Latest news with #NicotinamideMononucleotide
News18
2 days ago
- Health
- News18
Shefali Jariwala Took an Anti-Ageing Shot Before She Collapsed—Are These Treatments Fatal?
Last Updated: The tragic death of Shefali Jariwala has spotlighted the hidden risks of unsupervised anti-ageing treatments like glutathione and vitamin C injections The tragic and untimely death of actor-model Shefali Jariwala on the night of June 27 has left the entertainment industry in mourning and raised serious questions about the long-term health risks of anti-ageing treatments. While the exact cause of death is still under investigation, early reports indicate that Shefali had been on a regular regimen of anti-ageing injections, including glutathione and vitamin C, for nearly a decade. A source close to the family revealed that she took one such injection on the day of her death, despite fasting for a religious ritual, and collapsed hours later. As police and forensic experts investigate further, glutathione injections, vitamin C ampoules, and acidity pills have reportedly been recovered from her residence. This tragic case is now prompting a deeper examination into the world of anti-ageing drugs, particularly the growing popularity of intravenous treatments among celebrities and influencers. According to Dr. Aashna Kanchwala, Celebrity Cosmetologist & Aesthetic Physician, the pressure to stay camera-ready pushes many celebrities to embrace treatments that go beyond topical skincare. 'While skincare routines are a given, many famous personalities take it a step further with treatments and supplements that promise to slow down the ageing process," says Dr. Kanchwala. 'Botox and fillers are among the most common, relaxing facial muscles and restoring volume for a youthful look." She adds that NAD+ therapy, taken via IV or injections, is growing in popularity for its cell-repairing, energy-boosting benefits. Human Growth Hormone (HGH), though controversial, is used for enhancing skin texture, muscle tone, and vitality. Glutathione and collagen supplements, either in pills or injectables, are often used for skin brightening and detoxification, despite limited regulation. Dr. Debeshi, Medical Head & Founder, Lueur Aesthetics, lists several popular choices seen in celebrity wellness routines: 'Treatments like NMN (Nicotinamide Mononucleotide) and Resveratrol are known for boosting cellular energy and longevity. Collagen, hyaluronic acid, and vitamin C infusions are widely used for improving skin elasticity and hydration. Injectable procedures like Morpheus8 and Forma offer non-surgical skin tightening and rejuvenation." She emphasizes that while injectables like Botox and dermal fillers are mainstays in Hollywood, they should always be administered under medical supervision. What About Internal Ageing? Dr. Piyusha Bhagde, Founder and Chief Dermatologist, Skin Ethics Clinic, Akola, stresses the importance of understanding that ageing happens both externally and internally. 'External ageing can be managed with sunscreen, topical retinols, peptides, and antioxidants," she says. 'But internal ageing requires boosting cell metabolism with oral anti-ageing supplements like marine collagen, astaxanthin, CoQ10, resveratrol, curcumin, omega-3 fatty acids, and the latest, NAD+." She adds that injectable drips often cocktails of glutathione, vitamin C, and NAD+ are increasingly popular but carry risks when self-administered or poorly monitored. Additionally, advanced injectables like HA boosters, PDRN, exosomes, and PN are now being used to stimulate natural collagen and improve skin tone and texture. The Glutathione Question: How Safe Is It? Glutathione has become a buzzword in celebrity skincare, but it's not without concern. While oral and topical forms are generally considered safe, IV glutathione carries serious risks, including anaphylactic reactions and liver toxicity. A 2022 study published in Cureus highlights the lack of standardized dosing and insufficient clinical data on long-term safety. The same study calls for larger trials and warns against casual use without medical oversight. Can These Treatments Affect the Heart? While not all anti-ageing treatments pose direct cardiac threats, the combination of multiple supplements and injectables, especially in individuals with underlying health issues or during fasting or physical stress, may strain the body. High doses of vitamin C via IV can influence electrolyte balance and, in rare cases, impact heart rhythm. Glutathione injections may influence liver enzymes, and when paired with other metabolic boosters, could overstimulate the body. While anti-ageing treatments promise a youthful glow, they are not without risks—especially when misused or taken without supervision. The case of Shefali Jariwala is a sobering reminder that even well-known and widely used beauty treatments can have serious consequences when not administered responsibly. As Dr. Aashna Kanchwala rightly sums up, 'These treatments aren't one-size-fits-all. What works wonders for one person may be harmful to another. Supervised care is not optional—it's essential." Before choosing anti-ageing therapies, consult qualified medical professionals, and remember: youthful skin is good, but long-term health is better. About the Author Swati Chaturvedi Swati Chaturvedi, a seasoned media and journalism aficionado with over 10 years of expertise, is not just a storyteller; she's a weaver of wit and wisdom in the digital landscape. As a key figure in News18 More The News18 Lifestyle section brings you the latest on health, fashion, travel, food, and culture — with wellness tips, celebrity style, travel inspiration, and recipes. Also Download the News18 App to stay updated! First Published:
Indian Express
3 days ago
- Health
- Indian Express
Shefali Jariwala sudden death: Why anti-ageing medication, IV glutathione and Botox use should be under the scanner
What triggered sudden cardiac arrest in actor-performer Shefali Jariwala is the question that's on everybody's mind, especially after police found evidence of self-medication. Among the things bandied about in media reports are that she took anti-ageing pills and relied on skin improvement treatments like glutathione. Generally, most reports argue that she had built a drug dependency, and on a day she was fasting, she had reacted to something that may have sent her body into allergic shock, causing sudden death. But is that the real story? The real story that nobody wants to talk about is the pressure that social media exerts on prioritising agelessness, the extent of obsession that drives people to resort to all sorts of bio hacks being peddled online instead of going to a doctor, a greedy and unregulated supplement industry which peddles 'safe' ways to stop the wrinkles and an appearance-conscious world which imposes new standards of acceptance every day. We spoke with experts to find out why anti-ageing procedures go wrong. This comprises drugs or combinations of drugs and compounds which slow down there are concentrated supplements like those of the flavonoid quercetin — one of the most abundant polyphenols found in fruits, vegetables, nuts, wine, and black tea — curcumin, NR (Nicotinamide Riboside, a form of vitamin B3), NMN (Nicotinamide Mononucleotide, a compound broken down from Vitamin B3), and even repurposed concoctions made from drugs meant for other diseases. 'The problem with repurposed drugs is that they may have US FDA (Food and Drug Administration) and even CDSCO (Central Drugs Standard Control Organisation) approvals for a certain disease. But then their components are played around with by certain supplement makers claiming anti-ageing properties,' says Dr Rishi Parashar, Chairman, Dermatology, Sir Gangaram Hospital, Delhi. 'Besides, the so-called herbal supplements market is unregulated and we do not know what is being put into them or whether they are within safe limits. Also, many anti-ageing medications that are in clinical trials have not yielded any significant positive results. Most of these trials are animal studies and the results may be completely different in human trials. The efficacy of anti-ageing compounds, as being touted now, will take years to show results. Till then, what you read on social media is nothing short of quackery,' he adds. What about Botox injections going bad? Over the last 20 years, Dr Parashar has been administering Botox injections and fillers for anti-ageing. Derived from a bacterium called clostridium botulinum, its toxin paralyses and relaxes facial muscles and hence reduces wrinkles. 'The jab has been proven to be safe except for complications in very rare cases, most of which got resolved too. The only thing required is that they be administered by a registered dermatologist in a medical facility that meets stringent hygiene and safety standards. Some injectable treatments include prescription medication and so should only be administered by a qualified nurse or doctor, following an initial consultation,' insists Dr Parashar. Suspicions around Botox gained momentum in April 2024 when the US Centre for Disease Control and Prevention (CDC) released an alert warning that 22 women between 25 and 59 had 'harmful reactions' to counterfeit or mishandled Botox. Eleven people were hospitalised, and six were treated with an antitoxin because of concerns around botulism – a condition where the toxin spreads beyond the local site and attacks the central nervous system causing muscle paralysis, difficulty breathing and even death. Symptoms included blurry and double vision, drooping eyelids, difficulty swallowing, slurred speech, difficulty breathing, fatigue, and weakness. 'It was proven that all the women received injections from unlicensed or untrained people in places that were not healthcare centres. We have many such neighbourhood clinics mushrooming in India,' says Dr Parashar. Botox procedures are allowed only in certain parts of the face. If you apply the same routine elsewhere on your face or any other body part where it is not meant to, there will be adverse reactions. What's the truth about glutathione? Another compound that's much misunderstood is the antioxidant glutathione, often used for skin lightening because it manages to suppress the levels of melanin that regulates skin pigmentation. Hence its popularity in skin creams, serums and lotions, all meant for topical application. 