. By 24 months, treated mice showed stronger muscles with larger fibers, less fibrosis, and enhanced repair by satellite cells. Bone structure, particularly in females, remained more intact, suggesting protection against osteoporosis. 'KL treatment improved physical fitness, related to a reduction in muscle fibrosis and an increase in muscular regenerative capacity,' the researchers noted, The Brighter Side reported. In the brain, s-KL promoted new neuron growth in the hippocampus, the memory center, and boosted immune processes like phagocytosis, where cells clear toxic waste. This cleanup is vital as aging glial cells often fail to remove debris, contributing to cognitive decline. Transcriptomic analysis revealed increased gene activity tied to immune response and brain cell regeneration. 'We now have viral vectors that can reach the brain after being administered intravenously, which would make it easier to safely transfer this therapy to humans,' said Joan Roig-Soriano, the study's first author, per The Brighter Side. The findings aim to extend health span — the years spent in good health — rather than just lifespan. The team has filed patents for using Klotho to support cognition, strengthen bones and muscles, and increase longevity. While gene therapy was used in the study, direct protein delivery as a drug is also being explored, though a reliable method to target tissues without side effects is still needed. With global populations aging — experts predict a quarter of people in developed countries will be over 65 by 2060 — such treatments could ease the burden on health systems by preventing age-related diseases before they start. The study's results suggest Klotho could redefine aging, offering a future where decline is not inevitable.
Yahoo
25-06-2025
- Health
- Yahoo
Longevity expert Dr Mark Hyman's daily routine: the key to long living? A simple routine
I wake up and usually journal for a while, taking some meditative time. Then I'll work out in the gym — weight training and cardio — and then have a protein shake. I put a bunch of stuff in there including creatine, which is shown to be really helpful not only with muscle building but also cognitive health. Other nutritional supplements I think are important are omega 3, vitamin D, curcumin and oral nicotinamide mononucleotide. Then I have a sauna and a cold plunge most days. I have a wellness studio in my garage, with a hyperbaric chamber, a Pulsed Electromagnetic Fieldmat, laser robotherapy and a HYPOXI machine, so I play around with those. There are lots of interesting developments in longevity. There has been a lot of research around Klotho, which is emerging as a potential therapeutic gene therapy, stem cells, plasmapheresis and Hyperbaric Oxygen Therapy. You can reverse your biological age just through the basics, however. I reversed mine by four years in two years. The last time I checked my biological age was 39, through a methylation test. Right now, most people could probably live to 100 if they applied all the science. Most of the medicines today focus on symptom-based treatment. If you have a disease, they give you a drug and you have surgery. Functional medicine, by contrast, is a framework of scientific wellness. In order to have a healthy lifespan, a number of things are necessary: it's what you eat, it's exercise, it's getting adequate sleep, it's managing stress — and then there's a whole set of other additional therapies that can help activate the body's own healing system. There are built-in longevity switches, I call them, in the body. There are many ways to activate them that most people don't understand. You go to your regular doctor and ask them to help you get healthier and they reply: come back when you have a disease. That's really unfortunate because what we're now learning is that the human body has this immense capacity for healing and repair. We live in a coddled environment. Temperatures are always 16 degrees, we always have an abundance of food, we don't have to move our bodies and we don't have any stresses — historically humans had to deal with all kinds of physiological stresses, hot and cold and hunger. If you fast for a few days you activate a longevity switch. It's called autophagy — it's a bit like a self-cleaning oven. You have these Pac-man like lysosomes that chew up all the old proteins and recycle them. I do not eat a very inflammatory diet. Three things I always pick up at the grocery store are olive oil, small fish like sardines, herring and mackerel, and cruciferous vegetables. I've found a diet of nuts and seeds and vegetables and fruit and protein and olive oil really helps with the microbiome and resets your insulin signalling. Elevated insulin levels drive most ageing; they cause cancer, heart disease, dementia, diabetes, infertility and mental health issues. When you cut out all the crap and ultra-processed food, you increase longevity. I definitely don't drink. I might have a tequila once a month, but there's no safe amount of alcohol. Sleep is critical. It's repair time. I try to get eight hours of sleep and go to bed and wake up at the same time, but it's not easy. I have a lot of relationships, a lot of community. Your close friends — not social media — are a key part of longevity. Dr Mark Hyman leads the RoseBar Longevity Clinic at Six Senses Ibiza. A one-night stay starts at £552 based on two sharing, breakfast included,
Cision Canada
24-06-2025
- Health
- Cision Canada
Klotho Neurosciences, Inc. and the Okinawa Research Center for Longevity Science, Leading Experts on the Okinawa "Blue Zone", Announce a Plan to Study Tissue Levels of the Human Klotho Gene and Protein in the World's Longest-Lived Population
