logo
#

Latest news with #LBCL

Can Tumor Patterns Predict Lymphoma Treatment Success?
Can Tumor Patterns Predict Lymphoma Treatment Success?

Medscape

time19-06-2025

  • Health
  • Medscape

Can Tumor Patterns Predict Lymphoma Treatment Success?

Large B-cell lymphomas (LBCL) exhibit three distinct microenvironment archetype profiles defined by specific immune and stromal cell patterns. These profiles show divergent cell-cell communication pathways and correlate with different clinical outcomes following CD19 Chimeric Antigen Receptor (CAR) T-cell therapy. METHODOLOGY: Researchers employed single nucleus multiome sequencing of 232 Large B cell lymphoma tumors and controls to comprehensively define the cellular landscape and stereotypical patterns in lymphoma microenvironment archetype profiles. Analysis included 217 lymphomas (110 newly diagnosed and 107 relapsed/refractory cases) and 15 controls. Control tissues comprised nonmalignant reactive lymph nodes biopsied due to suspicion of lymphoma in patients with (n = 13) or without (n = 2) prior lymphoma diagnosis. Available remaining nuclei underwent DNA and RNA extraction followed by whole-exome sequencing (n = 174), low-pass whole-genome sequencing (n = 174), and bulk RNA sequencing (n = 208). TAKEAWAY: Cell subsets co-occurred in three distinct lymphoma microenvironment archetype profiles characterized by: sparsity of T cells with high frequencies of cancer-associated fibroblasts and tumor-associated macrophages; lymph node architectural cell types with naive and memory T cells; or activated macrophages and exhausted CD8+ T cells. Researchers identified that divergent patterns of cell-cell communication underpinned the transcriptional phenotypes of archetype-defining cell subsets. The Fibroblast/Macrophage archetype showed association with inferior outcomes following first-line rituximab plus chemotherapy treatment. Analysis revealed that patients with T-cell exhausted archetype tumors had significantly higher rates of progressive disease as best response to CD19 CAR T-cell therapy (4/6) compared to Lymph Node archetype (0/8; Fisher test, P = .017). IN PRACTICE: 'The assembly of nonmalignant components of human tumors into prototypical microenvironmental patterns, or archetypes, has been described across cancers. Each archetype consists of a dominant, interconnected cellular network that promotes tumor growth through divergent mechanisms. Furthermore, differences in cell frequency and function between microenvironment archetypes have been suggested as potential biomarkers for immunotherapy response,' the authors of the study wrote. SOURCE: The study was led by Michael Green, PhD, MD Anderson Cancer Center in Houston. It was published online in Cancer Cell . LIMITATIONS: According to the authors, the patient cohort's clinical heterogeneity, while reflecting real-world population, limited their ability to directly assess associations between archetypes and outcomes. The researchers noted that the Fibroblast/Macrophage archetype is linked to high-risk features and increases in prevalence in later therapy lines, while the Lymph Node archetype is associated with low-risk features and declines in prevalence, potentially skewing distribution among treated patients. The authors acknowledged uncertainty about whether LymphoMAPs remain stable between diagnosis and relapse or change with treatment. The researchers emphasized the need for studying LymphoMAP archetypes in uniformly treated cohorts and randomized trials, preferably with biopsies at both baseline and relapse. DISCLOSURES: The study received funding from the Schweitzer Family, the MD Anderson Lymphoid Malignancies Program and NCI P01 CA272295. Michael Green, PhD, reported ties with Sanofi, Kite/Gilead, Abbvie, Allogene, Bristol Myers Squibb, Arvinas, Johnson & Johnson, Daiichi Sankyo, and DAVA Oncology and stock ownership in KDAc Therapeutics. Todd Fehniger, MD, PhD, disclosed being an inventor on patent applications held by Washington University, as well as having relationships with Wugen Inc, Orca Bio, Indapta Therapeutics, HCW Biologics Inc, Affimed, AI Proteins, and the National Institutes of Health. Additional disclosures are noted in the original article.

