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Associated Press
5 days ago
- Business
- Associated Press
RESCUE-II Study Results Demonstrate Safety and Feasibility of the BASHIR™ Endovascular Catheter (BEC) in Treating Pulmonary Embolism (PE) On-The-Table (OTT)
New Britain, PA June 25, 2025 --( )-- NeThrombolex, Inc., a medical device manufacturer committed to advancing solutions for the treatment of arterial and venous thromboembolic diseases, announced the publication of the results from the RESCUE-II Study in JACC: Advances. The RESCUE-II Study was a single-center, prospective study evaluating the safety and feasibility of OTT pharmaco-mechanical lysis (PML) without postprocedural infusion when treating patients with acute intermediate-risk PE. 9 patients were enrolled and successfully treated with low dose r-tPA (4mg per pulmonary artery) using the BEC. At 48 hours, the mean RV/LV ratio decreased by 22.3%, and pulmonary artery obstruction, as measured by the Refined Modified Miller Index, was reduced by 29.2%. There were no major bleeding events, no deaths or serious adverse events through 30-day follow-up. 'This marks a significant milestone for our Company, as we are proud to contribute high quality evidence to the field and remain committed to advancing innovative treatments.' said Michael Cerminaro, President & CEO of Thrombolex. 'We would like to thank Senator Steve Santarsiero and the Department of Community and Economic Development of the Commonwealth of PA for their grant funding support of this important clinical research.' 'The RESCUE-II Study demonstrated encouraging safety and feasibility, while reinforcing the clinical value of this novel OTT protocol,' said, Dr. Vlad Lakhter, IC at Temple University Hospital. 'These results warrant further investigation in larger, multicenter trials like the RAPID-PE Study, which is currently enrolling patients.' An independent data safety monitoring board adjudicated all clinical events for the RESCUE-II Study, while imaging data was assessed by an independent Core laboratory. The publication is available online in JACC: Advances: About Thrombolex, Inc. Founded in 2016, Thrombolex is engaged in the design, development, and distribution of innovative endovascular catheters used in interventional procedures, particularly in pharmaco-mechanical lysis (PML) in patients who suffer from arterial and venous thromboembolic conditions. The Company is currently marketing eight (8) different FDA-cleared devices that are all based on the BASHIR™ Endovascular Catheter platform technology. For general inquiries, please contact Thrombolex at [email protected] or for more information about Thrombolex and its solutions, visit Contact Information: Thrombolex, Inc. Tony Litwiller (704) 408-0927 Contact via Email Read the full story here: RESCUE-II Study Results Demonstrate Safety and Feasibility of the BASHIR™ Endovascular Catheter (BEC) in Treating Pulmonary Embolism (PE) On-The-Table (OTT) Press Release Distributed by
Yahoo
14-06-2025
- Science
- Yahoo
Yikes: We Just Crossed a Planetary Boundary 66 Million Years in the Making
Here's what you'll learn when you read this story: Planetary boundaries outline how far past pre-industrial conditions Earth can get before anthropogenic activity has detrimental effects on the environment. While we have been dangerously close to the ocean acidity boundary for some time, it is now being breached, and the shells of some organisms are dissolving because of chemical reactions that deprive them of calcium carbonate. The boundary for ocean acidity was originally at 20% post-industrial, but researchers have now moved it back to 10% as a call to action before entire ecosystems start to disappear. When the asteroid that triggered the end-Cretaceous Mass Extinction crashed to Earth (and decimated the dinosaurs), it hit rocks that released sulfur and caused pH levels in the oceans to plummet. Ocean acidity levels became intolerable and led to more than half of all marine life dying out. 66 million years later, it's happening again. This time, there is no asteroid—just us humans. Anthropogenic activity such as deforestation and the burning of fossil fuels has released enormous amounts of emissions, primarily in the form of carbon dioxide. That CO2 has caused ocean pH levels to fall off a cliff and has lead to a 30% increase in acidity, which underwater habitats ranging from coral reefs to the deep ocean. The planetary boundary for ocean acidification—the limit of what Earth can tolerate before the onset of destructive consequences—is a 20% drop in the concentration of calcium carbonate (a common base often found in things like limestone and seashells) from pre-industrialization levels. It was already looming by 2020, but until recently, we had not breached. Now, however, researchers at the UK's Plymouth Marine Laboratory (PML) are nervous. In an effort led by biological oceanographer Helen Findlay (who is also Chair off the North East Atlantic Acidification Hub and an Executive Council Member for the Global Ocean Acidification Observing Network), experts found that the ocean acidification boundary had already been crossed by as much as 60% of subsurface ocean waters located 200 meters (about 656 feet) below the surface. 