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CNET
6 days ago
- Health
- CNET
Cortisol Imbalance: High Cortisol Symptoms and How to Fix Stress Levels
Cortisol is a hot topic these days, especially as many struggle to manage their stress. You may also have heard of the term "cortisol face" or "moon face," which can be attributed to high cortisol levels. "Cortisol is a hormone produced by the adrenal glands that helps regulate your metabolism, blood sugar, inflammation, blood pressure and sleep-wake cycle," explains Dr. Mark Hyman, co-founder and CMO of Function Health, which offers a cortisol lab test. "It's most known for managing the body's response to stress." But what exactly does a cortisol imbalance look like, and how does it affect the body? To find out, we consulted doctors for symptoms, causes, when to see a doctor for cortisol testing and how to regulate cortisol. What is cortisol? "Cortisol is a hormone produced by your adrenal glands in response to stress," says Dr. Fady Hannah Shmouni, medical director at Eli Health, which sells an instant cortisol test. "When a stressful situation arises, cortisol can help your body prepare to respond by increasing energy, focus or alertness." Shmouni states that in the short term, your body's cortisol response is necessary and helpful. However, chronic stress can cause cortisol to remain elevated, which can negatively affect your organs, including your brain. For instance, elevated cortisol can disrupt sleep, increase inflammation or impair memory. Dr. Andy Franklyn-Miller, a dual board-certified sports and exercise medicine physician, adds that cortisol is like your body's built-in alarm system and is often called the "stress hormone." "Cortisol is part of the glucocorticoid family, and it's released as part of the hypothalamic-pituitary-adrenal (HPA) axis, your body's stress response headquarters," Franklyn-Miller says. In the morning, your cortisol spikes to help you get moving. At night, it dips to help you rest. Where the adrenal glands are located. SEBASTIAN KAULITZKI/SCIENCESymptoms of cortisol imbalance "Cortisol imbalances often go unnoticed until symptoms become disruptive," explains Hyman. "If you feel wired at night, crash mid-afternoon or struggle to get restful sleep, your cortisol could be out of sync." Franklyn-Miller adds that it can be difficult to spot a cortisol imbalance, since it can mimic other conditions. However, telltale signs include persistent fatigue, trouble sleeping or unexplained weight changes. "Home wearables tracking heart-rate variability, such as Whoop, Oura or Apple Watch, can also give indirect clues, as low HRV often correlates with cortisol dysregulation due to stress and a reduction in HRV," he says. Symptoms of high cortisol "Under normal conditions, your cortisol levels peak in the morning to help you wake up and then gradually decrease throughout the day," Shmouni explains. "But if you experience chronic stress, your body may make excess cortisol, and one of the most common ways this shows up is in disruptions to energy patterns." Some common symptoms of high cortisol, according to Shmouni, include nighttime sleep disturbances, energy dips caused by blood sugar spikes and crashes, and feeling constantly tired. Hyman adds that chronically high cortisol can also lead to: Anxiety and irritability Weight gain Sleep disruptions, fatigue High blood pressure Frequent illnesses due to a weakened immune system Over time, Hyman states that elevated cortisol can cause more serious problems, like cardiovascular disease, insulin resistance and cognitive decline. High cortisol is often connected to conditions like Cushing's syndrome or chronic stress, according to Franklyn-Miller, who adds that weight gain can be especially noticeable in the midsection and face (also known as "moon face"). You can experience osteoporosis and muscle loss, since cortisol can break down tissue over time, or skin changes, like thinning skin, bruising easily or stretch marks. Symptoms of low cortisol Hyman states that low cortisol symptoms often include: Fatigue that doesn't improve with rest Low blood pressure Cravings for salt or sugar Dizziness upon standing Mood swings or depression "Low blood pressure, fogginess, weight loss and muscle weakness can occur; any serious symptoms are a sign that you should consult your doctor, as they could mean a more serious adrenal issue (like adrenal insufficiency) is at play," advises Shmouni. According to Franklyn-Miller, low cortisol is often seen in Addison's disease. People with Addison's disease may notice a darkening of the causes a cortisol imbalance? "There's no single cause of cortisol imbalance -- it's a result of multiple stressors piling up," says Hyman. "This can include: chronic psychological stress (work, relationships, trauma), poor sleep habits, blood sugar imbalances, overtraining without recovery, inflammation, infections and nutrient deficiencies, especially B vitamins and magnesium." Franklyn-Miller explains that the HPA axis is designed for short-term stress, so constant, long-term activation or suppression can lead to an imbalance. Stress If you deal with long periods of stress -- caused by