DEADLINE ALERT: Faruqi & Faruqi, LLP Investigates Claims on Behalf of Investors of Caribou Biosciences
DEADLINE ALERT: Faruqi & Faruqi, LLP Investigates Claims on Behalf of Investors of Caribou Biosciences

Associated Press

time17-02-2025

  • Business
  • Associated Press

DEADLINE ALERT: Faruqi & Faruqi, LLP Investigates Claims on Behalf of Investors of Caribou Biosciences

Faruqi & Faruqi, LLP Securities Litigation Partner James (Josh) Wilson Encourages Investors Who Suffered Losses Exceeding $50,000 In Caribou To Contact Him Directly To Discuss Their Options If you suffered losses exceeding $50,000 in between July 14, 2023 and July 16, 2024 and would like to discuss your legal rights, call Faruqi & Faruqi partner Josh Wilson directly at 877-247-4292 or 212-983-9330 (Ext. 1310). New York, New York--(Newsfile Corp. - February 17, 2025) - Faruqi & Faruqi, LLP, a leading national securities law firm, is investigating potential claims against Caribou Biosciences, Inc. ('Caribou' or the 'Company') (NASDAQ: CRBU) and reminds investors of the February 24, 2025 deadline to seek the role of lead plaintiff in a federal securities class action that has been filed against the Company. Faruqi & Faruqi is a leading national securities law firm with offices in New York, Pennsylvania, California and Georgia. The firm has recovered hundreds of millions of dollars for investors since its founding in 1995. See As detailed below, the complaint alleges that the Company and its executives violated federal securities laws by making false and/or misleading statements and/or failing to disclose that: (i) they had overstated CB-010's safety, efficacy, and durability relative to approved autologous CAR-T cell therapies in treating patients with r/r B-NHL and/or LBCL, as well as CB-010's overall clinical results and commercial prospects; (ii) Caribou was at significant risk of having insufficient cash, liquidity, and/or other capital to fund its current business operations, including preclinical research activities associated with the allogeneic CAR-NK platform; and (iii) all the foregoing was likely to have a significant negative impact on Caribou's business and operations. On June 2, 2024, Caribou issued a press release announcing that it had 'presented updated clinical data from the ongoing ANTLER Phase 1 trial that [purportedly] indicates a single dose of CB-010 . . . has the potential to rival the safety, efficacy, and durability of approved autologous CAR-T cell therapies.' The next day, Evercore ISI ('Evercore') analysts downgraded Caribou stock to 'in line' and dropped their price target to $3.00 from $13.00, stating that they were 'not yet convinced' that Caribou's therapy 'will be competitive and wait on the sidelines until data in 1H 2025.' In particular, the Evercore analysts stated, inter alia, that "[o]verall, efficacy of CB-010 in 2L [second-line] LBCL is not competitive vs autologous CAR-T with lower response rate and much shorter PFS [progression-free survival]', while also noting additional risks related to CB-010's safety and competition. On this news, Caribou's stock price fell $0.735 per share, or 25.52%, to close at $2.145 per share on June 3, 2024. Then, on July 16, 2024, Caribou disclosed in a filing with the United States Securities and Exchange Commission that it had 'discontinued preclinical research activities associated with its allogeneic CAR-NK platform and reduced its workforce by 21 positions, or approximately 12%", explaining that "[t]he Company is undertaking this reduction to extend its cash runway'. On this news, Caribou's stock price fell $0.09 per share, or 3.3%, to close at $2.64 per share on July 17, 2024. The court-appointed lead plaintiff is the investor with the largest financial interest in the relief sought by the class who is adequate and typical of class members who directs and oversees the litigation on behalf of the putative class. Any member of the putative class may move the Court to serve as lead plaintiff through counsel of their choice, or may choose to do nothing and remain an absent class member. Your ability to share in any recovery is not affected by the decision to serve as a lead plaintiff or not. Faruqi & Faruqi, LLP also encourages anyone with information regarding Caribou's conduct to contact the firm, including whistleblowers, former employees, shareholders and others. To learn more about the Caribou Biosciences class action, go to or call Faruqi & Faruqi partner Josh Wilson directly at 877-247-4292 or 212-983-9330 (Ext. 1310). Attorney Advertising. The law firm responsible for this advertisement is Faruqi & Faruqi, LLP ( Prior results do not guarantee or predict a similar outcome with respect to any future matter. We welcome the opportunity to discuss your particular case. All communications will be treated in a confidential manner.

