Latest news with #Microbiology
CBC
6 days ago
- Health
- CBC
New leader coming to Winnipeg's infectious disease lab
A new leader is coming to the National Microbiology Laboratory in Winnipeg, after its head stepped down just months after taking over leadership of the embattled laboratory that was previously at the centre of a security scandal involving a Chinese scientist. Microbiologist Jean Longtin will leave his position as vice-president of the laboratory on July 25, less than six months after taking on the role, and has accepted a position with Santé Québec that will begin in August, a spokesperson for Health Canada confirmed in an email Thursday. Health Canada also confirmed that Jason Kindrachuk, Canada Research Chair in the Molecular Pathogenesis of Emerging Viruses and an associate professor at the University of Manitoba Max Rady College of Medicine, will join the agency as the new vice-president of the lab beginning later this month. When Longtin took the reins of the federally run laboratory in January, he was tasked with implementing recommendations of the special committee on the Canada-China relationship. Those recommendations stemmed from concerns about Chinese espionage. In 2019, two Canadian researchers of Chinese origin, Xiangguo Qiu and her husband, Keding Cheng, were escorted out of the lab before later being fired. Declassified Canadian Security Intelligence Service documents tabled in the House of Commons in February 2024 said the couple provided confidential scientific information to China and posed a credible security threat to the country. The federal government said Longtin decided to take a role in Quebec to be closer to his family. Kindrachuk, who will begin his new role as head of the lab on July 28, has "significant experience in the areas of biochemistry and infectious diseases, and an extensive track record of scientific research," Health Canada said. His research has focused on the circulation, transmission and pathogenesis of emerging viruses that pose the greatest threat to global human and animal health, including Ebola viruses, coronaviruses and influenza viruses, the University of Manitoba website says. The lab in Winnipeg is a biosafety Level 4 infectious disease laboratory, the only one of its kind in Canada, and with maximum containment, scientists at the lab are able to work with pathogens including Ebola, Marburg virus and Lassa fever, the federal government says.
Business Wire
02-07-2025
- Business
- Business Wire
IntegraGen: Sales of €2.5 Million in the First Half of 2025 and Cash Position of €2.1 Million
EVRY, France--(BUSINESS WIRE)--Regulatory News: IntegraGen (FR0010908723 – ALINT – Eligible PEA PME), an OncoDNA company specializing in the genomics of cancer and rare genetic diseases, which performs interpretable genomic analyses for academic and private laboratories, announces today its unaudited sales for the first half of 2024. Sales for the first half came to €2,540K, down 34% compared with the first half of 2024 on a like-for-like basis (excluding revenues from the SeqOIA platform), contrary to expectations of weak growth, comparable to that of 2024, as announced by the Company in its press release dated April 29, 2025, on its results for the 2024 financial year. This decline is the result of reduced activity of over 40% on the Institut Pasteur's Mutualized Microbiology platform, linked to the drop in epidemiological sequencing, as well as to the decline in projects carried out on the Evry genomics platform, down by around 31%. This decline is the result of delays in the start-up of two major projects, the first samples of which were received by the company in May, as well as a general slowdown in research projects for academic and hospital customers. The company believes that the second half of the year, with the acceleration of major projects (notably UMBRELLA) and improved funding conditions for public research, should enable the situation to improve from the third quarter onwards. As of June 30 th, available cash, including the remainder on the loan granted to the parent company OncoDNA and repaid over the course of 2025, stood at €2.1m. The company used up €0.9m of cash in the first half of 2025, and at this rate may not have enough cash to ensure its financing for the next 12 months. In this context, the company is exploring all strategic options to improve its situation and expects to reduce cash consumption in the second half of the year through the reduction of operating costs, the launch of services for several existing customers, external sources of financing, a resumption of customer research projects, as well as the expected upturn in customers' research budgets. Given the high level of uncertainty surrounding public research funding, the Company is not maintaining its revenue growth forecasts for 2025. Bernard Courtieu, Chief Executive Officer of IntegraGen, comments: "The first half of the year has been extremely difficult, with both a sharp drop in academic and hospital research projects, linked to a reduction in public research financing, as well as a reduction in the budgets of several biotech companies in a sector affected by the general economic climate. Despite several successes such as the UMBRELLA project, whose operational launch was announced last month, IntegraGen needs to find new sources of funding to be able to ensure the continuity of its operations." Investors are invited to carefully read section 4.2 of the 2024 Management Report on 'Principal risks and uncertainties facing the Company'. Financial results for the first half of 2025 will be published in October. ABOUT INTEGRAGEN IntegraGen is an OncoDNA group company specializing in the genomics of cancer and rare genetic diseases. Backed by highly competent and qualified teams, IntegraGen is a leading player in DNA sequencing services and genomic data interpretation software. The company runs one of the largest NGS labs in France and operates for research institutes of excellence. As part of OncoDNA group, IntegraGen leverages the power of next generation sequencing with the mission of delivering the promise of precision medicine to patients. IntegraGen has about 40 employees and generated €8.5 million of turnover in 2024. Based in France, IntegraGen is part of the Belgian OncoDNA group present in Spain, UK, Germany and works with an international network of 35 distributors. The Group also provides biomarker testing and clinical interpretation tools to guide treatment and monitoring of late stage solid tumors and accelerate the development of new cancer drugs. IntegraGen is listed on Euronext Growth in Paris (ISIN: FR0010908723 – Mnemo: ALINT – Eligible PEA- PME).