factors like a high-pressure job, financial struggles or family responsibilities -- Shmouni says that cortisol can stay elevated in the body instead of fluctuating normally throughout the day. "This can create a cycle whereby elevated cortisol is not appropriately managed, resulting in prolonged cortisol release," he states. "If we don't see that someone's cortisol levels decline throughout the day, with a normal awakening response in the morning, it can be a sign that cortisol is dysregulated." Certain medications or medical conditions If you deal with chronically elevated cortisol levels, Shmouni says that this may be a side effect of medications like steroid inhalers, as one example. On the other hand, Franklyn-Miller reports that long-term use of corticosteroid drugs (e.g., prednisone) can shut down natural cortisol production, causing low cortisol. As Franklyn-Miller mentioned earlier, certain medical conditions, like Cushing's syndrome, can also cause high cortisol. "Cushing's syndrome, caused by tumors or excessive steroid use, floods the body with cortisol," he reports. When it comes to low cortisol, it may be caused by adrenal insufficiency. "Conditions like Addison's disease damage the adrenal glands, slashing cortisol production," Franklyn-Miller explains. Autoimmune disorders can also cause low cortisol, as the body attacks its own adrenal glands and reduces cortisol output. Your lifestyle: Sleep, exercise and nutrition "Poor sleep, overexercising or a high-sugar diet can spike cortisol by stressing the body," says Franklyn-Miller. When planning your workout, consider your stress and sleep. If you had trouble sleeping last night and are dealing with high stress at work, it may not be the best time for an intense workout. If you find that a workout leaves you feeling fatigued or sick, you may be going too hard. In addition to a high-sugar diet, alcohol and caffeine can also affect cortisol levels. For most adults, the FDA recommends 400 milligrams of caffeine or two to three 12-fluid-ounce cups of coffee. However, certain medications or conditions can make someone more sensitive to caffeine, so make sure to consult your doctor if you're unsure. According to the American Heart Association, it's advised to limit alcohol to two drinks per day for men and one drink per day for women. The National Institute on Alcohol Abuse and Alcoholism explains that in the US, a standard drink contains 14 grams or about 0.6 fluid ounces of "pure" ethanol. For sugar, the AHA states that men shouldn't consume more than nine teaspoons of added sugar daily. For women, consumption should be no more than six teaspoons of sugar per day. Ensure you're eating a balanced diet filled with colorful fruits and vegetables, leafy greens, whole grains and protein. And of course, make sure you're drinking enough to regulate cortisol "Regulating cortisol is like tuning an instrument -- it takes mindful adjustments to your lifestyle," says Franklyn-Miller, who recommends the follow strategies: Prioritize sunlight exposure after waking up: "Only 20 minutes can stimulate your circadian release of cortisol, helping with body balance." "Only 20 minutes can stimulate your circadian release of cortisol, helping with body balance." Focus on sleep: "Stick to a consistent sleep schedule." In general, 7 to 9 hours of sleep is recommended, but it depends on your age. "Stick to a consistent sleep schedule." In general, 7 to 9 hours of sleep is recommended, but it depends on your age. Manage stress: "Practices like mindfulness meditation, yoga or diaphragmatic breathing can calm the HPA axis." "Practices like mindfulness meditation, yoga or diaphragmatic breathing can calm the HPA axis." Exercise smart: "Moderate exercise, like walking or yoga, balances cortisol, but overtraining can spike it. Aim for 30 minutes most days." "Moderate exercise, like walking or yoga, balances cortisol, but overtraining can spike it. Aim for 30 minutes most days." Eat balanced meals: "Avoid high-sugar diets, which can elevate cortisol. Focus on whole foods, like vegetables, lean proteins and healthy fats. Omega-3s, found in fish, may lower cortisol." Hyman also recommends prioritizing fiber. "Avoid high-sugar diets, which can elevate cortisol. Focus on whole foods, like vegetables, lean proteins and healthy fats. Omega-3s, found in fish, may lower cortisol." Hyman also recommends prioritizing fiber. Limit caffeine: "Too much coffee can mimic stress, raising cortisol. Try cutting back after noon." When should you see a doctor about cortisol levels? "If you experience significant symptoms that interrupt your ability to participate in daily activities, or if you experience extreme changes in appetite, energy, mood or sleep, bring this up with your medical provider so that they can work with you to manage symptoms and make lifestyle adaptations," advises Shmouni. Franklyn-Miller adds, "Also, if lifestyle changes (better sleep, stress management) don't improve symptoms after a few months, or if you're on long-term steroids, get checked." He explains that the gold standard for checking cortisol is through lab tests for blood, saliva or urine samples. For these, consult your doctor.