NEW YORK, June 24, 2025 /CNW/ -- Klotho Neuroscience, Inc. (NASDAQ: KLTO), a US-based biogenetics company developing cell and gene- based treatments to address neurological conditions, including ALS, Alzheimer's Disease (AD) and Parkinson's Disease (PD), has announced that it is partnering with Drs. Makoto Suzuki, Craig and Bradley Willcox, Richard Allsopp, and Michio Shimabukuro of the Okinawa Research Center for Longevity Science (ORCLS), as part of its research program on Okinawa, Japan, where a comparatively high number people live extremely long and healthy lives, many reaching 100 years and more. Okinawa is the original Blue Zone, validated by nearly five decades of groundbreaking research by ORCLS, which led to the discovery of other "longevity hotspots" - areas of the world with high concentrations of where people live to exceptional ages, extending not only their lifespans but their healthspans. KLTO has preliminary data from ORCLS suggesting the human alpha-Klotho gene and its secreted alpha-Klotho protein isoform (s-KL) may contribute to healthy longevity and lifespan. As we grow old, α-Klotho blood and tissue levels decrease. The decrease in tissue levels precedes the onset of multiple pathologies and diseases of human organ systems. Importantly, replenishing the s-KL levels using gene therapy may help protect against neurodegenerative disorders, muscle loss, bone loss and heart, liver and kidney disfunction associated with aging. Commenting on this significant opportunity, Dr. Joseph Sinkule, the CEO of KLTO, noted that "animal studies using the Klotho gene in degenerative neurological conditions produced extremely interesting results. KLTO and ORCLS scientists believe the maintenance of optimum blood levels of the Klotho protein in later life correlates with longevity, whereas lower blood levels are associated with premature aging and a propensity to develop certain neurological disorders. While results in animal studies do not always translate into success in human clinical studies, we were very encouraged by the exceptional results, and believe that our patent protected secreted s-KL protein isoform of the Klotho gene holds real promise for the development of effective treatments for neurological disorders, as well as other age-related disorders such as sarcopenia, osteoporosis, diabetes and various renal and cardiovascular disorders. We are confident that our work with the highly experienced team of medical researchers and other well-known scientists at the ORCLS will provide groundbreaking evidence that the Klotho protein levels in humans are one of several highly critical factors for sustaining human health span, including avoidance of neurological and other age-related disorders." Dr. Bradley Willcox, MD, MSc, FGSA, FRSM, a leading member of the Okinawa Research Center for Longevity Science, stated that "for the last 50 years, our ORCLS Team, led by Dr. Makoto Suzuki, has been producing groundbreaking research on human aging and longevity. ORCLS scientists created the world's largest, ongoing study of centenarians in the world, discovered the first human longevity genes (Lancet, 1987), and were the first to validate and translate longevity gene findings in mice and other model organisms to humans (PNAS 2008), among other notable discoveries in aging. We have collected and banked biological samples and clinical data, including blood and tissue samples over many years. A selection of these centenarian blood samples will be analyzed in the first phase of our research partnership with KLTO, where we will assess blood levels of the Klotho protein to establish the role of the Klotho protein in promoting longevity and reducing the risks of neurodegenerative diseases, such as ALS, AD and PD, as well as diabetes and cardiovascular disorders." The Klotho gene was named after the mythologic Greek goddess, Clotho, who was said to "spin the thread of life." The Blue Zones are located in Okinawa, Japan; Ikaria, Greece; the Ogliastra Region of Sardinia; the Nicoya Peninsula in Costa Rica; and Loma Linda, USA. About Klotho Neurosciences, Inc. Klotho Neurosciences, Inc. (NASDAQ: KLTO), is a biogenetics company focused on the development of innovative, disease-modifying cell and gene therapies using a protein derived from a patented form of the "anti-aging" human Klotho gene (s-KL), and it's novel delivery systems to transform and improve the treatment of neurodegenerative and age-related disorders such as ALS, Alzheimer's, and Parkinson's disease. The company's current portfolio consists of its proprietary cell and gene therapy programs using DNA and RNA as therapeutics and genomics-based diagnostic assays. The company is managed by a team of individuals and advisors who are highly experienced in biopharmaceutical product development and commercialization. Investor Contact and Corporate Communications – Jeffrey LeBlanc, CFO [email protected] Website: Forward-Looking Statements: This press release contains forward-looking statements. These statements are made under the "safe harbor" provisions of the U.S. Private Securities Litigation Reform Act of 1995. These forward-looking statements generally are identified by the words "believe," "project," "expect," "anticipate," "estimate," "intend," "strategy," "future," "opportunity," "plan," "may," "should," "will," "would," "will be," "will continue," "will likely result," and similar expressions. Without limiting the generality of the foregoing, the forward-looking statements in this press release include descriptions of the Company's future commercial operations. Forward-looking statements are predictions, projections and other statements about future events that are based on current expectations and assumptions and, as a result, are subject to risks and uncertainties. Many factors could cause actual future events to differ materially from the forward-looking statements in this press release, such as the Company's inability to implement its business plans, identify and realize additional opportunities, or meet or exceed its financial projections and changes in the regulatory or competitive environment in which the Company operates. You should carefully consider the foregoing factors and the other risks and uncertainties described in the documents filed or to be filed by the Company with the U.S. Securities and Exchange Commission (the "SEC") from time to time, which could cause actual events and results to differ materially from those contained in the forward-looking statements. All information provided herein is as of the date of this press release, and the Company undertakes no obligation to update any forward-looking statement, except as required under applicable law.
