Latest news with #Lacutamab
Business Upturn
2 days ago
- Business
- Business Upturn
Cutaneous T-cell Lymphoma Market Anticipates Impressive Growth Trajectory at a CAGR of 7.1% During the Study Period (2020–2034)
New York, USA, July 21, 2025 (GLOBE NEWSWIRE) — Cutaneous T-cell Lymphoma Market Anticipates Impressive Growth Trajectory at a CAGR of 7.1% During the Study Period (2020–2034) | DelveInsight The dynamics of the cutaneous T-cell lymphoma market are anticipated to change owing to the improvement in research and development activities, increasing prevalence, and the rising geriatric population. Additionally, the expected launch of therapies such as HyBryte, PTX-100, Lacutamab, BMS-986369, ONO-4685, and others will also boost the CTCL market growth. DelveInsight's Cutaneous T-cell Lymphoma Market Insights report includes a comprehensive understanding of current treatment practices, emerging cutaneous T-cell lymphoma drugs, market share of individual therapies, and current and forecasted cutaneous T-cell lymphoma market size from 2020 to 2034, segmented into 7MM [the United States, the EU4 (Germany, France, Italy, and Spain), the United Kingdom, and Japan]. Key Takeaways from the Cutaneous T-cell Lymphoma Market Report According to DelveInsight's analysis, the market size for cutaneous T-cell lymphoma was found to be USD 995 million in the 7MM in 2024. in the 7MM in 2024. The United States accounted for the highest cutaneous T-cell lymphoma market size, approximately 70% of the total market size in 7MM in 2024, in comparison to the other major markets, i.e., EU4 countries (Germany, France, Italy, and Spain), the United Kingdom, and Japan. of the total market size in 7MM in 2024, in comparison to the other major markets, i.e., EU4 countries (Germany, France, Italy, and Spain), the United Kingdom, and Japan. Among the 7MM, the US accounted for the highest number of cases of CTCL in 2024, with nearly 3,000 cases. These cases are anticipated to increase by 2034. cases. These cases are anticipated to increase by 2034. Prominent cutaneous T-cell lymphoma companies, including Soligenix and Sterling Pharma Solutions, Prescient Therapeutics, Innate Pharma, Bristol-Myers Squibb, ONO Pharmaceutical, and others, are actively working on innovative cutaneous T-cell lymphoma drugs. and others, are actively working on innovative cutaneous T-cell lymphoma drugs. Some of the key cutaneous T-cell lymphoma therapies in the pipeline include HyBryte (Synthetic Hypericin/SGX301), PTX-100, Lacutamab (IPH4102), BMS-986369 (Golcadomide), ONO-4685 , and others. These novel cutaneous T-cell lymphoma therapies are anticipated to enter the cutaneous T-cell lymphoma market in the forecast period and are expected to change the market. , and others. These novel cutaneous T-cell lymphoma therapies are anticipated to enter the cutaneous T-cell lymphoma market in the forecast period and are expected to change the market. By 2034, among all the therapies in the late stage, the highest revenue is expected to be generated by POTELIGEO in the 7MM. in the 7MM. In May 2025, 4SC received a negative opinion from the Committee for Medicinal Products for Human Use (CHMP) regarding the Marketing Authorization Application (MAA) for KINSELBY, intended for the treatment of advanced-stage CTCL, leading to the decision to discontinue its further development and commercialization. received a negative opinion from the Committee for Medicinal Products for Human Use (CHMP) regarding the Marketing Authorization Application (MAA) for KINSELBY, intended for the treatment of advanced-stage CTCL, leading to the decision to discontinue its further development and commercialization. In March 2025, Prescient Therapeutics opened the first clinical site for its Phase IIa study of PTX-100 in patients with relapsed or refractory CTCL. opened the first clinical site for its Phase IIa study of PTX-100 in patients with relapsed or refractory CTCL. In February 2025, Citius Pharmaceuticals and its oncology-focused subsidiary, Citius Oncology, announced that LYMPHIR has been assigned a unique, permanent HCPCS J-code (J9161) by the CMS. The establishment of a permanent J-code marks a critical milestone in supporting patient access to LYMPHIR, providing