New York Post
01-07-2025
- Health
- New York Post
What being a vegetarian did to my biological age and nutrient makeup
I haven't touched seafood or meat in more than a decade, and aside from a daily multivitamin, I'm hardly what you'd call supplement-savvy. I feel healthy overall — but I had to wonder: Is my vegetarian lifestyle helping me age gracefully, or quietly wearing me down? To find out, I turned to Function Health's biological age test, a new service that promises to reveal how your body is aging on the inside and and empower you to take charge of your health. Dr. Mark Hyman, the company's founder, walked me through my results — including one major red flag I probably wouldn't have caught until it was already causing serious trouble. 7 Studies show that roughly 6% of the US population are vegetarians. Tamara Beckwith/NY Post But first: What is biological age? You've got two ages. Your chronological age is how many years you've lived. Your biological age reflects how your body is aging at the cellular level. A growing number of companies now offer tests that promise to reveal your biological age by analyzing factors like gut bacteria, blood proteins and DNA. Function Health launched its biological age test in 2023, backed by investors like Matt Damon and Pedro Pascal. For $499 a year, you get two rounds of testing: an initial assessment with 105 lab tests, then a follow-up three to six months later with 60-plus retests to track changes after you've had a chance to modify your diet, exercise and supplement intake. The process requires over two dozen vials of blood and a urine sample over two visits. My results came back in about a week, along with personalized insights from Function's clinicians. I scored 20.8 — 4.2 years younger than my actual age. 7 Biological age is a strong predictor of health. Function Health 'It means you're doing better than average,' Hyman told me, 'but the calculation is based on a largely sick population.' In the US, 6 in 10 adults have at least one chronic disease, while 4 in 10 have two or more, according to the CDC. Deficiencies detected Function's biological age test screens your blood for 102 biomarkers, and of them, 11 of mine were out of range. 'With low vitamin D, low iron and low anti-inflammatory omega 3's, I could immediately tell that you're a vegan or vegetarian,' Hyman said. While these nutrients exist in plant-based foods, they're typically found in higher quantities in animal products like fatty fish and liver. My low vitamin D levels could also be due to a lack of sunlight — since, like many Americans, I spend most of my time indoors. Vitamin D isn't just for bones. It also supports immune function, mood and muscle strength — and a deficiency can lead to fatigue, depression and chronic illness. I also had low ferritin, the protein that stores iron. 7 Function Health offers regular lab testing for people to track their health over time. Function Health Low ferritin can zap your energy, weaken your immune system, and even trigger hair loss. Left untreated, it can contribute to heart issues and cognitive decline. Then came the omega-3s. My blood showed low levels of EPA, DHA and DPA — all key fatty acids critical for brain, heart, and cellular health. This kind of imbalance has been linked to everything from depression and anxiety to cardiovascular disease and dementia. Not-so-sweet news Beyond vitamin gaps, my insulin levels also raised a red flag. While still in the 'acceptable' range, they were above optimal — which Hyman explained is a sign my body is working harder than it should to keep my blood sugar stable. 'This is also common in people who are vegan or vegetarian because they tend to have a higher carbohydrate intake,' he said. Reduced insulin sensitivity — a k a insulin resistance — can make it harder to manage weight or build muscle. Left unchecked, it can lead to prediabetes or Type 2 diabetes. 7 To find your biological age, Function Health conducts two blood tests and collects a urine sample. angellodeco – The red flag hiding in my blood But one number made Hyman hit the brakes: my 'extremely high' homocysteine levels. The normal range is up to 10.4 micromoles per liter. Mine was 27.8. 'That's just way, way out of range,' Hyman told me. 'That's usually a consequence of a genetic variation called MTHFR.' The MTHFR gene helps the body process key B vitamins and break down homocysteine. If it's not functioning properly, homocysteine builds up — and that can cause problems. 7 Some nutrients are more readily available in animal products. Prostock-studio – Elevated levels have been linked to heart disease, stroke, cognitive decline, osteoporosis and even pregnancy complications. 'You've really got to take this seriously,' Hyman warned. 'But it's super simple to fix.' No meat, no problem — with a few tweaks Every single issue flagged in my Function test can be improved — no steak required. 'Usually, if you're vegan or vegetarian, you'll be fine for a few years and then your health starts to degrade,' Hyman said. 'You don't have to start eating meat, but you do have to be on lifelong supplements.' Function provided me with a full action plan. 7 Dr. Mark Hyman is a family physician and a leader in functional medicine. Dr. Mark Hyman Top 5 foods I need to eat more of: Pasture-raised eggs Adzuki beans Black beans Black-eyed peas Chickpeas Foods to avoid: Peanut oil Sunflower oil Corn oil Safflower oil Shortening Recommended supplements: Berberine Fiber Red yeast rice Vitamin D Iron bisglycinate + vitamin C Folate B6 and B12 7 Supplements can help fill nutritional gaps in your diet. Brett – Hyman also recommended genetic testing to confirm if I have the MTHFR mutation. 'It's really great that we found this because you could have had it for years and not find out until you're 50 or 60 when something goes wrong,' he said. Despite the 11 flagged biomarkers, I told Hyman I felt great. His reply? A reality check. 'You don't notice there's an elephant standing on your foot until it gets off,' Hyman said. 'All of this stuff is going to make a significant impact on your health — maybe in the short term, but definitely in the long term.' Function recommends members get their blood tested at least once a year to track shifts in their biomarkers. With the suggested changes, Hyman said my biological age will drop even further in the coming months. In the meantime, you'll find me in the supplement aisle.