'The planetary boundaries assessment defines nine large scale Earth-system processes and associated boundaries that, if crossed, could generate unacceptable environmental change,' Findlay and her team said in a study recently published in the journal Global Change Biology. Creatures that make their own shells through calcification rely on calcium and carbonate molecules already floating around in the ocean. Too much carbon dioxide can throw off this process. When CO2 is absorbed by seawater, it reacts with water molecules to form carbonic acid (H2CO3), which easily breaks apart into hydrogen (H+) ions and bicarbonate (HCO3-) ions. The lonely hydrogen ions lower the pH of water, and the bicarbonate ions bring their own problems. Species that make their own shells need carbonate ions (CO32-) to bond to calcium, but they can't access them if they're already locked up in bicarbonates. So, as the amount of CO2 in the ocean goes up, the number of available carbonate ions gos down, and the organisms end up in a sticky spot. And the problems don't stop there. As rising temperatures heat up the ocean, warmer oceans hold less oxygen. This warmer water is more buoyant and does not mix as well with deeper, colder and more oxygenated water, so the shorter supply is used up faster. More oxygen breathed in than replenished leads to a deficit of oxygen known as hypoxia. Less oxygen means calcifying organisms have to use more energy to build and maintain their shells, the additional exposure to conditions with low oxygen can be even more dangerous for them. Low enough pH levels can cause shells and exoskeletons to actually dissolve, which is what led Findlay to suggest that the boundary of 20% less calcium carbonate (than existed in pre-industrial times) should be reset to 10%. This adjustment should give the ocean life affected a chance to recover and flourish again. And if carbon emissions continue to rise, thing will continue to look bleaker and bleaker for marine life. A separate but alarming NOAA experiment showed that some species of pteropods—tiny mollusks (also known as sea butterflies for the wing-like appendages they use to swim) that produce their own shells—could soon find themselves unable to maintain the shells they need to survive. In the study, researchers placed pteropod shells in water with carbonate levels adjusted to reflect projected carbonate levels for the year 2100. The shells dissolved after only 45 days. And even in today's oceans, pteropod shells off the coast of Antarctica have already been found to be dissolving. It might seem inconsequential for such small creatures to vanish, but the reality is that pteropods—along with other organisms considered zooplankton—form the base of an extensive food web that could suffer immensely if disrupted. Organisms that do not calcify will feel the effects of ocean acidification in other ways. If there is a significant enough change in ocean chemistry, for example, it will become difficult for some species of fish to detect predators. Findlay also found that the polar oceans have experienced the most significant change at the surface level, but the most unnerving shifts in the subsurface have happened in low-latitude and subpolar regions. If deep-water corals are not able to build exoskeletons, entire ecosystems that depend on them for food and shelter could be wiped out. And ecosystem loss could lead to entire populations ending up isolated in smaller areas where they are more vulnerable to dying out. 'The main advancement lies in shifting from an assessment based primarily on the changing chemistry to a more holistic approach that considers uncertainties, regional variations, subsurface impacts and the biological consequences of exceeding the boundary,' she said. There may be no extinction-level asteroid headed for Earth anytime soon, but if carbon emissions continue at the current rate, we could be creating a lethal asteroid effect of our own. You Might Also Like The Do's and Don'ts of Using Painter's Tape The Best Portable BBQ Grills for Cooking Anywhere Can a Smart Watch Prolong Your Life?
Borneo Post
13-06-2025
- Sport
- Borneo Post
Badudun Fest, Limbang Buffalo Race 2025 all set for October staging
(From left) Dr Abdul Rahman being briefed by Mohamad on preparations for this year's Badudun Festival and annual buffalo race, to take place at Kampung Lubuk Piasau this October. LIMBANG (June 14): The Badudun Festival and Buffalo Race 2025, another major activity listed on the Sarawak Tourism Calendar, will be held here this Oct 24 to 26 An iconic event for more than 30,000 Malays in northern Sarawak, it has been organised and run by the Limbang Malay Association (PML) since 2012 and for this year, the venue will be held at Kampung Lubuk Piasau here. Deputy Minister of Food Industry, Commodities and Regional Development Sarawak Datuk Dr Abdul Rahman Ismail, accompanied by PML chairman Mohamad Abu Bakar, visited the sites of the festival and buffalo race yesterday. 'The visits are meant to ensure that preparations can be made as well as possible, and we will do our best to ensure that the sites are in good condition,' said Dr Abdul Rahman, the assemblyman for Bukit Kota. Badudun, which literally means 'visiting', covers the 14 Malay villages along the Limbang River. Badudun Festival Buffalo Race limbang
Yahoo
13-06-2025
- Science
- Yahoo
New study claims the world's oceans are a ‘ticking time bomb'