Malaysian Reserve
13-06-2025
- Health
- Malaysian Reserve
Weekly Recap: 11 Health Press Releases You Need to See
A roundup of the most newsworthy healthcare press releases from PR Newswire this week, including advances in sleep apnea treatments, fall detection for seniors and diabetes research. NEW YORK, June 13, 2025 /PRNewswire/ — With thousands of press releases published each week, it can be difficult to keep up with everything on PR Newswire. To help healthcare journalists and consumers stay on top of the week's most newsworthy and popular releases, here's a recap of some major stories from the week that shouldn't be missed. The list below includes the headline (with a link to the full text) and an excerpt from each story. Click on the press release headlines to access accompanying multimedia assets that are available for download. Klotho Neuroscience, Inc. Announces an Approach to Increase Longevity and Healthy Life Span – Replace a Silenced Gene Called Alpha-Klotho ('α-Klotho')Recent clinical and pre-clinical studies and analysis indicates the potential to increase lifespan and reduce age-associated degeneration in multiple organ systems has be realized with a focus on the human gene called Klotho. Mosanna Therapeutics Launches with $80 Million to Advance Novel Nighttime Nasal Spray for Obstructive Sleep ApneaDespite OSA's prevalence, treatment has largely focused on mechanical solutions that are often uncomfortable and disruptive. Mosanna is pioneering a pharmaceutical solution for sleep apnea patients with MOS118, a nasal spray administered at bedtime that helps restore the body's natural airway reflex. Sage Adds AI-Powered Fall Detection and Wellness Trend Monitoring to its All-in-One Senior Care PlatformDespite the best efforts of frontline care teams, falls remain the leading cause of injury and liability in senior living. That's why the team developed Sage Detect, which uses advanced AI to interpret daily activity patterns with highly granular data points to deliver real-time emergency alerts and wellness trend insights. Elevation Oncology Enters into Agreement to Be Acquired by Concentra Biosciences for $0.36 in Cash per Share Plus a Contingent Value RightThe Elevation Oncology Board of Directors has unanimously determined that the acquisition by Concentra is in the best interests of all Elevation Oncology stockholders and has approved the Merger Agreement and related transactions. Nuevocor Announces FDA Clearance of IND for NVC-001 for LMNA-Related Dilated CardiomyopathyLMNA-related dilated cardiomyopathy (LMNA DCM) is one of the most aggressive forms of DCM, affecting approximately 100,000 individuals in the United States and Europe, who progress rapidly to end-stage heart failure. NVC-001 demonstrated significant benefits, including survival and cardiac function in preclinical models. Enters into Collaboration with Mayo Clinic for AI Co-Innovation ProjectCurrently deployed across 70+ health systems, unified platform enables hospitals to deliver AI-assisted services such as ambient documentation, digital whiteboards, patient engagement, and hospital-at-home services, all through a deeply integrated, enterprise-grade solution. The American Diabetes Association Debuts the 85th Scientific Sessions with Breakthrough Diabetes Research'This year's agenda showcases our dedication to pushing the boundaries of research, encouraging innovation, and ultimately enhancing the lives of people living with diabetes and obesity,' said Rita Rastogi Kalyani, MD, MHS, the ADA's president of medicine and science. Deep Apple Therapeutics Announces Collaboration with Novo Nordisk to Discover and Develop Oral Therapeutics for Cardiometabolic DiseasesDeep Apple will discover and optimize compounds using its proprietary drug discovery platform, which combines machine-learning-powered virtual screening with structural biology enabled by cryo-electron microscopy (cryo-EM). Novo Nordisk will receive exclusive global rights to develop, manufacture, and commercialize the resulting compounds and products in all indications. U.S. FDA Approves Expanded Indication for AbbVie's MAVYRET® (Glecaprevir/Pibrentasvir) as First and Only Treatment for People with Acute Hepatitis C Virus'If treated early with safe and effective therapies, providers can cure virtually all patients with hepatitis C before it escalates to chronic disease and eventually cirrhosis or liver cancer,' said John Ward, M.D., director, Coalition for Global Hepatitis Elimination. With this approval, providers can now treat HCV patients immediately at the time of diagnosis. A Safe Raw Milk Breakthrough: Tamarack Biotics Earns FDA Acceptance of Innovative TreatmentUsing advanced UV light technology, Tamarack's TruActive® process eliminates harmful pathogens while preserving the enzymes, proteins and immunity-supporting compounds that are often destroyed by traditional heat-based pasteurization. Cigna Healthcare Unveils