Time of India
13-06-2025
- Health
- Time of India
Best NMN supplements to boost NAD levels and support longevity, according to experts
Longevity science is all the rage in 2025, with all kinds of complex technologies for how to stay young for longer and fight the negative effects of ageing, but some of the most effective tools to counteract ageing are naturally occurring compounds already found in the body that can be easily boosted through supplementation. The key to well-being lives inside the human body; it's just a matter of optimizing the existing systems to ensure their smooth function and our flourishing. Is it really that simple? One super supplement that has shown immense promise in the longevity sphere and which is quickly gaining support worldwide is Nicotinamide Mononucleotide, also known as NMN. NMN improves your cellular health and boosts the levels of NAD produced by the body, which creates a wide range of benefits to help users feel younger, healthier, have more energy, and optimise their body's natural rhythms. Here is everything you need to know about this powerful nucleotide and a list of the best NMN supplements to take to start feeling your best. NMN and NAD: A Quick Science Lesson NMN, or Nicotinamide Mononucleotide, is a naturally occurring molecule that boosts the body's levels of NAD, also known as Nicotinamide adenine dinucleotide. To put it plainly, NMN is a messenger molecule, encouraging NAD to work its special cellular magic. We can think of NAD as a fuel or a battery that helps the cells in the body recharge themselves and keep us functioning at our optimal capacities. In a certain way, NMN is a kind of encouraging manager, making sure that NAD does its best work in the cell to keep the body healthy, strong, and resilient. Like many functions in the body, however, NAD levels decline with age, which leads to a slew of age-related ailments and limitations, from energy issues to DNA damage to metabolic imbalance. Given the ways that NAD levels start to lag with age, scientists and experts have begun to look into ways to keep the body's cellular powerhouses going strong in a safe and natural way, through supplementation. Promising studies suggest that NMN and the ways that it stimulates NAD production processes are at the heart of optimizing longevity science and helping to keep age-related decline at bay. Taking NMN supplements shows special promise with keeping individuals fit, healthy, and feeling their best, and medical experts from Mark Hyman to David Sinclair are touting NMN benefits for general well-being, vitality, and longevity. Why NMN Supplements Are Better Than Taking NAD Directly While one might assume that the most direct route to increasing NAD levels in the body would be by taking NAD directly, the scientific reality is that NMN supplements offer a far more effective approach to achieving this goal while enhancing overall well-being and health. NMN is readily absorbed by the human body, which enhances its stability and enables the body's systems to regulate NAD levels with greater precision. Serving as a precursor for Nicotinamide adenine dinucleotide production, Nicotinamide Mononucleotide sets the stage for a more meaningful and beneficial metabolic process and cellular synthesis, while also mitigating the potential negative effects of elevated NAD levels. Opting for direct NAD intake would, in many respects, be akin to putting the cart before the horse. Utilising an NMN supplement provides the body with the opportunity to efficiently boost NAD levels through its natural metabolic pathways. How to Choose the Best NMN Supplement for Your Body's Needs There are a number of different considerations to take into account when choosing an NMN supplement. Safety and effectiveness is of the utmost importance in any kind of choice about what to take for your health, so finding a reputable brand with excellent quality and transparent manufacturing practices is essential. Third-party testing with reputable scientific sources and supplements that meet industry standards are excellent way to ensure that a given NMN supplement is going to be right for your needs. Additionally, doing research about a preferred method of supplementation, whether powders or capsules, and reading customer reviews, testimonials, and anecdotal reports, can be a good way to begin choosing a preferred NMN supplement. Our top NMN picks 1. Wonderfeel Youngr™ NMN Wonderfeel Youngr™ NMN Wonderfeel Youngr ™ NMN supplements are carefully crafted, clinically tested, and thoughtfully dosed to optimise NMN and NAD levels in the body, which is why it's the best NMN supplement on the market currently. For everything from reasonable pricing to safety to optimised dosage, this top NMN supplement takes first prize. At 900mg NMN, they achieve the perfect potency to have real, substantive effects on the human body and leave users feeling their best. What's more, they incorporate a blend of NMN and other beneficial and complementary ingredients that have been shown to have a real impact on longevity, from resveratrol, a polyphenol and antioxidant powerhouse that is found in grapes, and hydroxytyrosol, another polyphenol virtuoso that is naturally found in olive oil. Wonderfeel Youngr ™ NMN supplements take some of the most formidable natural longevity compounds and molecules and fit them into a daily dosage that will leave you feeling refreshed, energised, and indeed, younger. The Wonderfeel Youngr™ NMN formula was developed by Professor Andrew Salzman, a Harvard MD and innovator in longevity science, and has been endorsed by Dr. Mark Hyman. The science shows that taking a higher dosage of NMN (in the 600-900 mg range) correlates with an optimal level of NAD, which in turn leads to better mitochondrial functioning. Mitochondrial functioning is at the base of cellular health, overall well-being, and resisting the negative effects of ageing. Together with the specialists at Wonderfeel, Salzman has developed an NMN supplement that gives subscribers the ideal dosage in a simple and all-natural form. Additionally, they include supportive ingredients like resveratrol, ergothioneine, and hydroxytyrosol, powerful organic polyphenols and antioxidants that collaborate with NMN to create a powerful and effective longevity supplement. For the formula Dr. Salzman stated, 'Just to give NMN without protecting against oxidant stress would be only half the story. Our focus at Wonderfeel is on getting mitochondria back to full health. By giving antioxidants, we nurture, we potentiate the efficacy, we augment the effect of NMN.' The Wonderfeel supplements are free from GMOs, preservatives, soy, gluten, and dairy. By staying close to the science and working with natural, safe, and ethically sourced ingredients, Wonderfeel Youngr™ has established itself as the best NMN brand. Anecdotal benefits among Wonderfeel Youngr™ NMN subscribers abound, including reduced inflammation, improved energy, smoother and more restful sleep cycles, better cognitive function, and more. At $2.70 per 1g of NMN, Youngr™ is not only an optimal dosage and formula, but an exceptional