'But the real risk is in the use of IV (intravenous) glutathione, which many Bollywood celebrities are endorsing too. The US Food and Drug Administration (FDA) does not approve its use for cosmetic skin lightening. It is not available with long-term safety data, and potential side effects include allergic reactions, low blood pressure, kidney injury and interference with the body's natural antioxidant balance. Various global health authorities even warn against its use for vanity purposes,' says cosmetic surgeon Dr Anup Dhir. The Central Drugs Standard Control Organisation (CDSCO) has not approved glutathione for skin lightening though it's widely used off-label for that purpose. 'It is actually authorised for intravenous use in conditions like alcoholic fatty liver, fibrosis, cirrhosis, and alcoholic hepatitis and sometimes to neutralise the toxicity from chemotherapy,' says Dr Dhir. Yet skin clinics administer glutathione injections, often alongside Vitamin C, for skin lightening. 'Research on the cosmetic effects of all IV infusions is limited. While some anecdotal evidence suggests positive results, these are often based on individual experiences rather than studies. Besides, how much of it is being absorbed by the body to make a remarkable skin tone difference is a matter of debate,' says Dr Dhir, who never advises this injection. IV products should only be given by a healthcare provider, not by a salon hand. 'That's why you see so many cases of skin eruptions and damage. A very important part of a glutathione injection is dosage, which needs to be calibrated and administered as per body weight. The recommended daily dose of glutathione for adults ranges from 500-2,000 mg per day when taken orally, or 10-20 mg/kg body weight when administered intravenously for disease supportive therapies. Who knows how much is being given for the skin?' asks Dr Dhir. Other potential risks include transmission of infectious agents, such as HIV, hepatitis C and B when a non-medical practitioner administers this treatment in a non-sterile facility. Do not buy online Dr Parashar argues for strict monitoring of online sales of such products. 'Users buy them on the basis of the label's declared promises as a safe beauty product. The platform aggregator is least concerned about the concentration of their ingredients or their side effects. Users go to the local skin clinic and get them administered. They wouldn't even know that they would have to seek prompt medical attention if something goes awry,' he warns.
7NEWS
19-06-2025
- Health
- 7NEWS
The Future of Ageing Starts Here: SRW's cutting-edge nutraceuticals for energy, mobility, and immune health
Great health starts from within as does beauty and while many of us like to rely on anti-ageing products, it's actually more about what we are putting into our bodies rather than what we are putting on. Science Research Wellness (SRW) Laboratories is a biotechnology company based in New Zealand, committed to changing the way people think about and experience ageing. Through close collaboration with world-leading scientists, SRW develops cutting-edge epigenetic tests and nutraceutical supplements designed to support individuals in ageing well by caring for their cellular health. At the core of SRW's mission is a scientific approach to wellness. Their range of supplements is carefully formulated to support essential biological functions, targeting energy production, joint mobility, and immune resilience. One of SRW's most popular products is their NMN supplement which retails for $92 a bottle, containing 500mg of pure Nicotinamide Mononucleotide per capsule. NMN is a naturally occurring molecule found in all life forms, vital for the body's production of NAD+, a compound essential for cellular energy, DNA repair, and metabolic function. While trace amounts exist in food, SRW's NMN supplement delivers a clinically relevant dose that supports healthy ageing, brain and heart health, and overall vitality. Shoppers have given the NMN supplement, a 4.7-star rating on SRW's website. 'This supplement made me feel great very rapidly,' one impressed shopper wrote. 'It has greatly improved my mood and I have more sustained energy,' a second shopper added. 'The SRW NMN is top quality, it powers me through the entire day,' a third reviewer commented. Another key product in SRW's portfolio is Skl¹ Mobility which retail for $129 a bottle and are designed to promote joint health, flexibility, and strength. As people age, joint mobility can diminish, impacting daily movement and comfort. Skl¹ supports those looking to maintain an active lifestyle, whether it's used as a complement to regular exercise or as part of a broader long-term plan for joint maintenance. SRW also offers Imm¹ Defence, a supplement formulated to support the immune system through periods of recovery, stress, or high exposure to illness. It's particularly beneficial for individuals who are frequently exposed to pathogens, such as parents, travellers, and healthcare workers, as well as for athletes and physically active individuals who rely on strong immune function for training recovery. Beyond their science-backed formulations, SRW Laboratories is also known for its commitment to sustainability and ethical manufacturing. Their supplements are made in GMP-certified facilities to ensure high standards of quality, purity, and potency. SRW holds FernMark accreditation, a government-endorsed symbol of authenticity and a mark of its New Zealand origin. field of cellular health and nutraceuticals.