coding clarity for physicians and facilities who administer LYMPHIR, and facilitating reimbursement. Discover which cutaneous T-cell lymphoma medications are expected to grab the market share @ Cutaneous T-cell Lymphoma Market Report Cutaneous T-cell Lymphoma Overview Cutaneous T-cell lymphoma (CTCL) is a form of non-Hodgkin lymphoma that begins in the skin, arising from T lymphocytes—a type of white blood cell that plays a key role in immune defense against infections and cancer. Unlike other lymphomas that typically originate in the lymph nodes or internal organs, CTCL starts in the skin, which itself functions as a major lymphoid organ. Although B-cell lymphomas are generally more common, T-cell lymphomas like CTCL are more frequently found in the skin. Diagnosing CTCL involves a comprehensive clinical evaluation, including a review of symptoms, physical examination, detailed medical history, and specialized diagnostic tests. These tests help identify the exact type and stage of the disease and guide treatment planning. Skin biopsies are a standard diagnostic tool, particularly because early CTCL can mimic benign skin disorders such as psoriasis. In many cases, multiple biopsies are needed to establish a definitive diagnosis due to the subtle and variable nature of early-stage CTCL. Cutaneous T-cell Lymphoma Epidemiology Segmentation The cutaneous T-cell lymphoma epidemiology section provides insights into the historical and current cutaneous T-cell lymphoma patient pool and forecasted trends for the 7MM. It helps recognize the causes of current and forecasted patient trends by exploring numerous studies and views of key opinion leaders. The cutaneous T-cell lymphoma market report proffers epidemiological analysis for the study period 2020–2034 in the 7MM segmented into: Total Incident Cases of CTCL Type-specific Cases of CTCL Gender-specific Cases of CTCL Stage-specific Cases of CTCL Treatment-eligible Pool in Early and Advanced Stages of CTCL Download the report to understand which factors are driving cutaneous T-cell lymphoma epidemiology trends @ Cutaneous T-cell Lymphoma Treatment Algorithm Cutaneous T-cell Lymphoma Treatment Market The treatment strategy for mycosis fungoides and Sézary syndrome, both forms of cutaneous T-cell lymphoma, varies depending on the extent of skin involvement and whether the disease has spread. Mycosis fungoides typically responds well to therapies directed at the skin or the whole body, whereas Sézary syndrome usually necessitates systemic treatment approaches. VALCHLOR (mechlorethamine) is the first and only FDA-approved topical formulation of mechlorethamine for patients with Stage IA or IB mycosis fungoides-type CTCL who have previously undergone skin-directed therapy. For patients with early-stage disease, topical corticosteroids are considered the first-line treatment. Additionally, topical Toll-like Receptor (TLR) agonists, which stimulate local production of interferons and cytokines to promote tumor cell death and enhance the immune response, have shown clinical benefit in managing limited-stage mycosis fungoides. In cases of advanced-stage mycosis fungoides or Sézary syndrome, a comprehensive and multidisciplinary approach is required. Management often involves combinations of skin-directed therapies, immune-modulating agents, and sequential systemic chemotherapy. However, for early-stage disease, multi-agent chemotherapy is generally avoided. Instead, a risk- and stage-adapted strategy, aligned with the National Comprehensive Cancer Network (NCCN) Guidelines, is typically used. This includes the use of biologic-response modifiers (such as bexarotene and interferon-alpha), histone deacetylase (HDAC) inhibitors (like romidepsin), or targeted therapies such as monoclonal antibodies or antibody-drug conjugates (e.g., mogamulizumab, brentuximab vedotin). Treatment choices are tailored to each patient, taking into account factors such as age, overall health, disease stage and burden, progression rate, and prior treatments. For advanced-stage CTCL (Stages IIB–IV), effective systemic therapies include HDAC inhibitors such as ISTODAX (romidepsin) and ZOLINZA (vorinostat). Notably, vorinostat was the first HDAC inhibitor to gain