value. With its excellent pricing and superior quality, Youngr™ is the top of our NMN supplement list. Buy NMN from Wonderfeel and become a subscriber 2. Wonderfeel NMN Capsuls™ Wonderfeel NMN Capsuls™ Another option for NMN supplementation from Wonderfeel is the Wonderfeel NMN Capsuls™. At the strongest dosage and potency, the Capsuls™ are an excellent choice if you are looking to see more noticeable results, faster, and in a purer form. This is the best pure NMN on the market, and it yields remarkable results. These have the same potential benefits of Wonderfeel Youngr ™ NMN, from physical improvements to improved memory and cognitive function, better sleep, and overall well-being, and more, but with greater purity and potency per capsule. At 500mg per capsule, Wonderfeel Capsuls™ NMN offer pure, optimally-dosed NMN for top-notch results. Wonderfeel Capsuls™ NMN maintain the same rigorous standards and high-quality as Wonderfeel Youngr™ NMN, undergoing third-party testing and full transparency around production. Just use a simple QR code to access the certifications of these supplements, and watch as your body aligns with its optimal patterns and abilities. With a subscription, Wonderfeel Capsuls™ NMN cost $52 a month for 60 capsules for high-quality, pure NMN. Make a worthy investment in your well-being The Reviews Are In: NMN Benefits So what are the specific NMN benefits? Science and research are ongoing and extremely auspicious, and research around NMN is a new frontier in the world of longevity science. As research continues to blossom and support personal reports, there are various scientific studies as well as individuals' experiences for anecdotal reference. Users of NMN supplements have reported a wide-ranging buffet of benefits. The fact that they are shared across age, experience, and demographics, coupled with its support from preliminary or ongoing scientific investigations, signifies a notably optimistic outlook for NMN in the world of longevity and wellness innovation. A selection of positive results attributed to taking NMN include: More Energy and Increased Vitality One of the most common benefits expressed among users of NMN supplements is an increase and improvement in energy and vitality. When you feed your cellular energy, your body's natural energy improves, reducing fatigue and elevating vital force in the body. Muscle Health and Athletic Performance One of the most pronounced and widely reported benefits of taking NMN is its ability to improve muscle health, muscle recovery, and physical performance in adults. Not only does it improve systems on the cellular level, but a recent study overseen by David Sinclair found that NAD-boosting molecules (read: NMN) helps to improve blood and nutrient supply to the muscles. Another study, in 2021, found that NMN renewed muscle strength and improved athletic performance (including grip strength, walking speed, and tests about moving from sitting to standing) in men over 65. Anecdotally, these outcomes have been shown in a wide range of individuals of all ages and experiences. NMN has huge potential to improve physical and athletic performance. Sharper Cognitive Function If you are getting a little lost in all this technical jargon, please don't beat yourself up. Your cognitive functioning for reading about the benefits of taking NMN might be improved by—you guessed it—taking NMN. Many researchers have found that NMN has an incredible potential to improve and preserve brain function due to its positive effect on neurovascular coupling, aka NVC. Scientists studying NMN, including Dr. David Sinclair, have found that the compound has a positive effect on maintaining memory and cognitive function. Weight Loss and Metabolism Stabilisation NMN is a naturally occurring key factor in metabolic function, so it stands to reason that NMN supplements can help optimise those metabolic processes. NMN can help to convert food into energy, manage fats and proteins, and stabilise blood sugar, which shows promise in weight management and broader metabolic health. Hair Growth As shown in a recent 2024 study, and in many reports by users, NMN can promote hair growth and the reversal of hair follicle atrophy and hair thinning. By lowering inflammatory factors that contribute to hair loss, NMN supplements can reverse hair loss and repopulate users' scalps with luscious, healthy locks. Skin Elasticity and Smoothness Sure, creams and moisturisers are a good start when it comes to skin health, but a lot of the issues that go into ageing skin happen on a level that's more than skin-deep. Being able to withstand UV rays and the general wear and tear of ageing, like wrinkles and fine lines, can come down to—you guessed it—cellular health. Studies suggest that the key to glowing skin could be found in the body's production of NAD, and anecdotal evidence from NMN users point to improvements in skin elasticity and skin smoothness as major noticeable effects. Heart Health An exciting study looked at NMN benefits in healthy middle-aged and older adults and found that it had a positive effect on their overall health, including on the health of their heart. This rigorous, randomised, double-blind, placebo-controlled, crossover trial found that NMN could have really beneficial effects on cardiovascular function and heart health, among other things. Doesn't that just warm your heart? Insulin Regulation Relevant to its ability to regulate and optimise metabolic function, NMN has been found to have a profound effect on helping the body manage blood sugar and reduce insulin resistance, a major problem associated with diabetes. NMN Supplements Common Questions and Considerations Now that we've looked at the incredible benefits of taking NMN supplements and how it has the potential to change your life for the better, here are some frequently asked questions about NMN that will help you understand more about how it all works. Side Effects and Safety Many people ask, what are the side effects of taking NMN supplements? As with any supplement, side effects are an important consideration to take and must be taken seriously. The good news with NMN supplements is that studies show that NMN intake is extremely well tolerated by the body, with few concerning side effects. A recent 8-week study conducted among healthy, middle-aged Japanese men found that not only does NMN show promise in improving sleep and metabolism, but also that it is well-tolerated by the body, with no concerning side effects. Higher doses, such as 1,200 mg or even up to 2,000 mg daily, have also been studied and are well-tolerated, according to research led by Professor David Sinclair of Harvard Medical School. Daily Dosage: How Much NMN Should You Take? As with any supplement, it's important to listen to your own body to determine the best dosage. Bodies process molecules and compounds in different ways and have different needs. The research points to the fact that 600mg to 1200 mg is a safe and effective starting point for NMN dosage, and esteemed doctor and longevity scientist David Sinclair recommends a daily 1000 mg dose to really reap the rewards