Latest news with #NIHSS
Business Wire
16-07-2025
- Health
- Business Wire
Imperative Care Presents Positive Imperative Trial Data from Patients Treated with Aspiration Thrombectomy for M2 Occlusions Using the Zoom System
CAMPBELL, Calif.--(BUSINESS WIRE)-- Imperative Care, Inc. today announced a late-breaking abstract with data from the Imperative Trial evaluating aspiration with the Zoom System in stroke patients with M2 occlusions, presented at the Society of NeuroInterventional Surgery (SNIS) 2025 22nd Annual Meeting in Nashville, Tenn. 'The Imperative Trial demonstrated excellent reperfusion and safety results in patients with M2 vessel occlusions treated with the Zoom System,' said Ariel Sutton, General Manager of Imperative Care Stroke. 'Engineered as a complete solution, the Zoom Stroke System helps physicians perform their procedures swiftly, efficiently, and with confidence. We have amassed a robust portfolio of clinical data on Zoom and its benefits, and look forward to further advancing research by funding the first randomized study of aspiration thrombectomy in M2 occlusions.' Clinical data from a sub-analysis of patients with M2 occlusions enrolled in the Imperative Trial (n=65) were presented by Justin Mascitelli, M.D., UT Health San Antonio. The sub-analysis reported a median age of 69, with a median presenting NIHSS score of 13. The results demonstrated: An 88% core-lab adjudicated rate of final mTICI≥2b reperfusion. Excellent clinical outcomes at 90 days, with a 56% mRS score of 0-1, and a 62% mRS score of 0-2. A symptomatic intracranial hemorrhage (sICH) rate of 1.5% (1/65), an all-cause mortality rate of 4.6% (3/65), and an all-intracranial hemorrhage (ICH) rate of 18.5% (12/65). 'These data suggest that excellent safety and clinical outcomes can be achieved with aspiration thrombectomy in patients with M2 occlusions,' said Dr. Justin Mascitelli, UT Health San Antonio. 'The clinical community has important questions around the impact of treating MeVO and DMVO patients given the ESCAPE-MeVO and DISTAL trial data evaluating stent retriever and the best medical-based treatments. It's critical that this topic be further explored with evidence-generating studies on aspiration specifically, which I believe will undoubtedly move the field – and most importantly patient outcomes – forward.' Imperative Care will fund an investigator-initiated, randomized clinical trial comparing continuous dual aspiration thrombectomy with the Zoom Stroke System plus best medical treatment versus best medical treatment alone for M2 vessel occlusions in stroke patients. This will be the first trial to look at an aspiration approach specifically for M2 occlusions with the goal of evaluating the potential impact of aspiration thrombectomy on these patients. About the Zoom Products The Zoom System is designed to be a complete stroke system from access through reperfusion for fast and effective clot removal in patients presenting with acute ischemic stroke. Imperative Care's Zoom System consists of the Zoom 35, 45, 55, 71 Catheters, Zoom 88 Large Distal Platform, Zoom 88 Support, Zoom POD and Zoom Aspiration/Zoom POD tubing, Zoom Canister and DuoPort Canister. All Zoom Catheters are designed with an asymmetric TRX™ Tip, which provides 15% greater clot engagement area at the tip of the catheter 1 and are constructed to enable smooth tracking through challenging vasculature. For complete product information, including indications, contraindications, warnings, precautions and adverse events, visit: About Imperative Care, Inc. Imperative Care is a commercial-stage medical technology company researching, developing and manufacturing connected innovations to elevate care for people affected by devastating vascular diseases such as stroke and pulmonary embolism. The company is focused on addressing specific gaps in treatment and care to make an impact across the entire patient journey. Imperative Care is based in Campbell, Calif. 1. Vargas J, Blalock J, Venkatraman A, et al. Efficacy of beveled tip aspiration catheter in mechanical thrombectomy for acute ischemic stroke. Journal of NeuroInterventional Surgery 2021;13:823-826. Dr. Justin Mascitelli is a paid consultant for Imperative Care.