FDA approval in 2006 for treating progressive, persistent, or relapsing CTCL. Learn more about the cutaneous T-cell lymphoma treatment options @ Cutaneous T-cell Lymphoma Treatment Guidelines Cutaneous T-cell Lymphoma Emerging Drugs and Companies Some of the drugs in the pipeline include HyBryte (Soligenix and Sterling Pharma Solutions), PTX-100 (Prescient Therapeutics), Lacutamab (Innate Pharma), Golcadomide (Bristol Myers Squibb), and others. HyBryte is a topical formulation containing hypericin, one of the most light-sensitive compounds known. The product has been granted both Orphan Drug Designation and Fast Track Designation by the U.S. FDA, along with orphan status from the European Medicines Agency (EMA). Soligenix showcased new clinical data supporting HyBryte's use in treating cutaneous T-cell lymphoma at two major events: the United States Cutaneous Lymphoma Consortium (USCLC) Workshop on March 6, 2025, and the American Academy of Dermatology (AAD) Annual Meeting held from March 7 to 11, 2025. In an April 2024 press release, the company stated it expects to report top-line results from its 18-week confirmatory FLASH2 study, being conducted in both the U.S. and Europe, during the second half of 2026. PTX-100 is a novel, first-in-class agent that inhibits a key enzyme involved in cancer progression by targeting the oncogenic Ras signaling pathway. The drug is currently undergoing a Phase IIa trial in patients with relapsed or refractory CTCL, with potential progression to a Phase IIb registration study. As outlined in Prescient Therapeutics' May 2025 investor update, the company expects to receive Orphan Drug Designation in Europe by Q3 2025. Additionally, an interim review of Phase IIa trial data is planned for Q4 2025 or early 2026. Prescient also announced in May 2025 that the first patient had been successfully dosed in this ongoing Phase IIa study. Lacutamab is a humanized, first-in-class antibody targeting KIR3DL2, designed to induce cytotoxicity. It is being tested in an open-label, multicohort Phase II study in CTCL and another Phase II study in peripheral T-cell lymphoma (PTCL). According to Innate Pharma's most recent annual update from May 2025, the company aims to begin a Phase III trial of lacutamab, with plans to pursue accelerated approval by 2027. Furthermore, long-term follow-up data from the TELLOMAK Phase II trial, focusing on patients with Sézary syndrome and mycosis fungoides, will be presented at the 2025 ASCO Annual Meeting on June 2 in Chicago, Illinois. The anticipated launch of these emerging cutaneous T-cell lymphoma therapies are poised to transform the cutaneous T-cell lymphoma market landscape in the coming years. As these cutting-edge cutaneous T-cell lymphoma therapies continue to mature and gain regulatory approval, they are expected to reshape the cutaneous T-cell lymphoma market landscape, offering new standards of care and unlocking opportunities for medical innovation and economic growth. To know more about new treatment for cutaneous T-cell lymphoma, visit @ Cutaneous T-cell Lymphoma Management Cutaneous T-cell Lymphoma Market Dynamics The cutaneous T-cell lymphoma market dynamics are anticipated to change in the coming years. The prognosis for most patients with CTCL is promising, especially with early detection and timely treatment, which can enable decades of survival with ongoing care. However, the disease's heterogeneity and involvement of multiple pathways create a strong foundation for the development of diverse targeted therapies. Emerging evidence supporting PTX-100's superior efficacy and safety over LYMPHIR further underscores the potential of targeting GGT1 inhibition. Combined with the limited pipeline activity in CTCL, this presents a significant opportunity for drug developers to innovate and bring novel therapies to an underserved market. Furthermore, many potential therapies are being investigated for the treatment of cutaneous T-cell lymphoma, and it is safe to predict that the treatment space will significantly impact the cutaneous T-cell lymphoma market during the forecast period. Moreover, the anticipated introduction of emerging therapies with improved efficacy and a further improvement in the diagnosis rate