of this wonder molecule. While it is important to do what feels right and trust your own biorhythms, experts like Sinclair and the scientists at companies like Wonderfeel suggest that a dosage lower than 400 mg is not as likely to have any perceptible effects on well-being. Furthermore, anything up to 2000 mg has been shown to be well-tolerated by the human body and can yield the best results. Harvard Doctor David Sinclair: NMN Advocate When we talk about taking an NMN supplement, listening to the experts is essential. Dr. David Sinclair, a well-respected aging researcher and Professor of Genetics at Harvard Medical School, has been a big advocate for NMN and a vocal participant in the ever-evolving discussion of its benefits. His entire career project is grounded in a holistic and substantive search for the most effective and safest frontiers in longevity science. Sinclair's research with mice has been instrumental in determining that increasing NAD levels in the body is the key to their living longer lives. His findings are miraculous and have helped in unlocking the science around a broader appreciation of the importance of NAD and the benefits of taking NMN. Furthermore, Dr. Sinclair has anecdotally shared that he himself takes a daily NMN dose of 1000 mg. When Should You Take NMN? The question of how much NMN to take is still evolving with the research. Again, everybody is different, so timing the dosage of the supplement is necessarily tied to an individual's experience and needs, with no codified timing constraints. Although consuming NMN in the morning may coincide with the body's natural NAD rhythm and potentially provide an energy boost, available research indicates that alternative timing options may also be viable. Research is still evolving and while one study proposes afternoon intake for enhanced energy levels and sleep quality among elderly users, some users and experts report that NMN works at various times throughout the day. It is important to consider individual factors when determining the most suitable timing for taking NMN. Experimenting with different times based on personal goals is advisable. Morning consumption of NMN may optimise energy levels throughout the day, whereas evening usage could facilitate deeper sleep. Does Taking NMN Everyday Improve Its Benefits? In brief: yes! NMN is not only considered safe for daily consumption; it can also improve users' experience of its many benefits. As research on NMN continues to evolve, staying informed about new findings and recommendations is essential for making informed decisions about its use. Much of the research shows real promise and potential for proving the lasting benefits of NMN supplementation with everyday use, and points to the fact that the real positive changes come from sustained and cumulative supplementation, rather than on-and-off use. Experts in the field suggest that everyday use is not only safe but advisable. Can Young People Take NMN? Again, research is evolving. NAD levels begin to decline after age thirty, and this may suggest that the effects of NMN are less felt or necessary for younger individuals who are already producing a healthy amount of NAD in their bodies. Ultimately, the decision for a young person to consider taking NMN comes down to their needs, as it depends on various factors such as their overall health status, specific health goals, and any existing medical conditions. There are anecdotal accounts of people younger than thirty benefiting from taking an NMN supplement. Additionally, staying informed about the latest research developments as it evolves in the field can offer exciting insights into the potential benefits and opportunities NMN supplementation may present for different age groups. Do You Need to Take NMN Along with TMG? There has been some concern that NMN supplements ought to be taken with Trimethylglycine, aka TMG. But does supplementing with NMN actually deplete the body's TMG levels? It's more complicated than a simple yes or no. TMG, or trimethylglycine, is a natural compound that's super important for our bodies. It helps with things like keeping our DNA healthy, supporting our liver, and giving us energy. The good news is, we can find TMG in lots of common foods we eat every day, like beets, quinoa, spinach, and seafood. Plus, our bodies are pretty good at keeping the right amount of TMG around to keep everything running smoothly. The question of whether you need to take extra TMG while taking an NMN supplement depends entirely on your body and your needs. It is certainly not necessary for everyone, but depending on your needs, whether you have methylation deficiencies, specific health considerations, or genetic variations, it may be the right choice for you. What is liposomal NMN? What about Sublingual? As research is ongoing and emergent, there is a great deal of discussion about the best way to take and metabolise NMN. Currently, there are three different methods of taking NMN supplements with different benefits and drawbacks: Capsules: The most popular and safest choice, easy to store, take, and use. The most popular and safest choice, easy to store, take, and use. Sublingual NMN: If you want to bypass the digestive system for faster results, taking NMN 'under the tongue' is another option, but research is still catching up, so it's unclear how effective this method is. If you want to bypass the digestive system for faster results, taking NMN 'under the tongue' is another option, but research is still catching up, so it's unclear how effective this method is. Liposomal NMN: This is a more sophisticated way to deliver NMN that, like sublingual supplementation, promises better absorption. However, also like sublingual NMN, research isn't quite there in proving its effectiveness. Given these options, it's our current belief and recommendation that NMN capsules are the best way to administer NMN and can yield the best results. Can You Boost NAD Through Diet and Behaviour? Because NMN is an organic, naturally occurring molecule that produces NAD in the human body, there are a number of ways that your body is already making this happen. This process can be improved through diet and behaviour. The science suggests that eating a balanced diet of whole foods with B vitamins and tryptophan has positive effects on NAD production. Particularly, food like avocados, leafy greens, and edamame are all excellent choices. Other habits like limiting one's alcohol consumption, regular exercise, intermittent fasting, and sun exposure, have all had positive effects on NAD levels. The science also suggests that NMN supplementation, in concert with these healthy habits, is the most efficient and effective way to harness some of these benefits. Companies like Wonderfeel have not only committed to producing safe, potent, and pure NMN, but also integrated their formulas with other natural ingredients shown to positively impact longevity. What's Better: NMN or NAD Directly? While it may follow that if what you're wanting to boost in the body is NAD, taking NAD supplements is actually less efficient, because it has a harder