Latest news with #MINOCA
Medscape
23-06-2025
- Health
- Medscape
CMR in MINOCA Linked to Improved Diagnosis and Management
TOPLINE: In a prospective study of over 300 patients with myocardial infarction with nonobstructive coronary arteries (MINOCA), cardiovascular magnetic resonance (CMR) was associated with meaningful changes in clinical diagnosis and/or management in 63% of patients and a similar increase in diagnostic certainty. METHODOLOGY: Previous CMR studies in MINOCA have focused on radiologic yield — a limited metric that does not reflect real‐world clinical utility. Prospective data on patient care are lacking. This prospective study conducted in Australia and the UK assessed the impact of CMR on diagnosis and management in 320 patients with MINOCA (mean age, 55.6 years; 52% men) recruited between January 2019 and July 2023. Patients were included if they had a hospital admission with acute features consistent with the Fourth Universal Definition of Myocardial Infarction, no obstructive coronary artery disease on angiography, and a clinician assessment indicating acute myocardial infarction as the most likely presentation. The treating cardiologists completed a questionnaire before and after CMR to record their working diagnosis, rate diagnostic certainty on a 1-10 scale (10 = most certain), and specify intended management, including medications and follow-up testing. The primary endpoint was a composite of change in clinical diagnosis or management after CMR. TAKEAWAY: CMR was associated with a change in diagnosis or management in 63% of patients (P < .001), with diagnosis revised in 38% and management changed in 50%. Diagnostic certainty increased significantly from a median score of 6-8 after CMR (P < .001), and diagnostic confidence numerically increased in 63% of patients. The absence of coronary atheroma, a pre-CMR diagnostic certainty score ≤ 5, and early CMR (performed within 14 days of hospital presentation) independently predicted a change in diagnosis or management, with 80% of patients with all three predictors vs 40% of those with none meeting the primary outcome. Of 172 patients initially prescribed dual antiplatelet therapy, 66 (38%) had it deprescribed following CMR, yielding a number needed to test of 3. IN PRACTICE: 'Integration of CMR into diagnostic imaging pathways may be reasonable to augment clinical diagnosis and management; however, further cost-effectiveness analyses are now warranted,' the study authors wrote. SOURCE: This study was led by Adil Rajwani, PhD, of the Royal Perth Hospital, Perth, Australia. It was published online on June 13, 2025, in Heart. LIMITATIONS: The study was limited by the impracticality of conducting a bias-free randomized trial of CMR vs no CMR. It was also limited by the assessment of CMR's impact only immediately after imaging, potentially missing later clinical insights. Medication protocols were not standardized, and the limited use of additional diagnostics such as optical coherence tomography may have influenced the findings. DISCLOSURES: This study was funded by a grant from the Royal Perth Hospital Medical Research Foundation in Australia. The authors declared having no conflicts of interest. This article was created using several editorial tools, including AI, as part of the process. Human editors reviewed this content before publication.
Time of India
10-05-2025
- Health
- Time of India
No blockage still a heart attack: Pune techie's case highlights a hidden threat, say doctors
Pune: When 49-year-old Vikram, an IT professional from Baner, was rushed to hospital with chest congestion and breathlessness, his family first thought it was probably severe acidity or a digestive issue. Vikram recounts the day: "I felt fatigued two days before the congestion in the chest. I had dismissed it as severe acidity and took some ENO, but later, I began experiencing an intense pain in the lower jaw too, and felt restless. That's when my wife took me to the hospital." Doctors there found Vikram's ECG to be abnormal and called for an angiography. "And although my doctors said I had suffered a heart attack, my angiogram revealed no blockages in the coronary arteries, which was baffling," Vikram said. He was diagnosed with a little-known condition called Myocardial infarction with non-obstructive coronary arteries, or MINOCA. "Sometimes, people can have a heart attack even when coronary arteries are not blocked. This is called MINOCA," senior cardiologist Dr Suhas Hardas, Vikram's treating doctor. Dr Hardas explained that a heart attack without blockage can be due to several factors. "It may be from transient clots (thrombi) that dissolve before testing, or due to coronary artery spasms, a sudden tightening of the artery often triggered by emotional or physical stress," he said. "In some cases, clots from elsewhere in the body (emboli) travel to the heart. Inflammation of the heart muscle (myocarditis) and stress-induced heart weakness (Takotsubo syndrome) can also damage the heart. These issues don't show up in standard imaging, but can still lead to heart injury," he said. Another possibility is microvascular dysfunction — problems in the tiny blood vessels of the heart that are not visible during routine tests. It's for such hidden reasons that doctors are now turning to advanced tools such as FFR (Fractional Flow Reserve) and CFR (Coronary Flow Reserve). "Micro-vascular dysfunction means there is a problem with the very small blood vessels in the heart, which is hard to detect. But now, a special pressure wire (already used to check FFR) can also measure IMR (Index of Microcirculatory Resistance) and CFR, helping doctors find and understand these tiny vessel problems. This technology will soon be available in India and will help diagnose and treat MINOCA better," Dr Hardas said. Kolkata-based cardiologist Dr PK Hazra said: "Unlike traditional heart attacks, MINOCA is 'non-atherosclerotic', meaning it is not related to LDL cholesterol. Though men can also suffer from MINOCA, especially smokers or cannabis users, it has been far more common in women." Dr Hazra added: "During Covid, MINOCA cases were seen due to spontaneous coronary thrombosis — a clot forming without cholesterol deposits. Many of these patients were middle-aged women dealing with mental health issues, depression, family problems, divorces, or simply living alone. Such mental trauma can lead to a heart attack. These cases are also treated like typical heart attacks, but in an angiogram, the arteries may look normal or show abnormalities that do not require stents or bypass surgery." Diagnosing MINOCA can be challenging as it does not follow the typical pattern of a heart attack. Doctors then rely on a combination of clues or symptoms, like chest pain or fatigue, ECG changes, elevated cardiac enzymes, and echocardiography. Recent studies have brought MINOCA into the spotlight. A paper in JAMA Cardiology said 6% to 8% of all heart attacks fall under the MINOCA category, with a disproportionate number occurring in younger individuals and post-menopausal women. The treatment remains the same in MINOCA. "Whenever there is a heart attack, the basic treatment is to give antiplatelet drugs, which are blood thinners. Next, injectable blood thinners can be used for a short time in the hospital. If the cause is stress-induced cardiomyopathy or myocarditis, medications to reduce stress, like beta-blockers, are given. Sometimes, calcium antagonists are also used to reduce spasms in the heart's arteries," Dr Hardas said. He also stressed on the importance of lifestyle changes: quitting smoking, regular aerobic exercises and a diet rich in antioxidants. "Legumes, berries and nuts help repair the heart at a cellular level. Prevention remains the best medicine," he added.