is expected to drive the growth of the cutaneous T-cell lymphoma market in the 7MM. However, several factors may impede the growth of the cutaneous T-cell lymphoma market. The diagnosis and treatment of cutaneous T-cell lymphoma remain challenging due to several factors: multiple biopsies are often required for a definitive diagnosis, potentially delaying appropriate treatment; the underlying mechanisms driving CTCL-associated pruritus are still poorly understood despite advances in research; targeted therapies frequently face issues of limited tolerance and efficacy, leading to discontinuation from toxicity or resistance; and the recent negative opinion and discontinuation of KINSELBY underscore regulatory risks, casting uncertainty over the future development of similar therapies. Moreover, cutaneous T-cell lymphoma treatment poses a significant economic burden and disrupts patients' overall well-being and QOL. Furthermore, the cutaneous T-cell lymphoma market growth may be offset by failures and discontinuation of emerging therapies, unaffordable pricing, market access and reimbursement issues, and a shortage of healthcare specialists. In addition, the undiagnosed, unreported cases and the unawareness about the disease may also impact the cutaneous T-cell lymphoma market growth. Cutaneous T-cell Lymphoma Report Metrics Details Study Period 2020–2034 Cutaneous T-cell Lymphoma Report Coverage 7MM [The United States, the EU-4 (Germany, France, Italy, and Spain), the United Kingdom, and Japan] Cutaneous T-cell Lymphoma Market CAGR 7.1% Cutaneous T-cell Lymphoma Market Size in 2024 USD 995 Million Key Cutaneous T-cell Lymphoma Companies Soligenix and Sterling Pharma Solutions, Prescient Therapeutics, Innate Pharma, Bristol-Myers Squibb, ONO Pharmaceutical, Kyowa Hakko Kirin, Pfizer (Seagen), Takeda, Helsinn Therapeutics, Citius Pharmaceuticals, Valeant Pharmaceuticals, Bausch Health, and others Key Cutaneous T-cell Lymphoma Therapies HyBryte (Synthetic Hypericin/SGX301), PTX-100, Lacutamab (IPH4102), BMS-986369 (Golcadomide), ONO-4685, POTELIGEO, ADCETRIS, VALCHLOR/LEDAGA, LYMPHIR, TARGRETIN, ISTODAX, and others Scope of the Cutaneous T-cell Lymphoma Market Report Cutaneous T-cell Lymphoma Therapeutic Assessment: Cutaneous T-cell Lymphoma current marketed and emerging therapies Cutaneous T-cell Lymphoma current marketed and emerging therapies Cutaneous T-cell Lymphoma Market Dynamics: Conjoint Analysis of Emerging Cutaneous T-cell Lymphoma Drugs Conjoint Analysis of Emerging Cutaneous T-cell Lymphoma Drugs Competitive Intelligence Analysis: SWOT analysis and Market entry strategies SWOT analysis and Market entry strategies Unmet Needs, KOL's views, Analyst's views, Cutaneous T-cell Lymphoma Market Access and Reimbursement Discover more about cutaneous T-cell lymphoma drugs in development @ Cutaneous T-cell Lymphoma Clinical Trials Table of Contents 1 Key Insights 2 CTCL Market Report Introduction 3 Executive Summary 4 Key Events 5 Epidemiology and Market Forecast Methodology 6 CTCL Market Overview at a Glance 7 Disease Background and Overview 8 CTCL Treatment 8.1 Treatment of Limited-stage Mycosis Fungoides/Sézary Syndrome 8.2 Treatment of Advanced-stage Mycosis Fungoides/Sezary Syndrome 8.3 CTCL Treatment Guidelines 9 Epidemiology and Patient Population 9.1 Key Findings 9.2 Assumptions and Rationale 9.3 Total Incident Cases of CTCL in the 7MM 9.4 The United States 9.5 EU4 and the UK 9.6 Japan 10 Patient Journey 11 CTCL Marketed Drugs 11.1 Key Competitors 11.2 POTELIGEO (mogamulizumab): Kyowa Hakko Kirin 11.2.1 Product Description 11.2.2 Regulatory Milestones 11.2.3 Other Developmental Activities 11.2.4 Clinical Development 11.2.4.1 Clinical Trial Information 11.2.5 Safety and Efficacy 11.2.6 Analyst Views 11.3 ADCETRIS (brentuximab vedotin): Pfizer (Seagen) and Takeda 11.4 VALCHLOR/LEDAGA (mechlorethamine): Helsinn Therapeutics 11.5 LYMPHIR/REMITORO/E7777/ONTAK (denileukin diftitox): Citius Pharmaceuticals 12 Discontinued Therapy 12.1 KINSELBY (resminostat): 4SC 12.1.1 Product Description 12.1.2 Other Developmental Activities 12.1.3 Clinical Development 12.1.3.1 Clinical Trials Information 12.1.4 Safety and Efficacy 12.1.5 Analyst Views 13 CTCL Emerging Therapies 13.1 Key Cross