Press Release Biocartis NV: Biocartis announces new data on early CAR-T vector load assessment with Idylla™ presented at ASTCT: A Potential Breakthrough in LBCL Treatment Monitoring
Press Release Biocartis NV: Biocartis announces new data on early CAR-T vector load assessment with Idylla™ presented at ASTCT: A Potential Breakthrough in LBCL Treatment Monitoring

Yahoo

time14-02-2025

  • Health
  • Yahoo

Press Release Biocartis NV: Biocartis announces new data on early CAR-T vector load assessment with Idylla™ presented at ASTCT: A Potential Breakthrough in LBCL Treatment Monitoring

PRESS RELEASE - 14/02/2025, 09:30 CET Biocartis announces new data on early CAR-T vector load assessment with Idylla™ presented at ASTCT: A Potential Breakthrough in LBCL Treatment Monitoring Mechelen, Belgium, 14 February 2025 – Biocartis NV ('Biocartis'), an innovative molecular diagnostics company, is pleased to announce that new research on the prototype Idylla™ CD19 CAR-T vector load Assay was presented as a poster at ASTCT in Honolulu, HI, US, on 13 February 2025. The new study1 (Bharadwaj et al, 20252) demonstrated that early CD19 CAR-T vector load quantification in peripheral blood may improve the prediction of clinical outcomes and toxicity management for patients receiving axicabtagene ciloleucel (axi-cel) for Large B-cell Lymphoma (LBCL). The study enrolled 100 patients undergoing axi-cel therapy. Blood samples were analyzed using both droplet digital PCR (ddPCR) centrally, and local testing in the 3 centers with the prototype Idylla™ CAR-T Assay on the Idylla™ Platform. The study positioned the Idylla™ Platform as an automated, local hospital testing system that can provide results in approximately 90 minutes with only 2 minutes of hands-on time, straight from 0.5 ml of blood. The results revealed a 98.6% concordance between the prototype Idylla™ CAR-T Assay and ddPCR, confirming its reliability as a potential early alternative to standard methods. Key Findings: Early CAR-T Vector load increase predicted severe ICANS: Patients experiencing a steep rise in CD19 CAR-T vector load within the first 5 days post-infusion were more likely to develop severe immune effector cell-associated neurotoxicity syndrome (ICANS). Day 3 Idylla™ measurements predicted ICANS severity: Predictive modeling identified day 3 vector load as a significant predictor of ICANS severity using Idylla™. Correlation with Progression-Free Survival (PFS): Patients were stratified into high and low vector load slope groups obtained during the first 5 days after infusion, with significant differences in PFS observed for both Idylla™ and ddPCR measurement methods. Kaplan-Meier curves revealed PFS rates separate by day 50 (100% vs. 70%), and persisted until the end of follow-up beyond day 300 (90% vs. 50%) for high vs. low vector load increases. These findings suggest that, once approved, local hospital testing with Idylla™ could revolutionize toxicity management and treatment monitoring in CAR-T therapy. By providing real-time, accessible vector load measurements, clinicians may better predict toxicity risk, personalize treatment strategies, and improve patient outcomes. W. Michael Korn, M.D., Chief Medical and Scientific Officer of Biocartis, commented: 'These findings underscore the power of early, local hospital testing in CAR-T therapy. By providing real-time insights into CAR-T expansion dynamics, Idylla™ may enable clinicians to better predict toxicity risks and optimize treatment strategy - ultimately improving patient outcomes.' ----- END ----- More information: info@ Biocartis NV. Generaal De Wittelaan 11B, 2800 Mechelen, Belgium About Biocartis With its revolutionary and proprietary Idylla™ Platform, Biocartis aspires to enable personalized medicine for patients around the world through universal access to molecular testing, by making molecular testing actionable, easy, fast and suitable for any lab. The Idylla™ Platform is a fully automated sample-to-result, real-time PCR (Polymerase Chain Reaction) based system designed to offer in-house molecular biomarker testing in only 3 hours, allowing fast and optimal treatment selection. ​Idylla™'s continuously expanding menu of molecular diagnostic tests and research assays addresses key unmet clinical needs. Today, Biocartis offers tests supporting melanoma, colorectal, lung, breast, thyroid, brain and blood cancer. More information: Follow us on X (Twitter): @Biocartis. The Idylla™ CAR-T Assay is a prototype and is not commercially available. The Biocartis and Idylla™ trademark and logo are used trademarks owned by Biocartis. © February 2025, Biocartis NV. All rights reserved. 1 This study was conducted with direct support from Biocartis.2 Bharadwaj, S. et al. (2025). Rapid increase in Blood CD19 CAR-T Vector Load during the First 5 Days Post Infusion is Associated with Severe ICANS. in to access your portfolio

DOWNLOAD THE APP

Get Started Now: Download the App

Ready to dive into a world of global content with local flavor? Download Daily8 app today from your preferred app store and start exploring.
app-storeplay-store