Latest news with #Margaret'sTrial
Metro
16 hours ago
- Health
- Metro
Man's deadly brain cancer disappears after experimental drug trial
Chloe Johnson Published July 23, 2025 4:47pm Link is copied Comments Ben Trotman, 43, was diagnosed with glioblastoma, an aggressive form of brain cancer where patients typically die within 12-to-18 months, in October of 2022. Now, however, he is showing no signs of the disease after being administered the immunotherapy drug ipilimumab (Picture: Marie Mangan/UCLH/PA Wire) Two months are receiving ipilimumab, Trotman married his wife Emily and, in April 2025, they welcomed their daughter, Mabel. At the time of diagnosis, a family friend recommended that Trotman should be referred to The National Hospital for Neurology and Neurosurgery at UCLH, where they met consultant medical oncologist Dr Paul Mulholland. Mulholland recruited Trotman to a clinical trial he was running, in which Trotman would be the first in the world to receive the immunotherapy drug ipilimumab to treat glioblastoma prior to standard treatment. Now aged 43 - two years and eight months on from having this treatment - Ben's scans are clear with no signs of tumour (Picture: UCLH) Trotman's wife, Emily, said: 'Getting this diagnosis was the most traumatic experience. We were grappling with the fact that Ben had gone from being apparently perfectly healthy to having months to live. Had we not met Dr Mulholland, that would have been it for us. We felt we had a lucky break in an otherwise devastating situation' (Picture: Marie Mangan/UCLH/PA Wire) Now, a new immunotherapy trial for this deadly form of cancer is now set to enrol 16 people over an 18-month period, following the remarkable outcome which saw Trotman's tumour vanish. The NHS study has been established in memory of Baroness Margaret McDonagh, who succumbed to the disease. Dame Siobhain McDonagh MP, sister to the Baroness, led a fundraising campaign to raise more than £1 million to cover the costs of the new trial. Patients diagnosed with glioblastoma will receive the immunotherapy drug ipilimumab prior to standard treatment, building on a previous study involving the same drug (Picture: Getty) Dame McDonagh, MP for Mitcham and Morden and chair of the all-party parliamentary group on brain tumours, said: 'My beloved sister Margaret was appalled to discover that there had been no advances in brain cancer treatment for decades when she was diagnosed with glioblastoma. Changing this was Margaret's final campaign and one that I have continued in her memory. I am so grateful to the many people who knew and respected Margaret, who have come together and helped to raise funds and campaign for this new trial that we are calling Margaret's Trial' (Picture: Marie Mangan/UCLH/PA Wire) Consultant medical oncologist, Dr Paul Mulholland, who is leading the new trial, said of Ben's recovery: 'It is very unusual to have a clear scan with glioblastoma, especially when he didn't have the follow-up surgery that had been planned to remove all of the tumour that was initially visible on scans. We hope that the immunotherapy and follow-up treatment Ben has had will hold his tumour at bay – and it has so far, which we are delighted to see' This new treatment will be administered at the NIHR UCLH's Clinical Research Facility and the National Hospital for Neurology and Neurosurgery. The patients will receive the drug ipilimumab before proceeding to standard treatments that may include surgery, radiotherapy and chemotherapy. Mulholland said of the trial: 'The crucial element of this trial is that patients will have their immune system boosted by the drug before they have any other treatment, when they are fit and well enough to tolerate the immunotherapy' (Picture: Getty) Your free newsletter guide to the best London has on offer, from drinks deals to restaurant reviews.