Time of India
13-06-2025
- Health
- Time of India
Best NMN supplements to boost NAD levels and support longevity, according to experts
Longevity science is all the rage in 2025, with all kinds of complex technologies for how to stay young for longer and fight the negative effects of ageing, but some of the most effective tools to counteract ageing are naturally occurring compounds already found in the body that can be easily boosted through supplementation. The key to well-being lives inside the human body; it's just a matter of optimizing the existing systems to ensure their smooth function and our flourishing. Is it really that simple? One super supplement that has shown immense promise in the longevity sphere and which is quickly gaining support worldwide is Nicotinamide Mononucleotide, also known as NMN. NMN improves your cellular health and boosts the levels of NAD produced by the body, which creates a wide range of benefits to help users feel younger, healthier, have more energy, and optimise their body's natural rhythms. Here is everything you need to know about this powerful nucleotide and a list of the best NMN supplements to take to start feeling your best. NMN and NAD: A Quick Science Lesson NMN, or Nicotinamide Mononucleotide, is a naturally occurring molecule that boosts the body's levels of NAD, also known as Nicotinamide adenine dinucleotide. To put it plainly, NMN is a messenger molecule, encouraging NAD to work its special cellular magic. We can think of NAD as a fuel or a battery that helps the cells in the body recharge themselves and keep us functioning at our optimal capacities. In a certain way, NMN is a kind of encouraging manager, making sure that NAD does its best work in the cell to keep the body healthy, strong, and resilient. Like many functions in the body, however, NAD levels decline with age, which leads to a slew of age-related ailments and limitations, from energy issues to DNA damage to metabolic imbalance. Given the ways that NAD levels start to lag with age, scientists and experts have begun to look into ways to keep the body's cellular powerhouses going strong in a safe and natural way, through supplementation. Promising studies suggest that NMN and the ways that it stimulates NAD production processes are at the heart of optimizing longevity science and helping to keep age-related decline at bay. Taking NMN supplements shows special promise with keeping individuals fit, healthy, and feeling their best, and medical experts from Mark Hyman to David Sinclair are touting NMN benefits for general well-being, vitality, and longevity. Why NMN Supplements Are Better Than Taking NAD Directly While one might assume that the most direct route to increasing NAD levels in the body would be by taking NAD directly, the scientific reality is that NMN supplements offer a far more effective approach to achieving this goal while enhancing overall well-being and health. NMN is readily absorbed by the human body, which enhances its stability and enables the body's systems to regulate NAD levels with greater precision. Serving as a precursor for Nicotinamide adenine dinucleotide production, Nicotinamide Mononucleotide sets the stage for a more meaningful and beneficial metabolic process and cellular synthesis, while also mitigating the potential negative effects of elevated NAD levels. Opting for direct NAD intake would, in many respects, be akin to putting the cart before the horse. Utilising an NMN supplement provides the body with the opportunity to efficiently boost NAD levels through its natural metabolic pathways. How to Choose the Best NMN Supplement for Your Body's Needs There are a number of different considerations to take into account when choosing an NMN supplement. Safety and effectiveness is of the utmost importance in any kind of choice about what to take for your health, so finding a reputable brand with excellent quality and transparent manufacturing practices is essential. Third-party testing with reputable scientific sources and supplements that meet industry standards are excellent way to ensure that a given NMN supplement is going to be right for your needs. Additionally, doing research about a preferred method of supplementation, whether powders or capsules, and reading customer reviews, testimonials, and anecdotal reports, can be a good way to begin choosing a preferred NMN supplement. Our top NMN picks 1. Wonderfeel Youngr™ NMN Wonderfeel Youngr™ NMN Wonderfeel Youngr ™ NMN supplements are carefully crafted, clinically tested, and thoughtfully dosed to optimise NMN and NAD levels in the body, which is why it's the best NMN supplement on the market currently. For everything from reasonable pricing to safety to optimised dosage, this top NMN supplement takes first prize. At 900mg NMN, they achieve the perfect potency to have real, substantive effects on the human body and leave users feeling their best. What's more, they incorporate a blend of NMN and other beneficial and complementary ingredients that have been shown to have a real impact on longevity, from resveratrol, a polyphenol and antioxidant powerhouse that is found in grapes, and hydroxytyrosol, another polyphenol virtuoso