Competition 13.2 HyBryte (Synthetic Hypericin/SGX301): Soligenix and Sterling Pharma Solutions 13.2.1 Product Description 13.2.2 Other Developmental Activities 13.2.3 Clinical Development 13.2.3.1 Clinical Trials Information 13.2.4 Safety and Efficacy 13.2.5 Analyst Views 13.3 PTX-100: Prescient Therapeutics 13.4 Lacutamab (IPH4102): Innate Pharma 14 CTCL: Seven Major Market Analysis 14.1 Key Findings 14.2 Market Outlook 14.3 Conjoint Analysis 14.4 Key Market Forecast Assumptions 14.4.1 Cost Assumptions and Rebate 14.4.2 Pricing Trends 14.4.3 Analogue Assessment 14.4.4 Launch Year and Therapy Uptake 14.5 Total Market Size of CTCL in the 7MM 14.6 The United States Market Size 14.7 EU4 and the UK Market Size 14.8 Japan 15 Unmet Needs 16 SWOT Analysis 17 KOL Views 18 CTCL Market Access and Reimbursement 18.1 United States 18.2 EU4 and the UK 18.3 Japan 18.4 Market Access and Reimbursement of CTCL 19 Bibliography 20 Report Methodology Related Reports Cutaneous T-cell Lymphoma Pipeline Cutaneous T-cell Lymphoma Pipeline Insight – 2025 report provides comprehensive insights about the pipeline landscape, pipeline drug profiles, including clinical and non-clinical stage products, and the key CTCL companies, including Mundipharma International, Shanghai Pharmaceuticals Holding, Moleculin Biotech, Inc., BeiGene, Mundipharma Research Limited, Jiangsu Simcere Biologics Co., Ltd, Teva Pharmaceuticals USA, Pfizer, Galderma R&D, Merck Sharp & Dohme LLC, Bio-Path Holdings, Inc., Kymera Therapeutics, Inc., Karyopharm Therapeutics Inc., among others. Non-Hodgkin's Lymphoma Market Non-Hodgkin's Lymphoma Market Insights, Epidemiology, and Market Forecast – 2034 report delivers an in-depth understanding of the disease, historical and forecasted epidemiology, as well as the market trends, market drivers, market barriers, and key NHL companies, including AbbVie, Genmab, Novartis, Angiocrine Bioscience, Autolus, Zentera Therapeutics, Jiangsu Hengrui Medicine, among others. Non-Hodgkin's Lymphoma Pipeline Non-Hodgkin's Lymphoma Pipeline Insight – 2025 report provides comprehensive insights about the pipeline landscape, pipeline drug profiles, including clinical and non-clinical stage products, and the key NHL companies, including Novartis, AstraZeneca, Genentech, BioInvent, Genmab, SystImmune, Nordic Nanovector, Pacylex Pharmaceuticals, Artiva Biotherapeutics, Inc., Chipscreen Biosciences, Ltd., Timmune Biotech Inc., Chia Tai Tianqing Pharmaceutical Group Co., Ltd., Gilead Sciences, Acerta Pharma BV, Adagene Inc, Conjupro Biotherapeutics, Inc., Rhizen Pharmaceuticals, Juventas Cell Therapy Ltd., Incyte Corporation, HUYA Bioscience International, SecuraBio, Genor Biopharma Co., Ltd., Kyowa Kirin Co., Ltd., Antengene Therapeutics Limited, Regeneron Pharmaceuticals, Jiangsu HengRui Medicine Co., Ltd., Xynomic Pharmaceuticals, Inc., BioTheryX, Inc., UWELL Biopharma, Kronos Bio, Bio-Thera Solutions, Spectrum Pharmaceuticals, Inc., Aptose Biosciences Inc., Miltenyi Biomedicine GmbH, Precision BioSciences, Inc., Teneobio, Inc., TCR2 Therapeutics, IGM Biosciences, Inc., among others. Peripheral T-Cell Lymphoma Market Peripheral T-Cell Lymphoma Market Insights, Epidemiology, and Market Forecast – 2034 report delivers an in-depth understanding of the disease, historical and forecasted epidemiology, as well as the market trends, market drivers, market barriers, and key PTCL companies, including Secura Bio, Shanghai YingLi Pharmaceutical, Dizal Pharmaceuticals, Viracta Therapeutics, Innate Pharma, CStone Pharmaceuticals, Affimed, Otsuka Pharmaceutical, Astex Pharmaceuticals, Autolus, Myeloid Therapeutics, Merck Sharp & Dohme, Bristol Myers Squibb, among others. Diffuse Large B-cell Lymphoma Market Diffuse Large B-cell Lymphoma Market Insights, Epidemiology, and Market Forecast – 2034 report delivers an in-depth understanding of the disease, historical and forecasted epidemiology, as well as the market trends, market drivers, market barriers, and key DLBCL companies, including Roche (Genentech), Biogen, Nektar Therapeutics, Merck, Allogene Therapeutics, Miltenyi Biomedicine, AstraZeneca, BioVaxys, ImmunoVaccine Technologies, Cellectar Biosciences, Galapagos, Novartis, Lyell, ImmPACT Bio, Pfizer, Kartos