Industry-Leading AI-Powered Digital Tools for a Simple and Reliable Customer ExperienceThe new digital features, which were developed with rigorous research and testing within a comprehensive artificial intelligence (AI) governance framework, are being made available in a phased rollout through Cigna Healthcare's myCigna member portal. They include an AI-powered virtual assistant, personalized provider matching, smart claim submission and more. For more news like this, check out all of the latest health-related releases from PR Newswire. Do you have a health press release to distribute? Sign up with PR Newswire to share your story with the audiences who matter most. Helping Journalists Stay Up to Date on Industry News These are just a few of the recent press releases that consumers and the media should know about. To be notified of releases relevant to their coverage area, journalists can set up a custom newsfeed with PR Newswire for Journalists. Once they're signed up, reporters, bloggers, and freelancers have access to the following free features: Customization: Users can create customized newsfeeds that will deliver relevant news right to their inbox. Newsfeed results can be targeted by keywords, industry, subject, geography, and more. Photos and Videos: Thousands of multimedia assets are available to download and include in a journalist or blogger's next story. Subject Matter Experts: Journalists will have access to ProfNet, a database of industry experts to connect with as sources or for quotes in their articles. Related Resources: Our journalist- and blogger-focused blog, Beyond Bylines, features regular media news roundups, writing tips, upcoming events, and more. About PR Newswire PR Newswire is the industry's leading press release distribution partner with an unparalleled global reach of more than 440,000 newsrooms, websites, direct feeds, journalists and influencers and is available in more than 170 countries and 40 languages. From our award-winning Content Services offerings, integrated media newsroom and microsite products, Investor Relations suite of services, paid placement and social sharing tools, PR Newswire has a comprehensive catalog of solutions to solve the modern-day challenges PR and communications teams face. For 70 years, PR Newswire has been the preferred destination for brands to share their most important news stories across the world. For questions, contact the team at
Yahoo
13-06-2025
- Health
- Yahoo
Weekly Recap: 11 Health Press Releases You Need to See
A roundup of the most newsworthy healthcare press releases from PR Newswire this week, including advances in sleep apnea treatments, fall detection for seniors and diabetes research. NEW YORK, June 13, 2025 /PRNewswire/ -- With thousands of press releases published each week, it can be difficult to keep up with everything on PR Newswire. To help healthcare journalists and consumers stay on top of the week's most newsworthy and popular releases, here's a recap of some major stories from the week that shouldn't be missed. The list below includes the headline (with a link to the full text) and an excerpt from each story. Click on the press release headlines to access accompanying multimedia assets that are available for download. Klotho Neuroscience, Inc. Announces an Approach to Increase Longevity and Healthy Life Span - Replace a Silenced Gene Called Alpha-Klotho ("α-Klotho")Recent clinical and pre-clinical studies and analysis indicates the potential to increase lifespan and reduce age-associated degeneration in multiple organ systems has be realized with a focus on the human gene called Klotho. Mosanna Therapeutics Launches with $80 Million to Advance Novel Nighttime Nasal Spray for Obstructive Sleep ApneaDespite OSA's prevalence, treatment has largely focused on mechanical solutions that are often uncomfortable and disruptive. Mosanna is pioneering a pharmaceutical solution for sleep apnea patients with MOS118, a nasal spray administered at bedtime that helps restore the body's natural airway reflex. Sage Adds AI-Powered Fall Detection and Wellness Trend Monitoring to its All-in-One Senior Care PlatformDespite the best efforts of frontline care teams, falls remain the leading cause of injury and liability in senior living. That's why the team developed Sage Detect, which uses advanced AI to interpret daily activity patterns with highly granular data points to deliver real-time emergency alerts and wellness trend insights. Elevation Oncology Enters into Agreement to Be Acquired by Concentra Biosciences for $0.36 in Cash per Share Plus a Contingent Value RightThe Elevation Oncology Board of Directors has unanimously determined that the acquisition by Concentra is in the best interests of all Elevation Oncology stockholders and has approved the Merger Agreement and related transactions. Nuevocor Announces FDA Clearance of IND for NVC-001 for LMNA-Related Dilated CardiomyopathyLMNA-related