that is naturally found in olive oil. Wonderfeel Youngr ™ NMN supplements take some of the most formidable natural longevity compounds and molecules and fit them into a daily dosage that will leave you feeling refreshed, energised, and indeed, younger. The Wonderfeel Youngr™ NMN formula was developed by Professor Andrew Salzman, a Harvard MD and innovator in longevity science, and has been endorsed by Dr. Mark Hyman. The science shows that taking a higher dosage of NMN (in the 600-900 mg range) correlates with an optimal level of NAD, which in turn leads to better mitochondrial functioning. Mitochondrial functioning is at the base of cellular health, overall well-being, and resisting the negative effects of ageing. Together with the specialists at Wonderfeel, Salzman has developed an NMN supplement that gives subscribers the ideal dosage in a simple and all-natural form. Additionally, they include supportive ingredients like resveratrol, ergothioneine, and hydroxytyrosol, powerful organic polyphenols and antioxidants that collaborate with NMN to create a powerful and effective longevity supplement. For the formula Dr. Salzman stated, 'Just to give NMN without protecting against oxidant stress would be only half the story. Our focus at Wonderfeel is on getting mitochondria back to full health. By giving antioxidants, we nurture, we potentiate the efficacy, we augment the effect of NMN.' The Wonderfeel supplements are free from GMOs, preservatives, soy, gluten, and dairy. By staying close to the science and working with natural, safe, and ethically sourced ingredients, Wonderfeel Youngr™ has established itself as the best NMN brand. Anecdotal benefits among Wonderfeel Youngr™ NMN subscribers abound, including reduced inflammation, improved energy, smoother and more restful sleep cycles, better cognitive function, and more. At $2.70 per 1g of NMN, Youngr™ is not only an optimal dosage and formula, but an exceptional value. With its excellent pricing and superior quality, Youngr™ is the top of our NMN supplement list. Buy NMN from Wonderfeel and become a subscriber 2. Wonderfeel NMN Capsuls™ Wonderfeel NMN Capsuls™ Another option for NMN supplementation from Wonderfeel is the Wonderfeel NMN Capsuls™. At the strongest dosage and potency, the Capsuls™ are an excellent choice if you are looking to see more noticeable results, faster, and in a purer form. This is the best pure NMN on the market, and it yields remarkable results. These have the same potential benefits of Wonderfeel Youngr ™ NMN, from physical improvements to improved memory and cognitive function, better sleep, and overall well-being, and more, but with greater purity and potency per capsule. At 500mg per capsule, Wonderfeel Capsuls™ NMN offer pure, optimally-dosed NMN for top-notch results. Wonderfeel Capsuls™ NMN maintain the same rigorous standards and high-quality as Wonderfeel Youngr™ NMN, undergoing third-party testing and full transparency around production. Just use a simple QR code to access the certifications of these supplements, and watch as your body aligns with its optimal patterns and abilities. With a subscription, Wonderfeel Capsuls™ NMN cost $52 a month for 60 capsules for high-quality, pure NMN. Make a worthy investment in your well-being The Reviews Are In: NMN Benefits So what are the specific NMN benefits? Science and research are ongoing and extremely auspicious, and research around NMN is a new frontier in the world of longevity science. As research continues to blossom and support personal reports, there are various scientific studies as well as individuals' experiences for anecdotal reference. Users of NMN supplements have reported a wide-ranging buffet of benefits. The fact that they are shared across age, experience, and demographics, coupled with its support from preliminary or ongoing scientific investigations, signifies a notably optimistic outlook for NMN in the world of longevity and wellness innovation. A selection of positive results attributed to taking NMN include: More Energy and Increased Vitality One of the most common benefits expressed among users of NMN supplements is an increase and improvement in energy and vitality. When you feed your cellular energy, your body's natural energy improves, reducing fatigue and elevating vital force in the body. Muscle Health and Athletic Performance One of the most pronounced and widely reported benefits of taking NMN is its ability to improve muscle health, muscle recovery, and physical performance in adults. Not only does it improve systems on the cellular level, but a recent study overseen by David Sinclair found that NAD-boosting molecules (read: NMN) helps to improve blood and nutrient supply to the muscles. Another study, in 2021, found that NMN renewed muscle strength and improved athletic performance (including grip strength, walking speed, and tests about moving from sitting to standing) in men over 65. Anecdotally, these outcomes have been shown in a wide range of individuals of all ages and experiences. NMN has huge potential to improve physical and athletic performance. Sharper Cognitive Function If you are getting a little lost in all this technical jargon, please don't beat