The Sun
30-05-2025
- Health
- The Sun
New threat to plummeting male fertility rates identified as common but ‘silent' parasite that ‘DECAPITATES sperm'
FERTILITY rates appear to have been declining in both men and women globally - and now scientists have found a common single-celled parasite may be a contributor. Male fertility rates in particular have been plummeting over the past half-century, with an analysis from 1992 showing a steady decrease in sperm counts and quality since the 1940s. 3 3 And a more recent study found male infertility rates increased nearly 80 per cent from 1990 to 2019. Declining fertility rates have been attributed to a combination of factors, including rising costs associated with raising children. But now accumulating evidence suggests parasitic infections could also be a threat. A study published in April this year showed for the first time "human sperm lose their heads upon direct contact" with a parasite called Toxoplasma gondii. Toxoplasma gondii causes toxoplasmosis - an often harmless infection but can cause serious problems in individuals with weakened immune systems, pregnant women, and newborns. The parasite is found in the faeces of infected cats and in undercooked meat. Writing for The Conversation, Bill Sullivan, Professor of Microbiology and Immunology, Indiana University, said how the "new study bolsters emerging findings that underscore the importance of preventing this parasitic infection". Foodbourne transmission and animal to human transmission are the top ways people can get toxoplasmosis. Eating raw or undercooked meat, particularly lamb, pork, and venison, is a primary source of infection. And eating unwashed fruits and vegetables that have been contaminated with cat faeces or soil can also lead to infection. Major health advice for couples as HSE offers new resources for anyone struggling with fertility Ingesting the parasite through contact with cat faeces (poop) or soil contaminated with cat faeces is a common way to get toxoplasmosis. Cleaning cat litter boxes without proper hygiene can also expose people to the parasite. While toxoplasmosis is generally harmless for most people with healthy immune systems, often causing no symptoms or mild, flu-like symptoms that resolve on their own, Sullivan said toxoplasma remains in the body for life as dormant cysts in brain, heart and muscle tissue. And these cysts can reactive and cause additional episode of severe illness that damage critical organ system. He explains: "Between 30 per cent and 50 per cent of the world's population is permanently infected with toxoplasma due to the many ways the parasite can spread. "Upon infection, toxoplasma spreads to virtually every organ and skeletal muscle. Evidence that toxoplasma can also target human male reproductive organs first surfaced during the height of the AIDS pandemic in the 1980s, when some patients presented with the parasitic infection in their testes. 3 "While immunocompromised patients are most at risk for testicular toxoplasmosis, it can also occur in otherwise healthy individuals. "Imaging studies of infected mice confirm that toxoplasma parasites quickly travel to the testes in addition to the brain and eyes within days of infection." Evidence in past studies suggesting toxoplasma can reside in male reproductive organs has prompted analysis of fertility in infected men. In the April 2025 study, researchyers from Germany, Uraguay and Chile observed that toxoplasma can reach the testes and epididymis - the tube where sperm mature and are stored - two days after infection in mice. Looking at what happens when the parasite comes into direct contact with human sperm in a test tube, they observed that after only five minutes, 22.4 per cent of sperm cells were beheaded. The number of decapitated sperm also increased the longer they interacted with the parasites. Sperm cells that maintained their head were often twisted and misshapen, and sperm cells had hole sin their head, suggesting the parasites were trying to invade them as it would any other type of cell. Sullivan added: "The evidence that toxoplasma can infiltrate male reproductive organs in animals is compelling, but whether this produces health issues in people remains unclear. "Testicular toxoplasmosis shows that parasites can invade human testes, but symptomatic disease is very rare. "Studies to date that show defects in the sperm of infected men are too small to draw firm conclusions at this time. "Additionally, some reports suggest that rates of toxoplasmosis in high-income countries have not been increasing over the past few decades while male infertility was rising, so it's likely to only be one part of the puzzle." Could you have toxoplasmosis? Toxoplasmosis is a common infection that you can catch from the poo of infected cats, or infected meat. It's usually harmless but can cause serious problems in some people. Most people who become infected with the toxoplasma gondii parasite don't show any signs of infection. The parasite can reside in the body for life without causing issues. However, if you do have symptoms, they can be mild and flu-like, such as fever, swollen lymph nodes, and muscle aches. According to the NHS, some people may have more serious symptoms including: confusion blurred vision slurred speech unsteady walking Your GP may do blood tests to see if you've been infected with toxoplasmosis. They can also prescribe medicines to treat the infection if necessary. Most people who get toxoplasmosis get better without treatment. However, you'll usually be given medicines, including antibiotics, if you: are pregnant have a weakened immune system, for example, you're taking immunosuppressant medicines or you have HIV have symptoms affecting your eyes To avoid toxoplasmosis: wear gloves while gardening, and wash your hands thoroughly afterwards wash your hands before preparing food and eating wash hands, knives and chopping boards thoroughly after preparing raw meat wash fruit and vegetables thoroughly to get rid of any traces of soil thoroughly cook meat, especially lamb, pork and venison avoid cat poo in cat litter and soil if you can, wearing gloves if you need to empty cat litter trays and washing your hands afterwards Don't: eat raw or undercooked meat, or cured meats like salami or parma ham have unpasteurised goats' milk or any products made from it touch pregnant sheep or lambs do not feed cats raw or undercooked meat