Rhyl Journal
5 days ago
- Health
- Rhyl Journal
Patients sought for new NHS trial for brain cancer after man sees tumour vanish
The NHS study will recruit 16 people over an 18-month period and has been set up in memory of Baroness Margaret McDonagh, who died of the disease. People diagnosed with deadly glioblastoma will receive immunotherapy with the drug ipilimumab before undergoing standard treatment, when their immune system is at its strongest. The trial, from University College London Hospital's National Hospital for Neurology and Neurosurgery, follows a previous one on the same drug which closed because of lack of recruitment. One patient from that trial, Ben Trotman, is still showing no signs of glioblastoma following the treatment – well over two years since he got the drug in a world first. Most people with glioblastoma die within 12-18 months. Mr Trotman was diagnosed with glioblastoma in October 2022, when he was 40. Now aged 43 and two years and eight months on from having the treatment, his scans are clear and there are no signs of tumour. Consultant medical oncologist, Dr Paul Mulholland, who is leading the new trial and treated Mr Trotman, said: 'It is very unusual to have a clear scan with glioblastoma, especially when he didn't have the follow-up surgery that had been planned to remove all of the tumour that was initially visible on scans. 'We hope that the immunotherapy and follow-up treatment Ben has had will hold his tumour at bay – and it has so far, which we are delighted to see.' Mr Trotman got married to Emily two months after the immunotherapy treatment and in April, his daughter Mabel was born. Mrs Trotman said: 'Getting this diagnosis was the most traumatic experience. We were grappling with the fact that Ben had gone from being apparently perfectly healthy to having months to live. 'Had we not met Dr Mulholland, that would have been it for us. We felt we had a lucky break in an otherwise devastating situation.' Mr Trotman went on to have the current standard treatment of radiotherapy and chemotherapy. He has quarterly scans, which continue to be clear. Mr Trotman said: 'We obviously don't know what the future holds but having had the immunotherapy treatment and getting these encouraging scan results has given Emily and I a bit of hope. 'We are focused on rebuilding the life we thought we had lost and enjoying being parents.' Dame Siobhain McDonagh MP led a fundraising campaign to raise more than £1 million to cover the costs of the new trial. Her sister, Baroness McDonagh, died from glioblastoma in 2023. Dame Siobhain said: 'My beloved sister Margaret was appalled to discover that there had been no advances in brain cancer treatment for decades when she was diagnosed with glioblastoma. 'Changing this was Margaret's final campaign and one that I have continued in her memory. 'I am so grateful to the many people who knew and respected Margaret who have come together and helped to raise funds and campaign for this new trial that we are calling Margaret's Trial.' Dr Paul Mulholland said: 'When I met Margaret she said to me 'what can I do to support you to cure this disease?'. 'I am incredibly grateful to her and to Siobhain whose campaigning and fundraising in her sister's memory has led to this new clinical trial opening for patients with this most aggressive form of brain cancer that has such a poor prognosis, with most patients surviving just nine months after diagnosis. 'The crucial element of this trial is that patients will have their immune system boosted by the drug before they have any other treatment, when they are fit and well enough to tolerate the immunotherapy. 'We're taking everything we have learned from previous trials into this new study and we are already planning follow-on trials. 'My aim is to find a cure for glioblastoma.' The National Brain Appeal is currently funding two posts in support of Dr Mulholland's research. Treatment will take place at the NIHR UCLH's Clinical Research Facility and at the National Hospital for Neurology and Neurosurgery. Patients interested in the new Win-Glio trial should discuss it with their consultant.
South Wales Guardian
5 days ago
- Health
- South Wales Guardian
Patients sought for new NHS trial for brain cancer after man sees tumour vanish
The NHS study will recruit 16 people over an 18-month period and has been set up in memory of Baroness Margaret McDonagh, who died of the disease. People diagnosed with deadly glioblastoma will receive immunotherapy with the drug ipilimumab before undergoing standard treatment, when their immune system is at its strongest. The trial, from University College London Hospital's National Hospital for Neurology and Neurosurgery, follows a previous one on the same drug which closed because of lack of recruitment. One patient from that trial, Ben Trotman, is still showing no signs of glioblastoma following the treatment – well over two years since he got the drug in a world first. Most people with glioblastoma die within 12-18 months. Mr Trotman was diagnosed with glioblastoma in October 2022, when he was 40. Now aged 43 and two years and eight months on from having the treatment, his scans are clear and there are no signs of tumour. Consultant medical oncologist, Dr Paul Mulholland, who is leading the new trial and treated Mr Trotman, said: 'It is very unusual to have a clear scan with glioblastoma, especially when he didn't have the follow-up surgery that had been planned to remove all of the tumour that was initially visible on scans. 'We hope that the immunotherapy and follow-up treatment Ben has had will hold his tumour at bay – and it has so far, which we are delighted to see.' Mr Trotman got married to Emily two months after the immunotherapy treatment and in April, his daughter Mabel was born. Mrs Trotman said: 'Getting this diagnosis was the most traumatic experience. We were grappling with the fact that Ben had gone from being apparently perfectly healthy to having months to live. 