yourself up. Your cognitive functioning for reading about the benefits of taking NMN might be improved by—you guessed it—taking NMN. Many researchers have found that NMN has an incredible potential to improve and preserve brain function due to its positive effect on neurovascular coupling, aka NVC. Scientists studying NMN, including Dr. David Sinclair, have found that the compound has a positive effect on maintaining memory and cognitive function. Weight Loss and Metabolism Stabilisation NMN is a naturally occurring key factor in metabolic function, so it stands to reason that NMN supplements can help optimise those metabolic processes. NMN can help to convert food into energy, manage fats and proteins, and stabilise blood sugar, which shows promise in weight management and broader metabolic health. Hair Growth As shown in a recent 2024 study, and in many reports by users, NMN can promote hair growth and the reversal of hair follicle atrophy and hair thinning. By lowering inflammatory factors that contribute to hair loss, NMN supplements can reverse hair loss and repopulate users' scalps with luscious, healthy locks. Skin Elasticity and Smoothness Sure, creams and moisturisers are a good start when it comes to skin health, but a lot of the issues that go into ageing skin happen on a level that's more than skin-deep. Being able to withstand UV rays and the general wear and tear of ageing, like wrinkles and fine lines, can come down to—you guessed it—cellular health. Studies suggest that the key to glowing skin could be found in the body's production of NAD, and anecdotal evidence from NMN users point to improvements in skin elasticity and skin smoothness as major noticeable effects. Heart Health An exciting study looked at NMN benefits in healthy middle-aged and older adults and found that it had a positive effect on their overall health, including on the health of their heart. This rigorous, randomised, double-blind, placebo-controlled, crossover trial found that NMN could have really beneficial effects on cardiovascular function and heart health, among other things. Doesn't that just warm your heart? Insulin Regulation Relevant to its ability to regulate and optimise metabolic function, NMN has been found to have a profound effect on helping the body manage blood sugar and reduce insulin resistance, a major problem associated with diabetes. NMN Supplements Common Questions and Considerations Now that we've looked at the incredible benefits of taking NMN supplements and how it has the potential to change your life for the better, here are some frequently asked questions about NMN that will help you understand more about how it all works. Side Effects and Safety Many people ask, what are the side effects of taking NMN supplements? As with any supplement, side effects are an important consideration to take and must be taken seriously. The good news with NMN supplements is that studies show that NMN intake is extremely well tolerated by the body, with few concerning side effects. A recent 8-week study conducted among healthy, middle-aged Japanese men found that not only does NMN show promise in improving sleep and metabolism, but also that it is well-tolerated by the body, with no concerning side effects. Higher doses, such as 1,200 mg or even up to 2,000 mg daily, have also been studied and are well-tolerated, according to research led by Professor David Sinclair of Harvard Medical School. Daily Dosage: How Much NMN Should You Take? As with any supplement, it's important to listen to your own body to determine the best dosage. Bodies process molecules and compounds in different ways and have different needs. The research points to the fact that 600mg to 1200 mg is a safe and effective starting point for NMN dosage, and esteemed doctor and longevity scientist David Sinclair recommends a daily 1000 mg dose to really reap the rewards of this wonder molecule. While it is important to do what feels right and trust your own biorhythms, experts like Sinclair and the scientists at companies like Wonderfeel suggest that a dosage lower than 400 mg is not as likely to have any perceptible effects on well-being. Furthermore, anything up to 2000 mg has been shown to be well-tolerated by the human body and can yield the best results. Harvard Doctor David Sinclair: NMN Advocate When we talk about taking an NMN supplement, listening to the experts is essential. Dr. David Sinclair, a well-respected aging researcher and Professor of Genetics at Harvard Medical School, has been a big advocate for NMN and a vocal participant in the ever-evolving discussion of its benefits. His entire career project is grounded in a holistic and substantive search for the most effective and safest frontiers in longevity science. Sinclair's research with mice has been instrumental in determining that increasing NAD levels in the body is the key to their living longer lives. His findings are miraculous and have helped in unlocking the science around a broader appreciation of the importance of NAD and the benefits of taking NMN. Furthermore, Dr. Sinclair has anecdotally shared that he himself takes a daily NMN dose of 1000 mg. When Should You Take NMN? The