time penetrating cellular and metabolic structures. Taking NMN is definitely the more efficient and effective method for boosting NAD. What About NMN and Resveratrol? More technical language incoming! Resveratrol is a fascinating natural compound abundant in the skin of grapes, and renowned for its ability to stimulate sirtuins, crucial proteins vital for cellular health. When combined with NMN, these two supplements exhibit a synergistic effect. NMN elevates NAD levels, thus amplifying resveratrol's capacity to activate sirtuins, resulting in a potent cellular rejuvenation partnership. We highly recommend pairing your NMN with resveratrol, because together they form an unstoppable collaboration. This is another area in which Wonderfeel Youngr™ NMN formula stands out as the top NMN supplement, for its integration of resveratrol in its formula. When Will NMN Supplements Take Effect? This all depends on your body, your health goals, and a number of factors. While many users report positive effects rather quickly, the most profound and substantial effects occur cumulatively, over the long-term. We encourage users to keep a journal to track their progress and note any benefits and changes that occur, and share them, as the science continues to unfold. While we cannot speak for you or how your body will metabolise NMN, it is worth mentioning that regularly using NMN supplements has brought a wave of shared positive experiences to many users in just a few weeks. The best NMN supplements, as listed in this article, can make huge differences in how a person feels. People who supplement with NMN report feeling more energised and enjoying an overall improved sense of well-being soon after starting NMN. This quick boost makes sense, since increased NMN promises the ability to rapidly convert into NAD, which can supercharge cellular energy production. The real magic of NMN unfolds over time. While immediate effects are promising, the long-term benefits—like sharper cognitive function, a healthier heart, and a more youthful appearance—often come more slowly. Since these are complex, whole body systemic changes that are occurring, these effects do not simply arise out of nowhere. These transformations involve intricate biological processes that take time to fully manifest. Our advice would be to keep up the consistency, and remember, the best is yet to come. Is it time to try NMN and optimise your body's natural rhythm?
Fox News
12-06-2025
- Health
- Fox News
Medical experts warn 'Big Food' is fighting back against Ozempic with addictive items for sale
Ozempic and other weight-loss drugs may be cutting through "food noise," yet the junk food industry is only getting louder, some medical experts claim. "Ozempic is breaking the food addiction cycle – but Big Food isn't going down without a fight," Dr. Mark Hyman, an internationally recognized advocate for functional medicine, said in a recent Instagram post. "For decades, ultraprocessed foods have been engineered to hijack the brain's reward system – perfecting the 'bliss point' of sugar, salt and fat to keep people hooked," the physician also said. As Americans work to take hold of their health and wellness – and as the government cracks down on artificial food additives – the snack food industry appears to be evolving to outsmart both drugs and lifestyle changes, according to some observers. "Big Food isn't happy," Hyman continued, expressing his point of view. "Our food system is broken. It's built to create addictions, push ultraprocessed junk and profit off public health crises." Weight-loss and life coach Charles D'Angelo, based in St. Louis, Missouri, agreed with that assessment. "The food industry is one of many things evolving to outsmart our judgment sometimes," D'Angelo told Fox News Digital. "They are even outsmarting these medications and different health trends by engineering foods that bypass your hunger and can ultimately lead you to be more reactive than you otherwise would be." Fox News Digital reached out to Novo Nordisk, the manufacturer of Ozempic, for comment. Hyper-palatable foods (HPF) are designed with combinations of palatability-inducing ingredients, fat, sugar and carbohydrates that together enhance a food's deliciousness and produce an artificially rewarding eating experience, according to the National Institutes of Health (NIH). The Consumer Brands Association, based in Arlington, Virginia, represents the interests of the consumer-packaged goods (CPG) industry. "The makers of America's trusted household brands deliver safe products to consumers and innovate to provide them with healthier options," Sarah Gallo, senior vice president of product policy for the Consumer Brands Association, told Fox News Digital. "No industry is closer to the consumer than this one," she added. "For decades, food and beverage companies have taken their cues from consumers on what products they want in the marketplace to meet their dietary and health goals – whether it's options low in sugar, sodium and saturated fats, no artificial colors or low-carb, high-protein and high-fiber options." D'Angelo said that even without added ingredients, however, marketing campaigns often mislead consumers into purchasing and eating or drinking foods they think are healthful when they're not, D'Angelo said. "That's not nutrition. It's marketing." "They're not just selling junk food anymore," D'Angelo said. "How many things do you see when you go down the grocery store aisle that say high-protein or low-carb, but they're still ultraprocessed? And it's engineered to hook you. That's not nutrition. It's marketing." Gallo said her organization is aligned with the goal of radical transparency and aiding consumers in making informed choices. "The industry has been actively engaged in initiatives to improve nutritional information accessibility for over a decade," Gallo said. One initiative is Facts Up Front, a voluntary program that presents key nutritional information on the front of packaging, facilitating quick assessment by consumers. Additionally, the industry has introduced SmartLabel, allowing consumers to access detailed nutritional information via QR codes. For more Lifestyle articles, visit Gallo said the Consumer Brands Association "stands ready" to work with the federal government "to continue to ensure the analysis of safe ingredients and increase consumer transparency." She added, "It's also why we are working with Congress to ensure the [U.S. Food and Drug Administration] is properly resourced to carry out this important work and moving to mandatory notifications for new ingredients." "We need clarity, awareness and a complete shift in mindset to take back ownership of our choices." Still, D'Angelo said, misleading labels can give people a false sense of confidence in their personal choices. "I see how people are being conditioned subtly and repeatedly to trust marketing over their own inner signals, their own inner judgment," he said. "That's why we need more than just willpower or medications. We need clarity, awareness and a complete shift in mindset to take back ownership of our choices."