'Had we not met Dr Mulholland, that would have been it for us. We felt we had a lucky break in an otherwise devastating situation.' Mr Trotman went on to have the current standard treatment of radiotherapy and chemotherapy. He has quarterly scans, which continue to be clear. Mr Trotman said: 'We obviously don't know what the future holds but having had the immunotherapy treatment and getting these encouraging scan results has given Emily and I a bit of hope. 'We are focused on rebuilding the life we thought we had lost and enjoying being parents.' Dame Siobhain McDonagh MP led a fundraising campaign to raise more than £1 million to cover the costs of the new trial. Her sister, Baroness McDonagh, died from glioblastoma in 2023. Dame Siobhain said: 'My beloved sister Margaret was appalled to discover that there had been no advances in brain cancer treatment for decades when she was diagnosed with glioblastoma. 'Changing this was Margaret's final campaign and one that I have continued in her memory. 'I am so grateful to the many people who knew and respected Margaret who have come together and helped to raise funds and campaign for this new trial that we are calling Margaret's Trial.' Dr Paul Mulholland said: 'When I met Margaret she said to me 'what can I do to support you to cure this disease?'. 'I am incredibly grateful to her and to Siobhain whose campaigning and fundraising in her sister's memory has led to this new clinical trial opening for patients with this most aggressive form of brain cancer that has such a poor prognosis, with most patients surviving just nine months after diagnosis. 'The crucial element of this trial is that patients will have their immune system boosted by the drug before they have any other treatment, when they are fit and well enough to tolerate the immunotherapy. 'We're taking everything we have learned from previous trials into this new study and we are already planning follow-on trials. 'My aim is to find a cure for glioblastoma.' The National Brain Appeal is currently funding two posts in support of Dr Mulholland's research. Treatment will take place at the NIHR UCLH's Clinical Research Facility and at the National Hospital for Neurology and Neurosurgery. Patients interested in the new Win-Glio trial should discuss it with their consultant.
Leader Live
5 days ago
- Health
- Leader Live
Patients sought for new NHS trial for brain cancer after man sees tumour vanish
The NHS study will recruit 16 people over an 18-month period and has been set up in memory of Baroness Margaret McDonagh, who died of the disease. People diagnosed with deadly glioblastoma will receive immunotherapy with the drug ipilimumab before undergoing standard treatment, when their immune system is at its strongest. The trial, from University College London Hospital's National Hospital for Neurology and Neurosurgery, follows a previous one on the same drug which closed because of lack of recruitment. One patient from that trial, Ben Trotman, is still showing no signs of glioblastoma following the treatment – well over two years since he got the drug in a world first. Most people with glioblastoma die within 12-18 months. Mr Trotman was diagnosed with glioblastoma in October 2022, when he was 40. Now aged 43 and two years and eight months on from having the treatment, his scans are clear and there are no signs of tumour. Consultant medical oncologist, Dr Paul Mulholland, who is leading the new trial and treated Mr Trotman, said: 'It is very unusual to have a clear scan with glioblastoma, especially when he didn't have the follow-up surgery that had been planned to remove all of the tumour that was initially visible on scans. 'We hope that the immunotherapy and follow-up treatment Ben has had will hold his tumour at bay – and it has so far, which we are delighted to see.' Mr Trotman got married to Emily two months after the immunotherapy treatment and in April, his daughter Mabel was born. Mrs Trotman said: 'Getting this diagnosis was the most traumatic experience. We were grappling with the fact that Ben had gone from being apparently perfectly healthy to having months to live. 'Had we not met Dr Mulholland, that would have been it for us. We felt we had a lucky break in an otherwise devastating situation.' Mr Trotman went on to have the current standard treatment of radiotherapy and chemotherapy. He has quarterly scans, which continue to be clear. Mr Trotman said: 'We obviously don't know what the future holds but having had the immunotherapy treatment and getting these encouraging scan results has given Emily and I a bit of hope. 'We are focused on rebuilding the life we thought we had lost and enjoying being parents.' Dame Siobhain McDonagh MP led a fundraising campaign to raise more than £1 million to cover the costs of the new trial. Her sister, Baroness McDonagh, died from glioblastoma in 2023. Dame Siobhain said: 'My beloved sister Margaret was appalled to discover that there had been no advances in brain cancer treatment for decades when she was diagnosed with glioblastoma. 'Changing this was Margaret's final campaign and one that I have continued in her memory. 'I am so grateful to the many people who knew and respected Margaret who have come together and helped to raise funds and campaign for this new trial that we are calling Margaret's Trial.' Dr Paul Mulholland said: 'When I met Margaret she said to me 'what can I do to support you to cure this disease?'. 'I am incredibly grateful to her and to Siobhain whose campaigning and fundraising in her sister's memory has led to this new clinical trial opening for patients with this most aggressive form of brain cancer that has such a poor prognosis, with most patients surviving just nine months after diagnosis. 'The crucial element of this trial is that patients will have their immune system boosted by the drug before they have any other treatment, when they are fit and well enough to tolerate the immunotherapy. 'We're taking everything we have learned from previous trials into this new study and we are already planning follow-on trials. 'My aim is to find a cure for glioblastoma.' The National Brain Appeal is currently funding two posts in support of Dr Mulholland's research. Treatment will take place at the NIHR UCLH's Clinical Research Facility and at the National Hospital for Neurology and Neurosurgery. Patients interested in the new Win-Glio trial should discuss it with their consultant.