Therapeutics, 2seventy bio, Regeneron Pharmaceuticals, BeiGene, Ranok Therapeutics, Constellation Pharmaceuticals, Genmab, IDP Discovery Pharma S.L., Immunitas Therapeutics, Monte Rosa Therapeutics, SymBio Pharmaceuticals, AVM Biotechnology, Autolus Therapeutics, Kymera Therapeutics, Otsuka Pharmaceutical, Caribou Biosciences, Adicet Bio, Gilead Sciences, Xynomic Pharmaceuticals, Amgen, among others. DelveInsight's Pharma Competitive Intelligence Service: Through its CI solutions, DelveInsight provides its clients with real-time and actionable intelligence on their competitors and markets of interest to keep them stay ahead of the competition by providing insights into the latest therapeutic area-specific/indication-specific market trends, in emerging drugs, and competitive strategies. These services are tailored to the specific needs of each client and are delivered through a combination of reports, dashboards, and interactive presentations, enabling clients to make informed decisions, mitigate risks, and identify opportunities for growth and expansion. Other Business Pharmaceutical Consulting Services Healthcare Conference Coverage Pipeline Assessment Healthcare Licensing Services Discover how a mid-pharma client gained a level of confidence in their soon-to-be partner for manufacturing their therapeutics by downloading our Due Diligence Case Study About DelveInsight DelveInsight is a leading Business Consultant and Market Research firm focused exclusively on life sciences. It supports pharma companies by providing comprehensive end-to-end solutions to improve their performance. Get hassle-free access to all the healthcare and pharma market research reports through our subscription-based platform PharmDelve. Connect with us on LinkedIn|Facebook|Twitter Disclaimer: The above press release comes to you under an arrangement with GlobeNewswire. Business Upturn takes no editorial responsibility for the same. Ahmedabad Plane Crash
Business Wire
19-05-2025
- Business
- Business Wire
Innate Pharma Highlights Abstracts Selected for ASCO 2025 Annual Meeting
MARSEILLE, France--(BUSINESS WIRE)--Regulatory News: Innate Pharma SA (Euronext Paris: IPH; Nasdaq: IPHA) (' Innate ' or the ' Company ') announced today that four abstracts with Innate's drugs in clinical development have been accepted for the American Society of Clinical Oncology (ASCO) 2025 Annual Meeting, taking place May 30-June 3, 2025 in Chicago, Illinois. ' We are looking forward to participating in the ASCO Annual Meeting 2025, where four abstracts with Innate's drugs in clinical development have been selected. In particular, we are pleased to share the long-term follow-up data from the TELLOMAK Phase 2 study, which underscores our continued commitment to advancing innovative therapies for patients," commented Dr Sonia Quaratino, Chief Medical Officer of Innate Pharma. ASCO abstract details: Lacutamab Abstract: 2522 Abstract Title: Lacutamab in patients with relapsed and refractory Sézary syndrome: Long term follow-up from the TELLOMAK phase 2 trial Session Type: Poster Session Session Title: Developmental Therapeutics—Immunotherapy Session Date and Time: Monday, June 2, 2025 – 1:30 – 4:30 PM CDT Abstract: 2523 Abstract Title: Lacutamab in patients with relapsed and/or refractory mycosis fungoides: Long-term follow-up and translational data from the TELLOMAK phase 2 trial Session Type: Poster Session Session Title: Developmental Therapeutics—Immunotherapy Session Date and Time: Monday, June 2, 2025 – 1:30 – 4:30 PM CDT IPH4502 Abstract: TPS3159 Abstract Title: A phase 1, open-label, multi-center study of the safety, tolerability, and efficacy of IPH4502 as a single agent in advanced solid tumors Session Type: Poster Session Session Title: Developmental Therapeutics—Molecularly Targeted Agents and Tumor Biology Session Date and Time: Monday, June 2, 2025 – 1:30 – 4:30 PM CDT Monalizumab (partnered with AstraZeneca) Abstract: 8046 Abstract Title: Neoadjuvant durvalumab (D) + chemotherapy (CT) + novel anticancer agents and adjuvant D ± novel agents in resectable non-small-cell lung cancer (NSCLC): Updated outcomes from NeoCOAST-2. Session Type: Poster Session Session Title: Lung Cancer—Non–Small Cell Local-Regional/Small Cell/Other