If you purchase an independently reviewed product or service through a link on our website, BGR may receive an affiliate commission. Our oceans are struggling. From bleaching in the coral reefs to increasing temperatures and rising sea levels, they've seen better days. To make matters worse, researchers now say our oceans may actually be a 'ticking time bomb' due to ocean acidification. Until recently, researchers have claimed that the acidity of the ocean had not crossed the 'planetary boundary.' However, a new study published by researchers at the UK's Plymouth Marine Laboratory (PML), the National Oceanic and Atmospheric Administration (NOAA) and Oregon State University's Co-operative Institute for Marine Resources Studies says that the boundary was reached five years ago. Today's Top Deals Best deals: Tech, laptops, TVs, and more sales Best Ring Video Doorbell deals Memorial Day security camera deals: Reolink's unbeatable sale has prices from $29.98 The reason that researchers say that the ocean's acidification is a ticking time bomb is because it will eventually cause irreparable damage to marine ecosystems and coastal economies. The study looked in-depth at data and determined that the deeper they looked into the ocean, the worse the findings were. In fact, they found that in some cases, the average ocean condition was already very close to or even beyond the planetary boundary for acidification. At just 200 meters below the surface (roughly 656 feet), 60% of the global oceans had already breached what is considered the 'safe' limit for acidification. These findings are just the latest in a long list of growing signs that the oceans are struggling in our ongoing fight against climate change. Other research has found that 21% of the ocean is losing access to sunlight, and parts of the ocean are warming 400% faster than they should. The only way to decrease the acidity in the ocean, the researchers claim, is to lower CO2 emissions. While many countries have been working on that, with Trump's administration making massive changes to the EPA and how it views carbon emissions, it's unlikely we'll see any meaningful change any time soon. Still, we can hold out hope that we'll eventually get this under control. Or, at the least, we'll finally figure out that trusting scientists is smarter than ignoring their warnings. More Top Deals Amazon gift card deals, offers & coupons 2025: Get $2,000+ free See the
Yahoo
09-06-2025
- Science
- Yahoo
‘Ticking time bomb': Ocean acidity crosses vital threshold, study finds
The deep oceans have crossed a crucial boundary that threatens their ability to provide the surface with food and oxygen, a new study finds. Nearly two-thirds of the ocean below 200 meters, or 656 feet, as well as nearly half of that above, have breached 'safe' levels of acidity, according to findings published on Monday in Global Change Biology. The fall in ocean pH is 'a ticking time bomb for marine ecosystems and coastal economies,' Steve Widdicombe, director of science at the United Kingdom's Plymouth Marine Laboratory (PML), said in a statement. The study was funded in part by the National Oceanographic and Atmospheric Administration (NOAA), a federal agency that has been targeted for steep cuts by the Trump White House, in large part because of its role in investigating climate change. Some of the biggest changes in deep water are happening off the coast of western North America, home to extensive crab and salmon fisheries, the study found. The core problem is one scientists have warned about for a long time: the continued global burning of fossil fuels, which releases carbon dioxide — an acid when dissolved in water — is making the seas and oceans more acidic. Or, technically, it's making them less basic, which is to say: Less hospitable to species such as corals and clams that form the foundation of the ocean's ecosystem. 'Most ocean life doesn't just live at the surface — the waters below are home to many more different types of plants and animals,' lead author Helen Findlay of PML. 'Since these deeper waters are changing so much, the impacts of ocean acidification could be far worse than we thought.' As of five years ago, Findlay's study noted, the oceans may have crossed a critical threshold in which oceanic levels of calcium carbonate — the main ingredient in limestones, and also the shells of those animals — fell to more than 20 percent below pre-industrial levels. If true, that shift would mean the Earth has passed seven out of nine of the critical 'planetary boundaries' needed to maintain its ecosystem, as the Potsdam Institute for Climate Impact Research found last year. That shift, Widdicombe of the Marine Lab said, means 'we're witnessing the loss of critical habitats that countless marine species depend on.' 'From the coral reefs that support tourism to the shellfish industries that sustain coastal communities,' he added, 'we're gambling with both biodiversity and billions in economic value every day that action is delayed.' The further implications are even more serious. The reasons for the ocean's rise in acid, or fall in base, is that its waters have absorbed about one-third of all the carbon dioxide released by surface burning of coal, oil and gas. But the more carbon dioxide it absorbs, the lower its ability to absorb more — meaning faster warming on the surface. Making that dynamic even more dramatic, seas and oceans have also absorbed 90 percent of the global heating that the Earth's surface would have otherwise experienced, according to NASA. In addition to absorbing heat and carbon dioxide, the ocean also provides 50 percent of the Earth's oxygen — which comes from the very marine ecosystems that warming and acidification are threatening. Ecosystem loss and fossil fuel burning mean that levels of oxygen below the surface are decreasing, as, more slowly, is oxygen above the surface. —Updated at 12:37 p.m. EDT Copyright 2025 Nexstar Media, Inc. All rights reserved. This material may not be published, broadcast, rewritten, or redistributed.