North Wales Chronicle
5 days ago
- Health
- North Wales Chronicle
Patients sought for new NHS trial for brain cancer after man sees tumour vanish
The NHS study will recruit 16 people over an 18-month period and has been set up in memory of Baroness Margaret McDonagh, who died of the disease. People diagnosed with deadly glioblastoma will receive immunotherapy with the drug ipilimumab before undergoing standard treatment, when their immune system is at its strongest. The trial, from University College London Hospital's National Hospital for Neurology and Neurosurgery, follows a previous one on the same drug which closed because of lack of recruitment. One patient from that trial, Ben Trotman, is still showing no signs of glioblastoma following the treatment – well over two years since he got the drug in a world first. Most people with glioblastoma die within 12-18 months. Mr Trotman was diagnosed with glioblastoma in October 2022, when he was 40. Now aged 43 and two years and eight months on from having the treatment, his scans are clear and there are no signs of tumour. Consultant medical oncologist, Dr Paul Mulholland, who is leading the new trial and treated Mr Trotman, said: 'It is very unusual to have a clear scan with glioblastoma, especially when he didn't have the follow-up surgery that had been planned to remove all of the tumour that was initially visible on scans. 'We hope that the immunotherapy and follow-up treatment Ben has had will hold his tumour at bay – and it has so far, which we are delighted to see.' Mr Trotman got married to Emily two months after the immunotherapy treatment and in April, his daughter Mabel was born. Mrs Trotman said: 'Getting this diagnosis was the most traumatic experience. We were grappling with the fact that Ben had gone from being apparently perfectly healthy to having months to live. 'Had we not met Dr Mulholland, that would have been it for us. We felt we had a lucky break in an otherwise devastating situation.' Mr Trotman went on to have the current standard treatment of radiotherapy and chemotherapy. He has quarterly scans, which continue to be clear. Mr Trotman said: 'We obviously don't know what the future holds but having had the immunotherapy treatment and getting these encouraging scan results has given Emily and I a bit of hope. 'We are focused on rebuilding the life we thought we had lost and enjoying being parents.' Dame Siobhain McDonagh MP led a fundraising campaign to raise more than £1 million to cover the costs of the new trial. Her sister, Baroness McDonagh, died from glioblastoma in 2023. Dame Siobhain said: 'My beloved sister Margaret was appalled to discover that there had been no advances in brain cancer treatment for decades when she was diagnosed with glioblastoma. 'Changing this was Margaret's final campaign and one that I have continued in her memory. 'I am so grateful to the many people who knew and respected Margaret who have come together and helped to raise funds and campaign for this new trial that we are calling Margaret's Trial.' Dr Paul Mulholland said: 'When I met Margaret she said to me 'what can I do to support you to cure this disease?'. 'I am incredibly grateful to her and to Siobhain whose campaigning and fundraising in her sister's memory has led to this new clinical trial opening for patients with this most aggressive form of brain cancer that has such a poor prognosis, with most patients surviving just nine months after diagnosis. 'The crucial element of this trial is that patients will have their immune system boosted by the drug before they have any other treatment, when they are fit and well enough to tolerate the immunotherapy. 'We're taking everything we have learned from previous trials into this new study and we are already planning follow-on trials. 'My aim is to find a cure for glioblastoma.' The National Brain Appeal is currently funding two posts in support of Dr Mulholland's research. Treatment will take place at the NIHR UCLH's Clinical Research Facility and at the National Hospital for Neurology and Neurosurgery. Patients interested in the new Win-Glio trial should discuss it with their consultant.