Thoracic Cancers Session Date and Time: Saturday, May 31, 2025 – 1:30 – 4:30 PM CDT About Innate Pharma Innate Pharma S.A. is a global, clinical-stage biotechnology company developing immunotherapies for cancer patients. Its innovative approach aims to harness the innate immune system through three therapeutic approaches: multi-specific NK Cell Engagers via its ANKET ® (Antibody-based NK cell Engager Therapeutics) proprietary platform and Antibody Drug Conjugates (ADC) and monoclonal antibodies (mAbs). Innate's portfolio includes several ANKET ® drug candidates to address multiple tumor types as well as IPH4502, a differentiated ADC in development in solid tumors. In addition, anti-KIR3DL2 mAb lacutamab is developed in advanced form of cutaneous T cell lymphomas and peripheral T cell lymphomas, and anti-NKG2A mAb monalizumab is developed with AstraZeneca in non-small cell lung cancer. Innate Pharma is a trusted partner to biopharmaceutical companies such as Sanofi and AstraZeneca, as well as leading research institutions, to accelerate innovation, research and development for the benefit of patients. Headquartered in Marseille, France with a US office in Rockville, MD, Innate Pharma is listed on Euronext Paris and Nasdaq in the US. Learn more about Innate Pharma at Follow us on LinkedIn and X. Information about Innate Pharma shares Disclaimer on forward-looking information and risk factors This press release contains certain forward-looking statements, including those within the meaning of applicable securities laws, including the Private Securities Litigation Reform Act of 1995. The use of certain words, including 'anticipate,' 'believe,' 'can,' 'could,' 'estimate,' 'expect,' 'may,' 'might,' 'potential,' 'should,' 'will,' or the negative of these and similar expressions, is intended to identify forward-looking statements. Although the Company believes its expectations are based on reasonable assumptions, these forward-looking statements are subject to numerous risks and uncertainties, which could cause actual results to differ materially from those anticipated. These risks and uncertainties include, among other things, the uncertainties inherent in research and development, including related to safety, progression of and results from its ongoing and planned clinical trials and preclinical studies, review and approvals by regulatory authorities of its product candidates, the Company's reliance on third parties to manufacture its product candidates, the Company's commercialization efforts and the Company's continued ability to raise capital to fund its development. For an additional discussion of risks and uncertainties, which could cause the Company's actual results, financial condition, performance or achievements to differ from those contained in the forward-looking statements, please refer to the Risk Factors ('Facteurs de Risque") section of the Universal Registration Document filed with the French Financial Markets Authority ('AMF'), which is available on the AMF website or on Innate Pharma's website, and public filings and reports filed with the U.S. Securities and Exchange Commission ('SEC'), including the Company's Annual Report on Form 20-F for the year ended December 31, 2024, and subsequent filings and reports filed with the AMF or SEC, or otherwise made public by the Company. References to the Company's website and the AMF website are included for information only and the content contained therein, or that can be accessed through them, are not incorporated by reference into, and do not constitute a part of, this press release. In light of the significant uncertainties in these forward-looking statements, you should not regard these statements as a representation or warranty by the Company or any other person that the Company will achieve its objectives and plans in any specified time frame or at all. The Company undertakes no obligation to publicly update any forward-looking statements, whether as a result of new information, future events or otherwise, except as required by law. This press release and the information contained herein do not constitute an offer to sell or a solicitation of an offer to buy or subscribe to shares in Innate Pharma in any country.