question of how much NMN to take is still evolving with the research. Again, everybody is different, so timing the dosage of the supplement is necessarily tied to an individual's experience and needs, with no codified timing constraints. Although consuming NMN in the morning may coincide with the body's natural NAD rhythm and potentially provide an energy boost, available research indicates that alternative timing options may also be viable. Research is still evolving and while one study proposes afternoon intake for enhanced energy levels and sleep quality among elderly users, some users and experts report that NMN works at various times throughout the day. It is important to consider individual factors when determining the most suitable timing for taking NMN. Experimenting with different times based on personal goals is advisable. Morning consumption of NMN may optimise energy levels throughout the day, whereas evening usage could facilitate deeper sleep. Does Taking NMN Everyday Improve Its Benefits? In brief: yes! NMN is not only considered safe for daily consumption; it can also improve users' experience of its many benefits. As research on NMN continues to evolve, staying informed about new findings and recommendations is essential for making informed decisions about its use. Much of the research shows real promise and potential for proving the lasting benefits of NMN supplementation with everyday use, and points to the fact that the real positive changes come from sustained and cumulative supplementation, rather than on-and-off use. Experts in the field suggest that everyday use is not only safe but advisable. Can Young People Take NMN? Again, research is evolving. NAD levels begin to decline after age thirty, and this may suggest that the effects of NMN are less felt or necessary for younger individuals who are already producing a healthy amount of NAD in their bodies. Ultimately, the decision for a young person to consider taking NMN comes down to their needs, as it depends on various factors such as their overall health status, specific health goals, and any existing medical conditions. There are anecdotal accounts of people younger than thirty benefiting from taking an NMN supplement. Additionally, staying informed about the latest research developments as it evolves in the field can offer exciting insights into the potential benefits and opportunities NMN supplementation may present for different age groups. Do You Need to Take NMN Along with TMG? There has been some concern that NMN supplements ought to be taken with Trimethylglycine, aka TMG. But does supplementing with NMN actually deplete the body's TMG levels? It's more complicated than a simple yes or no. TMG, or trimethylglycine, is a natural compound that's super important for our bodies. It helps with things like keeping our DNA healthy, supporting our liver, and giving us energy. The good news is, we can find TMG in lots of common foods we eat every day, like beets, quinoa, spinach, and seafood. Plus, our bodies are pretty good at keeping the right amount of TMG around to keep everything running smoothly. The question of whether you need to take extra TMG while taking an NMN supplement depends entirely on your body and your needs. It is certainly not necessary for everyone, but depending on your needs, whether you have methylation deficiencies, specific health considerations, or genetic variations, it may be the right choice for you. What is liposomal NMN? What about Sublingual? As research is ongoing and emergent, there is a great deal of discussion about the best way to take and metabolise NMN. Currently, there are three different methods of taking NMN supplements with different benefits and drawbacks: Capsules: The most popular and safest choice, easy to store, take, and use. The most popular and safest choice, easy to store, take, and use. Sublingual NMN: If you want to bypass the digestive system for faster results, taking NMN 'under the tongue' is another option, but research is still catching up, so it's unclear how effective this method is. If you want to bypass the digestive system for faster results, taking NMN 'under the tongue' is another option, but research is still catching up, so it's unclear how effective this method is. Liposomal NMN: This is a more sophisticated way to deliver NMN that, like sublingual supplementation, promises better absorption. However, also like sublingual NMN, research isn't quite there in proving its effectiveness. Given these options, it's our current belief and recommendation that NMN capsules are the best way to administer NMN and can yield the best results. Can You Boost NAD Through Diet and Behaviour? Because NMN is an organic, naturally occurring molecule that produces NAD in the human body, there are a number of ways that your body is already making this happen. This process can be improved through diet and behaviour. The science suggests that eating a balanced diet of whole foods with B vitamins and tryptophan has positive effects on NAD production. Particularly, food like avocados, leafy greens, and edamame are all excellent choices. Other habits like limiting one's alcohol consumption, regular