Medscape
18-06-2025
- Health
- Medscape
Head Position Matters in Stroke Care Before Thrombectomy
A flat 0° head positioning before thrombectomy was associated with a significantly less risk for early neurologic deterioration and all-cause mortality than a conventional 30° head elevation in adults with large vessel occlusion (LVO) stroke, a new study showed. METHODOLOGY: Researchers conducted the prospective, multicenter ZODIAC trial from 2018 to 2023 with 92 patients (mean age, 67 years; 52% men). All had LVO stroke confirmed on CT angiography and a viable penumbra and were eligible for thrombectomy within 24 hours of stroke. Participants were randomly assigned to receive either 0° (n = 45) or 30° (n = 47) head-of-bed positioning before thrombectomy. National Institutes of Health Stroke Scale (NIHSS) scores were assessed every 10 minutes until thrombectomy began. The primary endpoint was early neurologic deterioration, defined as a worsening of ≥ 2 NIHSS points before thrombectomy. Additional outcomes were severe neurologic deterioration (worsening of ≥ 4 NIHSS points) before thrombectomy, hospital-acquired pneumonia, and all-cause death within 3 months. TAKEAWAY: Early neurologic deterioration was more common in the 30° group than in the 0° group (55% vs 2%; hazard ratio [HR], 34.4; P < .001), as was severe neurologic deterioration (n = 20 vs n = 1; HR, 23.6; P = .002). < .001), as was severe neurologic deterioration (n = 20 vs n = 1; HR, 23.6; = .002). The all-cause mortality rate at 90 days was significantly lower in the 0° group than in the 30° group (4% vs 22%; P = .03). = .03). A greater proportion of patients in the 0° group than in the 30° group showed neurologic improvement at 24 hours post-thrombectomy (87% vs 60%; odds ratio, 0.2; P = .01). = .01). No participant in either group developed hospital-acquired pneumonia. IN PRACTICE: 'Results suggest that patients awaiting thrombectomy treatment for LVO stroke should be positioned with the head at 0° to ensure clinical stability and prevent worsening,' the investigators wrote. 'We posit that 0° head positioning is a bridging maneuver to thrombectomy, protecting ischemic tissue and possibly reducing infarct progression before definitive treatment,' they added. SOURCE: This study was led by Anne W. Alexandrov, PhD, University of Tennessee Health Science Center, Memphis, Tennessee. It was published online on June 04 in JAMA Neurology . LIMITATIONS: This study was limited by its small sample size and early termination, the lack of blinding to head position, and the exclusion of data on thrombectomy decisions. Additionally, patients transferred between facilities were excluded, which may have affected the 3-month outcomes. DISCLOSURES: Funding was provided by the NIH. Several investigators reported receiving a grant or per-patient payment from NIH during the study. One also reported being a paid co-investigator on the NIH grant for imaging core lab services. Full details are listed in the original article.
Zawya
09-05-2025
- Health
- Zawya
National Institute of Health and Social Studies (NIHSS) Honours 86 Graduates at Prestigious Healthcare Ceremony
The National Institute of Health and Social Studies (NIHSS) celebrated the graduation of 86 newly qualified healthcare professionals this morning during a formal ceremony held at the International Conference Centre Seychelles (ICCS). Presided over by His Excellency President Wavel Ramkalawan and First Lady Mrs. Linda Ramkalawan, the event was graced by several high-ranking officials, including the Speaker of National Assembly Mr. Roger Mancienne, Minister for Health, Mrs. Peggy Vidot; Minister for Education, Dr. Justin Valentin; Minister for Employment and Social Affairs, Mrs. Patricia Francourt; and Minister for Youth, Sports and Family, Mrs. Marie Celine Zialor The graduates, drawn from seven disciplines,Biomedical Laboratory Sciences, Emergency Medical Care, Environmental Health Sciences, Nursing, Occupational Therapy, Physiotherapy, and Health Care Assistance, represent the next generation of Seychelles' healthcare workforce. A highlight of the morning was the presentation of special awards recognising academic distinction, leadership, and clinical excellence. Mr. Jean Luc Rose, a graduate of the Diploma in Emergency Medical Care programme, was named Outstanding Graduate, earning the coveted President's Cup, along with a laptop and a government-sponsored scholarship. Mr. Rose was commended for his academic performance, leadership, and commitment to student life. Further accolades included the Overall Best Academic Award, presented to Ms. Solana Marie from the Diploma in Environmental Health Sciences programme, and the Ministry of Health's Overall Best in Practice Award, received by Ms. Ramlah Heneka from the Biomedical Laboratory Science cohort. Delivering the welcome address, NIHSS Director Mr. Ebrahim Ali described the occasion as 'a significant milestone not only for our students but for the future of healthcare in our country." He reiterated the Institute's core values—accountability, integrity, pursuit of excellence, respect, empowerment, scientific rigour, engagement, and teamwork—as guiding principles in building a resilient and responsive health system. "The transition from academic life to the workplace brings about real challenges but also presents great opportunities to be creative and apply innovative practices," Mr. Ali said, urging graduates to serve with compassion and commitment. The ceremony was punctuated by musical interludes from the NIHSS Choir, an inspiring speech from a former graduate, and a vote of thanks delivered by Ms. Ramlah Heneka. The event concluded with a commemorative group photograph capturing the graduates alongside dignitaries and faculty members. Distributed by APO Group on behalf of State House Seychelles.
