Latest news with #NULISAseq™CNSDiseasePanel120
Korea Herald
5 hours ago
- Health
- Korea Herald
Alamar Biosciences and the German Center for Neurodegenerative Diseases (DZNE) partner for Landmark Proteomic Profiling study in the Rhineland Study Cohort
NULISAseq™ CNS Disease Panel 120 and Inflammation Panel 250 to Power Biomarker Discovery in 23,000 Longitudinal Samples FREMONT, Calif., July 29, 2025 /PRNewswire/ -- Alamar Biosciences, a company powering precision proteomics to enable the earliest detection of disease, today announced a strategic collaboration with the German Center for Neurodegenerative Diseases (DZNE) to deploy its ultra-sensitive NULISAseq™ CNS Disease Panel 120 and Inflammation Panel 250 in the Rhineland Study—one of the world's most comprehensive and innovative longitudinal aging cohorts, as well as in some of the DZNE's clinical disease specific cohorts. This initiative will profile 23,000 plasma samples to accelerate biomarker discovery and advance understanding of healthy aging and neurodegeneration. "Understanding aging and dementia requires both advanced technology and deeply characterized cohorts," said Prof. Monique Breteler, Director of Population Health Sciences at DZNE and Principal Investigator of the Rhineland Study. "Integrating Alamar's multiplex panels into our research opens new opportunities to decode the molecular signatures of brain aging." The DZNE Rhineland Study is an ongoing, large-scale population-based cohort designed to investigate determinants of healthy aging and the development of neurodegenerative diseases across the lifespan. By utilizing Alamar's NULISAseq CNS Disease Panel 120, researchers will be able to measure hundreds of brain-related proteins from minimal blood volumes, with exceptional sensitivity and specificity. Notably, the CNS panel's ability to distinguish brain-derived phosphorylated tau from total phosphorylated tau in plasma represents a transformative advance for early detection and risk stratification of neurodegenerative conditions such as Alzheimer's disease. In addition, the NULISAseq Inflammation Panel 250 provides the most comprehensive and sensitive profiling of immune-related proteins implicated in aging and neuroinflammation associated with neurodegenerative diseases. The resulting proteomic data will be combined with the study's extensive clinical, demographic, and imaging datasets, enabling researchers to track protein changes over time, identify early biomarkers, and support the development of precision diagnostics and targeted therapies. "This partnership marks a major step forward in aging and dementia research," said Yuling Luo, PhD, Founder, Chairman and CEO of Alamar Biosciences. "With NULISA's unmatched sensitivity and the depth of the DZNE Rhineland Study, we can uncover novel protein biomarkers that reveal the trajectories of cognitive health and disease progression in aging populations." This collaboration reflects a shared commitment to scientific rigor, inclusivity, and innovation in neurodegenerative disease research. By capturing diverse aging trajectories in a deeply characterized population, Alamar and DZNE aim to drive earlier diagnosis, improved prognosis, and new therapeutic pathways for age-related brain disorders. About the DZNE Rhineland Study The DZNE (German Center for Neurodegenerative Diseases) Rhineland Study is an ambitious, population-based cohort following thousands of individuals across decades to uncover determinants of healthy aging and neurodegeneration. Detailed clinical, imaging, genetic, and lifestyle data are collected and harmonized to enable deep insights into the aging brain. Learn more about the DZNE at and about the DZNE Rhineland Study at About Alamar Biosciences, Inc. Alamar Biosciences is a privately held life sciences company with a mission to power precision proteomics to enable the earliest detection of disease. The company's proprietary NULISA Platform along with the ARGO HT System work seamlessly with the latest advances in genomics to achieve single digit attomolar detection sensitivity, greatly surpassing the most sensitive protein detection technology on the market today. For more information, please visit
Cision Canada
5 hours ago
- Health
- Cision Canada
Alamar Biosciences and the German Center for Neurodegenerative Diseases (DZNE) partner for Landmark Proteomic Profiling study in the Rhineland Study Cohort