dilated cardiomyopathy (LMNA DCM) is one of the most aggressive forms of DCM, affecting approximately 100,000 individuals in the United States and Europe, who progress rapidly to end-stage heart failure. NVC-001 demonstrated significant benefits, including survival and cardiac function in preclinical models. Enters into Collaboration with Mayo Clinic for AI Co-Innovation ProjectCurrently deployed across 70+ health systems, unified platform enables hospitals to deliver AI-assisted services such as ambient documentation, digital whiteboards, patient engagement, and hospital-at-home services, all through a deeply integrated, enterprise-grade solution. The American Diabetes Association Debuts the 85th Scientific Sessions with Breakthrough Diabetes Research"This year's agenda showcases our dedication to pushing the boundaries of research, encouraging innovation, and ultimately enhancing the lives of people living with diabetes and obesity," said Rita Rastogi Kalyani, MD, MHS, the ADA's president of medicine and science. Deep Apple Therapeutics Announces Collaboration with Novo Nordisk to Discover and Develop Oral Therapeutics for Cardiometabolic DiseasesDeep Apple will discover and optimize compounds using its proprietary drug discovery platform, which combines machine-learning-powered virtual screening with structural biology enabled by cryo-electron microscopy (cryo-EM). Novo Nordisk will receive exclusive global rights to develop, manufacture, and commercialize the resulting compounds and products in all indications. U.S. FDA Approves Expanded Indication for AbbVie's MAVYRET® (Glecaprevir/Pibrentasvir) as First and Only Treatment for People with Acute Hepatitis C Virus"If treated early with safe and effective therapies, providers can cure virtually all patients with hepatitis C before it escalates to chronic disease and eventually cirrhosis or liver cancer," said John Ward, M.D., director, Coalition for Global Hepatitis Elimination. With this approval, providers can now treat HCV patients immediately at the time of diagnosis. A Safe Raw Milk Breakthrough: Tamarack Biotics Earns FDA Acceptance of Innovative TreatmentUsing advanced UV light technology, Tamarack's TruActive® process eliminates harmful pathogens while preserving the enzymes, proteins and immunity-supporting compounds that are often destroyed by traditional heat-based pasteurization. Cigna Healthcare Unveils Industry-Leading AI-Powered Digital Tools for a Simple and Reliable Customer ExperienceThe new digital features, which were developed with rigorous research and testing within a comprehensive artificial intelligence (AI) governance framework, are being made available in a phased rollout through Cigna Healthcare's myCigna member portal. They include an AI-powered virtual assistant, personalized provider matching, smart claim submission and more. For more news like this, check out all of the latest health-related releases from PR Newswire. Do you have a health press release to distribute? Sign up with PR Newswire to share your story with the audiences who matter most. Helping Journalists Stay Up to Date on Industry News These are just a few of the recent press releases that consumers and the media should know about. To be notified of releases relevant to their coverage area, journalists can set up a custom newsfeed with PR Newswire for Journalists. Once they're signed up, reporters, bloggers, and freelancers have access to the following free features: Customization: Users can create customized newsfeeds that will deliver relevant news right to their inbox. Newsfeed results can be targeted by keywords, industry, subject, geography, and more. Photos and Videos: Thousands of multimedia assets are available to download and include in a journalist or blogger's next story. Subject Matter Experts: Journalists will have access to ProfNet, a database of industry experts to connect with as sources or for quotes in their articles. Related Resources: Our journalist- and blogger-focused blog, Beyond Bylines, features regular media news roundups, writing tips, upcoming events, and more. About PR Newswire PR Newswire is the industry's leading press release distribution partner with an unparalleled global reach of more than 440,000 newsrooms, websites, direct feeds, journalists and influencers and is available in more than 170 countries and 40 languages. From our award-winning Content Services offerings, integrated media newsroom and microsite products, Investor Relations suite of services, paid placement and social sharing tools, PR Newswire has a comprehensive catalog of solutions to solve the modern-day challenges PR and communications teams face. For 70 years, PR Newswire has been the preferred destination for brands to share their most important news stories across the world. For questions, contact the team at View original content to download multimedia: SOURCE PR Newswire Sign in to access your portfolio