Yahoo
12-05-2025
- Health
- Yahoo
Researcher issues warning about unexpected health risk lurking in coastal waters: 'Prevention is always better than cure'
It's the last thing anyone wants to think about when they're swimming in the ocean, but the contamination of raw sewage in sea waters is becoming what one researcher has called "an increasingly critical issue for public health." A February publication in the journal Microbiology, authored by Jonathan Cox of Aston University, provided an overview of the types and degrees of coastal water contamination from sewage, with a focus on the United Kingdom. Cox explained that several types of pathogenic bacteria are commonly found in such sources. These bacteria — including multiple strains of Vibrio, Chlamydia, E. Coli, Streptococci, and more — pose a "significant" risk to human health and the environment. Ingestion and inhalation of sewage-contaminated water have led to outbreaks of gastroenteritis and bacterial pneumonia. Exposure can also cause skin infections, ear and eye infections, and tonsillitis. As is the case with most public health threats, at-risk populations — much older, much younger, immunocompromised, and pregnant people — can be especially susceptible to serious illness. Aside from these human health concerns, the pathogens can endanger the balance and safety of entire coastal ecosystems. For example, the presence of sewage can cause algal blooms, which in turn can choke out resources like light and oxygen from reaching beneficial native plants and animals. And because shellfish serve as filter feeders — eating up organic matter or smaller organisms found in water — the bacteria can often accumulate within them. In fact, some people have developed severe food poisoning from affected shellfish. In grave cases, food poisoning can be fatal, but there are additional risks. The more this bacteria re-circulates in the food chain and food supply, and the more people are treated for the illness it causes, Cox warns, the more antimicrobial resistance may build, bringing weighty consequences. The World Health Organization estimated that bacterial antimicrobial resistance "was directly responsible for 1.27 million global deaths in 2019." Diarrheal disease, like gastroenteritis, is also a leading cause of mortality in children globally, driven largely by contaminated water and disproportionately impacting low- and middle-income countries. There, access to clean drinking water is often already compromised due to lack of infrastructure, ongoing conflict, drought, and more. Cox explains in the paper that while monitoring efforts and strict discharge standards are in place for sewage treatment plants, they may not be enough. "Storm overflows were intended to release surplus sewage into the sea on rare occasions," he writes, "but despite this intention, some water companies are responsible for up to 200 discharges of raw untreated sewage into our coastal waters each year." How often do you worry about the quality of your drinking water? Never Sometimes Often Always Click your choice to see results and speak your mind. Further, "during heavy rainfall events, water companies will continue to discharge untreated sewage into the sea," potentially almost as a matter of course when systems are overwhelmed. In a world where heat-trapping pollution sends global temperatures higher and higher, exacerbating extreme weather events like rainstorms and floods, contamination risks for coastal waters seem likely to increase. Many coastal communities are already geographically and infrastructurally vulnerable to storm surges and floods as sea levels rise, so they may face compounding problems. Researchers are developing new water treatment technologies, such as ultraviolet disinfection and phage applications, but many of these are currently too expensive to implement at scale. Sewage contamination isn't exactly the flashiest cause to root for — making some noise about it could improve investment in R&D so that one day these innovations might work where they're needed most. In the meantime, if you're swimming, surfing, paddling, or otherwise recreating in public waters, it's best to be cautious. According to the Centers for Disease Control and Prevention, you'll want to do your research, observe the actual water quality on site, never drink unclean water, avoid swimming if you're sick or have an open wound, and make sure to shower before and after your swim. "Whilst we're waiting for the improved management, innovation and investment that is required to solve the issue and save our seaside, don't bury your head in the sand regarding water quality," warns Cox. "Check before you swim. Afterall, prevention is always better than cure." Join our free newsletter for good news and useful tips, and don't miss this cool list of easy ways to help yourself while helping the planet.