NULISAseq™ CNS Disease Panel 120 and Inflammation Panel 250 to Power Biomarker Discovery in 23,000 Longitudinal Samples FREMONT, Calif., July 29, 2025 /CNW/ -- Alamar Biosciences, a company powering precision proteomics to enable the earliest detection of disease, today announced a strategic collaboration with the German Center for Neurodegenerative Diseases (DZNE) to deploy its ultra-sensitive NULISAseq™ CNS Disease Panel 120 and Inflammation Panel 250 in the Rhineland Study—one of the world's most comprehensive and innovative longitudinal aging cohorts, as well as in some of the DZNE's clinical disease specific cohorts. This initiative will profile 23,000 plasma samples to accelerate biomarker discovery and advance understanding of healthy aging and neurodegeneration. "Understanding aging and dementia requires both advanced technology and deeply characterized cohorts," said Prof. Monique Breteler, Director of Population Health Sciences at DZNE and Principal Investigator of the Rhineland Study. "Integrating Alamar's multiplex panels into our research opens new opportunities to decode the molecular signatures of brain aging." The DZNE Rhineland Study is an ongoing, large-scale population-based cohort designed to investigate determinants of healthy aging and the development of neurodegenerative diseases across the lifespan. By utilizing Alamar's NULISAseq CNS Disease Panel 120, researchers will be able to measure hundreds of brain-related proteins from minimal blood volumes, with exceptional sensitivity and specificity. Notably, the CNS panel's ability to distinguish brain-derived phosphorylated tau from total phosphorylated tau in plasma represents a transformative advance for early detection and risk stratification of neurodegenerative conditions such as Alzheimer's disease. In addition, the NULISAseq Inflammation Panel 250 provides the most comprehensive and sensitive profiling of immune-related proteins implicated in aging and neuroinflammation associated with neurodegenerative diseases. The resulting proteomic data will be combined with the study's extensive clinical, demographic, and imaging datasets, enabling researchers to track protein changes over time, identify early biomarkers, and support the development of precision diagnostics and targeted therapies. "This partnership marks a major step forward in aging and dementia research," said Yuling Luo, PhD, Founder, Chairman and CEO of Alamar Biosciences. "With NULISA's unmatched sensitivity and the depth of the DZNE Rhineland Study, we can uncover novel protein biomarkers that reveal the trajectories of cognitive health and disease progression in aging populations." This collaboration reflects a shared commitment to scientific rigor, inclusivity, and innovation in neurodegenerative disease research. By capturing diverse aging trajectories in a deeply characterized population, Alamar and DZNE aim to drive earlier diagnosis, improved prognosis, and new therapeutic pathways for age-related brain disorders. About the DZNE Rhineland Study The DZNE (German Center for Neurodegenerative Diseases) Rhineland Study is an ambitious, population-based cohort following thousands of individuals across decades to uncover determinants of healthy aging and neurodegeneration. Detailed clinical, imaging, genetic, and lifestyle data are collected and harmonized to enable deep insights into the aging brain. Learn more about the DZNE at and about the DZNE Rhineland Study at About Alamar Biosciences, Inc. Alamar Biosciences is a privately held life sciences company with a mission to power precision proteomics to enable the earliest detection of disease. The company's proprietary NULISA Platform along with the ARGO HT System work seamlessly with the latest advances in genomics to achieve single digit attomolar detection sensitivity, greatly surpassing the most sensitive protein detection technology on the market today. For more information, please visit
Cision Canada
a day ago
- Health
- Cision Canada
Alamar Biosciences Showcases Pioneering Brain-Derived pTau Data at the Alzheimer's Association International Conference (AAIC)
Groundbreaking Insights into Neurodegenerative Disease Biomarkers to be Unveiled through 30+ Posters and Presentations at International Meeting FREMONT, Calif., July 28, 2025 /CNW/ -- Alamar Biosciences, a company pioneering precision proteomics to drive the earliest detection of disease, today announced the presentation of NULISA™ data in over 30 scientific sessions and poster presentations at the AAIC conference held July 27-31 in Toronto, Canada. The NULISA platform is poised to redefine the landscape of biomarker detection, offering unprecedented sensitivity, specificity and multiplex detection for neurodegenerative disease diagnosis and monitoring. This year's AAIC marks the first public presentation of robust clinical data generated using NULISA to measure brain-derived pTaus alongside over 120 key CNS disease-related proteins, an achievement that could accelerate both early detection and therapeutic monitoring in Alzheimer's and related neurodegenerative conditions. "The presentation of brain-derived pTau data at AAIC is a testament to the power of the NULISA sensitivity and specificity and our team's dedication to advancing biomarker development for neurodegenerative diseases," said Yuling Luo, PhD, Founder, Chairman and CEO of Alamar Biosciences. These data will be presented during Alamar's product theater on Monday, July 28, 1:20 PM ET, featuring Prof. Jonathan Schott from University College London and the UK DRI, and Dr. Cheryl Wellington from the University of British Columbia. Highlights include: Brain-Derived pTau Performance: The presentation will showcase data from the 1946 Birth Cohort featuring the new brain-derived pTau isoforms using the NULISAseq™ CNS Disease Panel 120 in both presymptomatic and post-AD