exercise, intermittent fasting, and sun exposure, have all had positive effects on NAD levels. The science also suggests that NMN supplementation, in concert with these healthy habits, is the most efficient and effective way to harness some of these benefits. Companies like Wonderfeel have not only committed to producing safe, potent, and pure NMN, but also integrated their formulas with other natural ingredients shown to positively impact longevity. What's Better: NMN or NAD Directly? While it may follow that if what you're wanting to boost in the body is NAD, taking NAD supplements is actually less efficient, because it has a harder time penetrating cellular and metabolic structures. Taking NMN is definitely the more efficient and effective method for boosting NAD. What About NMN and Resveratrol? More technical language incoming! Resveratrol is a fascinating natural compound abundant in the skin of grapes, and renowned for its ability to stimulate sirtuins, crucial proteins vital for cellular health. When combined with NMN, these two supplements exhibit a synergistic effect. NMN elevates NAD levels, thus amplifying resveratrol's capacity to activate sirtuins, resulting in a potent cellular rejuvenation partnership. We highly recommend pairing your NMN with resveratrol, because together they form an unstoppable collaboration. This is another area in which Wonderfeel Youngr™ NMN formula stands out as the top NMN supplement, for its integration of resveratrol in its formula. When Will NMN Supplements Take Effect? This all depends on your body, your health goals, and a number of factors. While many users report positive effects rather quickly, the most profound and substantial effects occur cumulatively, over the long-term. We encourage users to keep a journal to track their progress and note any benefits and changes that occur, and share them, as the science continues to unfold. While we cannot speak for you or how your body will metabolise NMN, it is worth mentioning that regularly using NMN supplements has brought a wave of shared positive experiences to many users in just a few weeks. The best NMN supplements, as listed in this article, can make huge differences in how a person feels. People who supplement with NMN report feeling more energised and enjoying an overall improved sense of well-being soon after starting NMN. This quick boost makes sense, since increased NMN promises the ability to rapidly convert into NAD, which can supercharge cellular energy production. The real magic of NMN unfolds over time. While immediate effects are promising, the long-term benefits—like sharper cognitive function, a healthier heart, and a more youthful appearance—often come more slowly. Since these are complex, whole body systemic changes that are occurring, these effects do not simply arise out of nowhere. These transformations involve intricate biological processes that take time to fully manifest. Our advice would be to keep up the consistency, and remember, the best is yet to come. Is it time to try NMN and optimise your body's natural rhythm?
Time of India
04-06-2025
- Business
- Time of India
Samantha Ruth Prabhu faces backlash over supplement promotion from The Liver Doc
is once again in the eye of a social media storm, facing sharp criticism from Dr. Cyriac Abby Philips, popularly known as The Liver Doc. Recently, the doctor took to Instagram to call out the actress for promoting a supplement brand that claims to contain NMN (Nicotinamide Mononucleotide). Tired of too many ads? go ad free now Samantha had posted that as we age, NAD+ levels decline, leading to lower energy, slower recovery, and reduced focus, and suggested that NMN supplementation could reverse these effects. The Liver Doc calls out the actress for spreading misinformation However, The Liver Doc was quick to respond, accusing Samantha of spreading misinformation and branding her as 'science illiterate.' He strongly condemned her promotion of what he called 'fraud' supplements, warning the public to be wary of celebrities endorsing products without credible scientific backing. His Instagram post urged followers to avoid falling prey to such 'snake oil' salespeople and to trust only evidence-based medical advice from qualified doctors. Samantha defends her brand Interestingly, Samantha is not just promoting the supplement but is also a co-founder of the brand. She had expressed her belief in the brand's mission, emphasizing that it's about 'showing up for your future' and not seeking shortcuts. Samantha assured her followers that her brand products undergo rigorous third-party testing for heavy metals and microbial contamination, aiming to offer clean and science-driven supplements designed for longevity and performance. This is not the first clash between Samantha and The Liver Doc While Samantha has not publicly responded to Dr. Philips' recent criticism, this is not the first time they have clashed. Last year, The Liver Doc had also labeled her a 'fraud' for recommending hydrogen peroxide nebulisation. The ongoing back-and-forth highlights the contentious debate surrounding celebrity endorsements in the wellness space and the need for informed consumer choices.