Business Wire
14-05-2025
- Health
- Business Wire
Renowned Health Experts Partner with SuppCo to Revolutionize the Supplements Industry
NEW YORK--(BUSINESS WIRE)-- SuppCo, the health tech startup transforming how people discover, manage, and optimize their supplement routines, today announced partnerships with leading health experts to reshape the supplements industry and provide actionable protocols that support better outcomes and well-being. The advisor partnerships will give SuppCo users access to the exact supplement regimens recommended and followed by leading experts in critical areas of preventive health, from longevity and brain health to gut and metabolic health, to fertility, detox, and more. The SuppCo Experts and their respective health categories are: Dr. Mark Hyman, Longevity and Cognition Expert Dr. Natalie Crawford, Women's Hormones and Fertility Expert Dr. Darshan Shah, Metabolic Health and Men's Hormones Expert Dr. Robin Berzin, Gut Health Expert Thomas DeLauer, Fitness Expert Dr. Bruce Hoffman, Detox Expert Dr. Lanae Mullane, Immune Support and Energy Expert 'Our goal in partnering with these preeminent experts is to help all individuals make sense of a complex and confusing supplement industry to hit their goals. We're confident that by having access to validated protocols from credible doctors and category experts, consumers will be better equipped to understand supplements and make informed decisions regarding safe and high-quality products,' Steve Martocci, co-founder of SuppCo. Studies show consumers are increasingly growing weary of the supplements industry, without trustworthy resources for high-quality and effective product guidance. SuppCo was created to help people navigate the world of supplements with its easy-to-use, comprehensive mobile app and digital platform. Now, for the first time, consumers have direct access to precise supplement routines purpose-built by trusted experts, bridging the gap between cutting-edge health expertise and actionable supplement recommendations, and ultimately providing greater trust and transparency within an extremely fragmented industry. 'The supplement industry presents a complex and often opaque landscape. Navigating the variability in nutrient guidance, product quality and ingredient transparency poses significant challenges for supplement users, and not everyone has access to advice from a functional medicine doctor,' said Dr. Mark Hyman, co-founder and Chief Medical Officer of Function Health and founder of the Cleveland Clinic Center for Functional Medicine. 'SuppCo is breaking this narrative - making it easier than ever for people to make informed supplement choices by accessing expert guidance, and I'm thrilled to join this incredible mission and journey.' The SuppCo Experts have curated data-backed supplement protocols in critical health categories, which include: Comprehensive nutrient targets with specific dosages Science-backed rationales for each nutrient recommendation Product suggestions validated by SuppCo's TrustScore quality rating system Integration with routing tracking and scheduling tools Warnings around potential risks of interactions and user contexts Lifestyle interventions to support protocol effectiveness 'I'm regularly asked by women what supplements they should be using, and taking incorrect or low-quality supplements is a common problem I see in my practice today. For years I've struggled knowing there had to be a better way to help these individuals make sense of their supplements,' said Dr. Natalie Crawford, board-certified OBGYN/REI, co-founder of Fora Fertility and host of the 'As a Woman' podcast. 'Today, such a tool exists, and my patients now have quick access to the evidence-backed protocols I've developed for fertility and hormonal issues, all based on the same principles I use in my practice – and all for free.' SuppCo's Experts have also made their own personal supplement stacks available to users via the app and have provided significant feedback in the development of the platform, including features like the TrustScore product quality rating system. To follow the Expert Protocols, view their personal stacks, and download the SuppCo app, visit SuppCo is a health tech startup transforming how people discover, manage, and optimize their supplement routines. Via its app and website, SuppCo provides a revolutionary platform to help users make sense of supplements, leveraging their personalized stack analysis tools and TrustScore quality rating system to help users hit their health goals. For more information, visit and follow SuppCo on Instagram and X.