diagnosis samples, highlighting the superior ability of brain-derived pTaus to predict Alzheimer's disease years before it was diagnosed Correlations with Disease Progression: Data will demonstrate the correlation between brain-derived pTau levels and amyloid and Tau PET imaging Biomarkers for neuropathologies and AD co-pathologies: Analysis of a unique cohort of patients with autopsy-confirmed pathologies with the NULISAseq™ CNS Disease Panel 120 identified biomarkers for detecting neuropathologies and AD co-pathologies. Preclinical research: The NULISAseq™ Mouse Panel 120 demonstrated utility in analysis of plasma and brain homogenate samples from multiple clinical models of AD. The Alzheimer's Association International Conference (AAIC) is the world's premier forum for the scientific community focused on dementia and Alzheimer's research. Every year, the conference gathers leading experts, scientists, clinicians, and stakeholders to share the latest discoveries, foster collaborations, and accelerate the quest for effective diagnostics and therapies. See here for a full list of posters and presentations featuring NULISA data during the AAIC meeting. About Alamar Biosciences, Inc. Alamar Biosciences is a privately held life sciences company with a mission to power precision proteomics to enable the earliest detection of disease. The company's proprietary NULISA Platform along with the ARGO HT System work seamlessly with the latest advances in genomics to achieve single digit attomolar detection sensitivity, greatly surpassing the most sensitive protein detection technology on the market today. For more information, please visit
Korea Herald
15-05-2025
- Health
- Korea Herald
Alamar Biosciences Expands NULISAseq™ CNS Disease Panel 120 with Groundbreaking Blood-Based Brain-Derived pTau Assays
First-of-its-kind panel includes brain-derived pTau217, pTau181, pTau231, and total tau assays to advance neurodegenerative disease research FREMONT, Calif., May 15, 2025 /PRNewswire/ -- Alamar Biosciences, a company powering precision proteomics to enable the earliest detection of disease, today announced the expansion of its NULISAseq™ CNS Disease Panel 120 to include novel assays for brain-derived phosphorylated tau (pTau) proteins. The enhanced panel now features brain-derived pTau217, pTau181, pTau231, and total tau (tTau) protein measured directly from blood samples—delivering unprecedented sensitivity and specificity for the study of neurodegenerative diseases. Phosphorylated tau has emerged as a critical biomarker for early detection and monitoring of Alzheimer's disease and other tauopathies. The new additions to the CNS Disease 120 Panel are specifically designed to detect brain-derived forms of pTau, overcoming the limitations of current assays that cannot distinguish between peripheral and central tau species. This allows for the simultaneous measurement of two suites of multiple pTaus and tTau species, one specific for brain-derived and one combining brain- and peripheral tissue-derived Tau species. "Researchers have long sought a reliable, blood-based solution to track brain-derived tau pathology," said Dr. Yuling Luo, CEO, Founder and Chairman of Alamar Biosciences. "By integrating assays for pTau217, pTau181, pTau231, and total tau into our NULISAseq CNS Disease 120 Panel, we are enabling scientists to explore the full spectrum of tau pathology with exceptional sensitivity and throughput. This advancement is poised to accelerate biomarker-driven research and drug development in Alzheimer's Disease and related neurodegenerative disorders." "The ability to detect brain-derived pTau species directly from blood represents a transformative step in the early detection and monitoring of Alzheimer's Disease (AD) and related disorders," said Nicholas Ashton, Ph.D., Director of Neurodegenerative Biomarker Research at Banner Health. "Until now, we've been unable to differentiate between brain-derived and peripheral pTaus in a multiplexed manner. Recent evidence has underlined the importance of being able to detect brain-derived pTau for greater specificity for AD. Alamar's new CNS panel offers an unprecedented opportunity to further improve the diagnostic accuracy and clinical utilities of these biomarkers, which will dramatically impact patient care and clinical research." Alamar Biosciences remains committed to partnering with the neuroscience community to unlock biomarker insights that drive earlier diagnosis, patient stratification, and therapeutic monitoring. For more information about the NULISAseq CNS Disease Panel 120 and Alamar Biosciences' portfolio of proteomic solutions, visit About Alamar Biosciences, Inc. Alamar Biosciences is a privately held life sciences company with a mission to power precision proteomics to enable the earliest detection of disease. The company's proprietary NULISA Platform along with the ARGO™ HT System work seamlessly with the latest advances in genomics to achieve single digit attomolar detection sensitivity, greatly surpassing the most sensitive protein detection technology on the market today. For more information, please visit
