Latest news with #NicolaRooney
Yahoo
22-07-2025
- Health
- Yahoo
Parkinson's Disease Has a Smell That Some Dogs Can Detect
Dogs really can be trained to smell Parkinson's disease, according to new research from the United Kingdom. In a double blind trial, a Golden Retriever and a Labrador were able to sniff out which skin swabs came from people with Parkinson's. The smell of the oily secretions seemed to hold secret clues. "The dogs in this study achieved high sensitivity and specificity and showed there is an olfactory signature distinct to patients with the disease," says animal behavioral scientist Nicola Rooney from the University of Bristol. "Sensitivity levels of 70 percent and 80 percent are well above chance, and I believe that dogs could help us to develop a quick, non-invasive, and cost-effective method to identify patients with Parkinson's disease." Related: Today, there is no definitive early test for Parkinson's, which is why scientists are so interested in finding potential biomarkers of the disease on our skin. The knowledge that Parkinson's distinctly changes a person's body odor first came to light roughly a decade ago – all because of one woman. Twelve years before her husband's diagnosis of Parkinson's disease, Joy Milne could sense something was off – specifically, she could smell it. Milne, a Scottish nurse, is known as a 'super-smeller', and in 2016, she became famous among neuroscientists for her extraordinary abilities. In a small pilot study, Milne correctly identified each patient with Parkinson's disease based solely on the scent of their shirts. Her one misidentification turned out to be correct nearly a year later. The news raised an important question: If someone like Milne could smell Parkinson's years before it was diagnosed, could a dog do the same? Dogs are known to have incredible senses of smell, far more powerful than our own. Previous studies have found our pets can smell our stress, our coronavirus infections, and even our cancers – so if a distinct odor for Parkinson's does exist, then maybe a dog can sniff it out, too. In the past decade, a few preliminary trials have provided evidence for that hypothesis. But some only gave limited information on how the dogs were trained and tested. The recent trial from the UK is a collaboration between a program called Medical Detection Dogs and neuroscientists at the University of Manchester. One goal of the research is to figure out what the dogs are actually smelling, and why. In 2019, for instance, researchers at Manchester helped identify which odor compounds set the distinctive smell of Parkinson's apart. Their results were later confirmed by Milne, the serendipitous "super-smeller". A few years on, the odor compounds were used to create a diagnostic 'swab test' for Parkinson's, currently in testing. Perhaps, further down the road, trained dogs could help neuroscientists identify more unique biomarkers of the disease. The trouble is, though, not all canines are up to snuff. In the current trial, only 2 out of 10 dogs made it through training, and neither performed perfectly. One dog, for instance, falsely flagged a tenth of the odor swabs from healthy people as having Parkinson's. The other gave false alarms less than 2 percent of the time. Overall, however, the dogs could smell which person had Parkinson's at a rate well above chance, providing proof of principle. "We are extremely proud to say that once again, dogs can very accurately detect disease," says Claire Guest, the CEO of Medical Detection Dogs. "There is currently no early test for Parkinson's disease and symptoms may start up to 20 years before they become visible and persistent leading to a confirmed diagnosis. "Timely diagnosis is key… " The study was published in the Journal of Parkinson's Disease. Related News Expert Reveals What Can Happen if Testosterone Gel Rubs Onto Others Radioactive Waste Exposed Children in Missouri to Cancer Risks, Study Finds A Single Brain Scan Halfway Through Your Life Can Reveal How Fast You're Aging Solve the daily Crossword
Daily Mail
17-07-2025
- Health
- Daily Mail
Groundbreaking new method can detect Parkinson's years before symptoms with 98% accuracy
Your dog may be able to tell if you develop Parkinson's disease years before any symptom, a new study suggests. Parkinson's disease is a progressive neurological disorder that primarily affects movement, causing symptoms like tremors, stiffness and slow movement. Currently, this incurable disease can't be diagnosed with a definitive test and most patients do not know they have the condition until symptoms begin. However, now researchers from University of Bristol, UK have found that dogs can smell the signs of Parkinson's disease (PD) through skin swabs with 98 percent accuracy well before any other test. Lead author Dr Nicola Rooney, Associate Professor at Bristol Veterinary School said: 'Identifying diagnostic biomarkers of PD, particularly those that may predict development or help diagnose disease earlier is the subject of much ongoing research. 'I believe that dogs could help us to develop a quick non-invasive and cost-effective method to identify patients with Parkinson's disease.' As of 2025, over 1million Americans suffer from the neurological disorder and a new person is diagnosed with every six minutes, according to American Parkinson Disease Association. Despite mostly affecting older adults aged 65 and above, about 10 percent of people are diagnosed prior to age 40 with young-onset Parkinson's. During early stages of Parkinson's disease, the neurons in the brain responsible for producing a chemical called dopamine begin to slowly break down or die. Dopamine acts as a messenger between the parts of the brain and nervous system that help control and coordinate body movements. The lack of dopamine causes the primary symptoms of the disease to begin appearing including tremors, drooling, cramped or small handwriting, trouble swallowing and a loss of smell. Over time, as the neurons continue to die, the patients also begins to experience a slowness in movement, muscle stiffness, balance problems and begin to show signs of depression. Ultimately, those suffering from Parkinson's may be unable to stand or walk independently and require a wheelchair or are bedridden. They may also require around-the-clock care. Medication can help manage symptoms, but their effectiveness may decrease over time, requiring adjustments to treatment plans. In this study, published in The Journal of Parkinson's Disease, the British researchers trained two dogs, a golden retriever and black labrador. Both animals were given over 200 odor samples to learn how to recognize the difference in smell between skin oil (sebum) samples from individuals with Parkinson's and those without for weeks. Researchers have found that dogs can smell the signs of Parkinson's disease (stock image) The dogs were rewarded when they correctly identified a positive sample or accurately ignored a negative one. In a double-blind trial, where neither the handlers nor researchers knew which samples were which, the dogs were able to recognize nearly all Parkinson's-infected swabs. Moreover, they were also able to detect Parkinson's in swabs from people with multiple health conditions. As a result, the researchers concluded that the disease has a unique scent signature, and dogs could help identify it through subtle changes in the sebum produced by individuals with the disease. This could pioneer a faster, non-invasive way to detect the disease years earlier than current methods allow, experts claimed. Claire Guest, CEO of Medical Detection Dogs, the company that collaborated with the scientists, said: 'We are extremely proud to say that once again, dogs can very accurately detect disease. 'There is currently no early test for Parkinson's disease and symptoms may start up to 20 years before they become visible and persistent leading to a confirmed diagnosis. 'Timely diagnosis is key as subsequent treatment could slow down the progression of the disease and reduce the intensity of symptoms.' Previous research has shown that Parkinson's disease affects the production and composition of sebum in the skin which can lead to an altered odor. Since dogs have a highly developed sense of smell, far superior to humans, they are able to detect these subtle differences in scent and identify signs of the disease earlier than any other evaluation.
